• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.552-557
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• 2008

This paper introduces to schematic design for Korea Institute of Toxicology Second Campus at Jeong-eup and provides fundamental information and data in order to design this laboratory facility to meet the criteria of G.L.P(Good Laboratory Practice), AAALAC(Association for Assessment and Accreditation of Laboratory Animal Care) and so on. This paper especially focus on design criteria, HVAC(Heating Ventilating and Air Conditioning) equipment and systems, plumbing equipment and systems, maintenance of equipment and systems and energy saving system of this laboratory facility.

• Journal of Technologic Dentistry
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• v.37 no.3
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• pp.131-144
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• 2015

Purpose: This study set out to propose plans for more efficient and effective clinical practice by investigating the current state of clinical practice in the field of dental technology and thus provide basic data to develop pre- and post-education programs for clinical practice. Methods: The subjects include dental technicians at dental technical laboratories that were appointed as the place of clinical practice by the Department of Dental Technology of G University. The survey period spanned from December 22, 2014 to January 20, 2015. Total 250 questionnaires were distributed to them, and 190(76.0%) were returned. After excluding 23 whose answers were uncertain or seemed to lack reliability, total 167(66.8%) were used in final analysis. Results: 1. The most frequent practice the student did during clinical practice was articulator attachment, which was followed by pin operation or model making, one's own task and practice, sand and crow sculpturing, burying, casting, and grinding. 2. In case of going through the entire process, porcelain had the most students at 39(23.4%), being followed by crown & bridge at 28(16.8%), clinical model at 23(13.8%), full denture at 17(10.2%), and partial denture at 17(10.2%) in the order. 3. Of the students, 59.8%(30.5% for reinforced basic practice; 29.3% for intensive practice education) said that intensive practice education should be reinforced in school; and 22.3% said that intensive theory and practice education was needed, which indicates that 82.6% voiced their opinion of reinforcing education around practice. 4. The students felt that they lacked diligence, passion, and theoretical knowledge somewhat and were relatively good at clinical adaptation and operational skills. Conclusion: The findings show that the students felt an absolute lack of practice education as the school education was focused on theory and national exams in the field of dental technology, thus raising a need to reinforce practice education. Of all the respondents, 62.9% said there was a need to improve the current education with a focus on jobs. In future, education of dental technology should work to bring up able dental technicians that can perform in clinical dental technology right after graduation by reinforcing job-based practice education.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.13 no.2
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• pp.13-24
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• 2004

In everyday dental practice, one of the most important procedures is fixed prosthodontics which includes gold and ceramic restorative treatments. This procedure can be divided into tooth preparation, impression taking, laboratory work, occlusal adjustment and cementation. The first step is tooth preparation and it needs not only good techniques but also deep knowledge and understanding of oral biology. Also, there must be good knowledge of the principles and materials of the procedure. The patient's satisfaction can be achieved from natural contour, good shade, and precise margin fit, especially in ceramic restorations on anterior regions. It is essential to fastidiously prepare the tooth to make aesthetic restorations with a good margin fit. Tooth preparation techniques and three case reports of ceramic restorations on the anterior region are presented and discussed in this paper.

• The korean journal of orthodontics
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• v.19 no.2
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• pp.155-163
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• 1989

Indirect bonding is done by placing the brackets on a model in the laboratory and using a template or tray to transfer the laboratory positioning to the teeth. The advantages of this technique are 1. decreased chair time 2. less patient discomfort 3. accuracy of a attachment placement 4. good adaptation of attachment to tooth contour 5. occlusal relationship of brackets and opposing teeth can be checked The disadvantages of the technique are 1. complex laboratory procedure 2. sometimes difficult on very short clinical crowns 3. teeth with crowns, large buccal restoration will not bond 4. may not be fitted close, if poor adaptation 5. likely to be disturbed setting Several indirect bonding techniques have proved reliable in clinical practice. However, they differ in the way the brackets are attached temporarily to the model, the type of transfer tray or other mechanism used, the adhesive or sealant employed, whether segmented or full bonding used, and the way the transfer is removed so as not to exert excessive force on a still maturing bond.

