• The Korean Journal of Mycology
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• v.30 no.2
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• pp.142-146
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• 2002

In order to develop a new traditional liquor by using Paecilomyces japonica, alcohol fermentation condition was investigated. Ethanol was produced maximally when 1% P. japoniea and 10% koji were added into mash and fermented by Saccharomyces cerevisiae at $25^{\circ}C$ for 15 days. Sensory evaluation and physiological functionalities of P. japonica traditional liquors made by different addition ($0.1{\sim}2.0%$) of the fungus were also determined and compared. As 0.1% P. japonica was added to mash, the liquor was best acceptable, and its fibrinolytic activity and nitrite scavenging activity were 11.2U and 19.8%, respectively.

• KIPS Transactions on Software and Data Engineering
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• v.4 no.8
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• pp.321-330
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• 2015

In journal manuscript submission and review systems, authors can submit their manuscript at any time and editorial members are struggling to find proper reviewers for the submitted manuscripts and assign them to such reviewers. In order to solve this problem, we propose a greedy algorithm and a genetic algorithm to recommend proper reviewers for the submitted manuscripts. The proposed algorithms evaluate reviewers' speciality for the submitted manuscripts by using the submitted manuscripts' keywords and the reviewers expertises. In addition to that, they take the fairness among the reviewers' speciality and the review frequency for consideration. To verify the proposed algorithms, we apply them to the JIPS manuscript submission and review system that the Korea Information Processing Society has operated, and present the results in this paper. By performing the performance evaluation of the proposed algorithms, we finally show that the genetic algorithm outperforms the greedy algorithm in terms of the recommended reviewers' fitness.

• Toxicological Research
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• v.17
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• pp.227-236
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• 2001

The IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans has reviewed, summarized and evaluated 869 environmental agents and exposures as oj June 2000. This large collection includes all relevant published epidemiological data on cancer in exposed humans and results of bioassays for carcinogenicity in experimental animals. Since 1986. cancer data have been systematically supplemented by summaries of other toxicological data that are relevant to assessments of carcinogenic hazard. These include summaries qf genetic and related effects of chemicals. which have been prepared as Genetic Activity Profiles (GAP) by the U.S. EPA in collaboration with IARC. As the Mono-graphs have proved increasingly valuable and influential worldwide. they have evolved into an encyclopedia on environmental carcinogenic risks to humans. However. the Monographs have historically been prepared only as printed books with limited distribution. and the Monographs Programme has needed to adjust to expectations oj wider availability. Since 1998 the evaluations and summaries have been globally accessible by Internet from IARC (http://www.iarc.fr) and the GAP profiles by Internet from EPA (http://www.epa.gov/gapdb/). with the two web sites linked. Improved EPN/ARC GAP database and software. GAP2000. now link GAP profiles directly to the appropriate IARC web pages for summaries of evaluations of a given compound and its overall IARC classification. During the year 2000. by means of optical character recognition (OCR) technology the entire series of IARC Monographs is being converted to an electronic version. The first edition is now available commercially in CD-ROM format and will soon become available on-line at .

• Smart Structures and Systems
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• v.3 no.1
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• pp.51-68
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• 2007

High-strength concrete (HSC) is becoming increasingly attractive for various construction projects since it offers a multitude of benefits over normal-strength concrete (NSC). Unfortunately, current design provisions for shear capacity of RC slender beams are generally based on data developed for NSC members having a compressive strength of up to 50 MPa, with limited recommendations on the use of HSC. The failure of HSC beams is noticeably different than that of NSC beams since the transition zone between the cement paste and aggregates is much denser in HSC. Thus, unlike NSC beams in which micro-cracks propagate around aggregates, providing significant aggregate interlock, micro-cracks in HSC are trans-granular, resulting in relatively smoother fracture surfaces, thereby inhibiting aggregate interlock as a shear transfer mechanism and reducing the influence of compressive strength on the ultimate shear strength of HSC beams. In this study, a new approach based on genetic algorithms (GAs) was used to predict the shear capacity of both NSC and HSC slender beams without shear reinforcement. Shear capacity predictions of the GA model were compared to calculations of four other commonly used methods: the ACI method, CSA method, Eurocode-2, and Zsutty's equation. A parametric study was conducted to evaluate the ability of the GA model to capture the effect of basic shear design parameters on the behaviour of reinforced concrete (RC) beams under shear loading. The parameters investigated include compressivestrength, amount of longitudinal reinforcement, and beam's depth. It was found that the GA model provided more accurate evaluation of shear capacity compared to that of the other common methods and better captured the influence of the significant shear design parameters. Therefore, the GA model offers an attractive user-friendly alternative to conventional shear design methods.

