• 한국공간구조학회논문집
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• 제22권3호
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• pp.49-56
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• 2022

Tuned mass damper (TMD) is widely used to reduce dynamic responses of structures subjected to earthquake loads. A smart tuned mass damper (STMD) was proposed to increase control performance of a traditional passive TMD. A lot of research was conducted to investigate the control performance of a STMD based on analytical method. Experimental study of evaluation of control performance of a STMD was not widely conducted to date. Therefore, seismic response reduction capacity of a STMD was experimentally investigated in this study. For this purpose, a STMD was manufactured using an MR (magnetorheological) damper. A simple structure presenting dynamic characteristics of spacial roof structure was made as a test structure. A STMD was made to control vertical responses of the test structure. Two artificial ground motions and a resonance harmonic load were selected as experimental seismic excitations. Shaking table test was conducted to evaluate control performance of a STMD. Control algorithms are one of main factors affect control performance of a STMD. In this study, a groundhook algorithm that is a traditional semi-active control algorithm was selected. And fuzzy logic controller (FLC) was used to control a STMD. The FLC was optimized by multi-objective genetic algorithm. The experimental results presented that the TMD can effectively reduce seismic responses of the example structures subjected to various excitations. It was also experimentally shown that the STMD can more effectively reduce seismic responses of the example structures conpared to the passive TMD.

• 식물병연구
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• 제17권3호
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• pp.311-316
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• 2011

고추 흰가루병은 시설재배의 증가로 경제적인 피해가 증가하는 병해이다. 본 연구에서는 고추 유전자원의 흰가루병 저항성 평가를 위한 새로운 저항성 평가 방법을 개발하였다. S index라고 명명한 평가방법의 공식은 다음과 같다; (최상위 발병 엽수/정단부 엽수) - (최하위 발병 엽수/정단부 엽수). 흰가루병에 의해 발병된 고추 식물체에서 이병엽율과 S index는 81%(P = 0.01)의 정의 상관으로 고도의 유의성을 보였다. 그리고 34종의 유전자원에서 저항성을 평가한 결과, S index는 흰가루병 저항성 계통을 구분할 수 있는 것으로 확인되었다. 이들 중 Capsicum frutescens 인 3CA131과 C. baccatum인 3CA0162, 3CA174, 3CA176은 흰가루병에 강한 저항성으로 평가되었다. 이 결과는 고추 흰가루병 저항성품종 육성에서 Sindex의 유용성을 증명한 결과이다.

• 한국농공학회논문집
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• 제56권4호
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• pp.9-19
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• 2014

The objective of this study was to evaluate of the Tank model in simulating runoff discharge from rural watershed in comparison to the SWAT (Soil and Water Assessment Tool) model. The model parameters of SWAT was calibrated by the shuffled complex evolution-university Arizona (SCE-UA) method while Tank model was calibrated by genetic algorithm (GA) and validated. Four dam watersheds were selected as the study areas. Hydrological data of the Water Management Information System (WAMIS) and geological data were used as an input data for the model simulation. Runoff data were used for the model calibration and validation. The determination coefficient ($R^2$), root mean square error (RMSE), Nash-Sutcliffe efficiency index (NSE) were used to evaluate the model performances. The result indicated that both SWAT model and Tank model simulated runoff reasonably during calibration and validation period. For annual runoff, the Tank model tended to overestimate, especially for small runoff (< 0.2 mm) whereas SWAT model underestimate runoff as compared to observed data. The statistics indicated that the Tank model simulated runoff more accurately than the SWAT model. Therefore the Tank model could be a good tool for runoff simulation considering its ease of use.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2015년도 춘계학술대회 및 임시총회
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• pp.20-20
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• 2015