• Geomechanics and Engineering
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• v.23 no.5
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• pp.431-439
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• 2020

Soil-water retention curve (SWRC) contains key information for the application of unsaturated soil mechanics principles to engineering practice. The SWRC variables are commonly used to describe the hydro-mechanics of soils. Generally, these parameters are determined using the graphical method which can be time consuming. The SWRC is highly dependent on the pore size distribution (PSD). Theoretically, the PSD obtained by mercury intrusion porosimetry test can be used to determine some SWRC variables. Moreover, the relationship between SWRC and shrinkage curve has been investigated. A new method to determine total SWRC variables directly without curve-fitting procedure is proposed. Substituting the variables into linear SWRC equations construct SWRC. A good agreement was obtained between predicted and measured SWRCs, indicating the validity of the proposed method for unimodal SWRC.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.406-408
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• 2012

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.22-24
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• 2003

This presentation briefly will be introduced on new drug approval process and the review of safety and efficacy of drugs in Korea. First, we will present the regulation related to new drug registration [Regulation of the Efficacy and Safety Evaluation of Drugs, etc (Notification No. 2003-17), Standards for Toxicity Test of Drugs, etc(Notification 1999-61) and GLP Regulation for Nonclinical Laboratory Studies (Notification No. 2000-63)] and the regulation related to clinical trial [Guidelines to Clinical Study Authorization for Drugs (Notification No. 2002-65)] and [Korean Good Clinical Practice(KGCP, Notification No. 1999-67) Regulation]. (omitted)

• Journal of Technologic Dentistry
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• v.11 no.1
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• pp.23-34
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• 1989

The great sudenn change of circle of dental laboratory technology brought mary discord between the new growing environmental group and the old group, In order to know the satisfactory degree of dental laboratory heads about all dental College, This Study was conducted for 49 detal technicians who graduated from junior laboratory heads in Seoul and Kyoung Gi area. The results are abtained as follow- 1. By age The degree of Satisfaction of items about all graduate dental technician were "41$\sim$45 age" group 26.53%), "46$\sim$50 age" group 22.45%, "36$\sim$40 age" group 18.36%, "31$\sim$35 age" group 12.24%, "51$\sim$55 age" group and "56$\sim$60 age" group 8.16% 60$\sim$age group 4.08% in order. 2. By Job Career. The Highest degree item out of Satisfaction about all graduated dental dental technician was 21$\sim$25 years group 28.5%, 16$\sim$20 years 20.4%, 11$\sim$15 years group 12.24%, 26$\sim$20%, 6$\sim$10 years group 4.08%, below 5 years group 2.04% in order. 3. By managing term of respondent's dental laboratory. The Satisfactory degree of items about all gradate technician were 7$\sim$10 years group 36.73% over 15 years group 22.45%, 11$\sim$14 years group 20.41%, 3$\sim$6 years group 14.29% below 2 years group 6.12% in order 4. By dental technician number of respondent's dental laboratory. The satisfactory degree intems about man were as follow; 6$\sim$9 persons group is 42.86 % The Satisfactory degree items about woman were one persons group in 34.69% 5. By born place The dental laboratory heads mean of inters about all dental technician were Seoul group 20.64 %, Kyoung Gi 17.20 %, Jen Nam group 14.99 % Chung Nam 9.5%in order 6. The satisfactory degree of items about all graduate dental technician were neither good nor bad group 32.65%, bad 6.12%, By ability of adaptaton, The satisfactory degree items about man were neither good nor bad group 42.86%, bad group 40.82%. The satisfactory degree of items about woman were neither good nor bad group 40.82% bad group 36.73%. 7. By sincerity. The satisfactory degree of items about man dental technician who graduated from Junior College were neither good nor bad group 52.02%, bad group 4.08, The satisfactory degree about woman dental technician graduated from Junior College were neither good nor bad group 42.86%, bad group 6.12%. 8. By ability of basical of items about man were bad group 40.82 %. The satisfactory degree about woman were 46.94%. 9. By cooperation relation ship. The satisfactory degree of items about man were neither good nor bad group 42.86%, bad group 10.20%. The satisfactory degree about woman were neither good nor bad group 42.86%, bad group 10.20 %. 10. By ability of work. The satisfactory degree of items about man were neither good nor bad group 48.98%, bad group 4.08%. The satisfactory degree about woman were neither good nor bad group 42.86%, bad group 6.12 %. 11. By the curriculum of the dental technician. The satisfactory degree of items about man were neither good nor bad group 67.35%, bad group 2.04%, The satisfactory degree about woman were neither good nor bad group 61.22%, bad group 6.12%. 12. By occupational satisfaction. The satisfactory degree of items about all graduate dental technician were fatisfied group 14.29%. By the out look of employment. The satisfactory degree of items about man greduate dental technician were neither good nor bad group 34.69 %, bad group 10.20%, about woman graduate dental technician were neither good nor bad group 44.90%, bad group 10.20%, Their employment prospect is not so bright or oprimistic due to the glut supply by graduates in the job-seeking market 13. The satisfactory rate on the artificial dental manufacturing world in terms of effects produced by juror College graduate dental technicians shared good group 40.82% bad group 2.04% 14. By cognition of the number of graduate dental technician. The satisfactory degree of dental laboratory heads about man graduate dental technician were too many group 38.78%, few group 6.12% about woman graduated dental technician were neither good nor bad group 30.6% few group 10,20%, The employment opportunities for the artifical dental technicians are getting decreased because of their excessive cumber in supply 15. The opinion regarding the initial salary. ranging from \160,000 to \200,000 for the junior college graduate dental technicians shared 57.14%. The top ratio, while the satisfaction reate on the academic study period of "3-year" group shared 22%, also the top ratio. 16. The improvement policy and prblematic issues presonted by the owner and operatore of atriticial dental manufacturing plants are as shown below First; The viewpoint that they contribute to the improvement of people's oral health in terms of their mission as artificial dental technicians. Second: The cultivation of basic technical ability to cope with clinical practice upon graduation Third; They require guidance in study and research in their filed of profession, that tray may beable to estaclish a from theory.

