• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.431-431
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• 2011

Rio Narcea 는 스페인 북부에 위치한 Astuias 지역을 흐르는 Nalon River 의 한 지류로서 총연장 102km 유역 면적 1,135 m이며. 사행천으로 홍수 시 범람하기 쉬운 곡류천의 특성상 잦은 홍수피해를 받고 있는 지역이다. 특히 2010년 6월에는 일주일 사이에 홍수 피해가 두 번씩이나 발생함에 따라 수많은 인명피해가 발생하였고 사회 SOC 시설이 큰 타격을 입는 등 상당한 피해를 야기하였다. 이에 1D 및 2D 수리 모델링 프로그램을 이용하여 사행천에 수리특성을 분석하고, 그에 따른 홍수범람도를 작성하여 1D와 2D 모델링을 비교분석하였고 이를 이용하여 홍수 피해 방지 대책을 마련하는데 도움이 되고자 한다. 1D 모델링은 HEC-GeoRAS 및 HEC-RAS를 이용하였으며, 2D 모델링에는 IBER를 이용하였다. Arc-GIS 툴을 이용한 HEC-GeoRAS 기능을 사용하여 강의 단면을 구성하고 HEC-RAS를 이용하여 1차원 모델링을 수행하였으며, 2D 모델링에는 스페인의 CIMNE에서 개발한 2차원 수리해석 프로그램인 IBER를 사용하였는데, 이 프로그램은 부정류 해석과 난류 해석, 유사이동 및 Dam-break 등의 해석이 가능하다. 1D 및 2D 모델링의 결과 값으로 얻어진 수심 및 유속을 토대로 1D는 Arc-GIS를 이용, 2D는 IBER 프로그램 내에 기능을 이용하여 바르셀로나에서 주로 사용되는 Catalan Water Agency 기준에 의한 홍수범람도를 작성하였다. 각각의 1D 와 2D 모델링으로 작성한 홍수범람도를 비교분석해 본 결과 거의 유사하게 표현됨을 알 수 있었으며, 두 모델링 기법 모두 홈수범람도를 표현함에 있어서 유용하게 사용될 수 있을 것이라 생각된다. 대상지역의 관련 자료의 유무에 따라 구분하여 1D 혹은 2D 모델링 기법을 선택 사용할 수 있으며. 유역의 홍수발생시 인명과 재산 피해에 대비한 홍수범람 지도 및 홍수재해지도 제작에 도움이 될 것으로 판단된다.

• Biomedical Science Letters
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• v.18 no.2
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• pp.165-168
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• 2012

Hox proteins containing DNA-binding homedomain act as transcription factors important for anteroposterior body patterning during vertebrate embryogenesis. However, the precise mechanisms by which signal pathways are transduced to regulate the Hox gene expression are not clear. In the course of an attempt to isolate an upstream regulatory factor(s) controlling Hox genes, protein kinase B alpha (Akt1) has been identified as a putative regulator of Hox genes through in silico analysis (GEO profile). In the Gene Expression Omnibus (GEO) dataset GDS1784 at the NCBI (National Center for Biotechnology Information) site, Hox genes were differentially expressed depending on the presence or absence of Akt1. Since it was not well known how Akt1 regulates the specific Hox genes, whose transcription was reported to be regulated by epigenetic modifications such as histone acetylation, methylation etc., the expression of Gcn5, a histone acetyltransferase (HAT), was analyzed in wild type (WT) as well as in $Akt1^{-/-}$ mouse embryonic fibroblast (MEF) cells. RT-PCR analysis revealed that the amount of Gcn5 mRNA was similar in both WT and $Akt1^{-/-}$ MEFs. However, the protein level of Gcn5 was significantly increased in $Akt1^{-/-}$ MEF cells. The half life of Gcn5 was 1 hour in wild type whereas 8 hours in $Akt1^{-/-}$ MEF. These data all together, indicate that Gcn5 is post-transcriptionally down-regulated and the protein stability is negatively regulated by Akt1 in MEF cells.

• Journal of the Korean GEO-environmental Society
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• v.7 no.6
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• pp.5-12
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• 2006

This study was conducted to investigate the effect of operational parameters such as dosage of magnesium and phosphate, pH, reaction time and existence crystal core for the removal of nitrogen and phosphorus in anaerobic fermentation supernatant by struvite crystallization. Optimal mole ratio of $Mg^{2+}:NH_4{^+}:PO_4{^{3-}}$ was 1.2:1.0:1.2. Under the optimal molar ratio, removal ratio and reaction rate constant of $NH_4{^+}-N$ and $PO_4{^{3-}}-P$ were 79.2, 96.8%, 0.157 and $0.344min^{-1}$, respectively. Optimal pH and reaction time were 11 and 10 minutes, respectively, in the optimal molar ratio. Residual concentration of $NH_4{^+}-N$ and $PO_4{^{3-}}-P$ showed lowest value with 1 g/L of crystal core addition. SEM analysis of struvite crystallization with crystal core showed higher crystal core growth than that of without crystal core. Struvite precipitate proved to be orthorhomic crystal structure by XRD analysis.

