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Confidence Bounds following Adaptive Group Sequential Tests with Repeated Measures in Clinical Trials (반복측정자료를 가지는 적응적 집단축차검정에서의 신뢰구간 추정)

  • Joa, Sook Jung;Lee, Jae Won
    • The Korean Journal of Applied Statistics
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    • v.26 no.4
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    • pp.581-594
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    • 2013
  • A group sequential design can end a clinical trial early if a confirmed efficacy or a futility of study medication is found during clinical trials. Adaptation can adjust the design of clinical trials based on accumulated data. The key to this methodology is considered to control the overall type 1 error rate while maintaining the integrity of clinical trials. The estimation would be more complex and the sample size calculation will be more difficult if the clinical trials have repeated measurement data. Lee et al. (2002) suggested a repeated observation case by using the independent increments properties of the interim test statistics and investigated the properties of the proposed confidence interval based on the stage-wise ordering. This study extend Lee et al. (2002) to adaptive group sequential design. We suggest test statistics for the adaptation as redesigning the second stage of clinical trials and induce the stage-wise confidence interval of parameter of interests. The simulation will help to confirm the suggested method.

Simulation of Air Quality Over South Korea Using the WRF-Chem Model: Impacts of Chemical Initial and Lateral Boundary Conditions (WRF-Chem 모형을 이용한 한반도 대기질 모의: 화학 초기 및 측면 경계 조건의 영향)

  • Lee, Jae-Hyeong;Chang, Lim-Seok;Lee, Sang-Hyun
    • Atmosphere
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    • v.25 no.4
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    • pp.639-657
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    • 2015
  • There is an increasing need to improve the air quality over South Korea to protect public health from local and remote anthropogenic pollutant emissions that are in an increasing trend. Here, we evaluate the performance of the WRF-Chem (Weather Research and Forecasting-Chemistry) model in simulating near-surface air quality of major Korean cities, and investigate the impacts of time-varying chemical initial and lateral boundary conditions (IC/BCs) on the air quality simulation using a chemical downscaling technique. The model domain was configured over the East Asian region and anthropogenic MICS-Asia 2010 emissions and biogenic MEGAN-2 emissions were applied with RACM gaseous chemistry and MADE/SORGAM aerosol mechanism. Two simulations were conducted for a 30-days period on April 2010 with chemical IC/BCs from the WRF-Chem default chemical species profiles ('WRF experiment') and the MOZART-4 (Model for OZone And Related chemical Tracers version 4) ('WRF_MOZART experiment'), respectively. The WRF_MOZART experiment has showed a better performance to predict near-surface CO, $NO_2$, $SO_2$, and $O_3$ mixing ratios at 7 major Korean cities than the WRF experiment, showing lower mean bias error (MBE) and higher index of agreement (IOA). The quantitative impacts of the chemical IC/BCs have depended on atmospheric residence time of the pollutants as well as the relative difference of chemical mixing ratios between the WRF and WRF_MOZART experiments at the lateral boundaries. Specifically, the WRF_MOZART experiment has reduced MBE in CO and O3 mixing ratios by 60~80 ppb and 5~10 ppb over South Korea than those in the WRF-Chem default simulation, while it has a marginal impact on $NO_2$ and $SO_2$ mixing ratios. Without using MOZART-4 chemical IC, the WRF simulation has required approximately 6-days chemical spin-up time for the East Asian model domain. Overall, the results indicate that realistic chemical IC/BCs are prerequisite in the WRF-Chem simulation to improve a forecast skill of local air quality over South Korea, even in case the model domain is sufficiently large to represent anthropogenic emissions from China, Japan, and South Korea.

Air Fuel Ratio Determination Method for Alternative Fuel Based on Carbon Balance and Linear Equation (탄소 균형과 1차식에 의한 대체 연료의 공연비 산정법)

  • Lee, Jae-Won;Kwon, Soon-Tae;Park, Chan-Jun;Ohm, In-Young
    • Journal of Energy Engineering
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    • v.17 no.4
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    • pp.182-188
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    • 2008
  • This paper is to compare the carbon-balanced and liner air-fuel ratio determination methods for alternative fuels. In the previous work, expansion of Eltinge chart, unburned hydrocarbon compensation, comparison of the results from various methods were discussed. It has been also concluded that Eltinge method might be regarded as the most general equation of AFR determination among the existing ones. In the recent years, however, increasing demand for the environmental preservation, including global warming-up protection, and energy conservation lead to introduce the alternative fuel to the internal combustion engine. Therefore, the exact calculations of AFR for these fuels are needed. Especially, for the fuel that contains oxygen, all AFR calculation equations except Eltinge have to be re-formulated. In this paper, the AFR for alternative fuel were calculated by re-formulated carbon balance, accuracy of which was already confirmed, and linear equations, which are newly proposed by statistical method for each fuel. The results show that AFRs based on carbon balance have a little more error compared with gasoline, however, the accuracy is enough for this formula to apply to various fuel. The proposed linear equation also have excellent accuracy below $\lambda=1.2$.

