• 대한본초학회지
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• 제24권1호
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• pp.1-7
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• 2009

Objectives : The purpose of this study is to investigate on storage characteristics of Herbal materials treated with Gamma-irradiation(10 KGy). Methods : This experiments were carried out by field survey and storage characteristics were carried out by physicochemical determination. Results : Antimicrobial activity of oriental medicine materials(Angelica dahurica Radix, Glehnia littoralis Radix) were examined, together with investigation of effects on gamma-irradiation. Oriental medicine materials contaminated in microbial cell were tend to be pinhole in packaging materials(polypropylene) by bug and Larva. At the same time, PVDC (polyvinylldichloride) package also was founded in bug and Larva by microbial contamination during storage in room temperature. Conclusions : In conclusion, it is very desirable to dose gamma-irradiation(10 KGy) in these oriental medicine materials in order to prevent microbial activity.

• 한국식품저장유통학회지
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• 제24권1호
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• pp.116-124
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• 2017

해방풍이 가지는 건강 기능성 소재로서의 가치를 확인하고자, 해방풍 부위별 용매추출물의 항산화 활성 및 면역조절 효과를 조사하였다. 해방풍 부위별 용매추출물의 추출 수율은 10.73-30.57이며, 총 폴리페놀 및 총 플라보노이드 함량은 해방풍 잎 70% 에탄올 추출물(EL)에서 각각 10.79 g/100 g 및 2.01 g/100 g으로 가장 높은 값을 나타내었다. DPPH radical 및 ABTS radical 소거활성은 해방풍 잎 70% 에탄올 추출물(EL)이 $100-1,000{\mu}g/mL$ 농도에서 12.90-84.70% 및 11.78-57.64%로 가장 우수한 radical 소거활성을 나타내었으며, superoxide radical 소거활성 및 FRAP 활성은 해방풍 잎 70% 에탄올 추출물(EL)이 $100-1,000{\mu}g/mL$ 농도에서 각각 49.91-84.05% 및 $255.38-975.28{\mu}M$로 가장 우수한 활성을 나타내었다. 대식세포주인 RAW 264.7 세포에 해방풍 부위별 용매추출물을 처리하였을 때 nitric oxide 생성 억제능을 확인하기 위해 분석한 결과, 추출용매에 따른 nitric oxide 생성량은 70% 에탄올 및 70% 메탄올 추출물에서 가장 낮은 생성량을 보였으며, 해방풍 부위별에 따른 nitric oxide 생성량은 뿌리, 잎 및 씨앗 순으로 낮았다. 그 중에서 해방풍 뿌리 70% 에탄올 추출물(ER)에서 가장 낮은 nitric oxide 생성량을 보여 우수한 nitric oxide 억제 효과를 확인하였으며, 이를 이용하여 기능성 소재, 미용식품 및 화장품 제조용 원료 등 다양하게 활용 가능할 것으로 사료된다.

• 대한한의학방제학회지
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• 제31권3호
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• pp.171-182
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• 2023

Objectives : Saposhnikoviae Radix (SR) and Glehniae Radix (GR) have been frequently used in traditional medicine to treat diseases related to 'wind' syndrome, but there have been cases where it has been mixed in a state where the plant of origin is not clear. In this study, to select materials for conducting preclinical cerebral infarction research, the network pharmacology analysis method was used to select suitable medicinal materials for the study. Methods : In this study, a Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) based network pharmacology analysis method was used, and oral bioavailability (OB), drug likeness (DL), Caco-2 and BBB permeability were utilized to select compounds with potential activity. For the values of each variable used in this study, OB ≥ 20%, DL ≥ 0.18, Caco-2 ≥ 0, and BBB ≥ -0.3 were applied, then networks of bioactive compounds, target proteins, and target diseases was constructed. STRING database was used to construct a protein-protein interaction network. Results : It was confirmed that SR rather than GR has various target proteins and target diseases based on network pharmacological analysis using TCMSP database. And it was analyzed that the bioactive compounds only in SR act more on neurovascular diseases, and both drugs are expected to be effectively used for cardiovascular diseases. Conclusions : In our future study, SR will be used in an ischemic stroke mouse model, and the mechanism of action will be explored focusing on apoptosis and cell proliferation.

• 생약학회지
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• 제7권4호
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• pp.233-235
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• 1976

Substances $I{\sim}VII$ are isolated from the root of Glehnia littoralis which has been often used as a subsitute of Bang-Poong in Korea. White needle crystalline substance of $C_{29}H_{50}O$, m.p. $137{\sim}139^{\circ}C$ was confirmed as ${\beta}-sitosterol$ through elemental analysis, derivative synthesis, IR and physicochemical tests. Moreover, it was concluded that white needle crystal of $C_{12}H_{8}O_{4}$, m.p. $188{\sim}189^{\circ}$ was confirmed as bergapten, through a contrast test with standard substance and by UV and IR-spectra. It was found that substance III and VII coincided with the Rf values of imperatorin and umbelliferone and to its colors under the UV-ray, and its similarity to UV-spectrum can be recognized, but their melting points are remarkedly different respectively.

• 한국약용작물학회지
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• 제25권2호
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• pp.102-107
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• 2017

Background: The present study was conducted to investigate the fatty acid content and habitat conditions of Glehnia littoralis in the Korean midwest region. Methods and Results: The emergence area of G. littoralis was 36.1 m from the coastline at an elevation of 4.2 m and slope of 4.3%. The soil of the habitat was sandy, the pH was 8.4, organic matter content was 0.4%, $P_2O_5$ content was 9.1 mg/kg and the content of K, Ca, Mg and Na were 0.09, 9.31, 0.43 and $0.23cmol^+/kg$, respectively. Other plants growing in this area with G. littoralis included 16 taxa. Plant with high coverage and frequency were Carex kobomugi, Elymus mollis, Imperata cylindrica var. koenigii, Lathyrus japonicus, Calystegia soldanella and Carex pumila. In the seeds of G. littoralis, the maximum fatty acid content was 65.5% oleic acid, 28.7% linoleic acid, 4.3% palmitic acid, 1.5% stearic acid, and 0.2% linolenic acid. Conclusions: In G. littoralis of Korean midwest, the scope of collection and cultivation for medicinal purposes was broad, because differences in associated vegetation, soil composition, and fatty acid content owing to habitat conditions was low.

• 약학회지
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• 제56권1호
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• pp.55-59
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• 2012

This study was carried out to investigate the content of sulfur dioxide residues in the medicine prepared from crue drugs. Total 29 pills that contains salvia miltiorrhiza root, anemarrhena rhizome, fritillaria bulb, glehnia root, asparagus tuber, lycium fruit, moutan root bark, cimicifuga rhizome, pinellia tuber, dipsaci radix, codonopsis pilosula root, liriope tuber, achyranthes root, prepared aconite, aurantii fructus immaturus, corydalis tuber, dioscorea rhizome were examined by the modified Monier_Willams method. Sulfur dioxide were detectd in all the tested samples, and were found over MRLs (30 mg/ kg to medicinal herbs) in 8 samples (27.6%). Especilly, "i2" pills contains 132.46 mg/kg sulfur dioxide that is 4 times over than MRLs.