• YAKHAK HOEJI
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• v.44 no.6
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• pp.539-544
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• 2000

Many diabetic patients develop serious complications during the course of the disease, including cardiovascalar disorders, nepropathy, neuropathy and retinopathy. Because some physiological changes occurring in diabetes mellitus patients could alter the pharmacokinetics of drugs used to treat the disease, the pharmacokinetics of gentamycin was investigated after intravenous administration (2 mg/kg) to control rabbits and acute or chronic alloxan-induced diabetes mellitus rabbits (AIDRs). After intravenous administration, the serum concentrations of gentamycin were significantly higher between 6 and 12 hr in chronic AIDRs compared with those in control rabbits. The AUC was significant greater in chronic ($31.91\;{\pm}\;3.76\;{\mu}g/ml{\cdot}hr$) AIDRs than that in control ($21.60\;{\pm}\;2.45\;{\mu}g/ml{\cdot}hr$) rabbits. Total body clearance (CLt) in AIDRs were significantly decreased compared with that in control rabbits. Cumulative urinary excretion of gentamycin was decreased, although not significantly, in AIDRs compared with that in control rabbits.

• Journal of Environmental Health Sciences
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• v.1 no.1
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• pp.46-51
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• 1974

The agar plate titrations of antibiotic sensitivities of Salmonella and Shigella isolated from human during 1967 to 1972 were studies. 1. The most effective antibiotics against Salmonella and Shigella were chloramphenicol, tetracycline, kanamycin, minomycin, and gentamycin. 2. All strain of Salmonella typhi were resistant to cloxacilline. 3. The most effective antibiotics against Shigella were kanamycin, gentamycin and minomycin.

• Korean Journal of Animal Reproduction
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• v.19 no.1
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• pp.1-7
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• 1995

This study was accomplished to illuminate factors of contamination of microbes in the culture medium and effect of antibiotics on prevention of contamination in the medium when bovine follicular oocyte was matured, fertilized and developed in vitro. 1. When washed or unwashed semen diluted with TCM 199 was incubated for 24∼72hr, contamination was come out. 2. When diluted semen with TCM 199 which has penicillin, streptomycin, gentamycin, kanamycin or nystatin was incubated for 24∼72hr, contamination was not come out only in kanamycin. 3. When imported semen which was diluted in TCM 199 with penicillin, streptomycin, gentamycin, kanamycin or nystatin was incubated for 24∼72hr, contamination was not come out in all treatments. 4. When semen which was diluted in BO, CZB, Ham's F10 or TCM 199 was incubated for 24∼72hr, kanamycin showed no contamination in all treatments, but gentamycin showed contamination in CZB, Ham's F10 and TCM 199. 5. When the semen diluted in BO was moved at 24hr after incubation into BO and incubated for 72hr, contamination was not come out, but when it was moved into the TCM 199 and incubated for 72hr, contamination was come out at 48 to 72hr of incubation. 6. When the semen diluted in BO, BO＋BSA or BO＋FBS containing gentamycin, kanamycin or nystatin was incubated for 24∼72hr, the diluted semen in BO or BO＋BSA showed no contamination in all antibiotics but the diluted semen in BO＋FBS showed no contamination only in kanamycin. 7.The Pseudomonas cepacia, Serratia liquefaciens, Klebsiella pneumaniae was respectively isolated in the semen of A, B, and C bull and the microbes are highly affected by amikacin, tobramycin and kanamycin. 8. When bovine folicular oocyte was in vitro matured, fertilized and developed in the simple medium with kanamycin, 26.6% was developed to over 32cell stage embryo.

• Microbiology and Biotechnology Letters
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• v.10 no.3
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• pp.163-169
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• 1982

The possible effects in vivo on the duel usage of sinseng saponin and antibiotics were studied in vitro with microorganisms. Streptomycin.sulfate, kanamycin.sulfate and gentamycin.sulfate as being an aminoglycoside-antibiotic substance showed a general synergism by the interaction of ginseng saponin and these antibiotics. But kanamycin.sulfate and gentamycin.sulfate did not show a synergism in their original antimicrobial activity against Er-winia aroideoe. Chloramphenicol as being a benzene derivative displayed an increased antimicrobial activity by the interactions of ginseng saponin and this antibiotic against Salmonella typhi, Aerobacter aerogenes and the genus Serrotia. This antibiotic also showed the decreased antimicrobial activity against Bacillus subtilis, Bacillus megaterium and Escherichia coli, but did not show an uniform antimicrobial activity against others.