Design of Road Surface Drainage Facilities Based on Varied Flow Analysis (부등류 해석을 기반으로 한 노면배수시설 설계)

  • Ku, Hye-Jin;Kim, Jin-Soo;Park, Hyung-Seop;Jun, Kyung-Soo
    • Journal of Korea Water Resources Association
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    • v.41 no.12
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    • pp.1173-1185
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    • 2008
  • The design methods of the road surface drainage facilities were compared for the improvement of design method. We have developed four computational design models classified by the methods to determine the duration of design rainfall and to analyze the flow of a linear drainage channel. The critical duration was determined by assuming the critical duration to be 10 minutes or by finding the duration of design storm being similar to the travel time of flow by trial and error. The flow of a linear drainage channel was analyzed as the uniform flow or the varied flow. The design models were applied to the artificial road surface drainage facilities with various channel slopes and road shoulder slopes. If the rainfall intensity of the 10 minutes duration was applied, the outlet spacing obtained from the design based on the varied flow analysis was larger than the uniform flow analysis only when the channel slope and the road shoulder slope was small. On the other hands, if the duration of design rainfall was determined by calculating the travel time, the varied flow analysis brought about larger outlet spacing than the uniform analysis for all conditions. However, the model of the critical duration concept and the varied flow analysis resulted in smaller outlet spacing than the current design method employing the rainfall of 10 minutes duration and the uniform flow analysis.

A Study for how a CEO's moral management influences on his employees' absorbing into their business in a Stock company (증권회사 CEO의 윤리경영이 조직몰입에 미치는 영향 연구)

  • Kang, Chang-Won
    • Journal of Distribution Science
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    • v.6 no.1
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    • pp.63-77
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    • 2008
  • The source of a business competition is man and the core of a business success depends on people's ability, efforts and cooperation. Therefore, modern managers are making varied efforts to perform the ethical management for the organization immersion and job satisfaction of the employees. The managers of the financial agencies including the enterprises competing in the global market, face numerous ethical issues and problems. Considering the reality that financial institutions are actively asked to perform the responsibility and duties sincerely, the tasks how the head of financial agency will accept the social study of the level of ethics and change the level of recognition, and how he will settle it as the natural feature in the institution, become an important management target. In addition, it is necessary to figure out how the ethical management of the head of the financial agency will affect the organizational immersion of the employees. Based on the objective of this study, we attempted to confirm how the ethical management will of the head of the financial institution would affect the organizational immersion, the employees' mental result variables. Through this study, it became necessary for the directors of the financial institutions to search for the methods to improve the system of management and enhance the observance will of the business ethics so that they may not cause the disposition of the violation of the business ethics owing to the enforcement to achieve the target of the results of the business or the error recognition of the norm. Further, the heads of banks will have to set a management policy focused on the democratic management and the ethical justice based on the participating methods to induce the cooperative commitment of the stock company employees not to be shifted from the globalization and the competitive society.

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Sensor Fusion of Localization using Unscented Kalman Filter (Unscented Kalman filter를 이용한 위치측정 센서융합)

  • Lee, Jun-Ha;Jung, Kyung-Hoon;Kim, Jung-Min;Kim, Sung-Shin
    • Journal of the Korean Institute of Intelligent Systems
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    • v.21 no.5
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    • pp.667-672
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    • 2011
  • This paper presents to study the sensor fusion of positioning sensors using UKF(unscented Kalman filter) for positioning accuracy improvement of AGV(automatic guided vehicle). The major guidance systems for AGV are wired guidance and magnetic guidance system. Because they have high accuracy and fast response time, they are used in most of the FMS(flexible manufacturing system). However, they had weaknesses that are high maintenance cost and difficult of existing path modification. they are being changed to the laser navigation in recent years because of those problems. The laser navigation is global positioning sensor using reflecters on the wall, and it have high accuracy and easy to modify the path. However, its response time is slow and it is influenced easily by disturbance. In this paper, we propose the sensor fusion method of the laser navigation and local sensors using UKF. The proposed method is improvement method of accuracy through error analysis of sensors. For experiments, we used the axle-driven forklift AGV and compared the positioning results of the proposed method with positioning results of the laser navigation. In experimental result, we verified that the proposed method can improve positioning accuracy about 16%.

Probe Vehicle Data Collecting Intervals for Completeness of Link-based Space Mean Speed Estimation (링크 공간평균속도 신뢰성 확보를 위한 프로브 차량 데이터 적정 수집주기 산정 연구)

  • Oh, Chang-hwan;Won, Minsu;Song, Tai-jin
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.19 no.5
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    • pp.70-81
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    • 2020
  • Point-by-point data, which is abundantly collected by vehicles with embedded GPS (Global Positioning System), generate useful information. These data facilitate decisions by transportation jurisdictions, and private vendors can monitor and investigate micro-scale driver behavior, traffic flow, and roadway movements. The information is applied to develop app-based route guidance and business models. Of these, speed data play a vital role in developing key parameters and applying agent-based information and services. Nevertheless, link speed values require different levels of physical storage and fidelity, depending on both collecting and reporting intervals. Given these circumstances, this study aimed to establish an appropriate collection interval to efficiently utilize Space Mean Speed information by vehicles with embedded GPS. We conducted a comparison of Probe-vehicle data and Image-based vehicle data to understand PE(Percentage Error). According to the study results, the PE of the Probe-vehicle data showed a 95% confidence level within an 8-second interval, which was chosen as the appropriate collection interval for Probe-vehicle data. It is our hope that the developed guidelines facilitate C-ITS, and autonomous driving service providers will use more reliable Space Mean Speed data to develop better related C-ITS and autonomous driving services.