Endophytic fungi are microorganisms inhabiting living plant tissues without causing apparent harm to the host. They are drawing increasing attention due to their ability to produce various bioactive compounds as well as their effects on host growth and resistance to biotic and abiotic stresses. As a first step to assess biodiversity of plant associated fungi in Korea and the following evaluation on diverse biological activities, we are collecting endophytic fungi from plant in wild followed by systematic long-term storage in liquid nitrogen. Molecular identification using ITS sequences was also incorporated for pure culture by hyphal tip isolation. As of April 2015, about 1,400 fungal strains had been isolated from about 170 plant taxa. Fungal isolates belonging to Pleosporales, Diaporthales, Glomerellales, Hypocreales, and Xylariales were the most abundant. These collections are being used for several complementary researches, including screening of isolates with novel bioactive compounds or conferring drought stress resistance, phylogenetic and genomic study. Genome sequencing was performed for 3 isolates, one Xylaria sp. strain JS573 producing griseofulvin, an antifungal compound, and two Fusarium spp. strains JS626 and JS1030, which are assumed to be new species found in Korea. More detailed analysis on these genomes will be presented. These collections and genome informations will serve as invaluable resources for identifying novel bioactive materials in addition to expand our knowledge on fungal biodiversity.

• 대한조선학회논문집
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• 제49권2호
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• pp.174-181
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• 2012

In this paper, the Flow Control Fin(FCF) optimization has been carried out using computational fluid dynamics(CFD) techniques. This study focused on evaluation for the performance of the FCF attached in the stern part of the ship. The main advantage of FCF is to enhance the resistance performance through the lift generation with a forward force component on the foil section, and the propulsive performance by the uniformity of velocity distribution on the propeller plane. This study intended to evaluate these functions and to find optimized FCF form for minimizing viscous resistance and equalizing wake distribution. Four parameters of FCF are used in the study, which were angle and position of FCF, longitudinal location, transverse location, and span length in the optimization process. KRISO 300K VLCC2(KVLCC2) was chosen for an example ship to demonstrate FCF for optimization. The optimization procedure utilized genetic algorithms (GAs), a gradient-based optimizer for the refinement of the solution, and Non-dominated Sorting GA-II(NSGA-II) for Multiobjective Optimization. The results showed that the optimized FCF could enhance the uniformity of wake distribution at the expense of viscous resistance.

• 대한의용생체공학회:의공학회지
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• 제25권3호
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• pp.207-215
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• 2004

본 연구에서는 유전 프로그램을 이용하여 6가지 형태의 금속 와이어 배치를 가진 전극을 생성하여 각 전극이 3차원 형태의 달팽이관에 미치는 기계적인 영향과 그 거동을 유한요소법을 이용하여 분석하였다. 그리고 전극이 삽입되는 달팽이관은 helico-spiral 근사방법에 의해 결정된 식을 이용하였으며, 고실계단(scala tympani)의 형태는 실제 고실계단 단면의 영상정보를 추출하여 얻어내었다. 해석결과 금속 와이어가 평행하게 배치될 경우 가장 큰 힘을 달팽이관 외벽에 전달하며, 삽입에도 가장 큰 힘이 필요한 것을 알 수 있었다. 그리고 달팽이관은 3차원 구조이므로 전극이 삽입되면서 삽입 전에 자극 사이트가 바라보도록 설정한 방향보다 조금 돌아감을 확인하였다. 이 연구의 결과로부터 전극의 강성이 외상(trauma)을 줄이는데 중요하다는 것을 알 수 있다.

• 한국지능시스템학회논문지
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• 제7권4호
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• pp.82-92
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• 1997

본 논문에서는, 퍼지 측도와 퍼지 적분을 이용한 상호 작용 시스템의 모델 및 이의 식별볍을 제시한다. 모델 식별은 다음과 같은 세 단계를 거쳐 이루어 지는데, 그 첫번째는 모델의 구조 식별이고 두번째는 식별된 구조를 갖는 모델의 파라메터 식별이다. 그리고 마지막으로는 식별된 구조와 파라메터를 갖는 모델의 최적성을 판단하여, 최적의 모델을 선정하게 된다. 본 논문에서는 최적 모델의 식별을 위하여 유전자 알고리즘 및 통계적 모델 선택 기준을 이용하여, 최적 모델들의 후보군으로부터 최적모델을 선정하는 알고리즘을 제시한다. 본 논문에서 제시된 모델 및 이의 식별법의 타당성을 보이기 위하여, 주관적 평가 데이타 및 시계열 데이타에 적용하여 그 결과를 나타내었으며, 또한 기존의 다른 모델들로부터 얻어진 결과와 비교 검토하였다.

• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.79-84
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• 2004

Three synthetic chemicals, benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol were selected for genotoxicity testing, based on production quantity and available genotoxic data. In our previous report, benzoyl chloride induced chromosomal aberrations in Chinese hamster lung (CHL) fibroblast in vitro with and without metabolic activation, while 2-propyn-l-ol and 2-phenoxy ethanol induced only with metabolic activation. To compare the genotoxicity of chromosome aberration assay, the single cell gel electrophoresis (comet) assay subjected using CHL cells. As a result, statistically significant differences of tail moment values of benzoyl chloride, 2-propyn-1-ol, and 2-phenoxy ethanol were observed compared with control values on almost all concentrations with S9 or without S9 metabolic activation system. This results suggest that genotoxic results of the comet assay and the chromosome aberration assay show correlationship of genotoxicity in the CHL fibroblast. In summary, the positive result of chromosome aberration of benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol was also induced DNA damages in comet assay with same cell line. Consequently, comet assay will be useful and more accurate tool to detect and to confirm the genotoxicity especially DNA damages in CHL fibroblast.

• 대한핵의학회지
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• 제23권1호
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• pp.1-6
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• 1989

The occurrence of thyroid disorders is connected with iodine deficiency, defective synthesis or releasing of thyroid hormone and endemicity. Genetic factors are known as a single gene defects, interaction of multiple genes with environmental factors, as well as chromosomal aberrations. Diofnosis thyroid disorders is enforced by I-131 uptake test, thyroid scanning with I-131 or Tc-99 m and serum radioimmunoassays of T3, T4, free T4 and TSH. They were largely classified as hypothyroidism, hyperthyroidism, simple goiter and normal. The pedigree of 58 families was drawn by propositus, and then the correlation between thyroid disorders and TSH levels was analyzed. The results are as follows: 1) The offsprings and their mothers of 15 families were hypothyroidism, THS level was 5 folds for offsprings and 4 folds for mothers in comparison with control group. 2) 13 families were hyperthyyroidism in siblings but their mothers were normal in thyroid function, TSH level of the siblings was lower than control group. 3) Though the offsprings and their mothers of 10 families were similar to TSH level of control group, they are all simple goiter, familial thyroid disorders, in other thyroid function test. The familial thyroid disorders suggested that these transmitted from mothers to offsprings with X-linked dominant or autosomal dominant inheritance.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 추계학술대회
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• pp.35-39
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• 1997

Recent development of human genetics and techniques of gene transfer and expression have opened the way for investigating novel approaches based on the genetic modification of cells to treat both inherited and acquired diseases. This approach is referred to as gene therapy. Over the past few years, gene therapy has moved from the laboratory to phase I clinical trials. Although the clinical performance of gene transfer experiments is still in an early phase of development, the NIH of Health Recombinant DNA Advisory Comittee (RAC) has approved more than 150 protocols that involve gene transfer or putative gene therapy procedures in clinical settings. Many sectors of society in United States have participated in the design and formulation of these clinical trials through local Institutional Review Boards, the National Institutes of Health (NIH) RAC, the Chemotherapy Evaluation Program of the National Cancer institute, and the FDA. Currently, clinical trials involving gene modification are under way at many medical centers throughout the United Slates. The goals of these trials are as follows. (1) The design should be directed to short-term achievable goals. (2) Each clinical trial is best considered as an intermediate step in a multistep process. (3) The design should identify evaluable proximate endpoints for toxicity and for efficacy, (4) The potential benefits and possible risks for patients participating in these trial should be defined.