• Asian-Australasian Journal of Animal Sciences
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• 제16권6호
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• pp.789-793
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• 2003

An investigation was conducted on 729 Hariana cows maintained at Government Livestock Farm, Hisar, from 1973 to 1999, with an objective to compare the efficiency of various selection indices for attaining desired genetic gains in the index traits. The various traits included were age at first calving (AFC), service period (SP), calving interval (CI), days to first service (DFS), number of services per conception (NSPC), lactation milk yield (LY), peak yield (PY), dry period (DP). Except for LY, PY and AFC the heritabilities of all other traits were low. Desirable associations among reproductive traits are supportive of the fact that any one of these traits incorporated in simultaneous selection is expected to cause correlated response in other traits. Production traits (LY and PY) were positively correlated, while DP had low negative genetic correlation with LY, and high genetic correlation with PY. Thus, DP can be taken as additional criteria in selection index for better over all improvement. Almost all production traits except DP had low negative correlation with AFC, SP, DFS and CI meaning that reduction in reproduction traits up to certain level may increase production performance. While, the correlation of NSPC with LY and PY was moderate positive. Among four trait indices I23: incorporating PY, AFC, SP and NSPC and among three trait indices I1: incorporating LY, AFC and SP were the best as these required least number of generations (4.87 and 1.35, respectively) to attain desired goals. Next in order of preference were PY or LY along with DP and SP as the best indices (I20 and I16) of which, index with PY may be preferred instead of LY as it produced considerably high correlated response in LY and reduction in NSPC as well.

• Asian-Australasian Journal of Animal Sciences
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• 제22권5호
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• pp.611-617
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• 2009

This study was aimed at a genetic evaluation of Iranian Holstein cattle for milk and fat yields and calculating daughter yield deviation (DYD) of bulls. The data file that was used in this research included 367,943 first three lactation records of 186,064 Holstein cows which calved between 1983 and 2006 in 11,806 herd-year-season groups. The model included herd-year-season of calving and age at calving as fixed effects and animal and permanent environment as random effects. Mean breeding values of cows for each year were regressed on birth year to estimate genetic trends. Genetic trends in milk and fat yields were greater for cows born after 1997 (59.38 kg/yr and 1.11 kg/yr for milk yield and fat yield, respectively). Animal evaluations were partitioned into contribution from parent average, yield deviation (YD) and progeny. DYD of bulls was calculated as described by VanRaden and Wiggans (1991). DYD provides an indication of the performance of the daughters of a bull without consideration of his parents or sons. Variance of bull DYD was greater than variance of their predicted transmitting ability (PTA). Correlation of bull DYD and PTA was dependent on the number of daughters and when this increased, the correlation of DYD and PTA was increased. Also as lactation number of daughters increased, the correlation of bull DYD and PTA was increased.

• 한국작물학회지
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• 제45권4호
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• pp.245-250
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• 2000

This study was conducted to analyze the responses of some agronomic traits to the different cultural environments and relations among the agronomic traits for selecting sesame varieties with higher cultural stabilities. The indexes for stability parameters measured were coefficient of variability, heritabilities, genetic correlations and path coefficients of agronomic traits according to locations and years in Korea. The heritabilities of agronomic traits showed different by locations and years. Number of seeds per capsule and 1000 seeds weight showed higher heritabilities, but stem length and seed weight per plant showed relatively lower heritabilities. Average heritabilities of some agronomic traits in 1998 were comparatively higher than those of 1999. Of six areas, Jinju area showed biggest coefficient of yield variability in 1998-1999. Iksan and Taegu areas showed higher heritabilities in 1998, but Iksan and Jinju areas showed lower heritabilities in 1999. Genetic correlations were slightly higher than corresponding phenotypic correlations. Stem length showed positive genetic correlation with the number of capsules per plant, and seed weight per plant and the number of capsule per plant showed positive genetic correlation with seed weight per plant. On the analysis of path coefficients, stem length and number of capsules effected highly on grain yield. Great regional variations were observed on the effects of agronomic traits on grain yield. Higher direct effects of stem length on grain yield were observed at Suwon, Chungwon, Taegu, Jinju and Naju areas, but in Iksan area was observed higher direct effect of the number of capsules per plant on grain yield in 1998. In 1999, higher direct effect of stem length on grain yield was observed at Chungwon and Suwon areas. Iksan and Taegu areas were also observed higher direct effect of the number of capsule per plant on grain yield.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.513-517
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• 2015

