• Neonatal Medicine
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• v.17 no.2
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• pp.266-269
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• 2010

Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population has Gilbert's syndrome. Commonly, Gilbert's syndrome causes mild symptoms. However, a case of Gilbert's syndrome with severe neonatal hyperbilirubinemia is presented here. The patient developed jaundice three days after birth. Five days after birth, the patient's total serum bilirubin level was 34 mg/dL. The patient received intensive phototherapy and was given oral phenobarbital. Hemolytic hyperbilirubinemia was excluded on the basis of laboratory tests. Heterozygote polymorphisms of the promoter region (-3279T>G) and exon 1 (211G>A) were found in UGT1A1 gene. After discharge, the patient did not require any further treatment. This is the first case of proven Gilbert's syndrome with severe neonatal hyperbilirubinemia in Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.17 no.4
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• pp.266-269
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• 2014

Gilbert syndrome is the most common inherited disorder of bilirubin glucuronidation. It is characterized by intermittent episodes of jaundice in the absence of hepatocellular disease or hemolysis. Hereditary spherocytosis is the most common inherited hemolytic anemia and is characterized by spherical, osmotically fragile erythrocytes that are selectively trapped by the spleen. The patients have variable degrees of anemia, jaundice, and splenomegaly. Hereditary spherocytosis usually leads to mild-to-moderate elevation of serum bilirubin levels. Severe hyperbilirubinemia compared with the degree of hemolysis should be lead to suspicion of additional clinical conditions such as Gilbert syndrome or thalassemia. We present the case of a 12-year-old boy with extreme jaundice and nausea. The diagnosis of hereditary spherocytosis was confirmed by osmotic fragility test results and that of Gilbert syndrome by genetic analysis findings.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.6
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• pp.657-661
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• 2014

Gilbert's syndrome is one that shows a benign course with intermittent unconjugate hyperbilirubinemia without any evidence of hepatobiliary tract disease or hemolysis. It is often found in a health examination or blood laboratory test by chance. In particular, patients who are taking drugs, including herbal medicine should be careful for their medication due to the possibility of associations with changes in liver function because of drug metabolism, sometimes they have to quit the use of the medication for a certain period and often they should get an additional test. Two male patients increased serum total bilirubin level without other systemic symptoms in screening test for clinical herb medicine pharmacokinetics study. Therefor they was diagnosed with suspected Gilbert's syndrome. They had been calory deprivation test with 24 hours fasting state. They also performed liver function test and ultrasonogram for evaluation of hepatobiliary tract disease. Total serum bilirubin was markedly increased, especially unconjugate bilirubin level higher over the two times than base line after they had been calory deprivation for 24 hours, They was not found another abnormality all laboratory results and physical examination. This study is a report on two cases of hyperbilirubinemia, diagnosed as Gilbert's syndrome, which were found in the process of a clinical pharmacokinetic study of a decoction of medicinal herbs.

• Journal of Korean Medicine for Obesity Research
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• v.11 no.2
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• pp.69-74
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• 2011

Objectives: The modified fasting therapy(MFT) of traditional korean medicine uses very low calorie diet on a patient with chronic disease and obesity. During the fasting period of MFT, calorie intake is restricted under 600kcal. Adverse events such as hunger, heartburn, headache, and hair loss can occur because of fasting. In case of Gilbert's syndrome, Jaundice can arise without disorder of liver function and hemolysis because of increase of unconjugated bilirubin. We experienced a case of Gilbert's syndrome patient who appeared jaundice during the fasting period, so we report about that with literature review.

• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.634-640
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• 2005

Objective : This study was designed to investigate the effects of herbal medicine on jaundice caused by hepatic resection. Methods : This study was carried out on one patient with jaundice ensued by hepatic resection. The patient was admitted on October 25th, and treated until November 13th, 2004, using acupuncture and herbal medicine(Hepacure-I and Ex.Sosiho-tang.) Result : After 18 days, clinical symptoms had improved. Results of total bilirubin, ALP, GGT tests and urinalysis also showed improvement. Conclusions : These result support a role for this combination of acupunture and herbal medicine in treatment of chronic liver disease.