• Molecular & Cellular Toxicology
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• v.2 no.1
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• pp.21-28
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• 2006

Gadolinium chloride ($GdCl_{3}$) was known to block Kupffer cells and generally its toxicity study based on blocking these cells. Therefore, $GdCl_{3}$ frequently used to study toxic mechanisms of hepatotoxicants inducing injury through Kupffer cells. We also tried to investigate the effect of $GdCl_{3}\;on\;CCl_{4}$ toxicity, typical hepatotoxicants. Administration of $GdCl_{3}$ to mice significantly suppressed AST (asparatate amino transferase), ALT (alanine amino transferase) levels which were increased by $CCl_{4}$ treatment. However, $GdCl_{3}$ didn't inhibit the phagocytotic activity of Kupffer cells. Malondialdehyde (MDA) is a good indicator of the degree of lipid peroxidation. In this study, MDA increased by $GdCl_{3}$ administration not by $CCl_{4}$. To understand the toxicity of $GdCl_{3}$, we analyzed global gene expression profile of mice liver after acute $GdCl_{3}$ injection. Four hundred fifty two genes were differentially expressed with more than 2-fold in at least one time point among 3 hr, 6 hr, and 24 hr. Several genes involved in fibrogenesis regulation. Several types of pro-collagens (Col1a2, Col5a2, Col6a3, and Col13a1) and tissue inhibitor of metal-loproteinase1 (TIMP1) were up regulated during all the time points. Genes related to growth factors, chemokines, and oxidative stress, which were known to control fibrogenesis, were significantly changed. In addition, $GdCl_{3}$ induced abnormal regulation between lipid synthesis and degradation related genes. These data will provide the information about influence of $GdCl_{3}$ to hepatotoxicity.

• The Journal of the Convergence on Culture Technology
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• v.8 no.4
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• pp.289-296
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• 2022

The purpose of this study was to examine the students' responses and self-understanding in the liberal arts and personality class, one of the compulsory liberal arts subjects at S University. The results of the study are as follows. First, the degree of influence on students' positive change in this class was higher than normal using a five-step Likert scale. In particular, as a result of the film discussion conducted by the researcher, satisfaction was very high. Second, as a result of picture test analysis, changes in coping ability through stress and resource scales were seen in the students, and it was an opportunity for students to understand themselves by looking into their minds. This study presented example of classes that can cultivate students' personality through literature, art, and video, and cultivate their qualities as global citizens, such as responsibility, leadership, cooperation, consideration, communication, and empathy, through discussion.

• Earthquakes and Structures
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• v.22 no.6
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• pp.539-548
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• 2022

Steel plate shear walls (SPSWs) are one of the most important and widely used lateral load-bearing systems. The reason for this is easier execution than reinforced concrete (RC) shear walls, faster construction time, and lower final weight of the structure. However, the main drawback of SPSWs is premature buckling in low drift ratios, which affects the energy absorption capacity and global performance of the system. To address this problem, two groups of SPSWs under cyclic loading were investigated using the finite element method (FEM). In the first group, several series of circular rings have been used and in the second group, a new type of SPSW with concentric circular rings (CCRs) has been introduced. Numerous parameters include in yield stress of steel plate wall materials, steel panel thickness, and ring width were considered in nonlinear static analysis. At first, a three-dimensional (3D) numerical model was validated using three sets of laboratory SPSWs and the difference in results between numerical models and experimental specimens was less than 5% in all cases. The results of numerical models revealed that the full SPSW undergoes shear buckling at a drift ratio of 0.2% and its hysteresis behavior has a pinching in the middle part of load-drift ratio curve. Whereas, in the two categories of proposed SPSWs, the hysteresis behavior is complete and stable, and in most cases no capacity degradation of up to 6% drift ratio has been observed. Also, in most numerical models, the tangential stiffness remains almost constant in each cycle. Finally, for the innovative SPSW, a relationship was suggested to determine the shear capacity of the proposed steel wall relative to the wall slenderness coefficient.

