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Mitochondrial Fission: Regulation and ER Connection

  • Lee, Hakjoo;Yoon, Yisang
    • Molecules and Cells
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    • v.37 no.2
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    • pp.89-94
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    • 2014
  • Fission and fusion of mitochondrial tubules are the main processes determining mitochondrial shape and size in cells. As more evidence is found for the involvement of mitochondrial morphology in human pathology, it is important to elucidate the mechanisms of mitochondrial fission and fusion. Mitochondrial morphology is highly sensitive to changing environmental conditions, indicating the involvement of cellular signaling pathways. In addition, the well-established structural connection between the endoplasmic reticulum (ER) and mitochondria has recently been found to play a role in mitochondrial fission. This minireview describes the latest advancements in understanding the regulatory mechanisms controlling mitochondrial morphology, as well as the ER-mediated structural maintenance of mitochondria, with a specific emphasis on mitochondrial fission.

Optimal Tuning of a Fuzzy Controller Using Boxs“Complex”Algorithm

  • Whalen, Thomas;Schott, Brian
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1993.06a
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    • pp.1350-1353
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    • 1993
  • A fuzzy control system typically requires“tuning,”or adjuctment of the parameters defining its linguistic variables. Automating this process amounts to applying a second“metacontrol”layer to drive the controller and plant to desired performance levels. Current methods of automated tuning rely on a single crisp numeric functional to evaluate control system performance. A generalization of Box's complex algorithm allows more realistic tuning based on lexicographic aggregation of multiple ordinal scales of performance, such as effectiveness and efficiency. The method is presented and illustrated using a simple inverted pendulum control system.

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Strategies for Worksite Health Interventions to Employees with Elevated Risk of Chronic Diseases

  • Meng, Lu;Wolff, Marilyn B.;Mattick, Kelly A.;DeJoy, David M.;Wilson, Mark G.;Smith, Matthew Lee
    • Safety and Health at Work
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    • v.8 no.2
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    • pp.117-129
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    • 2017
  • Chronic disease rates have become more prevalent in the modern American workforce, which has negative implications for workplace productivity and healthcare costs. Offering workplace health interventions is recognized as an effective strategy to reduce chronic disease progression, absenteeism, and healthcare costs as well as improve population health. This review documents intervention and evaluation strategies used for health promotion programs delivered in workplaces. Using predetermined search terms in five online databases, we identified 1,131 published items from 1995 to 2014. Of these items, 27 peer-reviewed articles met the inclusion criteria; reporting data from completed United States-based workplace interventions that recruited at-risk employees based on their disease or disease-related risk factors. A content rubric was developed and used to catalogue these 27 published field studies. Selected workplace interventions targeted obesity (n = 13), cardiovascular diseases (n = 8), and diabetes (n = 6). Intervention strategies included instructional education/counseling (n = 20), workplace environmental change (n = 6), physical activity (n = 10), use of technology (n = 10), and incentives (n = 13). Self-reported data (n = 21), anthropometric measurements (n = 17), and laboratory tests (n = 14) were used most often in studies with outcome evaluation. This is the first literature review to focus on interventions for employees with elevated risk for chronic diseases. The review has the potential to inform future workplace health interventions by presenting strategies related to implementation and evaluation strategies in workplace settings. These strategies can help determine optimal worksite health programs based on the unique characteristics of work settings and the health risk factors of their employee populations.

The Role of Polyunsaturated Fatty Acids In the Canine Epidermis: Normal Structural and Functional Components, Inflammatory Disease State Components, and as Therapeutic Dietary Components (개의 상피에 있어서 정상구조와 기능적 성분, 염증질환 상태에서의 성분 및 치료용 규정식 성분으로서의 다불포화 지방산의 역할(7))

  • Schick M.P.;Schick Robert O.;Reinhart Gregory A.
    • Journal of the korean veterinary medical association
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    • v.33 no.2
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    • pp.71-76
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    • 1997
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EC/CALS-related Projects in the Engineering Information Systems Lab

  • Fulton, Robert E.;Peak, Russell S.
    • Proceedings of the CALSEC Conference
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    • 1999.07a
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    • pp.147-164
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    • 1999
  • ㆍ Strong emphasis on X-analysis integration (XAI/DAI) ㆍ Multi-Representation Architecture (MRA) - Addressing fundamental XAI/DAI issues - General methodology $\longrightarrow$ Flexibility & broad application(omitted)

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Microsystems for Whole Blood Purification and Electrophysiological Analysis

  • Han, Arum;Han, Ki-Ho;Mohanty Swomitra K.;Frazier A. Bruno
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.5 no.1
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    • pp.1-10
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    • 2005
  • This paper presents the development of a microsystem for whole blood purification and electrophysiological analysis of the purified cells. Magnetophoresis using continuous diamagnetic capture (DMC) was utilized for whole cell purification and electrical impedance spectroscopy (EIS) was utilized for electrophysiological analysis of the purified cells. The system was developed on silicon and plastic substrates utilizing conventional microfabrication technologies and plastic microfabrication technologies. Using the magnetophoretic microseparator, white blood cells were purified from a sample of whole blood. The experimental results of the DMC microseparator show that 89.7% of the red blood cells (RBCs) and 72.7% of the white blood cells (WBCs) could be continuously separated out from a whole blood using an external magnetic flux of 0.2 T. EIS was used as a downstream whole cell analysis tool to study the electrophysiological characteristics of purified cells. In this work, primary cultured bovine chromaffin cells and human red blood cells were characterized using EIS. Further analysis capabilities of the EIS were demonstrated by successfully obtaining unique impedance signatures for chromaffin cells based on the whole cell ion channel activity.