• Journal of Korean Neurosurgical Society
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• v.53 no.1
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• pp.1-5
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• 2013

Objective : The purpose of this study was to evaluate the characteristics and surgical outcomes of familial hemifacial spasm (HFS) and to discuss the role of genetic susceptibility. Methods : Between 2001 and 2011, 20 familial HFS patients with ten different pedigrees visited our hospital. The data from comprehensive evaluation of these patients, including clinical, radiological and electrophysiological data and surgical outcomes were reviewed to characterize familial HFS and to compare the characteristics between familial HFS and sporadic HFS. Results : According to the family tree, the inheritance pattern was difficult to define clearly using these data. Radiologic findings suggested that the vertebral artery (VA) was a more frequent offender in familial HFS than in sporadic cases (35.0% vs. 10.0%, p<0.001). Chi-square test showed that there were no correlation between VA tortuosity and underlying morbidity such as diabetes or hypertension (p=0.391). Eighteen out of 19 patients who underwent microvascular decompression showed no residual spasm. Other features of familial HFS overlap with sporadic cases. These findings suggest that certain genetic susceptibilities rather than hypertension or diabetes may influence vascular tortuosity and HFS development. Conclusion : In this study, familial HFS seems not so different from sporadic cases. Authors thought familial HFS could have heterogeneous etiology. Further study of familial HFS including clinical, anatomic, genetic, and molecular information may help identify a gene or trait that can provide insight into the mechanisms of sporadic and familial HFS.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.25-25
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• 2018

The Fukushima Daiichi Nuclear Power Plant accident in March 2011 caused severe radioactive contamination in the surrounding environment. Since the accident, much attention has been paid to the biological and genetic consequences of organism inhabiting the contaminated area. The effect of radiation exposure on genetic mutation rates is little known, especially for low doses and in situ conditions. Evaluating DNA mutation by low levels of radiation dose is difficult due to the rare mutation event and lack of sequence information before the accident. In this study, correlations with air dose levels and somatic DNA mutation rates were evaluated using Next Generation Sequencer for the clonal plant, Phyllostachys edulis. This bamboo is known to spread an identical clone throughout Japan, and it has the advantage that we can compare genetic mutation rate among identical clone growing different air dose levels. We collected 94 samples of P. edulis from 14 sites with air dose rates from $0.04{\sim}7.80{\mu}Gy/h$. Their clonal identity was confirmed by analysis using 24 microsatellite markers, and then, sequences among samples were compared by MIG sequence. The sequence data were obtained from 2,718 loci. About ~200,000 bp sequence (80 bp X 2,718 loci) were obtained for each sample, and this corresponds to about 0.01% of the genome sequence of P. edulis. In these sequences, 442 loci showed polymorphism patterns including recent origin mutation, old mutation, and sequence errors. The number of mutations per sample ranged from 0 to 13, and did not correlate with air dose levels. This result indicated that DNA mutations have not accumulated in P. edulis living in the air doses levels less than $10{\mu}Gy/h$. Our study also suggests that mutation rates can be assessed by selecting an appropriate experimental approach and analyzing with next generation sequencer.

• Korean Journal of Food Science and Technology
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• v.34 no.1
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• pp.109-113
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• 2002

To develop a new traditional liquor by using chamomile, the condition of alcohol fermentation was investigated by the addition of 5%, 10%, 15% nuruk, and 20% chamomile into mash. The maximum amount of ethanol was produced when 20% chamomile and 15% nuruk were added to cooked rice and fermented by Saccharomyces cerevisiae at $25^{\circ}C$ for 10 days. The acceptability and physiological functionalities of chamomile liquors with different concentrations $(1{\sim}20%)$ of chamomile were compared. The C-5 chamomile liquor which was prepared by adding 5% chamomile into mash showed the best acceptability in the sensory evaluation test and color test, and its fibrinolytic activity, tyrosinase inhibitory activity, and nitrite scavenging activity were good.

