• Proceedings of the KWS Conference
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• 2000.04a
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• pp.224-227
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• 2000

• Smart Structures and Systems
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• v.12 no.6
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• pp.595-617
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• 2013

Semi-active control equipments are used to effectually enhance the seismic behavior of structures. Magneto-rheological (MR) dampers are semi-active devices that can be utilized to control the response of structures during seismic loads and have received voracious attention for response suppression. They supply the adaptability of active devices and stability and reliability of passive devices. This paper presents an optimal fuzzy logic control scheme for vibration mitigation of buildings using magneto-rheological dampers subjected to near-fault ground motions. Near-fault features including a directivity pulse in the fault-normal direction and a fling step in the fault-parallel direction are considered in the requisite ground motion records. The membership functions and fuzzy rules of fuzzy controller were optimized by genetic algorithm (GA). Numerical study is performed to analyze the influences of near-fault ground motions on a building that is equipped with MR dampers. Considering the uncontrolled system response as the base line, the proposed method is scrutinized by analogy with that of a conventional maximum dissipation energy (MED) controller to accentuate the effectiveness of the fuzzy logic algorithm. Results reveal that the fuzzy logic controllers can efficiently improve the structural responses and MR dampers are quite promising for reducing seismic responses during near-fault earthquakes.

• Journal of Korean Association for Spatial Structures
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• v.14 no.3
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• pp.75-84
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• 2014

When adjacent tall buildings experience earthquake excitation, structural pounding may happen. In order to mitigate seismic pounding damage to adjacent structures, many studies have been done to date. Tuned mass dampers (TMD) are widely used for reduction of dynamic responses of building structures subjected to earthquake excitations. If a TMD is shared between adjacent buildings and it shows good control performance, it will be effective and economic means to reduce seismic responses of adjacent structures. In this study, control performance of a shared tuned mass damper (STMD) for seismic response reduction of adjacent buildings has been evaluated. For this purpose, two 8-story example buildings were used and multi-objective genetic algorithms has been employed for optimal design of the stiffness and damping parameters of the STMD. Based on numerical analyses, it has been shown that a STMD can effectively control dynamic responses and reduce the effect of pounding between adjacent buildings subjected to earthquake excitations in comparison with a traditional TMD.

• Journal of Plant Biotechnology
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• v.40 no.2
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• pp.59-64
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• 2013

Auxin is a key plant hormone which regulates overall plant growth development. A number of researches to investigate auxin signaling identified three major classes of early auxin response genes: AUX/IAA, GH3 and SMALL AUXIN UP RNA (SAUR). Among these genes, in planta functions of SAUR gene family are largely ambiguous, while both AUX/IAA and GH3 genes are analyzed to mediate negative feedback on auxin response. SAUR genes encode small plant-specific proteins. SAUR gene products are highly unstable and transiently expressed in the tissue- and developmental-specific manners in response to auxin and various environmental stimuli. In the decades, molecular and genetic approaches to elucidate in planta functions of SAURs have been hampered by several factors such as the unstable molecular features and functional redundancy among them. However, a series of recent studies focusing on several subgroups of SAUR gene family made significant progress in our understanding of its biochemical and physiological functions. These works suggest that many SAUR proteins mainly regulate auxin-related cell expansion and auxin transport. In this review, the recent progress in SAUR research and prospects for crop improvement through its genetic manipulation are discussed.

• Molecules and Cells
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• v.26 no.4
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• pp.368-372
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• 2008

Recent molecular and genetic studies in rice, a short-day plant, have elucidated both conservation and divergence of photoperiod pathway genes and their regulators. However, the biological roles of rice genes that act within the autonomous pathway are still largely unknown. In order to better understand the function of the autonomous pathway genes in rice, we conducted molecular genetic analyses of OsFVE, a rice gene homologous to Arabidopsis FVE. OsFVE was found to be ubiquitously expressed in vegetative and reproductive organs. Overexpression of OsFVE could rescue the flowering time phenotype of the Arabidopsis fve mutants by up-regulating expression of the SUPPRESSOR OF OVEREXPRESSION OF CO1 (SOC1) and down-regulating FLOWERING LOCUS C (FLC) expression. These results suggest that there may be a conserved function between OsFVE and FVE in the control of flowering time. However, OsFVE overexpression in the fve mutants did not rescue the flowering time phenotype in in relation to the response to intermittent cold treatment.

• Journal of Korean Association for Spatial Structures
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• v.24 no.2
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• pp.65-73
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• 2024

In this study, we propose an optimal design method by applying the Prefabricated Buckling Restrained Brace (PF-BRB) to structures with asymmetrically rigidity plan. As a result of the PF-BRB optimal design of a structure with an asymmetrically rigidity plan, it can be seen that the reduction effect of dynamic response is greater in the case of arrangement considering the asymmetric distribution of stiffness (Asym) than in the case of arrangement in the form of a symmetric distribution (Sym), especially It was confirmed that at an eccentricity rate of 20%, the total amount of reinforced PF-BRBs was also small. As a result of analyzing the dynamic response characteristics according to the change in eccentricity of the asymmetrically rigidity plan, the distribution of the reinforced PF-BRB showed that the larger the eccentricity, the greater the amount of damper distribution around the eccentric position. Additionally, when comparing the analysis models with an eccentricity rate of 20% and an eccentricity rate of 12%, the response reduction ratio of the 20% eccentricity rate was found to be large.