• Journal of Microbiology and Biotechnology
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• v.32 no.10
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• pp.1262-1274
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• 2022

Cholangiocarcinoma (CCA) is a complex and refractor type of cancer with global prevalence. Several barriers remain in CCA diagnosis, treatment, and prognosis. Therefore, exploring more biomarkers and therapeutic drugs for CCA management is necessary. CCA gene expression data was downloaded from the TCGA and GEO databases. KEGG enrichment, GO analysis, and protein-protein interaction network were used for hub gene identification. miRNA were predicted using Targetscan and validated according to several GEO databases. The relative RNA and miRNA expression levels and prognostic information were obtained from the GEPIA. The candidate drug was screened using pharmacophore-based virtual screening and validated by molecular modeling and through several in vitro studies. 301 differentially expressed genes (DEGs) were screened out. Complement and coagulation cascades-related genes (including AHSG, F2, TTR, and KNG1), and cell cycle-related genes (including CDK1, CCNB1, and KIAA0101) were considered as the hub genes in CCA progression. AHSG, F2, TTR, and KNG1 were found to be significantly decreased and the eight predicted miRNA targeting AHSG, F2, and TTR were increased in CCA patients. CDK1, CCNB1, and KIAA0101 were found to be significantly abundant in CCA patients. In addition, Molport-003-703-800, which is a compound that is derived from pharmacophores-based virtual screening, could directly bind to CDK1 and exhibited anti-tumor activity in cholangiocarcinoma cells. AHSG, F2, TTR, and KNG1 could be novel biomarkers for CCA. Molport-003-703-800 targets CDK1 and work as potential cell cycle inhibitors, thereby having potential for consideration for new chemotherapeutics for CCA.

• Journal of the Korean GEO-environmental Society
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• v.12 no.2
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• pp.63-68
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• 2011

The aim of this study was 1,4-dioxane's degradation efficiency and toxicity test applying E-beam. The experiments were shows that the degradation efficiency in the initial concentration of 1,4-dioxane and the irradiation capacity of E-beam and the degree of mineralization based on a change of scavenger gas. The biological toxicity test by using on of green algae, Pseudokirchneriella Subcapitata was conducted to lead the reducing toxicity. Degradation efficiency of 1,4-dioxane was improved when E-beam irradiation intensity was higher and the efficiency of TOC removal using Radical scavenger gas was increased by $N_2O$, $O_2$ and $N_2$ in order. In 4 days(96hrs), toxicity test results indicated that toxicity effect was decreased by increase of E-beam irradiation intensity.

• Journal of the Korean GEO-environmental Society
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• v.15 no.12
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• pp.87-95
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• 2014

Recently, there are increasing technical needs for foundation retrofit project such as vertical extension of apartment building. This paper focuses on the load distribution characteristics of existing and reinforcing piles when reinforcing pile is installed to the existing foundation. Allowable bearing load was initially applied on the foundation slab supported with four existing piles and then, one reinforcing pile was installed at the center of foundation slab and additional load was applied. The experimental results showed the Load Distribution Ratio (LDR) between existing and reinforcing piles converged after the applied load exceeded allowable bearing capacity of all piles. Laboratory tests were also performed for the cases of 60 %, 80 %, 100 % unloading level of allowable bearing load. After unloading step, one reinforcing pile was installed at the center of foundation slab and additional load was applied. The results showed that reloading load level at which LDR between existing and reinforcing piles converged decreased as the amount of unloading load increased.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.354-363
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• 2017

The purpose of this study sought to analyze the achievement of educational training of IS-Geo's (International School for Geoscience Resources; IS-Geo's) according to the structural relationships between these components by incorporating variables and those that affect learning outcomes from the Learning ecological perspective. Therefore, from January 2014 to December 2015, data analysis was conducted based on the data collected by the questionnaire for class satisfaction, which was conducted after the operation of the educational training program. The principal result is as follows. First of all, Interventions that affect learning outcomes from the learning ecology perspective have resulted in internal factors of both learning motivation and learning development, intermediate factors of both contents of education and learning curriculum, external factors of both learner support and quality of instructors. The structural relationships between the designed factors of performance indicators of interdisciplinary achievement and sub-factors have been influenced in the structural implications of internal factors, intermediate factors, and external factors that affect the learning outcomes of educational trainees who participated in the educational training programs of IS-Geo's. Also, internal factors, intermediate factors, and external factors have directly affected learning outcomes for educational trainees.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.5
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• pp.506-513
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• 2020