Background: Growing evidence suggests that the members of the ubiquitin-proteasome system (UPS) are important for tumorigenesis. HERC4, one component, is a recently identified ubiqutin ligase. However, the expression level and function role of HERC4 in lung cancer remain unknown. Our objective was to investigate any correlation between HERC4 and development of lung cancer and its clinical significance. Materials and Methods: To determine HERC4 expression in lung cancer, an immunohistochemistry analysis of a tissue microarray containing samples of 10 lung normal tissues, 15 pulmonary neuroendocrine carcinomas, 45 squamous epithelial cancers and 50 adenocarcinomas was conducted. Receiver operating characteristic (ROC) curve analysis was applied to obtain a cut-off point of 52.5%, above which the expression of HERC4 was regarded as "positive". Results: On the basis of ROC curve analysis, positive expression of HERC4 was detected in 0/10 (0.0%) of lung normal tissues, in 4/15 (26.7%) of pulmonary neuroendocrine carcinomas, in 13/45 (28.9%) of squamous epithelial cancers and in 19/50 (38.0%) of adenocarcinomas. It showed that lung tumors expressed more HERC4 protein than adjacent normal tissues (${\chi}^2$=4.675, p=0.031). Furthermore, HERC4 positive expression had positive correlation with pT status (${\chi}^2$=44.894, p=0.000), pN status (${\chi}^2$=43.628, p=0.000), histological grade (${\chi}^2$=7.083, p=0.029) and clinical stage (${\chi}^2$=72.484, p=0.000), but not age (${\chi}^2$=0.910, p=0.340). Conclusions: Our analysis suggested that HERC4 is likely to be a diagnostic biomarker for lung cancer.

• Asian-Australasian Journal of Animal Sciences
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• 제28권10호
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• pp.1407-1418
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• 2015

A total of 32,817 test-day milk yield (TDMY) records of the first lactation of 4,056 Girolando cows daughters of 276 sires, collected from 118 herds between 2000 and 2011 were utilized to estimate the genetic parameters for TDMY via random regression models (RRM) using Legendre's polynomial functions whose orders varied from 3 to 5. In addition, nine measures of persistency in milk yield ($PS_i$) and the genetic trend of 305-day milk yield (305MY) were evaluated. The fit quality criteria used indicated RRM employing the Legendre's polynomial of orders 3 and 5 for fitting the genetic additive and permanent environment effects, respectively, as the best model. The heritability and genetic correlation for TDMY throughout the lactation, obtained with the best model, varied from 0.18 to 0.23 and from -0.03 to 1.00, respectively. The heritability and genetic correlation for persistency and 305MY varied from 0.10 to 0.33 and from -0.98 to 1.00, respectively. The use of $PS_7$ would be the most suitable option for the evaluation of Girolando cattle. The estimated breeding values for 305MY of sires and cows showed significant and positive genetic trends. Thus, the use of selection indices would be indicated in the genetic evaluation of Girolando cattle for both traits.

