• Environmental Mutagens and Carcinogens
• /
• v.24 no.2
• /
• pp.79-84
• /
• 2004

Three synthetic chemicals, benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol were selected for genotoxicity testing, based on production quantity and available genotoxic data. In our previous report, benzoyl chloride induced chromosomal aberrations in Chinese hamster lung (CHL) fibroblast in vitro with and without metabolic activation, while 2-propyn-l-ol and 2-phenoxy ethanol induced only with metabolic activation. To compare the genotoxicity of chromosome aberration assay, the single cell gel electrophoresis (comet) assay subjected using CHL cells. As a result, statistically significant differences of tail moment values of benzoyl chloride, 2-propyn-1-ol, and 2-phenoxy ethanol were observed compared with control values on almost all concentrations with S9 or without S9 metabolic activation system. This results suggest that genotoxic results of the comet assay and the chromosome aberration assay show correlationship of genotoxicity in the CHL fibroblast. In summary, the positive result of chromosome aberration of benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol was also induced DNA damages in comet assay with same cell line. Consequently, comet assay will be useful and more accurate tool to detect and to confirm the genotoxicity especially DNA damages in CHL fibroblast.

• The Korean Journal of Nuclear Medicine
• /
• v.23 no.1
• /
• pp.1-6
• /
• 1989

The occurrence of thyroid disorders is connected with iodine deficiency, defective synthesis or releasing of thyroid hormone and endemicity. Genetic factors are known as a single gene defects, interaction of multiple genes with environmental factors, as well as chromosomal aberrations. Diofnosis thyroid disorders is enforced by I-131 uptake test, thyroid scanning with I-131 or Tc-99 m and serum radioimmunoassays of T3, T4, free T4 and TSH. They were largely classified as hypothyroidism, hyperthyroidism, simple goiter and normal. The pedigree of 58 families was drawn by propositus, and then the correlation between thyroid disorders and TSH levels was analyzed. The results are as follows: 1) The offsprings and their mothers of 15 families were hypothyroidism, THS level was 5 folds for offsprings and 4 folds for mothers in comparison with control group. 2) 13 families were hyperthyyroidism in siblings but their mothers were normal in thyroid function, TSH level of the siblings was lower than control group. 3) Though the offsprings and their mothers of 10 families were similar to TSH level of control group, they are all simple goiter, familial thyroid disorders, in other thyroid function test. The familial thyroid disorders suggested that these transmitted from mothers to offsprings with X-linked dominant or autosomal dominant inheritance.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1997.11a
• /
• pp.35-39
• /
• 1997

Recent development of human genetics and techniques of gene transfer and expression have opened the way for investigating novel approaches based on the genetic modification of cells to treat both inherited and acquired diseases. This approach is referred to as gene therapy. Over the past few years, gene therapy has moved from the laboratory to phase I clinical trials. Although the clinical performance of gene transfer experiments is still in an early phase of development, the NIH of Health Recombinant DNA Advisory Comittee (RAC) has approved more than 150 protocols that involve gene transfer or putative gene therapy procedures in clinical settings. Many sectors of society in United States have participated in the design and formulation of these clinical trials through local Institutional Review Boards, the National Institutes of Health (NIH) RAC, the Chemotherapy Evaluation Program of the National Cancer institute, and the FDA. Currently, clinical trials involving gene modification are under way at many medical centers throughout the United Slates. The goals of these trials are as follows. (1) The design should be directed to short-term achievable goals. (2) Each clinical trial is best considered as an intermediate step in a multistep process. (3) The design should identify evaluable proximate endpoints for toxicity and for efficacy, (4) The potential benefits and possible risks for patients participating in these trial should be defined.

• 한국HCI학회:학술대회논문집
• /
• 2009.02a
• /
• pp.685-689
• /
• 2009

Evolutionary Computation is not only widely used in optimization and machine learning, but also being applied in creating novel structures and entities. This paper proposes evolutionary topic maps that can suggest new and creative knowledge not easily producible by humans. Interactive evolutionary computation method is applied into topic maps in order to accept human evaluation on feasibility of intermediate topic maps. Evolutionary topic maps are creativity support tools, helping users to encounter new and creative knowledge. Further work can greatly improve the system by providing more operations, preventing over-convergence, and overcoming user fatigue problem by providing more intuitive user interface, better visualization, and interpolation mechanisms.