A Feasibility Study for Mapping Using The KOMPSAT-2 Stereo Imagery (아리랑위성 2호 입체영상을 이용한 지도제작 가능성 연구)

  • Lee, Kwang-Jae;Kim, Youn-Soo;Seo, Hyun-Duck
    • Journal of the Korean Association of Geographic Information Studies
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    • v.15 no.1
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    • pp.197-210
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    • 2012
  • The KOrea Multi-Purpose SATellite(KOMPSAT)-2 has a capability to provide a cross-track stereo imagery using two different orbits for generating various spatial information. However, in order to fully realize the potential of the KOMPSAT-2 stereo imagery in terms of mapping, various tests are necessary. The purpose of this study is to evaluate the possibility of mapping using the KOMPSAT-2 stereo imagery. For this, digital plotting was conducted based on the stereoscopic images. Also the Digital Elevation Model(DEM) and an ortho-image were generated using digital plotting results. An accuracy of digital plotting, DEM, and ortho-image were evaluated by comparing with the existing data. Consequently, we found that horizontal and vertical error of the modeling results based on the Rational Polynomial Coefficient(RPC) was less than 1.5 meters compared with the Global Positioning System(GPS) survey results. The maximum difference of vertical direction between the plotted results in this study and the existing digital map on the scale of 1/5,000 was more than 5 meters according as the topographical characteristics. Although there were some irregular parallax on the images, we realized that it was possible to interpret and plot at least seventy percent of the layer which was required the digital map on the scale of 1/5,000. Also an accuracy of DEM, which was generated based on the digital plotting, was compared with the existing LiDAR DEM. We found that the ortho-images, which were generated using the extracted DEM in this study, sufficiently satisfied with the requirement of the geometric accuracy for an ortho-image map on the scale of 1/5,000.

Performance Evaluation of Scheduling Algorithm for VoIP under Data Traffic in LTE Networks (데이터 트래픽 중심의 LTE망에서 VoIP를 위한 스케줄링 알고리즘 성능 분석)

  • Kim, Sung-Ju;Lee, Jae Yong;Kim, Byung Chul
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.12
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    • pp.20-29
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    • 2014
  • Recently, LTE is preparing to make a new leap forward LTE-A all over the world. As LTE privides high speed service, the role of mobile phones seems to change from voice to data service. According to Cisco, global mobile data traffic will increase nearly 11-fold between 2013 and 2018. Mobile video traffic will reach 75% by 2018 from 66% in 2013 in Korea. However, voice service is still the most important role of mobile phones. Thus, controllability of throughput and low BLER is indispensable for high-quality VoIP service among various type of traffic. Although the maximum AMR-WB, 23.85 Kbps is sufficient to a VoIP call, it is difficult for the LTE which can provide tens to hundreds of MB/s may not keep the certain level VoIP QoS especially in the cell-edge area. This paper proposes a new scheduling algorithm in order to improve VoIP performance after analyzing various scheduling algorithms. The proposal is the technology which applies more priority processing for VoIP than other applications in cell-edge area based on two-tier scheduling algorithm. The simulation result shows the improvement of VoIP performance in the view point of throughput and BLER.

How sun spot activity affects on positioning accuracy?: Case study of solar storm (태양 흑점활동이 측위오차에 미치는 영향: 태양폭풍 사례연구)

  • Yoo, Yun-Ja;Cho, Deuk-Jae;Park, Sang-Hyun
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2011.06a
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    • pp.27-28
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    • 2011
  • A solar flares have the 11-year cycle and release a large energy which may produce coronal mass ejections (CME). The NOAA (National Oceanic and Atmospheric Administration) predicted that the sun spot activity will be maximized in 2013-2014. A strong solar flare can cause the disturbance of global positioning system including various communication of TV, radio broadcasting. The actual solar storm in 1989 caused power outages in Canada during 9 hours and about 600 million people had experienced a blackout. Such a solar storm can shorten the GPS satellite's life span about 5 to 10 years which can be resulted in economic loss considering the amount of multi-billion won. This paper analyzed the recent solar storm of X-class occurred on 15th of February about 10:45 this year that was reached Korea (Bohyun observatory) on 18th of February about 10:30 (local time), and compared with the data of before and after a week. The proton data of 18th of February considered that the solar strom reached on earth showed a fluctuation compared to the data of before and after a week. The positioning results at Daejeon also showed higher positioning error compared to the data of before and after a week results.

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