• BMB Reports
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• 제50권11호
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• pp.535-536
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• 2017

A novel approach has been used to identify functional interactions relevant to human disease. Using high-throughput human-yeast genetic interaction screens, a first draft of disease interactome was obtained. This was achieved by first searching for candidate human disease genes that confer toxicity in yeast, and second, identifying modulators of toxicity. This study found potentially disease-relevant interactions by analyzing the network of functional interactions and focusing on genes implicated in amyotrophic lateral sclerosis (ALS), for example. In the subsequent proof-of-concept study focused on ALS, similar functional relationships between a specific kinase and ALS-associated genes were observed in mammalian cells and zebrafish, supporting findings in human-yeast genetic interaction screens. Results of combined analyses highlighted MAP2K5 kinase as a potential therapeutic target in ALS.

• Journal of Welding and Joining
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• 제24권5호
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• pp.67-73
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• 2006

Laser welding is suitable for welding to the aluminum alloy sheet. In order to apply the aluminum laser welding to production line, parameters should be optimized. In this study, the optimal welding condition was searched through the genetic algorithm in laser welding of AA5182 sheet with AA5356 filler wire. Second-order polynomial regression model to estimate the tensile strength model was developed using the laser power, welding speed and wire feed rate. Fitness function for showing the performance index was defined using the tensile strength, wire feed rate and welding speed which represent the weldability, product cost and productivity, respectively. The genetic algorithm searched the optimal welding condition that the wire feed rate was 2.7 m/min, the laser power was 4 kW and the welding speed was 7.95 m/min. At this welding condition, fitness function value was 137.1 and the estimated tensile strength was 282.2 $N/mm^2$.

• Steel and Composite Structures
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• 제19권4호
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• pp.1035-1053
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• 2015

A genetic algorithm-based minimum weight design method is presented for steel frames containing composite beams, semi-rigid connections and column bases. Genetic Algorithms carry out optimum steel frames by selecting suitable profile sections from a specified list including 128 W sections taken from American Institute of Steel Construction (AISC). The displacement and stress constraints obeying AISC Allowable Stress Design (ASD) specification and geometric (size) constraints are incorporated in the optimization process. Optimum designs of three different plane frames with semi-rigid beam-to-column and column-to-base plate connections are carried out first without considering concrete slab effects on floor beams in finite element analyses. The same optimization procedures are then repeated for the case of frames with composite beams. A program is coded in MATLAB for all optimization procedures. Results obtained from the examples show the applicability and robustness of the method. Moreover, it is proved that consideration of the contribution of concrete on the behavior of the floor beams enables a lighter and more economical design for steel frames with semi-rigid connections and column bases.

• 한국공간구조학회논문집
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• 제2권3호
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• pp.61-70
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• 2002

The objective of this study is the development of a size and shape discrete optimum design algorithms, which is based on the genetic algorithms and the fuzzy theory. This algorithms can perform both size and shape optimum designs of plane and space trusses. The developed fuzzy shape-GAs (FS-GAs) was implemented in a computer program. For the optimum design, the objective function is the weight of structures and the constraints are limits on loads and serviceability. This study solves the problem by introducing the FS-GAs operators into the genetic.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 하계종합학술대회 논문집
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• pp.452-455
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• 1999

We introduce an evolutionary approach to on-line learning for mobile robot control using reconfigurable hardware. We use genetic programming as an evolutionary engine. Control programs are encoded in tree structure. Genetic operators, such as node mutation, adapt the program trees based on a set of training cases. This paper discusses the advantages and constraints of the evolvable hardware approach to robot learning and describes a FPGA implementation of the presented genetic programming method.

• Asian-Australasian Journal of Animal Sciences
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• 제13권7호
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• pp.883-887
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• 2000

One way of evaluating the effectiveness of a dairy breeding program is to measure response to selection. This may be direct or indirect. The objectives of this study were to estimate expected progress for direct selection on milk, fat and protein yields; to estimate the expected correlated responses on indirect selection for milk, fat and protein yields in Zimbabwean Holstein cattle and to establish the effect of selection intensity on responses. The Animal Model contained fixed effects of herd, year of calving, calving month, dry period, milking frequency and additive effects pertaining to cows, sires and dams. AIREML software package was used to analyse the data. The genetic and phenotypic parameters obtained in this study were used to compute direct and correlated responses to selection. Because of the higher heritabilities in first parity, genetic progress was found to be greater when selection was practised on first parity cows as compared to later lactations. It is therefore recommended that older cows in the herd be replaced with improved heifers so as to enhance genetic progress.

