• 한방안이비인후피부과학회지
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• 제30권3호
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• pp.103-118
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• 2017

Objectives : The purpose of this study is to analyze recent research trend on pathology of Meniere's Disease and review the results in Korean Medicine. Methods : We searched MEDLINE on the title "Meniere's Disease" and "pathology" in recent 5 years and searched OASIS with KISS on the title "Meniere's Disease". Results : We found 21 studies on MEDLINE, 9 studies on OASIS and KISS about Meniere's Disease. The results are as follow. 1. In western medicine, the pathology of Meniere's disease is supposed to be related with endolymphatic hydrops and autoimmunity. The causes of endolymphatic hydrops are studied in various viewpoints such as disorder of endolymph drainage and homeostasis abnormality of endolymph. And autoimmunity is assumed to be associated with genetic factor. 2. In Korean medicine, Meniere's disease were mainly treated with acupuncture and hebal medicine. Conclusions : Korean medicinal approaches on pathology of Meneire's disease can be significant in view of endolymphatic hydrops. And on the basis of those outcomes, much more studies have to be researched for Korean medicinal treatment of Meneire's disease.

• 한국산림과학회지
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• 제58권1호
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• pp.27-33
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• 1982

Populs alba${\times}$P. glandulosa의 우수(優秀)한 교잡종(交雜種)을 육성(育成)하기 위해서 형질(形質)이 우량(優良)한 교배양친수(交配兩親樹)를 선발(選拔)해야 하므로 이들 양친수(兩親樹)에 대한 유전분산(遺傳分散)과 유전력(遺傳力)을 조사(調査)한 결과(結果) 교배모수간(交配母樹間)에 유전분산(遺傳分散)은 크고 유전력(遺傳力)은 83%로서 높은 편이었다. 즉, P. alba(토착종(土着種))보다는 P. alba(토착종(土着種))${\times}$alba (이태이(伊太利))의 형질(形質)이 우수(優秀)하고 화분수(花粉樹)인 P. glandulosa는 유전변이(遺傳變異)가 좁고 유전력(遺傳力)도 17% 밖에 되지 않았다. 즉 화분수(花粉樹)의 두 개체(個體)(A와 B)는 같은 형질(形質)을 나타내고 수목원(樹木園)(C)에 있는 것은 다소 형질(形質)이 다른 것으로 나타났다. 또한 삽목발근률(揷木發根率)에서도 위의 결과(結果)와 같이 교배모수간(交配母樹間)에 차이(差異)가 있고 화분수간(花粉樹間)에는 큰 차이(差異)가 없었다. P. alba(토착종(土着種))가 P. alba(토착종(土着種))${\times}$ alba(이태리(伊太利))를 교배모수(交配母樹)로 한 것보다 삽목발근률(揷木發根率)이 높고 화분수(花粉樹)인 P. glandulosa의 두 화분수(花粉樹)(A와 B)는 같으나 수목원(樹木園)(C) 것은 약간 떨어지는 편으로 두 화분수(花粉樹)와는 형질(形質)이 다소 다른 것 같다.

• Journal of Animal Science and Technology
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• 제57권8호
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• pp.28.1-28.7
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• 2015

Background: The physiologic characteristics of the cashmere trait and many of the differentially expressed genes relevant to hair cycling have been extensively studied, whereas genes involved in the prenatal development of hair follicles have been poorly investigated in cashmere goats. The aim of this study, therefore, was to quantify the time-course changes in the expressions of $TR{\alpha}$ and CRABPII genes in the fetal skin of Chinese cashmere goats at the multiple embryonic days (E70, E75, E80, E90, E100, E120 and E130) using real-time quantitative PCR (RT-qPCR). Results: RT-qPCR showed that $TR{\alpha}$ was expressed at E70 with relatively high level and then slightly decreased (E75, E80, and E90). The highest expression of $TR{\alpha}$ mRNA was revealed at E130 (P > 0.05). The expression pattern of CRABPII mRNA showed an 'up-down-up' trend, which revealed a significantly highest expression at E75 (P < 0.05) and was down-regulated during E80 to E120 (P < 0.05) and mildly increased at E130, subsequently. Conclusion: This study demonstrated that $TR{\alpha}$ and CRABPII genes expressed in different levels during prenatal development of cashmere. The present study will be helpful to provide the comprehensive understanding of $TR{\alpha}$ and CRABPII genes expressions during cashmere formation and lay the ground for further studies on their roles in regulation of cashmere growth in goats.

