• International Journal of Industrial Entomology and Biomaterials
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• v.19 no.1
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• pp.143-154
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• 2009

Single nucleotide polymorphisms (SNPs) are the most frequent form of variation in the genome of any organism. Owing to their greater abundance, they are considered useful for identifying cultivars, construction of higher density linkage maps, and detection of genes (QTLs) associated with complex agronomic traits and diseases. Although, SNPs have been used recently for constructing a high density genetic map in silkworm and a set of 118 SNPs have been identified in tasar silkworms, not much progress has been made in sericulture to utilize the vast potential of SNPs. Thus, this review mainly focuses on some of the important methods of SNP discovery, validation and genotyping. Emphasis has also been given to the possible uses of SNP genotyping in the improvement of silkworms and their host plants.

• Proceedings of the Korean Society of Computer Information Conference
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• 2009.01a
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• pp.189-192
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• 2009

게임에서 주인공 캐릭터나 MPC(Non Player Character)가 목적지까지의 경로를 찾는 것은 매우 중요하다. 또한 캐릭터가 이동 중 다양한 오브젝트와 벽을 만나면 이를 회피해야 하며 최단 경로로 이동해야 한다. 본 논문에서는 게임 맵에서 캐릭터의 길 찾기 방법으로 유전 알고리즘을 이용하는 방법을 제안하였다. 특히, 유전 알고리즘의 구성요소 중해 집합을 구성하는 염색체 인코딩 방법을 제안하였다. 본 논문에서 제안한 염색체의 인코딩은 캐릭터의 이동 방향을 비트 스트링으로 표현하였다. 캐릭터가 현재 위치에서 이동할 수 있는 방향은 8 방향이다. 따라서 하나의 방향을 표현하기 위해서는 3비트의 이진스트링으로 나타낼 수 있다. 하나의 해를 나타내는 염색체는 3비트의 이진 스트링을 맵을 나타내는 그래프의 노드 수만큼 할당하여 구성할 수 있다.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.236-244
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• 2003

Summary: The analysis of human genetic variation is one of the key issues far the understanding of the different drug response among individuals and many programs are developed for this purpose. However, current publicly available programs have so many limitations such as time complexity problem for the analysis of large amount of alleles or SNPs, difficult manipulation for installation, data import, and usage, and low-quality visual output. Here we present workbench for SNP anlaysis, SNPAnalyzer. SNPAnalyzer consists of 3 main modules: 1)Hardy-Weinberg Equilibrium ,2) Haplotype Estimation, and 3) Linkage Disequilibrium. Each module has several different widely-used algorithms for the extensive analysis and can handle large amount of alleles and SNPs with simple format. Analysis results are displayed in user-friendly formats such as table, graph and map. SNPAnalyzer is developed using C and C$^{++}$ and users can easily access through web-interftce. Availability: SNPAnalyzer can be freely implemented at http://www.istech.info/istech/board/login_form.jsp

• Journal of Integrative Natural Science
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• v.10 no.4
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• pp.202-208
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• 2017

Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organs including the liver, gut, lungs, kidney, heart, brain and plasma. It is involved in gout pathogenesis. Hence, in the present study, Hologram based Quantitative Structure Activity Relationship Study was performed on a series of Xanthine Oxidase antagonist named 2-(indol-5-yl) thiazole derivatives. The best HQSAR model was obtained using Atoms, Bonds, Connection, Hydrogen, Chirality and Donor Acceptor as fragment distinction parameter using hologram length 71 and 4 components with fragment size of minimum 2 and maximum 5. Significant cross-validated correlation coefficient ($q^2$= 0.563) and non cross-validated correlation coefficients ($r^2$= 0.967) were obtained. The model was then used to evaluate the six external test compounds and its $r^2{_{pred}}$ was found to be 0.798. Contribution map show that presence of propyl ring in indole thiazole makes big contributions for improving the biological activities of the compounds. We hope that our HQSAR model and analysis will be helpful for future design of xanthine oxidase antagonists.

• Journal of Integrative Natural Science
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• v.10 no.4
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• pp.209-215
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• 2017

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. CXCR2 antagonist may reduce the neutrophil chemotaxis and alter the inflammatory response because the neutrophilic inflammation in the lung diseases is found to be largely regulated through CXCR2 receptor. Hence, in the present study, Topomer based Comparative Molecular Field Analysis (Topomer CoMFA) was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The best Topomer COMFA model was obtained with significant cross-validated correlation coefficient ($q^2$ = 0.487) and non cross-validated correlation coefficients ($r^2$ = 0.980). The model was evaluated with six external test compounds and its $r^2{_{pred}}$ was found to be 0.616. The steric and electrostatic contribution map show that presence of bulkier and electropositive group around cyclopropyl ring may contribute more for improving the biological activities of these compounds. The generated Topomer CoMFA model could be helpful for future design of novel and structurally related CXCR2 antagonists.