• International Journal of Aeronautical and Space Sciences
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• 제14권4호
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• pp.341-349
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• 2013

This paper considers the optimum design of flexbeam cross-sections for a full-scale bearingless helicopter rotor, using an efficient hybrid optimization algorithm based on particle swarm optimization, and an improved genetic algorithm, with an effective constraint handling scheme for constrained nonlinear optimization. The basic operators of the genetic algorithm, of crossover and mutation, are revisited, and a new rank-based multi-parent crossover operator is utilized. The rank-based crossover operator simultaneously enhances both the local, and the global exploration. The benchmark results demonstrate remarkable improvements, in terms of efficiency and robustness, as compared to other state-of-the-art algorithms. The developed algorithm is adopted for two baseline flexbeam section designs, and optimum cross-section configurations are obtained with less function evaluations, and less computation time.

• ALGAE
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• 제34권1호
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• pp.35-43
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• 2019

Genetic study of haploid organisms offers the advantage that mutant phenotypes are directly displayed, but has the disadvantage that strains carrying lethal mutations are not readily maintained. We describe an approach for generating and performing genetic analysis of diploid strains of Chlamydomonas reinhardtii, which is normally haploid. First protocol utilizes self-mating diploid strains that will facilitate the genetic analysis of recessive lethal mutations by offering a convenient way to produce homozygous diploids in a single mating. Second protocol is designed to reduce the chance of contamination and the accumulation of spontaneous mutations for long-term storage of mutant strains. Third protocol for inducing the meiotic program is also included to produce haploid mutant strains following tetraploid genetic analysis. We discuss implication of self-fertile strains for the future of Chlamydomonas research.

• Asian-Australasian Journal of Animal Sciences
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• 제5권4호
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• pp.623-628
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• 1992

Records on weaning (3803) and yearling weight (2990) of beef cattle (Bibos banteng) from the Bali Cattle Improvement Project were examined. A mixed model analysis involving all main non-genetic effects (village, year of birth, season of birth, age of dam, sex of calf, all significant interactions and age at weighing as a covariate) as fixed effects and sire nested within village as a random effect was undertaken. Variance components were estimated by Henderson's Method III. Paternal half-sib components of variance and covariance were used to estimate heritabilities of weaning and yearling weights, as well as their genetic and phenotypic correlations. Heritability estimates ($\pm$ standard error) obtained by Henderson's Method III for weaning and yearling weights were $.11{\pm}.03$ and $.13{\pm}.04$, respectively while the phenotypic and genetic correlations were estimated as .32 and $.64{\pm}.10$, respectively. The parameters estimated in this study were at the lower end of the range of reported values from various breeds. It is concluded that further information should be gathered to assist in estimating genetic parameters for other economic traits of Bali beef cattle and to provide more accurate estimates for weaning and yearling weights. These parameters should then be used to formulate a selection program to enable the genetic improvement of Bali Beef cattle.

• Composites Research
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• 제23권4호
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• pp.14-20
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• 2010

본 연구에서는 마이크로 유전자 알고리즘을 이용하여 외부 수압을 받는 필라멘트 와인딩 복합재 원통의 최적설계를 수행하였다. 목적함수는 파손하중과 좌굴하중을 동시에 고려하여 설계하중을 최대화하는 것이다. 좌굴 및 파손해석은 MSC.NASTRAN을 이용하였고, Carroll의 공개된 마이크로 유전자 알고리즘에 기초한 최적화작업을 수행하였다. 설계변수로는 헬리컬(helical) 와인딩 각도와 후프(hoop) 와인딩 층의 두께비가 고려되었다. 본 연구를 통해 마이크로 유전자 알고리즘을 이용하여 다양한 형상을 갖는 필라멘트 와인딩 복합재 원통의 좌굴 및 파손하중 최적화가 가능함을 확인하였고, 제안된 알고리즘이 일반 유전자 알고리즘과 비교해서도 높은 효율을 보였다.