• Safety and Health at Work
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• v.2 no.1
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• pp.34-38
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• 2011

Objectives: The antimicrobial activity of silver nanoparticles has resulted in their widespread use in many consumer products. Yet, despite their many advantages, it is also important to determine whether silver nanoparticles may represent a hazard to the environment and human health. Methods: Thus, to evaluate the genotoxic potential of silver nanoparticles, in vivo genotoxicity testing (OECD 474, in vivo micronuclei test) was conducted after exposing male and female Sprague-Dawley rats to silver nanoparticles by inhalation for 90 days according to OECD test guideline 413 (Subchronic Inhalation Toxicity: 90 Day Study) with a good laboratory practice system. The rats were exposed to silver nanoparticles (18 nm diameter) at concentrations of $0.7\;{\times}\;10^6$ particles/$cm^3$ (low dose), $1.4\;{\times}\;10^6$ particles/$cm^3$ (middle dose), and $2.9\;{\times}\;10^6$ particles/$cm^3$ (high dose) for 6 hr/day in an inhalation chamber for 90 days. The rats were killed 24 hr after the last administration, then the femurs were removed and the bone marrow collected and evaluated for micronucleus induction. Results: There were no statistically significant differences in the micronucleated polychromatic erythrocytes or in the ratio of polychromatic erythrocytes among the total erythrocytes after silver nanoparticle exposure when compared with the control. Conclusion: The present results suggest that exposure to silver nanoparticles by inhalation for 90 days does not induce genetic toxicity in male and female rat bone marrow in vivo.

• Toxicological Research
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• v.28 no.4
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• pp.225-233
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• 2012

The present study was carried out to examine the toxicity and target organs of oral cholera vaccine (OCV) after repeated oral administration in Sprague-Dawley rats for 6 weeks (3 administrations, once every 2 weeks). OCV is an inactivated oral cholera vaccine that contains Vibrio cholerae and confers protection against cholera caused by V. cholera serogroups O1 (Inaba and Ogawa serotypes) and O139 (strain 4260B). The animals were orally administered either OCV placebo (negative control) or OCV at a dose equivalent to 240 times the anticipated human dose. Throughout the administration period, no significant change was detected in clinical signs, body weight, food or water consumption, urinalysis results, hematological and clinical biochemistry test results, organ weights, necropsy, or histopathological examination results. Minor changes were found in hematological and clinical biochemistry tests; however, these changes were within normal ranges. The above results suggest that oral administration of OCV in rats did not induce any toxicologically meaningful changes, and the target organs could not be determined. This study was conducted in accordance with the guidelines established by Good Laboratory Practice (2009-183, KFDA, December 22, 2009) and the OECD Principles of Good Laboratory Practice (1997).