• Animal Bioscience
• /
• 제35권6호
• /
• pp.938-947
• /
• 2022

Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury. Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected. Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver. Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis.

• 대한의용생체공학회:의공학회지
• /
• 제9권1호
• /
• pp.37-46
• /
• 1988

Synthetic biodegradable polymers are of great interest for biomedical applications such as surgical sutures and drug delivery systems. The copolymers of ${alpha}-amino$ acids and ${alpha}-hydroxy$ matrices having the required permeability for drugs. Poly (glycine.co-lactic acid) and poly (glycine-co-glycolic acid) have been synthesized by ring-opening polymerization. Morpholine-2, 5-diane, lactide, and glycolid have been used as starting materials for polydepsipeptides. The synthesized monomers and copoylmers have been identified by NMR and FT-lR spectrophotometer. The thermal properties and glass transition temperatures ($T_g$) of the copolymers have been measured by differential scanning calorimetry. The $T_g$ values of poly (glycine-co-lactic acid) and poly (glycine co.glycolic acid) are increased with increasing mole fraction of morpholine-2, 5-dione in the copolymers.

• Toxicological Research
• /
• 제19권4호
• /
• pp.311-314
• /
• 2003

This study was performed to investigate the effects of glycine on the development of tolerance to and physical dependence on morphine. Repeated administration of morphine (10 mg/kg) developed tolerance and physical dependence. Glycine (100, 200 and 400 mg/kg) was administered intraperitoneally (i.p.) to mice for 7 days prior to the morphine injection. Analgesic effects were estimated by the tail flick methods. The inhibitory degree of the development of morphine-induced analgsic tolerance by i.p. administration of glycine was evidenced by the increase in analgesic response to morphine. Glycine inhibited the development of tolerance to morphine. In addition, we separately measured jumping response as the naloxone-precipitated withdrawal sign in mice that had received the same morphine. Glycine reduced the number of jumping behaviors in morphine dependent mice. These results suggest that glycine might be useful the prevention or treatment of morphine tolerance and physical dependence.

• 한국세라믹학회지
• /
• 제40권1호
• /
• pp.77-80
• /
• 2003

수용액 내에서 질화물 박막의 산화저항성 흡착 피막의 형성을 확인하기 위하여 Si$_3$N$_4$분말 표면의 glycine 흡착 거동을 조사하였다. 염기성분위기에서 glycine은 Si$_3$N$_4$ 분말 표면에 포화 흡착되었으며 이러한 흡착거동은 Si$_3$N$_4$ 박막의 경우에도 동일하게 일어날 것으로 예상되었다. Glycine을 첨가한 CeO$_2$ 슬러리를 제조하고 PH에 따른 Si$_3$N$_4$와 SiO$_2$ 박막의 연마시험을 수행하여 연마율은 감소하고 선택비는 증가하는 것을 확인하였다. 실험에서 얻은 최대 선택비는 pH=12에서 35 이상이었다. 이는 염기성 분위기에서 glycine이 해리하여 막 표면에 화학흡착하고 산화와 용해를 억제함으로써 연마율을 낮추고 선택비 향상에 기여하였기 때문으로 판단된다. 아미노산 계열의 첨가제를 CeO$_2$계 CMP용 슬러리에 적용하는 경우 산화물/질화물 박막의 선택비를 향상시키는데 효과적임을 확인하였다.

• Journal of Animal Science and Technology
• /
• 제47권2호
• /
• pp.205-220
• /
• 2005

This study was conducted to investigate the effect of the addition of glycine betaine to the diet on growth performance in pigs. A total of 400 pigs were divided into 4 feeding stages(Growing I: 23.10 $\pm$ 1.43, Growing II: 37.69$\pm$ 1.62, Finishing I: 66.51 $\pm$3.44 and Finishing II: 90.42$\pm$ 2.17 kg of initial body weight) then each feeding stage was divided into 4 treatment groups(Control: 0 0/0, Tl : 0.2 0/0, T2: 0.4% and T3 : 0.6 % of glycine betaine, respectively). The average daily gain and feed efficiency of T2 and T3 were significantly increased(p< 0.05) by dietary glycine betaine in stage I, 2 and 3. This result indicates that dietary glycine betaine could influence the pig growth performance. In feeding stage 4, the average daily gain and feed efficiency were significantly increased in 0.4% glycine betaine feeding group compared with other dietary groups(p < 0.05). Results suggest that feeding the pigs 0.4 % glycine betaine could be the most efficient dietary level. Crude protein, ether extract and crude ash digestibilities of 0.4% glycine betaine fed group were significantly increased compared with those of control group(p < 0.05). However, no significant difference was found in nutrient digestibilities among glycine betaine fed groups. Apparent faecal amino acid digestibilities of 0.4% glycine betaine fed group were more significantly higher than that of control group. The 0.4% glycine betaine fed group was significantly increased in apparent faecal amino acid digestibility compared with those of other glycine betaine fed group. No significant difference was shown in amount of microflora population between control and glycine betaine fed groups. Ammonia and hydrogen sulfide gas emission were significantly decreased in 0.4% glycine betaine feeding group compared with other dietary groups(p < 0.05).