• Journal of Animal Science and Technology
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• 제63권1호
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• pp.36-45
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• 2021

Presently, there is an increased demand for livestock products all over the world which has led to more devotion on improving livestock population. Although goats have been bred for a long time in Korea, but there is not much research conducted on traditional Korean black goat (Capra hircus coreanae) compared to other livestock populations. Mutton consumption has been dramatically changing from medicinal use to edible meat and this trend directs the black goat populations declining and also mutton import quantities are increasing consistently. The present study introduced a new estrus synchronizing technique with subsequent artificial insemination (AI) for Korean black goats to enable crossbreeding with non-native breeds for the small or subsistent farmers. Our data highlighted that, the percentage of motile sperm from the electro-ejaculated samples declined significantly after freezing and melting. In addition, the sperm motility significantly declined with regard to sperm incubation period (0, 5, 60, and 120 min at 37℃) and was negatively correlated (64.2 ± 7.9%, 63.3 ± 5.8%, 49.9 ± 6.3%, and 35.9 ± 7.6%, respectively) in frozen-thawed sperm samples. Moreover, the E2 levels were unchanged even 24 h after controlled internal drug releas (CIDR) withdrawal. But, 48 h and 72 h after CIDR removal, E2 levels increased significantly. These data helps us to consider the two time points for AI; CIDR removal after 24 h, at which E2 decreases, and after 48 h, as the time at which progesterone increases. Additionally, the AI after 48 h of CIDR removal group exhibited significantly higher pregnancy and parturition rates (42.9%) compared to AI after 24 h after CIDR removal 28.6% group. In conclusion, these studies will propose an optimal estrus synchronisation process with subsequent timing of AI and also will promote the Korean black goat breeding industry.

• Journal of the Korean Data and Information Science Society
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• 제20권6호
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• pp.1049-1060
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• 2009

국내 금융시장의 변동성의 확대는 개인투자자들의 직접투자를 어렵게 만들면서 펀드를 통한 간접 투자 비중을 증가시켰다. 본 연구의 목적은 여러 가지 형태의 펀드 중에서도 인덱스펀드를 바탕으로 초과수익을 추구하는 인핸스드 인덱스 펀드 모델을 구축하는데 있다. 유전자알고리즘을 활용하여 인덱스펀드 관리를 위한 포트폴리오 최적화 모델을 제안하고, 이렇게 얻은 인덱스펀드의 수익에 초과수익을 얻을 수 있도록 기준지수의 일별 거래대금과 종가를 활용하였다. 실증분석 결과 본 연구의 제안모델은 코스피 200의 움직임을 잘 반영하고 있으며, 이를 활용한 전략은 순수 인덱스펀드에 의한 단순매수 후 보유 전략보다 적절한 개수의 종목을 편입시킨다면 높은 수익률을 가져다줌을 알 수 있었다.

• 전기학회논문지
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• 제66권5호
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• pp.757-764
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• 2017

As the reduction of greenhouse gases(GHGs) emission has become a global issue, the microgrid markets are growing rapidly. With the sudden changes in the market, Korean government suggested a new business model called 'Self-Sufficient Energy Islands'. Its main concern is a stand-alone microgrid composed of Distributed Energy Resources(DERs) such as Renewable Energy Sources(RESs), Energy Storage System(ESS) and Fuel Cell, in order to minimize the emission of GHGs. According to these trend, this paper is written to propose an optimal sizing method of DERs in a stand-alone microgrid by using Genetic Algorithm(GA), one of the representative stochastic methods. It is to minimize the net present cost with the variables, size of RESs and ESS. In the process for optimization, the sunless days are considered as additional constraints. Through the case study analysis, the size of DERs installed in a microgrid system has been computed using the proposed method in MATLAB. And the result of MATLAB is compared with that of HOMER(Hybrid Optimization of Multiple Energy Resources), a well-known energy modeling software.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.10009-10013
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• 2014

Background: Vitamin D receptor (VDR) gene has been a subject of extensive pharmacogenetic research recently. Association studies between different types of cancers including prostate cancer (PCa) and VDR gene polymorphism have also been conducted. The objective of this study was to find possible associations between PCa and VDR gene polymorphisms in the Pakistani population. Materials and Methods: A total of 162 subjects, including prostate cancer patients and controls, were genotyped for Apa I, Taq I and Fok I polymorphisms in the VDR gene using allele specific PCR, PCR-RFLP and direct DNA sequencing. Allelic frequencies were tested for Hardy-Weinberg equilibrium and associations between the genetic markers and PCa were calculated using logistic regression. Results: Apa I CC genotype was found to have strongest association with PCa risk, and "A" genotype was found to have protective effect. Fok I and Taq I did not have appreciable levels of association with PCa, although Taq I "TC" heterozygotes seemed to have some protective effect. Similarly the "C" allele of Fok I also seemed to have protective effect. Conclusions: To our knowledge, this is the first report showing association between VDR gene polymorphisms and PCa in Pakistan. Our findings may be somewhat skewed because of small sample size and tendency of consanguineous marriages in Pakistani society; nevertheless, it shows the trend of association and protective effects of certain VDR gene polymorphisms against PCa.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3989-3995
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• 2016