• Korean journal of aerospace and environmental medicine
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• v.30 no.3
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• pp.83-85
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• 2020

In commemoration of Vol. 30, Issue 3, our journal prepared five review articles and one original paper. The global outbreak of COVID-19 in 2020 has impacted our society, and especially the aviation and travel industries have been severely damaged. Kwon presented the aviation medical examination regulations related to COVID-19 announced by the Ministry of Land, Infrastructure, and Transport of the Republic of Korea. Lim summarized various efforts of airlines to overcome the crisis in the aviation industry. He also discussed the management of these aircraft as the number of airplanes landing for long periods increased. Finally, he suggested various quarantine guidelines at airports and onboard aircraft. COVID-19 has had a profound impact on mental health as well as physical effects. Kim investigated the impact of COVID-19 on mental health and suggested ways to manage the stress caused by it. The Internet of Things (IoT) refers to a technology in which devices communicate with each other through wired or wireless communication. Hyun explained the current state of the technology of the IoT and how it could be used, especially in the aviation field. In the area of airline service, various situations arise between passengers and crew. Therefore, role-playing is useful in performing education to prepare and respond to passengers' different needs appropriately. Ra introduced the conceptual background and general concepts of role-playing and presented the actual role-play's preparation process, implementation, evaluation, and feedback process. For a fighter to fly for a long time and perform a rapid air attack, air refueling is essential, which serves refueling from the air rather than from the aircraft base. Koo developed a questionnaire based on the HFACS (Human Factors Analysis and Classification System) model and used it to conduct a fighter pilot survey and analyze the results.

• Journal of Korean Dental Hygiene Science
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• v.5 no.1
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• pp.39-45
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• 2022

Background: Dental hygienists undergo 3 or 4 years of college education, and dental hygienist education must receive continuous feedback through evaluation. The purpose of this study was to compare the educational performance of students from the Department of Dental Hygiene in 2018 with those from other departments in the healthcare field. Methods: We used data from the National Assessment of Student Engagement in Learning, conducted by the Korean Educational Development Institute in 2018. The survey data of 55 dental hygiene students and 60 healthcare students at K University were provided after excluding all identifying information. An independent t-test was used for comparisons between the Department of Dental Hygiene and other healthcare departments. Results: Regarding class-related activities, dental hygiene students were passive in presentations, discussions, and projects and had significantly lower grades in cooperative learning and challenging learning. Regarding extra-class activities, dental hygiene students had significantly lower global learning and external experiences, domestic experiences, club activities, and interactions with professors. Regarding learning outcomes, students had significantly lower grades in writing, speaking, critical and analytical thinking, data evaluation, understanding of data meaning, problem-solving ability, goal setting and execution, core content extraction, human and material resource utilization, creative convergence thinking, statistical understanding and analysis, information technology use, collaboration, sense of community, stress management, time management, and foreign language proficiency. Conclusions: Dental hygiene education requires innovation in educational methods and efforts of instructors to improve poor learning activities and outcomes.

• Computers and Concrete
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• v.32 no.2
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• pp.217-232
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• 2023

Numerous studies have been performed on the behavior of pile foundations in cold regions. This study first attempted to employ artificial neural networks (ANN) to predict pile-bearing capacity focusing on pile data recorded primarily on cold regions. As the ANN technique has disadvantages such as finding global minima or slower convergence rates, this study in the second phase deals with the development of an ANN-based predictive model improved with an Elephant herding optimizer (EHO), Dragonfly Algorithm (DA), Genetic Algorithm (GA), and Evolution Strategy (ES) methods for predicting the piles' bearing capacity. The network inputs included the pile geometrical features, pile area (m²), pile length (m), internal friction angle along the pile body and pile tip (Ø°), and effective vertical stress. The MLP model pile's output was the ultimate bearing capacity. A sensitivity analysis was performed to determine the optimum parameters to select the best predictive model. A trial-and-error technique was also used to find the optimum network architecture and the number of hidden nodes. According to the results, there is a good consistency between the pile-bearing DA-MLP-predicted capacities and the measured bearing capacities. Based on the R2 and determination coefficient as 0.90364 and 0.8643 for testing and training datasets, respectively, it is suggested that the DA-MLP model can be effectively implemented with higher reliability, efficiency, and practicability to predict the bearing capacity of piles.

