• Tuberculosis and Respiratory Diseases
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• 제75권5호
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• pp.181-187
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• 2013

The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the efficacy and toxicity of some treatment agents, as do genetic alterations, which can be important predictive factors in treatment selection. Molecular markers, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement, are the best predictors of response to specific tyrosine kinase inhibitor treatment agents. As the majority of patients with NSCLC present with unresectable disease, it is therefore crucial to optimize the use of tissue samples for diagnostic and predictive examinations, particularly for small biopsy and cytology specimens. Therefore, each institution needs to develop a diagnostic approach requiring close communication between the pulmonologist, radiologist, pathologist, and oncologist in order to preserve sufficient biopsy materials for molecular analysis as well as to ensure rapid diagnosis. Currently, personalized medicine in NSCLC is based on the histologic subtype and molecular status. This review summarizes strategies for tissue acquisition, histologic subtyping and molecular analysis for predictive testing in NSCLC.

• Journal of Electrical Engineering and Technology
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• 제4권1호
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• pp.19-27
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• 2009

This paper presents a newly developed optimization algorithm, the Bee Optimization Algorithm (BeeOA), to solve the economic power dispatch (EPD) problem. The authors have developed a derivative free and global optimization technique based on the working of the honey bee. The economic power dispatch problem is a nonlinear constrained optimization problem. Classical optimization techniques fail to provide a global solution and evolutionary algorithms provide only a good enough solution. The proposed approach has been examined and tested on two test systems with different objectives. A simple power dispatch problem is tested first on 6 generators and then the algorithm is demonstrated on 13 thermal unit systems whose incremental fuel cost function takes into account the value point loading effect. The results are promising and show the effectiveness and robustness of the proposed approach over recently reported methods.

• 전기학회논문지
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• 제66권3호
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• pp.557-562
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• 2017

In this paper, we show the design of a rotary joint transition for the X-band channel in a rotatable microwave communication system. The transition seems complicated to make a channel between two coaxial cables through a cylindrical waveguide. To make a broad-band performance in the X-band with low insertion loss and return loss given the constraint on the length and radius of this complicated-looking cylindrical structure, Genetic Algorithm optimization is adopted to check the validity of an intensive parametric study in the design. The structure is fabricated and tested to show how valid the design method is as well as good frequency responses.

• Journal of information and communication convergence engineering
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• 제5권1호
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• pp.35-41
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• 2007

In this paper, a modified Fuzzy C-Means (MFCM) algorithm is presented for nonlinear blind channel equalization. The proposed MFCM searches the optimal channel output states of a nonlinear channel, based on the Bayesian likelihood fitness function instead of a conventional Euclidean distance measure. In its searching procedure, all of the possible desired channel states are constructed with the elements of estimated channel output states. The desired state with the maximum Bayesian fitness is selected and placed at the center of a Radial Basis Function (RBF) equalizer to reconstruct transmitted symbols. In the simulations, binary signals are generated at random with Gaussian noise. The performance of the proposed method is compared with that of a hybrid genetic algorithm (GA merged with simulated annealing (SA): GASA), and the relatively high accuracy and fast searching speed are achieved.

• Journal of information and communication convergence engineering
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• 제3권1호
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• pp.43-48
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• 2005

In this paper, the adaptive fuzzy logic controller(AFLC) is proposed, which uses real-coding genetic algorithm showing a good performance on convergence velocity and diversity of population among evolutionary computations. The effectiveness of the proposed AFLC was demonstrated by computer simulation for speed control system of AC servo motor. As a result of simulation for the AC servo motor, it is shown the proposed AFLC has the better performance on overshoot, settling time and rising time than the PI controller which is used when tuning AFLC.

• 한국산학기술학회논문지
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• 제14권3호
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• pp.1372-1377
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• 2013

본 논문은 신경망을 이용한 간섭 신호 제어로써 합성 다층 퍼셉트론에 입각하여 셀룰라 이동 통신에서의 수신된 신호들을 역전파 학습알고리즘을 이용하여 검파하는 것에 대하여 소개하였다. 그리고 컴퓨터 시뮬레이션 결과를 통하여 공동 간섭과 협대역 간섭의 실제 음색에서 기존에 쓰여진 레이크 수신기보다 더 낮은 비트 오차 확률을 가지는 NNAC(neural network adaptive correlator)에 대하여 분석 하였다.

• Journal of Genetic Medicine
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• 제18권1호
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• pp.1-7
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• 2021

The oocyte quality is of great importance in infertility as it reflects the follicle developmental potential and further affects the embryo development, clinical pregnancy outcomes. The analysis of gene expression in somatic cells is an important study to better clinical in vitro fertilization (IVF) outcomes in embryo selection reflecting the appropriate communication between the oocyte and somatic cells. Specifically, somatic cell transcriptomic technology can help assess biomarkers of oocyte and embryo ability. The present article aims to overview the basic aspect of folliculogenesis and review studies involving changes in candidate gene expression of cumulus or granulosa cell related to clinical outcomes in human IVF.

• BMB Reports
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• 제54권5호
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• pp.253-259
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• 2021

Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.

• Molecules and Cells
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• 제45권5호
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제35권1호
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• pp.8-14
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• 2024

Autism spectrum disorder (ASD) is a heterogeneous developmental disorder characterized by impairments in two core areas: 1) social communication and interaction and 2) restricted and repetitive patterns of behaviors and interests. In general, ASD is known to be a lifelong disorder. Follow-up studies from childhood to adulthood have reported that the severity of the key symptoms ASD decreases over time. However, chronic health problems including mental health occur in many patients with ASD. The prevalence of ASD has increased from around 0.04% in the 1970s to 2.8% at present. The average age of diagnosis in developed countries is 38-120 months of age. Recent evidence suggests that biological factors which include genetic, congenital, immunological, neuroanatomical, biochemical, and environmental ones are important in causing autism. Until now, early signs and various risk factors of ASD have been suggested.