• Journal of Microbiology and Biotechnology
• /
• 제4권2호
• /
• pp.95-101
• /
• 1994

The effects of glycine on cell growth and L-omithine production were investigated in shake-flask and jar fermentor cultures of a citrulline auxotrophic mutant, Brevibacterium ketoglutamicum BK 1046. In the shake-flask culture, the optimal concentration of glycine for L-ornithine production was found to be 20 g/l. In the jar fermentor culture with the glycine at an initial concentration of 20 g/l, L-ornithine production increased by 28%, compared to that of the culture with no glycine added. 37 g/l of L-ornithine was produced when additional feeding of glycine (5 g/l) was made. This was a significant improvement in L-ornithine production compared to that (ca. 24 g/l) of the corresponding batch culture conducted without glycine. According to the stoichiometric analysis with the batch fermentation results, the experimental and theoretical L-ornithine yields based on the glucose consumption were 0.24 and 0.59, respectively. This indicates that the performance of L-ornithine fermentation can further be improved by the supplementation of glycine and the development of a mutant strain possessing a higher growth yield.

• Food Science and Biotechnology
• /
• 제18권5호
• /
• pp.1180-1185
• /
• 2009

This study was aimed to investigate the effect of glycine supplementation on the growth of Leuconostoc mesenteroides and Lactobacillus plantarum during kimchi fermentation. As preliminary experiment, the effect of supplementation of glycine (0-2.0%, w/v) to MRS medium on the growth of Leuc. mesenteroides and L. plantarum was evaluated. At 2.0% glycine in the MRS medium, cell growth rate was inhibited by 79% for L. plantarum and 27% for Leuc. mesenteroides. Subsequently, different concentrations of glycine (0, 0.5, and 2.0%, w/v) were applied for kimchi fermentation for 21 days, at $5^{\circ}C$. At day 14, the pH and titratable acidity (TA) of kimchi supplemented with 2.0% glycine were 4.83 and 0.38%, respectively, whilst the control kimchi had a pH of 4.49 and TA of 0.44%, respectively. The ratio of Leuconostoc/ Lactobacillus in kimchi increased as the concentration of glycine increased. The results show that the presence of glycine affected the growth of the 2 lactic acid bacteria, particularly of L. plantarum.

• Archives of Pharmacal Research
• /
• 제26권12호
• /
• pp.1074-1078
• /
• 2003

The effects of glycine on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice was examined. A single administration of morphine (10 mg/kg, s.c.) induced hyperactivity as measured in mice. The morphine-induced hyperactivity was inhibited by pretreatment with glycine (100, 200 and 400 mg/kg, i.p.). In addition, it was found repeated administration of morphine (10 mg/kg, s.c.) to mice daily for 6 days caused an increase in motor activity which could be induced by a subsequent morphine dose, an effect known as reverse tolerance or sensitization. Glycine (100, 200 and 400 rng/kg, i.p.) also inhibited morphine-induced reverse tolerance. Mice that had received 7 daily repeated administrations of morphine also developed postsynaptic dopamine receptor supersensitivity, as shown by enhanced ambulatory activity after administration of apomorphine (2 mg/kg, s.c.). Glycine inhibited the development of postsynaptic dopamine receptor supersensitivity induced by repeated administration of morphine. It is suggested that the inhibitory effects of glycine might be mediated by dopaminergic (DAergic) transmission. Accordingly, the inhibition by glycine of the morphine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity suggests that glycine might be useful for the treatment of morphine addiction.

• 한국식품과학회지
• /
• 제24권1호
• /
• pp.11-13
• /
• 1992

MRS 배지에 Lactobacillus plantarum을 접종하고 200ppm lysozyme에 0.1% glycine 또는 0.1%lysine을 단독 및 혼합 첨가하여 균의 성장 억제효과를 조사하였다. 각 첨가구 모두 대조구에 비하여 접종균 성장 억제효과가 높았으며, 특히 lysozyme과 glycine 혼합첨가구는 그 효과가 현저하므로 각각을 농도별로 조합첨가하였을 때 상승 또는 병용효과가 있었다. Lysozyme과 glycine 각각의 농도가 증가할수록 성장 억제효과는 증가하였으며, lysozyme 200ppm 이상과 glycine 0.5% 이상의 조합에서는 100% 성장 억제효과를 나타내었다. 또한 배지에 120ppm lysozyme과 0.1, 1, 10mM의 EDTA를 단독 및 혼합첨가하고 균의 성장 억제효과를 조사하였으며, 모든 첨가구에서 대조구보다 높은 억제효과를 나타내었고, 120ppm 이상의 lysozyme과 0.8mM 이상의 EDTA 혼합첨가구에서는 97% 억제효과가 인정되었다.

• 대한화학회지
• /
• 제24권5호
• /
• pp.356-360
• /
• 1980

팔면체 구조를 갖는 Co(Ⅲ) glycine methyl ester 착물을 합성하고 원소분석과 적외선 스펙트럼 및 핵자기공명스펙트럼을 이용하여, 이들 착물의 구조에 관하여 고찰하였다. 이들 중 $[Co(gly)_2(glycinemethylester)Cl]Cl_2$ 착물은 양이온 교환수지인 Dowex 50W-X8을 이용하여 분히하였으며, 가능한 기하학적 이성질체는 $C_1-cis(0-0), C_2-cis(0-0), trans(0-0)$ 형태의 구조를 가지고 있음을 확인하였다.