Background: Childhood acute lymphoblastic leukemia (ALL) is a heterogeneous genetic disease and its etiology remains poorly understood. Recent genome wide association and replication studies have highlighted specific polymorphisms contributing to childhood ALL predispositions mostly in European populations. It is unclear if these observations generalize to other populations with a lower incidence of ALL. The current case-control study evaluated variants in ARID5B (rs7089424, rs10821936), IKZF1 (rs4132601) and CEBPE (rs2239633) genes, which appear most significantly associated with risk of developing childhood B-lineage ALL. Materials and Methods: Using TaqMan assays, genotyping was conducted for 162 de novo B-lineage ALL cases and 150 unrelated healthy controls in India. Appropriate statistical methods were applied. Results: Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B-rs10821936 (p=0.028, p=0.026). Both rs10821936 (p=0.019; OR 0.67; 95% CI=0.47-0.94) and rs4132601 (p=0.018; OR 0.67; 95%CI 0.48-0.94) were associated with reduced disease risk. Moreover, gender-analysis revealed male-specific risk associations for rs10821936 (p=0.041 CT+CC) and rs4132601 (p=0.005 G allele). Further, ARID5B-rs7089424 and CEBPE-rs2239633 showed a trend towards decreased disease risk but without significance (p=0.073; p=0.73). Conclusions: Our findings provide the first evidence that SNPs ARID5B-rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children. Understanding the effects of these variants in different ethnic groups is crucial as they may confer different risk of ALL within different populations.

• Asian-Australasian Journal of Animal Sciences
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• 제19권10호
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• pp.1390-1393
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• 2006

Data spread over 11 years (1986-1996) pertaining to a synthetic population developed by inter se mating of half-breds of Corriedale and Russian Merino with Nali maintained at CCS Haryana Agricultural University, Hisar were utilized for the estimation of genetic parameters for growth traits. The means for birth weight (BWT), weaning weight (WWT), six month body weight (SWT), yearling weight (YWT), preweaning daily gain (PRW) and post weaning daily gain (POW) were 3.35 kg, 10.79 kg, 13.28 kg, 18.96 kg, 82.6 gm and 27.6 gm, respectively. The effects of year and season of birth and sex of lamb were significant for all the traits under study except the effect of season of birth for WWT, SWT and PRW. No definite trend was observed over the years for the averages of body weight and gain. Lambs born during the spring season performed better for BWT, WWT and PRW while the performance of lambs born during autumn was better for the other traits included in the study. The male lambs were heavier than the females for body weight at all stages and gain in weight. The heritability estimates for WWT and PRW were low; for BWT and SWT were moderate and for YWT and POW were high. Birth weight had high heritability and high genetic correlations with subsequent body weights and gains but due to the presence of a maternal effect on BWT and WWT, a sequential selection procedure is recommended for the improvement of growth rate in sheep.

• Asian-Australasian Journal of Animal Sciences
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• 제15권9호
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• pp.1371-1377
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• 2002

During a 5-yr period, 1994-1998, pre-weaning and weaning data were collected on 591 calves produced by mating either straightbred Jersey, straightbred Limousin or $F_1$ (Limousin${\times}$Jersey) bulls to mature purebred Jersey or Limousin cows. Traits recorded included birth and weaning weight, height, length, girth, fat depth and a measure of muscle (ratio of stifle to hip width expressed as a percentage). All traits were analyzed assuming a model with sire and dam random effects that included effects of year and date of birth, sex, breed and year${\times}$sex interaction. Main effects were generally significant with few exceptions. Direct genetic effects were large for weight, height, girth and muscle with a breed trend from purebred Jersey (small) to purebred Limousin (large). At weaning, the maternal effect of the Jersey dam was positive for weight (10.9${\pm}$4.9 kg), girth (3.7${\pm}$1.0 cm) and muscle (6.0${\pm}$0.9%). Heterosis was highly significant and positive only for fat depth (1.5${\pm}$0.2 mm) with the $F_1$ progeny being the fattest, followed by the backcrosses, then purebred Jersey and purebred Limousin. Also, significant (p<0.001) but negative heterosis was observed for weight, girth and muscle. The change in ranking for fat depth relative to other traits is a reflection of the large heterotic effects relative to direct effects on fat depth. Epistatic effects were not significant on any trait at birth or weaning. This study has indicated the possibility of exploiting the positive heterotic and maternal effects for fat depth and muscularity to meet specific meat quality and quantity demand by consumers.