Due to climate change, there is an increasing risk of complex (hybrid) disasters, comprising rising sea-levels, typhoons, and torrential rains. This study focuses on Marine City, Busan, a new residential city built on a former landfill site in Suyeong Bay, which recently suffered massive flood damage following a combination of typhoons, storm surges, and wave overtopping and run-up. Preparations for similar complex disasters in future will depend on risk impact assessment and prioritization to establish appropriate countermeasures. A framework was first developed for this study, followed by the collection of data on flood prediction and socioeconomic risk factors. Five socioeconomic risk factors were identified: (1) population density, (2) basement accommodation, (3) building density and design, (4) design of sidewalks, and (5) design of roads. For each factor, absolute criteria were determined with which to assess their level of risk, while expert surveys were consulted to weight each factor. The results were classified into four levels and the risk level was calculated according to the sea-level rise predictions for the year 2100 and a 100-year return period for storm surge and rainfall: Attention 43 %, Caution 24 %, Alert 21 %, and Danger 11 %. Finally, each level, indicated by a different color, was depicted on a complex disaster risk map.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.719-722
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• 2016

Background: Cholangiocarcinoma (CCA) is a serious health problem in Thailand, particularly in northeastern and northern regions, but epidemiological studies are scarce and the spatial distribution of CCA remains to be determined. A database for the population at risk is required for monitoring, surveillance and organization of home health care. This study aim was to geo-visually display the distribution of CCA in northeast Thailand, using a geographic information system and Google Earth. Materials and Methods: A cross-sectional survey was carried out in 9 sub-districts and 133 villages in Chum Phuang district, Nakhon Ratchasima province during June and October 2015. Data on demography, and the population at risk for CCA were combined with the points of villages, sub-district boundaries, district boundaries, and points of hospitals in districts, then fed into a geographical information system. After the conversion, all of the data were imported into Google Earth for geo-visualization. Results: A total of 11,960 from 83,096 population were included in this study. Females and male were 52.5%, and 47.8%, the age group 41-50 years old 33.3%. Individual risk for CCA was identifed and classified by using the Korat CCA verbal screening test as low (92.8%), followed by high risk (6.74%), and no (0.49%), respectively. Gender ($X^2$-test=1143.63, p-value= 0.001), age group ($X^2$-test==211.36, p-value=0.0001), and sub-district ($X^2$-test=1471.858, p-value=0.0001) were significantly associated with CCA risk. Spatial distribution of the population at risk for CCA in Chum Phuang district was viewed with Google Earth. Geo-visual display followed Layer 1: District, Layer 2: Sub-district, Layer 3: Number of low risk in village, Layer 4: Number of high risk in village, and Layer 5: Hospital in Chum Phuang District and their related catchment areas. Conclusions: We present the first risk geo-visual display of CCA in this rural community, which is important for spatial targeting of control efforts. Risk appears to be strongly associated with gender, age group, and sub-district. Therefor, spatial distribution is suitable for the use in the further monitoring, surveillance, and home health care for CCA.

• Journal of Korean Society for Geospatial Information Science
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• v.1 no.2 s.2
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• pp.223-235
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• 1993

This study associates with socio-economic status in a slice section area of Chicago metropolitan to get spatial patterns of urban windows. GSIS(Geo-spatial Information System) has been monitored with several statistic methods, and geo-spatial map presentations. From the grouping analysis, the result displays that most suburban town have high income values, such as Elmhurst, Melrose Park, North Lake(Income ranges between $25,000${\sim}$30,000 : 1980 Sensus data). The factors produced form both analyses of SAS and BMDP are socio-ethnic, economic, hispanic, black, life expectancy, and multiple car ownership. In the study area the socio-ethnic factor is striking, and is composed of nine out of the fourteen varialbles. Geo-spatial 3-D mapping represents a socio-economic configuration of the study area. The high income value areas are Elmhurst and North Lack, and a spot between Belmont Ave. and the Lake Shore. Economic configuration is a vital importance of socio-economic activities in the urban areas. In the study area a minimum average income level is about $4,364 and maximun is $30,311.