• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.9 no.5
• /
• pp.1218-1224
• /
• 2008

Located on the upstream of a gene, the promoter region that plays a very important role in the control of gene expression as a signal part has various binding sites for transcription factors. These binding sites are present in various parts of the promoter region and assume an aspect of highly conserved consensus sequence pattern. This paper deals with the introductions of search methods for consensus pattern, including Wataru method, EM algorithm, MEME algorithm, Genetic algorithm and Phylogenetic Footprinting method, and intends to give future prospects of research on this field.

• Clinical and Experimental Pediatrics
• /
• v.59 no.11
• /
• pp.432-439
• /
• 2016

Asthma is recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Accumulating evidence suggests that respiratory viral infections in early life constitute a major environmental risk factor for the development of childhood asthma. Respiratory viral infections have also been recognized as the most common cause of asthma exacerbation. The advent of molecular diagnostics to detect respiratory viruses has provided new insights into the role of human rhinovirus (HRV) infections in the pathogenesis of asthma. However, it is still unclear whether HRV infections cause asthma or if wheezing with HRV infection is simply a predictor of childhood asthma. Recent clinical and experimental studies have identified plausible pathways by which HRV infection could cause asthma, particularly in a susceptible host, and exacerbate disease. Airway epithelial cells, the primary site of infection and replication of HRV, play a key role in these processes. Details regarding the role of genetic factors, including ORMDL3, are beginning to emerge. This review discusses recent clinical and experimental evidence for the role of HRV infection in the development and exacerbation of childhood asthma and the potential underlying mechanisms that have been proposed.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.5 no.7
• /
• pp.1374-1383
• /
• 2001

In the fuzzy control method behaves more robustness than conventional control method, we propose a intelligent control method that membership functions and scaling factor of the fuzzy logic controller are optimized by genetic algorithm under off-line, and then fuzzy logic controller is constructed by the optimization parameters under on-line. In order to verify the usefulness of the proposed control method, we are applied to one link manipulator, and confirmed that the proposed control method is reduced the fuzzy rule base and is the better performance than the conventional fuzzy control method.

• The Transactions of the Korean Institute of Electrical Engineers A
• /
• v.54 no.2
• /
• pp.51-60
• /
• 2005

In this paper, we design the GA-fuzzy precompensator of a Power System Stabilizer for Thyristor Controlled Series Capacitor(TCSC-PSS) for enhancement of power system stability. Here a fuzzy precompensator is designed as a fuzzy logic-based precompensation approach for TCSC-PSS. This scheme is easily implemented by adding a fuzzy precompensator to an existing TCSC-PSS. And we optimize the fuzzy precompensator with a genetic algorithm for complements the demerit such as the difficulty of the component selection of fuzzy controller, namely, scaling factor, membership function and control rules. Nonlinear simulation results show that the proposed control technique is superior to conventional TCSC-PSS in dynamic responses over the wide range of operating conditions and in convinced robust and reliable in view of structure.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.21 no.3
• /
• pp.141-146
• /
• 2010

This summary of literature during the past year reviews published studies relating to risk factors for depressive disorders in children and adolescents. Risk factors include environmental toxins, socio-environmental, and genetic factors. As depression has a complex, multifactorial causal mechanism, it is likely that the accumulation and/ or interaction among multiple risk factors lead to depression. Findings related to the result of toxin exposure have been difficult to interpret given that risk factors tend to interact and that higher mental functions are not easily measurable. However, some findings have been consistent. Clinical research data has also shown that the risk for negative outcomes may be modified both by genetic and environmental factors through a gene environment interplay mechanism.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2003.07a
• /
• pp.730-733
• /
• 2003

Dual coding technique is one of the popular techniques to reduce the dynamic false contours on PDP. Subfield pattern is a key factor affecting the performance of dual coding technique. In this paper, an optimum subfield selection method based on genetic algorithm is proposed. Two types of string structures are defined to account for all the possible configurations of the dual coding subfield patterns. Genetic operators are proposed for optimization of dual coding subfield pattern. Quantitative measures to describe degrees of dynamic false contours and checkerboard patterns are defined. Experimental results indicate that dual coding subfield pattern that is determined by proposed method reduces dynamic false contours and checkerboard patterns.

• Proceedings of the KIEE Conference
• /
• 1999.07b
• /
• pp.812-814
• /
• 1999

In this paper, we are applied the Genetic Algorithm (GA) to design of fuzzy logic controller (FLC) for a DC Servo-Motor Speed Control. GA is used to design of the membership functions and scaling factor of FLC. To evaluate the performances of the proposed FLC, we make an experiment on FLC for the speed control of an actual DC servo-motor system with nonlinear characteristics. Experimental results show that proposed controller have better performance than those of PD controller.

• Journal of Mechanical Science and Technology
• /
• v.17 no.7
• /
• pp.966-977
• /
• 2003

This paper investigates how intentional mistuning of bladed disks reduces their sensitivity to unintentional random mistuning. The class of intentionally mistuned disks considered here is limited, for cost reasons, to arrangements of two types of blades (A and B, say). A two-step procedure is then described to optimize the arrangement of these blades around the disk to reduce the effects of unintentional random mistuning. First, a pure optimization effort is undertaken to obtain the pattern (s) of the A and B blades that yields small/the smallest value of the largest amplitude of response to a given excitation in the absence of unintentional random mistuning using Genetic Algorithm. Then, in the second step, a qualitative/quantitative estimate of the sensitivity for the optimized intentionally mistuned bladed disks with respect to unintentional random mistuning is performed by analyzing their amplification factor, probability density function and passband/stopband structures. Examples of application with simple bladed disk models demonstrate the significant benefits of using this class of intentionally mistuned disks.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.4
• /
• pp.1885-1887
• /
• 2014

Skin metastases of breast cancer are usually late events in the course of tumor progression and signify a poor prognosis. They may remain as a therapeutic challenge especially after failure of standard treatments. Topical interventions, together with or without radiotherapy, may only palliate the symptoms temporarily. However, there may be alternative treatment modalities for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy. There are various genetic alterations in tumors and therapeutic potential of expression patterns for factors like epidermal growth factor receptor may have important clinical implications in case of disease refractory to the conventional treatments. Here, we clarified the therapeutic options and genetic alterations in skin metastatic breast cancer patients refractory to standard chemotherapeutics.

• Biomolecules & Therapeutics
• /
• v.26 no.1
• /
• pp.69-80
• /
• 2018

Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects: generating additional energy, providing more anabolic molecules for biosynthesis, and rebalancing cellular redox states in cancer cells. Metabolic pathways are considered the pipelines to supply metabolic cofactors of epigenetic modifiers. In this regard, cancer metabolism, whereby cellular metabolite levels are greatly altered compared to normal levels, is closely associated with cancer epigenetics, which is implicated in many stages of tumorigenesis. In this review, we provide an overview of cancer metabolism and its involvement in epigenetic modifications and suggest that the metabolic adaptation leading to epigenetic changes in cancer cells is an important non-genetic factor for tumor progression, which cooperates with genetic causes. Understanding the interaction of metabolic reprogramming with epigenetics in cancers may help to develop novel or highly improved therapeutic strategies that target cancer metabolism.