• Journal of Korea Trade
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• 제23권4호
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• pp.17-29
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• 2019

Purpose - This study examines the relationship between public-private partnerships and the performance of ports based on three factors: the quality of the port infrastructure, container throughput, and logistic performance in three Latin American countries, Mexico, Panama, and Brazil, for the period of 1994-2017. Design/methodology - The selected countries are top ranked in terms of container throughput in Latin America. The methodology employs secondary data from the World Bank (Quality of Port Infrastructure, Logistics Performance Index, and Private Participation in infrastructure database). Findings - Overall, the results revealed that the private investment of these countries varies significantly over the past couple decades. Panama, with the least public-private investment over the study period, performs better than Mexico and Brazil with regards to port quality infrastructure and container throughput. For ports in the selected countries to keep up with global competition, there is a need to enhance efficiency. Originality/value - Compared with ports in Asia, Latin American ports are lagging behind with respect to container throughput and efficiency. This study suggests greater collaboration from the private sector, academia, and other organizations, as well as a review of the regulatory framework to ensure better transparency and project allocation. Throwing more light on the public-private investment environment of Mexico, Brazil, and Panama, this study offers policy makers and regulators insightful information on port infrastructure.

• 전기전자학회논문지
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• 제27권3호
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• pp.333-339
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• 2023

세계적으로 웨어러블 디바이스의 시장이 확장하고 있으며, 이를 위한 효율적인 PMIC의 수요 또한 늘어나고 있다. 웨어러블 디바이스용 PMIC 특성상 높은 에너지 효율과 작은 면적이 필요하다. 프로세스 기술의 발전으로 저전력 설계가 가능하지만, 기존의 아날로그 LDO 레귤레이터는 전원 전압이 낮아짐에 따라 설계의 어려움이 있다. 본 논문에서는 이중 루프 디지털 LDO용 coarse-fine ADC를 제안한다, ADC의 설계는 55 nm CMOS 공정으로 진행하였고 34.78 dB와 5.39 bits의 SNR과 ENOB를 갖는다.

• 유통과학연구
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• 제21권4호
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• pp.69-80
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• 2023

Purpose: In the landscape of global challenges, the adoption of new technologies and the implementation of intellectual capital are seen as the main vehicles to enhance banking operations. Inspired by this issue, our study is to discover the effect of technological investments and intellectual capital on one of the most important dimensions of banking operations, namely deposit intermediation. Research design, data and methodology: To tackle this concern, we utilize the data of 12 banks from 2011 to 2020 in Vietnam, and perform the multivariate regression analysis as well as provide different robustness tests. Results: Our empirical analysis demonstrates that a surge in technological expenditures would foster distribution of deposit intermediation of banks. Also, the blend of technology spending and intellectual capital plays a key role in boosting this function of banks. Conclusions: The study would bring one of new evidence for bank managers and national authorities in Vietnam, where has undergone the completely reform period in banking system. Accordingly, technological innovation and intellectual capital should be taken into consideration when managers and regulators build business strategies and related policies. The findings are also useful for nations bearing a close resemblance to Vietnamese financial system.

• IMMUNE NETWORK
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• 제23권1호
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• pp.5.1-5.28
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• 2023

Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These lineage-determining TFs act in concert with multiple layers of transcriptional regulators to alter the epigenetic landscape, including DNA methylation, histone modification and threedimensional chromosome architecture, in order to facilitate the specific Th gene expression programs that allow for phenotypic diversification. Accumulating evidence indicates that Th cell differentiation is not as rigid as classically held; rather, extensive phenotypic plasticity is an inherent feature of T cell lineages. Recent studies have begun to uncover the epigenetic programs that mechanistically govern T cell subset specification and immunological memory. Advances in next generation sequencing technologies have allowed global transcriptomic and epigenomic interrogation of CD4+ Th cells that extends previous findings focusing on individual loci. In this review, we provide an overview of recent genome-wide insights into the transcriptional and epigenetic regulation of CD4+ T cell-mediated adaptive immunity and discuss the implications for disease as well as immunotherapies.