• The Journal of the Acoustical Society of Korea
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• v.18 no.8
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• pp.32-41
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• 1999

In this paper, an inversion method using chirp signals and two near field receivers is proposed. Inversion problems can be formulated into the probabilistic models composed of signals, a forward model and noise. Forward model to simulate chirp signals is chosen to be the source-wavelet-convolution planewave modeling method. The solution of the inversion problem is defined by a posteriori pdf. The wavelet matching technique, using weighted least-squares fitting, estimates the sediment sound-speed and thickness on which determination of the ranges for a priori uniform distribution is based. The genetic algorithm can be applied to a global optimization problem to find a maximum a posteriori solution for determined a priori search space. Here the object function is defined by an L₂norm of the difference between measured and modeled signals. The observed signals can be separated into a set of two signals reflected from the upper and lower boundaries of a sediment. The separation of signals and successive applications of the genetic algorithm optimization process reduce the search space, therefore improving the inversion results. Not only the marginal pdf but also the statistics are calculated by numerical evaluation of integrals using the samples selected during importance sampling process of the genetic algorithm. The examples applied here show that, for synthetic data with noise, it is possible to carry out an inversion for sedimentary layers using the proposed inversion method.

• Journal of the Korean Solar Energy Society
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• v.36 no.5
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• pp.73-89
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• 2016

To assure maximum economic benefits and the energy performance of solar water heating systems, the proper sizing of components and operating conditions need to be optimized. In recent years, a number of studies to design optimally solar water heating systems have been tried. This paper presents a design method for optimizing the various capacity-related and installation-related design variables based on life cycle cost using a genetic algorithm. The design variables considered in this study included the types and numbers of solar collector and auxiliary heaters; the types of storage tanks and heat exchangers; the solar collector slope; mass flow rates of the fluid on the hot and cold sides. The suggested method was applied for optimizing a solar water heating system for an elementary school in Seoul, South Korea. In addition, the effectiveness of the proposed optimization method was assessed by analyzing the obtained optimal solutions of six case studies, each of which was simulated with different solar fractions. It is observed that a trade-off between the equipment cost and the energy cost results in an optimal design that yields the lowest life cycle cost. Therefore, it could be helpful to apply the optimal solar water heating system by comparing the various design solutions obtained by using the optimization method instead of the engineer's experience and intuition.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.49 no.1
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• pp.69-72
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• 2004

Somaclonal variation, defined as phenotypic and genetic variations among regenerated plants from a parental plant, could be caused by changes in chromosome structure, single gene mutation, cytoplasm genetic mutation, insertion of transposable elements, and DNA methylation during plant regeneration. The objective of this study was to evaluate DNA variations among somaclonal variants from the cotyledonary node culture in soybean. A total of 61 soybean somaclones including seven $\textrm{R}_1$ lines and seven $\textrm{R}_2$ lines from Iksannamulkong as well as 27 $\textrm{R}_1$ lines and 20 $\textrm{R}_2$ lines from Jinju 1 were regenerated by organogenesis from the soybean cotyledonary node culture system. Field evaluation revealed no phenotypic difference in major agronomic traits between somaclonal variants and their wild types. AFLP and SSR analyses were performed to detect variations at the DNA level among somaclonal variants of two varieties. Based on AFLP analysis using 36 primer sets, 17 of 892 bands were polymorphic between Iksannamulkong and its somaclonal variants and 11 of 887 bands were polymorphic between Jinju 1 and its somaclonal variants, indicating the presence of DNA sequence change during plant regeneration. Using 36 SSR markers, two polymorphic SSR markers were detected between Iksannamulkong and its somaclonal variants. Sequence comparison amplified with the primers flanking Satt545 showed four additional stretches of ATT repeat in the variant. This suggests that variation at the DNA level between somaclonal variants and their wild types could provide basis for inducing mutation via plant regeneration and broadening crop genetic diversity.