• Journal of Integrative Natural Science
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• v.10 no.4
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• pp.192-196
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• 2017

Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organs including the liver, gut, lungs, kidney, heart, brain and plasma. It is involved in gout pathogenesis. Hence, in the present study, topomer based Comparative Molecular Field Analysis (topomer CoMFA) was performed on a series of Xanthine oxidase antagonist named 2-(indol-5-yl) thiazole derivatives. The best topomer CoMFA model was obtained with significant cross-validated correlation coefficient ($q^2$ = 0.572) and non cross-validated correlation coefficients ($r^2$ = 0.937). The model was evaluated with six external test compounds and its $r^2{_{pred}}$ was found to be 0.553. The steric and electrostatic contribution map show that presence of bulky and electropositive group in indole thiazole ring is necessary for improving the biological activities of the compounds. The generated topomer CoMFA model could be helpful for future design of novel and structurally related xanthine oxidase antagonists.

• Plant Biotechnology Reports
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• v.2 no.2
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• pp.93-112
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• 2008

Medicinal and aromatic plants (MAPs) are important sources for plant secondary metabolites, which are important for human healthcare. Improvement of the yield and quality of these natural plant products through conventional breeding is still a challenge. However, recent advances in plant genomics research has generated knowledge leading to a better understanding of the complex genetics and biochemistry involved in biosynthesis of these plant secondary metabolites. This genomics research also concerned identification and isolation of genes involved in different steps of a number of metabolic pathways. Progress has also been made in the development of functional genomics resources (EST databases and micro-arrays) in several medicinal plant species, which offer new opportunities for improvement of genotypes using perfect markers or genetic transformation. This review article presents an overview of the recent developments and future possibilities in genetics and genomics of MAP species including use of transgenic approach for their improvement.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1998.06b
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• pp.16.1-164
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• 1998

This paper describes Facial Expression Explorer to search for the components of a facial expression and to map the expression to other expressionless figures like a robot, frog, teapot, rabbit and others. In general, it is a time-consuming and laborious job to create a facial expression manually, especially when the facial expression must personify a well-known public figure or an actor. In order to extract a blending ratio from facial images automatically, the Facial Expression Explorer uses Networked Genetic Algorithm(NGA) which is a fast method for the convergence by GA. The blending ratio is often used to create facial expressions through shape blending methods by animators. With the Facial Expression Explorer a realistic facial expression can be modeled more efficiently.

• Korean Journal of Microbiology
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• v.26 no.1
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• pp.32-36
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• 1988

The yeast gene HOM3 encodes aspartokinase, which catalyses the first step (aspartate to and from beta-aspartyl phosphate) of common pathway to threonine and methionine. The yeast HOM3 gene expression is known to be regulated by threonine and methionine specific control, and also by general control of amino acid biosynthesis. Isolation and characterization of the HOM3 gene are essential for the molecular genetic study on its regulation of expression. A recombinant plasmid pSC3 (15.5kb, vector YCp50) has been cloned into E. coli HB101 from yeast genomic library through their complementing activity of HOM3 mutation in a yeast recipient strain M34-24B. Organization of the plasmid was characterized by delineation of restriction cleavage sites in the insert fragment.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2003.06a
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• pp.114-117
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• 2003

본 논문에서는 video stream내의 움직이는 객체 정보를 추정하고 동적 GTM(genetic tree-map) 알고리즘을 사용하여 얼굴 영역 검출 기법을 제안한다. 기존의 일반적인 객체 추정 기법은 클러스터(cluster)과정을 통하여 영상 정보를 분할하고 그 중 움직이는 객체 부분을 복원함으로서 추정하였다. 제안하는 기법은 BMA(block matching algorithm)［1］ 알고리즘을 사용하여 video stream 에서 움직이는 객체 정보를 얻고 클러스터 알고리즘으로 PCA(principal component analysis)를 사용한다. PCA 기법은 입력 데이터에 관해 통계적 특성을 이용하여 주성분을 찾는다. 주축과 영역분할 알고리즘을 사용하여 데이터를 분할하고, 분할된 객체 정보를 사용하여 특정 객체만을 추정하는 것이 가능하다. 이렇게 추정된 객체를 얼굴영역의 feature에 대하여 신경망 학습인 동적 GTM 알고리즘을 사용하여 생성된 동적 GTM 맵의 정보에 따라 객체의 얼굴영역만을 추출해 낼 수 있다［2-6］.