• Journal of Ecology and Environment
• /
• v.36 no.1
• /
• pp.57-63
• /
• 2013

This study compared the antimicrobial activity and total phenolic content of three Pinus plants (Pinus densiflora, P. thunbergii, P. rigida) for the first time. The antimicrobial activity of the water fraction of methanol extract of fresh leaves was stronger than that of fallen leaves at any concentrations. The water fraction of crude methanol extract from fresh leaves of P. thunbergii showed a higher growth inhibitory activity against gram-positive and gram-negative bacteria than that of P. densiflora and P. rigida. The results from the disc diffusion method followed by measurements of minimal inhibition concentration (MIC) indicate that Bacillus subtilis was the most sensitive microorganism with the lowest MIC value. The highest total phenolic content was found in fresh leaves of P. rigida and P. thunbergii. The assay showed that the fresh leaves of the three Pinus plants contained higher total phenolic content than fallen leaves of the three plants. The antimicrobial activity was related with the total phenolic content.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.67 no.5
• /
• pp.601-610
• /
• 2018

The purpose of this paper is to establish a new optimum Generator Maintenance Scheduling(GMS) considering renewable energy generator. In this paper, the total renewable energy generation is estimated using hourly capacity factor of renewable energy generator. The GMS was optimized with the objective function of maximizing the minimum reserve rate, minimizing the probabilistic production cost, minimizing the loss of load expectation, and minimizing $CO_2$ emissions. In the case study of this paper, GMS considering renewable energy and GMS not considering renewable energy are shown by each objective function. And it shows scenarios of the reliability, the environmental and economical factors when two nuclear power plants inputted and ten coal thermal power plants shut downed respectively.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2002.11b
• /
• pp.422-427
• /
• 2002

This paper focuses on the formulation and validation of an automatic strategy for the selection of the locations and directions of strain gauges to capture at best the modal response of a blade in a series of modes. These locations and directions are selected to render the strain measurements as robust as possible with respect to random mispositioning of the gauges and gauge failures. The approach relies on the evaluation of the signal-to-noise ratios of the gauge measurements from finite element strain data and includes the effects of gauge size. A genetic algorithm is used to find the strain gauge locations-directions that lead to the largest possible value of the smallest modal strain signal-to-noise ratio, in the absence of gauge failure, or of its expected value when gauge failure is possible. A fan blade is used to exemplify the applicability of the proposed methodology and to demonstrate the effects of the essential parameters of the problem, i.e. the mispositioning level, the probability of gauge failure, and the number of gauges.

• The Plant Pathology Journal
• /
• v.25 no.4
• /
• pp.422-428
• /
• 2009

Studies were conducted to identify the sources of resistance in mungbean recombinant inbred lines (RILs) in Thailand against mungbean yellow mosaic disease (MYMD). 146 mungbean RILs in $F_8$ series were evaluated in a field including resistant parent NM-10-12-1 and susceptible parent KPS 2 during summer 2008 under high inoculum pressure. The RILs were subsequently scored for disease symptom severity ratings (DSSR) using a new scale. Observations regarding DSSR and % disease index (%DI) showed that the tested RILs responded differently to the disease. A large number of RILs (132) were found highly susceptible, 12 were susceptible, 3 were tolerant and one was resistant. Overall screening results showed that three RILs, viz. line no. 30, 100 and 101 had minimum DSSR and % disease index thus they are good source of resistance to MYMD in spite of high disease pressure and can therefore be used directly as varieties to manage the disease in Thailand.

• Journal of Electrical Engineering and Technology
• /
• v.3 no.1
• /
• pp.52-59
• /
• 2008

This paper describes the secant method for solving the economic dispatch (ED) problem with generator constraints and transmission losses. The ED problem is an important optimization problem in the economic operation of a power system. The proposed algorithm involves selection of minimum and maximum incremental costs (lambda values) and then the evaluation of optimal lambda at required power demand is done by secant method. The proposed algorithm has been tested on a power system having 6, 15, and 40 generating units. Studies have been made on the proposed method to solve the ED problem by taking 120 and 200 units with generator constraints. Simulation results of the proposed approach were compared in terms of solution quality, convergence characteristics, and computation efficiency with conventional methods such as lambda iterative method, heuristic methods such as genetic algorithm, and meta-heuristic methods like particle swarm optimization. It is observed from different case studies that the proposed method provides qualitative solutions with less computational time compared to various methods available in the literature.

• Clinical and Experimental Pediatrics
• /
• v.52 no.2
• /
• pp.152-158
• /
• 2009

Reduced fetal growth is independently associated with increased risk of health problems in later life, particularly type 2 diabetes and cardiovascular diseases. Insulin resistance appears to be a key component underlying these metabolic complications. It is suggested that detrimental fetal environment may program insulin resistance syndrome. An insulin-resistant genotype may also result in both low birth weight and insulin resistance syndrome, and it is likely that the association of low birth weight with insulin resistance is the result of both genetic and environmental factors. Early postnatal rapid catch-up growth is closely related to risk for subsequent metabolic diseases. Fat mass is strikingly reduced in neonates born small for gestational age (SGA), and recent data suggest that insulin resistance seen in catch-up growth is related to the disproportionate catch-up in fat mass compared with lean mass. Endocrine disturbances are also recognized in SGA children, but overt clinical problems are infrequent in childhood. Cognitive impairment is reported in some children born SGA, especially those who do not show catch-up growth, in whom early neurodevelopmental evaluation is required. Breast feeding, also known to be protective against the long-term risk of obesity, may prevent some intellectual impairment in SGA children. Calorie-dense feeding does not seem to be appropriate in SGA infants. We must balance the positive effect of nutrition on neural development against rapid fat deposition and the future risk of insulin resistance.