• 인터넷정보학회논문지
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• 제20권6호
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• pp.143-156
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• 2019

국내외 미디어 시장에서 OTT의 파급력이 막대해짐에 따라 OTT에 대한 규제 논의도 활발해지고 있다. 우리나라에서는 특히 OTT와 방송의 유사성에 입각한 공정경쟁 환경 조성의 필요성, 사회문화적 영향력의 규율 필요성이 제기되고 있으며, 그 근거로서 해외의 규제 도입 및 논의 사례가 활용되어 왔다. 이에 본 논문에서는 OTT의 다양한 유형을 바탕으로 해외 시장 동향을 분석하고, 해외 정책규제 사례의 국내 적용 타당성을 고찰했다. 사업자 성격, 사업모형, 콘텐츠 형식, 전달 방식 등을 복합적으로 고려해 6개 OTT 유형(집적, 중개, 중개-집적, 멀티스크린, 아울렛, 아울렛-실시간)을 도출하고, 이를 중심으로 해외 서비스들의 동향을 살펴보았다. 그 결과 OTT 서비스의 형태는 현재도 끊임없이 진화하고 있으며, 콘텐츠 차별화를 중심으로 한 경쟁이 격화되고 있었다. 동태적 혁신이 계속되고 있는 OTT 시장에 섣부른 경쟁규제를 도입하는 것은 경계할 필요가 있다. 또한 OTT 규제 논의의 배경 논거로 자주 활용되는 미국, 유럽연합, 영국 및 일본의 사례를 확인한 결과, OTT에 방송으로서 규제를 적용하는 사례로는 적절하지 않은 것으로 나타났다. 오히려 해외 사례는 자국 내 미디어 산업의 경쟁을 활성화하고 콘텐츠 생태계의 건전성을 높이는 데 초점이 있었다. 따라서 OTT 규제 논의는 규제의 강화가 아니라 기존 방송에 대한 규제를 완화하는 방향으로, 또한 국내 사업자의 규제 포섭이 아니라 글로벌 사업자에 대한 실효적 관할권 확보를 우선시하는 방향으로 진행되어야 할 것이다.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.26.1-26.9
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• 2016

Objectives Korea's Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed. Methods Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory documents regarding the limitation of animal experiments and its alternatives in order to discuss the regulatory adoption of alternative tests. Results Depending on the tonnage of the chemical used, the data required ranges from acute and other short-term studies for a single exposure route to testing via multiple exposure routes and costly, longer-term studies such as a full two-generation reproducibility toxicity. The European Registration, Evaluation, Authorization and Restriction of Chemicals regulation provides for mandatory sharing of vertebrate test data to avoid unnecessary duplication of animal use and test costs, and obligation to revise data requirements and test guidelines "as soon as possible" after relevant, validated replacement, reduction or refinement (3R) methods become available. Furthermore, the Organization for Economic Cooperation and Development actively accepts alternative animal tests and 3R to chemical toxicity tests. Conclusions Alternative tests which are more ethical and efficient than animal experiments should be widely used to assess the toxicity of chemicals for K-REACH registration. The relevant regulatory agencies will have to make efforts to actively adopt and uptake new alternative tests and 3R to K-REACH.

• 대한산업공학회지
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• 제37권1호
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• pp.64-73
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• 2011

Oil price prediction is an important issue for the regulators of the government and the related industries. When employing the time series techniques for prediction, however, it becomes difficult and challenging since the behavior of the series of oil prices is dominated by quantitatively unexplained irregular external factors, e.g., supply- or demand-side shocks, political conflicts specific to events in the Middle East, and direct or indirect influences from other global economical indices, etc. Identifying and quantifying the relationship between oil price and those external factors may provide more relevant prediction than attempting to unclose the underlying structure of the series itself. Technically, this implies the prediction is to be based on the vectoral data on the degrees of the relationship rather than the series data. This paper proposes a novel method for time series prediction of using Semi-Supervised Learning that was originally designed only for the vector types of data. First, several time series of oil prices and other economical indices are transformed into the multiple dimensional vectors by the various types of technical indicators and the diverse combination of the indicator-specific hyper-parameters. Then, to avoid the curse of dimensionality and redundancy among the dimensions, the wellknown feature extraction techniques, PCA and NLPCA, are employed. With the extracted features, a timepointspecific similarity matrix of oil prices and other economical indices is built and finally, Semi-Supervised Learning generates one-timepoint-ahead prediction. The series of crude oil prices of West Texas Intermediate (WTI) was used to verify the proposed method, and the experiments showed promising results : 0.86 of the average AUC.

