• Title/Summary/Keyword: Gompertz modeling

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Application of Optimized Gompertz Algorithm for Estimation of Controlled Drug Release (Gompertz modeling을 이용한 약물유출 예측시스템의 최적화)

  • Choe, Se-Woon;Woo, Young Woon
    • Journal of the Korea Society of Computer and Information
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    • v.19 no.12
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    • pp.219-225
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    • 2014
  • A Gompertz modeling, sigmoid in shape, is a widely used application for social science, natural science, engineering, and medical research to allow confident approximation and accurate analysis and has been applied to estimate an elderly population on aging of population. Due to the high toxicity of currently available drug delivery vehicles, various efforts have been made to reduce side-effects in clinical fields, but its application to preclinical and clinical studies is limited and there are some difficulties to optimize the parameters of Gompertz modeling applicable to preclinical studies. Therefore, in this study, we demonstrated the ability of sickle red blood cells loaded by hypotonic dialysis then photosensitized and light-activated ex vivo for controlled release and simultaneously optimized Gompertz function to evaluate controlled drug release properties of photosensitized sickle red blood cells to reduce pain-related treatments in cancer patients.

Modeling Growth of Canopy Heights and Stem Diameters in Soybeans at Different Groundwater Level (지하 수위가 다른 조건에서 콩의 초장과 경태 모델링)

  • Choi, Jin-Young;Kim, Dong-Hyun;Kwon, Soon-Hong;Choi, Won-Sik;Kim, Jong-Soon
    • Journal of the Korean Society of Industry Convergence
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    • v.20 no.5
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    • pp.395-404
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    • 2017
  • Cultivating soybeans in rice paddy field reduces labor costs and increases the yield. Soybeans, however, are highly susceptible to excessive soil water in paddy field. Controlled drainage system can adjust groundwater level (GWL) and control soil moisture content, resulting in improvement soil environments for optimum crop growth. The objective of this study was to fit the soybean growth data (canopy height and stem diameter) using Gompertz model and Logistic model at different GWL and validate those models. The soybean, Daewon cultivar, was grown on the lysimeters controlled GWL (20cm and 40cm). The soil textures were silt loam and sandy loam. The canopy height and stem diameter were measured from the 20th days after seeding until harvest. The Gompertz and Logistic models were fitted with the growth data and each growth rate and maximum growth value was estimated. At the canopy height, the $R_2$ and RMSE were 0.99 and 1.58 in Gompertz model and 0.99 and 1.33 in Logistic model, respectively. The large discrepancy was shown in full maturity stage (R8), where plants have shed substantial amount of leaves. Regardless of soil texture, the maximum growth values at 40cm GWL were greater than the value at 20cm GWL. The growth rates were larger at silt loam. At the stem diameter, the $R_2$ and RMSE were 0.96 and 0.27 in Gompertz model and 0.96 and 0.26 in Logistic model, respectively. Unlike the canopy height, the stem diameter in R8 stage didn't decrease significantly. At both GWLs, the maximum growth values and the growth rates at silt loam were all larger than the values at sandy loam. In conclusion, Gompertz model and Logistic model both well fit the canopy heights and stem diameters of soybeans. These growth models can provide invaluable information for the development of precision water management system.

Modeling Exponential Growth in Population using Logistic, Gompertz and ARIMA Model: An Application on New Cases of COVID-19 in Pakistan

  • Omar, Zara;Tareen, Ahsan
    • International Journal of Computer Science & Network Security
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    • v.21 no.1
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    • pp.192-200
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    • 2021
  • In the mid of the December 2019, the virus has been started to spread from China namely Corona virus. It causes fatalities globally and WHO has been declared as pandemic in the whole world. There are different methods which can fit such types of values which obtain peak and get flattened by the time. The main aim of the paper is to find the best or nearly appropriate modeling of such data. The three different models has been deployed for the fitting of the data of Coronavirus confirmed patients in Pakistan till the date of 20th November 2020. In this paper, we have conducted analysis based on data obtained from National Institute of Health (NIH) Islamabad and produced a forecast of COVID-19 confirmed cases as well as the number of deaths and recoveries in Pakistan using the Logistic model, Gompertz model and Auto-Regressive Integrated Moving Average Model (ARIMA) model. The fitted models revealed high exponential growth in the number of confirmed cases, deaths and recoveries in Pakistan.