• Clinical and Experimental Vaccine Research
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• v.13 no.2
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• pp.105-120
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• 2024

Vaccines are one of the most important and effective tools in the prevention of infectious diseases and research about all the aspects of vaccinology are essential to increase the number of available vaccines more and more safe and effective. Despite the unquestionable value of vaccinations, vaccine hesitancy has spread worldwide compromising the success of vaccinations. Currently, the main purpose of vaccination campaigns is the immunization of whole populations with the same vaccine formulations and schedules for all individuals. A personalized vaccinology approach could improve modern vaccinology counteracting vaccine hesitancy and giving great benefits for human health. This ambitious purpose would be possible by facing and deepening the areas of vaccinomics and adversomics, two innovative areas of study investigating the role of a series of variables able to influence the immune response to vaccinations and the development of serious side effects, respectively. We reviewed the recent scientific knowledge about these innovative sciences focusing on genetic and non-genetic basis involved in the individual response to vaccines in terms of both immune response and side effects.

• Journal of Environmental Policy
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• v.8 no.4
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• pp.1-24
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• 2009

As commercial use of genetic resources increases in modern society, calls for fair and equitable sharing of the benefits thereof have become increasingly prominent, particularly from developing countries. As a result, negotiations have been ongoing for the "International Regime on Access and Benefit Sharing (ABS)" for genetic resources as a successor to the non-binding Bonn Guideline. 2010 has been set as the target date for the Agreement. As South Korea is more likely to be a user country of genetic resources, it will be necessary for it to take part in the negotiating process and contribute to creating the International Regime on ABS, to ensure both appropriate access to genetic resources and fair and equitable sharing of the benefits arising there from. To develop appropriate response strategies for South Korea, it is critical not only to closely examine the negotiations within the framework of the CBD but also to engage in discussions within thescope of related international organizations and domestic legislation. To achieve this goal, it is imperative for South Korea to form a comprehensive Government Response System, composed of relevant governmental bodies including the Ministry of Foreign Affairs and Trade, and the Ministry of Environment, etc.

• Nutrition Research and Practice
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• v.13 no.4
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• pp.302-309
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• 2019

BACKGOURND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects. However, no study has reported the regulatory effect of C. turczaninowii extract on the arterial inflammatory response. This study therefore investigated modulation of the arterial inflammatory response after exposure to C. turczaninowii extract, using human aortic vascular smooth muscle cells (HAoSMCs). MATERIALS/METHODS: Scavenging activity of free radicals, total phenolic content (TPC), cell viability, mRNA expressions, and secreted levels of cytokines were measured in LPS-stimulated (10 ng/mL) HAoSMCs treated with the C. turczaninowii extract. RESULTS: C. turczaninowii extract contains high amounts of TPC ($225.6{\pm}21.0mg$ of gallic acid equivalents/g of the extract), as well as exerts time-and dose-dependent increases in strongly scavenged free radicals (average $14.8{\pm}1.97{\mu}g/mL$ $IC_{50}$ at 40 min). Cell viabilities after exposure to the extracts (1 and $10{\mu}g/mL$) were similar to the viability of non-treated cells. Cytokine mRNA expressions were significantly suppressed by the extracts (1 and $10{\mu}g/mL$) at 6 hours (h) after exposure. Interleukin-6 secretion was dose-dependently suppressed 2 h after incubation with the extract, at $1-10{\mu}g/mL$ in non-stimulated cells, and at 5 and $10{\mu}g/mL$ in LPS-stimulated cells. Similar patterns were also observed at 24 h after incubation with the extract (at $1-10{\mu}g/mL$ in non-stimulated cells, and at $10{\mu}g/mL$ in the LPS-stimulated cells). Soluble intracellular vascular adhesion molecules (sICAM-1) secreted from non-stimulated cells and LPS-stimulated cells were similarly suppressed in a dose-dependent manner after 24 h exposure to the extracts, but not after 2 h. In addition, sICAM-1 concentration after 24 h treatment was positively related to IL-6 levels after 2 h and 24 h exposure (r = 0.418, P = 0.003, and r = 0.524, P < 0.001, respectively). CONCLUSIONS: This study demonstrates that C. turczaninowii modulates the arterial inflammatory response, and indicates the potential to be applied as a therapeutic use for atherosclerosis.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.116.2-117
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• 2003

Late blight, caused by Phytophthora infestans, is one of the most destructive disease on potato and tomato cultivation. To analysis genetic diversity P. infeatans isolates were collected from potato and tomato fields in Korea. These pathogens contained both Al and A2 mating type with metalaxyl-resistant and sensitive isolates. Polymorphisms showed base on RAPD (Random Amplified Polymorphic DNA) in both potato and tomato isolates of P. infestans. Cluster analysis showed high level genetic variation in potato isolates of P. infestans than tomato isolates. P. infestans isolates were observed genetic diversity among them but not grouped among isolates related mating type and metalaxyl response. These results exhibited that P. infestans isolates showing genetic difference among them were distributed in Korea.