• 미생물학회지
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• 제46권2호
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• pp.113-121
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• 2010

인산 결핍기에 직면한 Bacillus subtilis는 PhoP-PhoR twocomponent system (TCS)를 통해 이러한 상황을 인식하고 생존을 유지하기 위해 Pho regulon으로 불리는 일련의 유전자들의 발현을 조절한다. 이때 histidine kinase인 PhoR은 자동 인산화되어, 인산을 response regulator인 PhoP에 전달한다. 인산화된 PhoP (PhoP~P)는 Pho regulon 유전자의 프로모터(promoter) 부위에 존재하는 반복되는 6 bp의 잘 보존된 PhoP 결합서열에 결합하여 해당 유전자의 발현을 활성화시키거나 억제한다. 이러한 Pho regulon 신호전달 시스템은 최소한 세 개의 TCS (PhoP-PhoR, ResD-ResE TCS, SpoOA phosphorelay), 광범위한 탄소대사 조절자(CcpA), 전위기 조절자(AbrB, ScoC) 등을 포함하는 신호전달 시스템과 밀접하게 상호 연결되어 있을 뿐만 아니라, 생육에 필수적인 YycF-YycG TCS와 상호조절을 통한 밀접한 관련을 가지고 있다. Pho regulon에 의한 인산결핍 스트레스 반응을 이해하는데 많은 진척이 있었으나, 많은 의문들은 여전히 남아있다. 이러한 의문들을 푸는 일은 B.subtilis의 응용연구에 중요한 정보를 제공할 것이다.

• Journal of Forest and Environmental Science
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• 제33권4호
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• pp.330-341
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• 2017

Tropical forests play a key role for functioning of the planet and maintenance of life. These forests support more than half of the world's species, serve as regulators of global and regional climate, act as carbon sinks and provide valuable ecosystem services. Forest floor biomass and litterfall dynamics was measured in different sites influenced by fire in a seasonally dry tropical forest of Bhoramdeo wildlife sanctuary of Chhattisgarh, India. The forest floor biomass was collected randomly placed quadrats while the litterfall measured by placing stone-block lined denuded quadrat technique. The seasonal mean total forest floor biomass across the fire regimes varied from $2.00-3.65t\;ha^{-1}$. The total litterfall of the study sites varied from $4.75-7.56t\;ha^{-1}\;yr^{-1}$. Annual turnover of litter varied from 70-74% and the turnover time between 1.35-1.43 years. Monthly pattern of forest floor biomass indicated that partially decayed litter, wood litter and total forest floor were differed significantly. The seasonal variation showed that leaf fall differed significantly in winter season only among the fire regimes while the wood litter was found non significant in all the season. This study shows that significant variation among the site due to the forest fire. Decomposition is one of the ecological processes critical to the functioning of forest ecosystems. The decomposing wood serves as a saving account of nutrients and organic materials in the forest floor. Across the site, high fire zone was facing much of the deleterious effects on forest floor biomass and litter production. Control on such type of wildfire and anthropogenic ignition could allow the natural recovery processes to enhance biological diversity. Chronic disturbances do not provide time for ecosystem recovery; it needs to be reduced for ecosystem health and maintaining of the high floral and faunal biodiversity.

• Journal of Microbiology and Biotechnology
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• 제18권5호
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• pp.828-836
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• 2008

The biocontrol rhizobacterium Pseudomonas sp. M18 can produce two kinds of antibiotics, namely pyoluteorin (Plt) and phenazine-1-carboxylic acid (PCA), and is antagonistic against a number of soilborne phytopathogens. In this study, a luxR-type quorum-sensing regulatory gene, vqsR, was identified and characterized immediately downstream of the Plt gene cluster in strain MI8. A vqsR-inactivated mutant led to a significant decrease in the production of Plt and its biosynthetic gene expression. However, this was restored when introducing the vqsR gene by cloning into the plasmid pME6032 in trans. The vqsR mutation did not exert any obvious influence on the production of PCA and its biosynthetic gene expression and the production of N-acylhomoserine lactones (C4 and C8-HSLs) and their biosynthetic gene rhlI expression. Accordingly, these results introduce VqsR as a regulator of Plt production in Pseudomonas spp., and suggest that the regulatory mechanism of vqsR in strain M18 is distinct from that in P. aeruginosa. In addition, it was demonstrated that vqsR mutation did not have any obvious impact on the expression of Plt-specific ABC transporters and other secondary metabolic global regulators, including GacA, RpoS, and RsmA.