• Asian-Australasian Journal of Animal Sciences
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• 제28권4호
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• pp.476-484
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• 2015

The objective of this study was to estimate genetic and phenotypic parameters for linear type traits, as well as milk yield (MY), fat yield (FY) and protein yield (PY) in 18,831 Holstein cows reared in 495 herds in Brazil. Restricted maximum likelihood with a bivariate model was used for estimation genetic parameters, including fixed effects of herd-year of classification, period of classification, classifier and stage of lactation for linear type traits and herd-year of calving, season of calving and lactation order effects for production traits. The age of cow at calving was fitted as a covariate (with linear and quadratic terms), common to both models. Heritability estimates varied from 0.09 to 0.38 for linear type traits and from 0.17 to 0.24 for production traits, indicating sufficient genetic variability to achieve genetic gain through selection. In general, estimates of genetic correlations between type and production traits were low, except for udder texture and angularity that showed positive genetic correlations (>0.29) with MY, FY, and PY. Udder depth had the highest negative genetic correlation (-0.30) with production traits. Selection for final score, commonly used by farmers as a practical selection tool to improve type traits, does not lead to significant improvements in production traits, thus the use of selection indices that consider both sets of traits (production and type) seems to be the most adequate to carry out genetic selection of animals in the Brazilian herd.

• Asian-Australasian Journal of Animal Sciences
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• 제26권4호
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• pp.470-475
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• 2013

The objective of this study was to estimate genetic parameters that are to be used for across-herd genetic evaluations of seed stock pigs at GGP level. Performance data with pedigree information collected from swine breeder farms in Korea were provided by Korea Animal Improvement Association (AIAK). Performance data were composed of final body weights at test days and ultrasound measures of back fat thickness (BF), rib eye area (EMA) and retail cut percentage (RCP). Breeds of swine tested were Landrace, Yorkshire and Duroc. Days to 90 kg body weight (DAYS90) were estimated with linear function of age and ADG calculated from body weights at test days. Ultrasound measures were taken with A-mode ultrasound scanners by trained technicians. Number of performance records after censoring outliers and keeping records pigs only born from year 2000 were of 78,068 Duroc pigs, 101,821 Landrace pigs and 281,421 Yorkshire pigs. Models included contemporary groups defined by the same herd and the same seasons of births of the same year, which was regarded as fixed along with the effect of sex for all traits and body weight at test day as a linear covariate for ultrasound measures. REML estimation was processed with REMLF90 program. Heritability estimates were 0.40, 0.32, 0.21 0.39 for DAYS90, ADG, BF, EMA, RCP, respectively for Duroc population. Respective heritability estimates for Landrace population were 0.43, 0.41, 0.22, and 0.43 and for Yorkshire population were 0.36, 0.38, 0.22, and 0.42. Genetic correlation coefficients of DAYS90 with BF, EMA, or RCP were estimated to be 0.00 to 0.09, -0.15 to -0.25, 0.22 to 0.28, respectively for three breeds populations. Genetic correlation coefficients estimated between BF and EMA was -0.33 to -0.39. Genetic correlation coefficient estimated between BF and RCP was high and negative (-0.78 to -0.85) but the environmental correlation coefficients between these two traits was medium and negative (near -0.35), which describes a highly correlated genetic response to selection on one or the other of these traits. Genetic Trends of all three breeds tend to be towards bigger EMA or greater RCP and shorter DAYS90 especially from generations born after year 2000.

• Journal of Animal Science and Technology
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• 제46권2호
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• pp.145-154
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• 2004

