• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.111-111
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• 2003

• Proceedings of the Korean Society of Food Hygiene and Safety Conference
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• 2003.11a
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• pp.65-70
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• 2003

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.111-111
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• 2003

Recently, cancer chemoprevention with strategies using foods and medicinal herbs has been regarded as one of the most visible fields for cancer control. The genistein in soy, the American ginseng and the resveratrol in a grape are well known as that has antiproliferative properties in human breast cancer.(omitted)

• Korean Journal of Plant Resources
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• v.36 no.4
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• pp.282-289
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• 2023

Glycyrrhiza korshinskyi Grig. (Gk), which is a new variety of Glycyrrhiza, was developed by the National Institute of Horticultural and Herbal Science in Korea Rural Development Administration. It is improved the limitations of traditional Glycrrhiza species such as G. uralensis Fisch., G. glabra L., and G. inflata Batal. and has been reported various pharmacological effects. The aim of this study is to investigate the protective effect of Gk on the acute pancreatitis, because which has not been revealed yet. AP was induced via intraperitoneal injection of cerulein (50 ㎍/kg) hourly for 7 times in C57BL/6 mice. Gk water extract (20 or 50 mg/kg) or saline was administrated via oral gavage 1 h before the first injection of cerulein. The mice were sacrificed at 5 h after the final injection of cerulein. The inflammatory cell infiltration in pancreatic tissue was decreased by the administration of Gk water extract compared to the AP group. Also, serum amylase and lipase levels were decreased by the administration of Gk water extract compared to the AP group. These results suggest that Gk have protective effect on the acute pancreatitis.