A Study on Modeling and Forecasting of Mobile Phone Sales Trends (이동통신 단말기 판매 추이에 대한 모형 및 수요예측에 관한 연구)

  • Kim, Min-Jeong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.6
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    • pp.157-165
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    • 2016
  • Among high-tech products, the mobile phone has experienced a rapid rate of innovation and a shortening of its product life cycle. The shortened product life cycle poses major challenges to those involved in the creation of forecasting methods fundamental to strategic management and planning systems. This study examined whether the best model applies to the entire diffusion life span of a mobile phone. Mobile phone sales data from a specific mobile service provider in Korea from March of 2013 to August of 2014 were analyzed to compare the performance of two S-shaped diffusion models and two non-linear regression models, the Gompertz, logistic, Michaelis-Menten, and logarithmic models. The experimental results indicated that the logistic model outperforms the other three models over the fitted region of the diffusion. For forecasting, the logistic model outperformed the Gompertz model for the period prior to diffusion saturation, whereas the Gompertz model was superior after saturation approaches. This analysis may help those estimate the potential mobile phone market size and perform inventory and order management of mobile phones.

Modeling for Prediction of Potato Late Blight (Phytophthora infestans) (감자역병 진전도 예측모형 작성)

  • 안재훈;함영일;신관용
    • Korean Journal Plant Pathology
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    • v.14 no.4
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    • pp.331-338
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    • 1998
  • To develop the model for prediction of potato late blight progress, the relationship between severity index of potato late blight transformed by the logit and Gompit transformation function and cumulative severity value (CSV) processing weather data during growing period in Taegwallyeong alpine area, 1975 to 1992 were examined. When logistic model and Gompertz model were compared by determining goodness of fit for progressive degree of late blight using CSV as independent variable, the coefficients of determination were higher as 0.742 in the logistic model than 0.680 in the Gompertz model. Parameters in logistic model were composed of progressive rate and initial value of logistic model. Initial value was calculated in -3.664. The progressive rate of potato late blight was 0.137 in cv. Superior, 0.136 in cv. Irish Cobbler, and 0.070 in cv. Jopung without fungicide sprays. According to in crease of the number of spray times the progressive rate was lowered, was 0.020 in cv. Superior under the conventional program of fungicide sprays, 10 times sprays during cropping season. Equation of progressive rate, b1=0.0088 ACSV-0.033 (R2=0.976), was written by examining the relationship between the parameters of progressive rate of late blight and the average CSV (ACSV) quantifing weather information. By estimating parameters of logistic function, model able to describe the late blight progress of potato, cv. Superior was formulated in Y=4/(1+39.0·exp((0.0088 ACSV-0.033)·CSV).

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Modeling for Prediction of the Turnip Mosaic Virus (TuMV) Progress of Chinese Cabbage (배추 순무모자이크바이러스(TuMV)병 진전도 예측모형식 작성)

  • 안재훈;함영일
    • Korean Journal Plant Pathology
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    • v.14 no.2
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    • pp.150-156
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    • 1998
  • To develop a model for prediction of turnip mosaic virus(TuMV) disease progress of Chinese cabbage based on weather information and number of TuMV vector aphids trapped in Taegwallyeong alpine area, data were statistically processed together. As the variables influenced on TuMV disease progress, cumulative portion(CPT) above 13$^{\circ}C$ in daily average temperature was the most significant, and solar radiation, duration of sunshine, vector aphids and cumulative temperature above $0^{\circ}C$ were significant. When logistic model and Gompertz model were compared by detemining goodness of fit for TuMV disease progress using CPT as independent variable, regression coefficient was higher in the logistic model than in the Gompertz model. Epidemic parameters, apparent infection rate and initial value of logistic model, were estimated by examining the relationship between disease proportion linearized by logit transformation equation, In(Y/Yf-Y) and CPT. Models able to describe the progression of TuMV disease were formulated in Y=100/(1+128.4 exp(-0.013.CPT.(-1(1/(1+66.7.exp(-0.11.day). Calculated disease progress from the model was in good agreement with investigated actual disease progress showing high significance of the coefficient of determination with 0.710.