• Journal of Advanced Navigation Technology
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• v.28 no.4
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• pp.524-531
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• 2024

In a global environment, airlines are striving to secure competitiveness and generate profits through customer satisfaction. The first thing to do in order to provide services to customers is the safety of the aircraft, and the basis for realizing safety is the continuous maintenance of maintenance quality. The degree of development of aviation technology is progressing unimaginably fast, but the overall environment of aviation mechanics working at the front line to maintain maintenance quality remains largely unchanged. This study aims to identify the level of education and training provided to aircraft maintenance engineers and safety culture, and to examine the effect of self-esteem on maintenance quality. Previous studies have been conducted on maintenance engineers' education and training, organizational performance, and job stress, but there has been a lack of studies on maintenance quality. Therefore, this study aims to identify the relationship between variables affecting maintenance quality and to suggest implications for improving maintenance quality through empirical analysis.

• Journal of the Korean Geotechnical Society
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• v.21 no.10
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• pp.5-16
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• 2005

Geosynthetic-reinforced and pile-supported embankments have been increasingly used and researched around the world. The inclusion of one or multiple geosynthetic reinforcements over the pile is intended to enhance the efficiency of load transfer from soft ground to piles, to reduce total and differential settlement and increase global or local stability. In this paper, the reinforcement effectiveness and arching effect of the geogrid-reinforced and pile-supported embankments have been studied in terms of field model tests and numerical analysis with varying the space between piles and reinforcement. 2-dimensional numerical analysis has been conducted using the FLAC (Fast Lagrangian Analysis of Continua) program. And load transfer mechanisms between soil-piles-geogrid were investigated. The mechanisms of load transfer can be considered as a combination of embankment soil arching, tension geogrid, and stress concentration due to the stiffness difference between pile and soft ground. Based on the field model test and numerical analysis results, it was found that the geosynthetic reinforcement slightly interferes with soil arching, and helps reduce differential settlement of the soft ground. Also. at the D/b=3 (D: spacing of pile cap, b: diameter of pile), the total settlement is reduced by about $40\%$ compared to that without reinforcement. For $D/b{\ge}6$, the effectiveness of geogrid reinforcement in reducing settlement is negligible.

• Journal of the Korean Geotechnical Society
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• v.15 no.3
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• pp.41-70
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• 1999

The benefits of utilizing internal reinforced members, such as soil nails and ground anchors, in maintaining stable excavations and slopes have been known among geotechnical engineers to be very effective. Occasionally, however, both soil nails and ground anchors are simultaneously used in one excavation site. In the present study, a method of limit equilibrium stability analysis of the excavation zone reinforced with the vertically or horizontally mixed nail-anchor system is proposed to evaluate the global safety factor with respect to a sliding failure. The postulated failure wedges are determined based on the results of the $FLAC^{2D}\; 및\; FLAC^{3D}$ program analyses. This study also deals with a determination of the required thickness of the shotcrete facing. An excessive facing thickness may be required due to both the stress concentration and the relative displacement at the interface zone between the soil nailing system and the ground anchor system. A simple finite element method of analysis is presented to estimate the corresponding relative displacement at the interface zone between two different support systems. As an efficient resolution to reduce the facing thickness, the modified bearing plate system is also proposed. Finally with various analysis related to the effects of design parameters, the predicted displacements are compared with the results of the $FLAC^{2D}$ program analyses.

• Korean Journal of Play Therapy
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• v.21 no.4
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• pp.491-507
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• 2018

The purpose of this study is to validate the Play Participation Attitude Scale for parents of preschoolers, which was developed by the Delphi survey. 447 parents of 9 daycare centers in Seoul and Incheon were recruited for this study and, finally, data from 339 parents were used to perform exploratory factor analysis, confirmatory factor analysis, correlation analysis, multiple regression analysis, and reliability analysis. The results of the study are as follows. First, factor analyses revealed that the global fit of the sensitively play (7 items), responsively play (6 items), and delightfully play(7 items) three-factor model was good. Second, the internal consistency of the Play Participation Attitude Scale was good. Third, there was a statistically significant positive correlation between the current scale and the parents' playfulness scale, indicating concurrent validity. Finally, higher scores of the Play Participation Attitude Scale and its three factors significantly predicted lower scores of parenting stress and higher scores of the preschoolers' self-control ability. These findings revealed that this new measure to be both valid and reliable and specifically suggests what kind of attitude is appropriate for parents to adopt when participating in preschoolers' play.