• Journal of Veterinary Clinics
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• v.10 no.1
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• pp.55-60
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• 1993

To investigate e effect of antimicrobial ointments on wound healing wound contraction was measured in rabbits with daily application of ointments. Full thickness skin defects(1cm$\times$1cm) were made in three different areas on the back. Percentage of wound contraction based on wound area measured on the day of surgery was calculate every other day until day 9. The percentages of wound contraction in saline and gentamycin solution-treated groups were 86.0% and 75.0%, respectively and higher than those in animicrobial ointments, especially gentamycin cream, silver sulfadiazine and madecasol ointments. It was suggested that the effect of antimicrobial ointments on wound healing were not superior to at of physiological saline in respect to wound contraction in rabbits.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.276.1-276.1
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• 2000

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.185-192
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• 1986

Antimicrobial susceptibility of the bacterial strains isolated from clinical specimens during the period from June, 1983 to June, 1986 in Yeungnam Medical Center was studied and the following results were obtained. 1. Staphylococcus aureus was highly susceptible to cephalothin and its susceptibility to methicillin was gradually reduced. 2. Streptococcus strains except enterococcus were generally susceptible to penicillin, while most enterococci were suscesceptible to only ampicillin. 3. Gram-negative rods including Escherichia coli were highly susceptible to amikacin and tobramycin. 4. Serratia were generally less susceptible to the amtimicrobials tested than other Enterobacteriaceae. Among them, Serratia marcescens showed the highest susceptibility to amikacin and chloramphenicol. 5. Pseudomonas aeruginosa revealed the highest susceptibility to amikacin and tobramycin and moderate susceptibility to carbenicillin and gentamycin. 6. Acinetobacter calcoaceticus revealed low susceptibility to most antimicrobials tested, showing only 30% susceptibility to amikacin, tobramycin and gentamycin in 1986.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.133-140
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• 2009

Caveolin may be a molecular target for modulation of aging process in cochlear hair cells and have association with oxotoxicity. First we investigated the basal expression of caveolin-1, caveolin-2, caveolin-3, nitric oxide synthase, and superoxide dismutase in UB/OC-1 cochlear hair cell line. By using a RNA interference technique, we investigated whether down-regulation of caveolin influenced telomerase activity and reactive oxygen species (ROS) production in cochlear hair cells. In addition, cisplatin and gentamycin, known ototoxic drugs, were administered to the cochlear cells to determine their impact on caveolin expression. Further attempts at elucidating cellular aging mechanism with caveolin and ototoxic drugs were carried out. The main discoveries were the presence of caveolin-1 in UB/OC-1 cells and that down-regulation of caveolin-1 reduced protein kinase A activity. Telomerase was activated by caveolin down-regulation and caveolin down-regulation inhibited oxidative stress at the mitochondrial level. When cisplatin and gentamycin were administered to the cochlear hair cells during a caveolin expression state, a decrease in telomerase activity and increase ROS activity was observed. Caveolin-1 may modulate the senescent mechanisms in cochlear cells. An increase in caveolin-1 levels can lead to ROS production in the mitochondria which may cause ototoxicity.

• Korean Journal of Food Science and Technology
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• v.31 no.3
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• pp.751-756
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• 1999

The inhibitory effect of antibiotics on growth of lactobacillus, streptococcus and bifidobacteria was examined to develop the selective media to isolate and enumerate bifidobacteria from the fermented foods containing various lactic bacteria. The growth of lactic bacteria was inhibited seriously but that of bifidobacteria was not inhibited by gentamycin or ripampicin at the concentration of more than $100\;{\mu}g/mL$. However lactic bacteria did not grow in MRS broth containing $50\;{\mu}g/mL$ of ampicillin and the growth inhibition of bifidobacteria occurred. The growth inhibition of bifidobacteria was more severe than lactic bacteria in $100\;{\mu}g/mL$ of fosfomycin. Therefore, the MRS medium containing $80\;{\mu}g/mL$ of neomycin sulfate, $50\;{\mu}g/mL$ of gentamycin, $50\;{\mu}g/mL$ of rifampicin, $15\;{\mu}g/mL$ of nalidixic acid and $3\;{\mu}g/mL$ of lithium chloride was concluded selective for bifidobacteria, but restrictive for the other lactic bacteria present in Kimchi and cheese.

• Korean Journal of Veterinary Research
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• v.20 no.2
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• pp.159-165
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• 1980

A total of 98 strains of Bordetella bronckiseptica isolated from pigs affected the infectious atrophic rhinitis(AR) during 1978 were surveyed for drug sensitivity to 26 chemotherapeutic agents, and minimum inhibitory concentration(MIC), incidence rate of resistant strain and resistant patern from the strains which were obtained from the different pig farm in Jeonnam province were examined. The results obtained are summarized as follows. 1. Most of the strains tested were resistant to Ampicillin (AB, PC), spiramycin(SPO, sulfa drugs (SD) (MIC:$400.0{{\mu}g/ml}$) and streptomycin(SM) (MIC:$200.0{{\mu}g/ml}$). Of the 75.0% of strains were also resistant to penicillin(PC) (MIC:$200.0{{\mu}g/ml}$) and of the 14.3 of strains were inhibited to grow to tetracycline(TC), chlortetracycline(CTC), oxytetracyc-line(OTC), erythromycin(EM), tylosin(TS), leucomycin (LM) and chloramphenicol (CP) (MIC:$6.25{{\mu}g/ml}$). On the other hand, most of the strains tested were inhibited to grow to kanamycin(KM), gentamycin(GM) neomycin(NM) (MIC:$25.0{{\mu}g/ml}$) and to colistin(CL) (MIC:$12.5{{\mu}g/ml}$). 2. Incidence rate of resistant strains to main chemotherapeutic agents was 100.0% of sulfa drugs, 96.4% of streptomycin, 85.7% of penicillin, tetracycline, chloramphenicol and erythromycin, 46.4% of gentamycin, 17.9% of colistin and 0.0% of kanamycin and nalidixic acid.