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Comparative Study on Growth Patterns of 25 Commercial Strains of Korean Native Chicken

  • Manjula, Prabuddha;Park, Hee-Bok;Yoo, Jaehong;Wickramasuriya, Samiru;Seo, Dong-Won;Choi, Nu-Ri;Kim, Chong Dae;Kang, Bo-Seok;Oh, Ki-Seok;Sohn, Sea-Hwan;Heo, Jung-Min;Lee, Jun-Heon
    • Korean Journal of Poultry Science
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    • v.43 no.1
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    • pp.1-14
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    • 2016
  • Prediction of growth patterns of commercial chicken strains is important. It can provide visual assessment of growth as function of time and prediction body weight (BW) at a specific age. The aim of current study is to compare the three nonlinear functions (i.e., Logistic, Gompertz, and von Betalanffy) for modeling the growth of twenty five commercial Korean native chicken (KNC) strains reared under a battery cage system until 32 weeks of age and to evaluate the three models with regard to their ability to describe the relationship between BW and age. A clear difference in growth pattern among 25 strains were observed and classified in to the groups according to their growth patterns. The highest and lowest estimated values for asymptotic body weight (C) for 3H and 5W were given by von Bertalanffy and Logistic model 4629.7 g for 2197.8 g respectively. The highest estimated parameter for maturating rate (b) was given by Logistic model 0.249 corresponds to the 2F and lowest in von Bertalanffy model 0.094 for 4Y. According to the coefficient of determination ($R^2$) and mean square of error (MSE), Gompertz and von Bertalanffy models were suitable to describe the growth of Korean native chicken. Moreover, von Bertalannfy model was well described the most of KNC growth with biologically meaningful parameter compared to Gompertz model.

A Flexible Statistical Growth Model for Describing Plant Disease Progress (식물병(植物病) 진전(進展)의 한 유연적(柔軟的)인 통계적(統計的) 생장(生長) 모델)

  • Kim, Choong-Hoe
    • Korean journal of applied entomology
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    • v.26 no.1 s.70
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    • pp.31-36
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    • 1987
  • A piecewise linear regression model able to describe disease progress curves with simplicity and flexibility was developed in this study. The model divides whole epidemic into several pieces of simple linear regression based on changes in pattern of disease progress in the epidemic and then incorporates the pieces of linear regression into a single mathematical function using indicator variables. When twelve epidemic data obtained from the field experiments were fitted to the piecewise linear regression model, logistic model and Gompertz model to compare statistical fit, goodness of fit was greatly improved with piecewise linear regression compared to other two models. Simplicity, flexibility, accuracy and ease in parameter estimation of the piece-wise linear regression model were described with examples of real epidemic data. The result in this study suggests that piecewise linear regression model is an useful technique for modeling plant disease epidemic.

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Prediction of Seedling Emergence and Early Growth of Eleocharis kuroguwai Ohwi under Evaluated Temperature (상승된 온도 조건에서 올방개(Eleocharis kuroguwai)의 출아 및 초기생장 예측)

  • Kim, Jin-Won;Moon, Byeong-Chul;Lim, Soo-Hyun;Chung, Ji-Hoon;Kim, Do-Soon
    • Korean Journal of Weed Science
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    • v.30 no.2
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    • pp.94-102
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    • 2010
  • Field and pot experiments were conducted to investigate seedling emergence and early growth of Eleocharis kuroguwai panted on different dates. Non-linear regression analyses of observed data against effective accumulated temperature (EAT) with the Gompertz model showed that the Gompertz model works well in describing seedling emergence and early growth of E. kuroguwai regardless of planting date and soil burial depth. EATs required for 50% of the maximum seedling emergence of E. kuroguwai planted at 1, 3 and 5 cm soil burial depth in the pot experiment were estimated to be 54.5, 84.0 and $118.0^{\circ}C$, respectively, and $56.7^{\circ}C$ when planted at 1 cm in the field experiment. EATs required for 50% of the maximum leaf number of E. kuroguwai planted at 1, 3 and 5 cm soil burial depth in the pot experiment were estimated to be 213.3, 249.0 and $291.6^{\circ}C$, respectively, and $239.5^{\circ}C$ when planted at 1 cm in the field experiment. Therefore, models developed in this study thus predicted that if rotary tillage with water is made on 27 May under $+2^{\circ}C$ elevated temperature condition, dates for 50% of the maximum seedling emergence, 5 leaf stage and 5 cm plant height of E. kuroguwai buried at 3 cm soil depth were predicted to be 2 June, 10 June and 12 June. These dates are 1 day earlier for the seedling emergence and 3 days earlier for the early growth as compared with current temperature condition, suggesting that earlier application of herbicides is required for effective control of E. kuroguwai.