본 연구에서는 57,316두의 농장 검정된 돼지 자료를 이용하여 유전 모수를 추정하였다. 현재 돼지 등급 제도가 도체 위주로 진행되고 있어 농장의 경제적 이익을 고려한다면, 향후 경제 가치를 고려한 정확한 선발 지수를 설정하여 정확히 추정된 육종가를 바탕으로 국가 단위 개량체계가 확립되어야 유전적 개량을 이룰 수 있을 것으로 사료된다. 조사된 형질들에 대한 유전력은 품종에 따라 다소의 차이는 있었지만, 평균 등지방 두께에 대하여 0.46${\sim}$0.65, 최후 늑골 등지방 두께에 대하여 0.42${\sim}$0.61, 등심 깊이에 대하여 0.28 ${\sim}$0.31, 정육율에 대하여 0.50${\sim}$0.60, 일당 증체량에 대하여 0.45${\sim}$0.55, 90kg 도달 일령에 대하여 0.38${\sim}$0.50 및 100kg 도달 일령에 대하여 0.40～0.50의 범위에서 추정되었다. 추정된 유전력이 일반적으로 알려진 형질들의 유전력과 유사하고, 성별 및 품종별로 뚜렷한 일관성을 나타내는 것으로 미루어 다형질 개체 모형 하에서 DF-REML에 의한 유전력의 추정이 효과적인 것으로 생각된다. 조사된 형질의 유전력은 도체 형질에 대해서는 중도의 유전력을 보였으며 나머지 성장 형질에 있어서는 고도의 유전력을 나타냈다. 본 연구의 결과로 미루어 성장 형질에 대한 개량이 유의적으로 이루어 질 수 있음을 나타내었다. 등지방 두께, 일당 증체량 및 90kg 도달 일령간의 유전 상관은 그다지 높지는 않았지만 이들 형질간에 유전적 관계가 있는 것으로 나타났으나, 이들간의 작용 방향이 서로 바람직하지 않은 상관 관계를 가지는 경우가 있어, 어느 한 형질에 치우친 선발은 다른 형질을 불량하게 할 수 있음을 보였다. 등 부위 등지방 두께와 등심 깊이간의 상관이 Duroc 종과 타 품종간에 차이가 있을 뿐 다른 형질에서는 품종간의 차이를 나타내지 않았다. 등심 깊이의 경우 성장 형질이 우수할 수록 넓은 경향을 보였으나 정육율의 경우는 정 반대의 상관을 나타냈다. 반면에 등심 깊이와 정육율의 경우에는 낮은 정의 상관 관계를 나타내어 이들 형질을 다같이 개량하기 위해서는 선발 지수식에 의한 조화있는 개량이 필요한 것으로 사료된다. 표현형 상관에 있어서도 유전 상관과 비슷한 결과가 추정되었다.

• Genomics & Informatics
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• 제16권4호
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• pp.33.1-33.9
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• 2018

Recently, there have been many studies in medicine related to genetic analysis. Many genetic studies have been performed to find genes associated with complex diseases. To find out how genes are related to disease, we need to understand not only the simple relationship of genotypes but also the way they are related to phenotype. Multi-block data, which is a summation form of variable sets, is used for enhancing the analysis of the relationships of different blocks. By identifying relationships through a multi-block data form, we can understand the association between the blocks in comprehending the correlation between them. Several statistical analysis methods have been developed to understand the relationship between multi-block data. In this paper, we will use generalized canonical correlation methodology to analyze multi-block data from the Korean Association Resource project, which has a combination of single nucleotide polymorphism blocks, phenotype blocks, and disease blocks.

• 농업과학연구
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• 제46권3호
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• pp.497-506
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• 2019

The aim of this study was to estimate the factors that can be used as a predictive indicator of antler productivity in elk. Body weight and antler data from 115 stags raised at the Animal Genetic Resources Research Center in Korea were used in this study. The function for the average antler weight was derived by age, which was $y=-3.4693+5.3747x-0.8x^2+0.0424x^3$, and $R^2$ was 0.991. The analysis of the relationship between body weight at birth and the 1st and 2nd year and the antler weight after the 2nd year showed a correlation between them. There was a correlation between the antler weight of 1 and 2 year old stags and the weight of 2 year old stags as well; especially, both antler weights for the 1st and 2nd year were highly correlated with the antler weight of the 4th year. However, there was no relationship between the antler main beam length for the 1st and 2nd year and the antler weight after the 3rd year. Therefore, it is expected that a large amount of antler will be obtained in the future if proper management is carried out for young deer from birth to 2 years old. Additionally, the results of this study are expected to be useful for the development of a deer breeding program and the deer industry.