• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.191-196
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• 2005

Genetic networks are a key to unraveling dynamic properties of biological processes and regulation of genes plays an essential role in dynamic behavior of the genetic networks. A popular characterization of regulation of the gene is a kinetic model. However, many kinetic parameters in the genetic regulation have not been available. To overcome this difficulty, in this report, state-space approach to modeling gene regulation is presented. Second-order systems are used to characterize gene regulation. Interpretation of coefficients in the second order systems as resistance, capacitance and inductance is studied. The mathematical methods for transient response analysis of gene regulation to external perturbation are investigated. Criterion for classifying gene into three categories: underdamped, overdamped and critical damped is discussed. The proposed models are applied to yeast cell cycle gene expression data.

• Clinical and Experimental Pediatrics
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• v.60 no.1
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• pp.1-9
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• 2017

Malformations of cortical development are rare congenital anomalies of the cerebral cortex, wherein patients present with intractable epilepsy and various degrees of developmental delay. Cases show a spectrum of anomalous cortical formations with diverse anatomic and morphological abnormalities, a variety of genetic causes, and different clinical presentations. Brain magnetic resonance imaging has been of great help in determining the exact morphologies of cortical malformations. The hypothetical mechanisms of malformation include interruptions during the formation of cerebral cortex in the form of viral infection, genetic causes, and vascular events. Recent remarkable developments in genetic analysis methods have improved our understanding of these pathological mechanisms. The present review will discuss normal cortical development, the current proposed malformation classifications, and the diagnostic approach for malformations of cortical development.

• Structural Engineering and Mechanics
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• v.23 no.4
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• pp.325-337
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• 2006

A hybrid structural design and optimization methodology that combines the strengths of genetic algorithms, local search techniques, and parallel computing is developed to evolve optimal truss systems in this research effort. The primary objective that is met in evolving near-optimal or optimal structural systems using this approach is the capability of satisfying user-defined design criteria while minimizing the computational time required. The application of genetic algorithms to the design and optimization of truss systems supports conceptual design by facilitating the exploration of new design alternatives. In addition, final shape optimization of the evolved designs is supported through the refinement of member sizes using local search techniques for further improvement. The use of the hybrid approach, therefore, enhances the overall process of structural design. Parallel computing is implemented to reduce the total computation time required to obtain near-optimal designs. The support of human-computer interaction during layout optimization and local optimization is also discussed since it assists in evolving optimal truss systems that better satisfy a user's design requirements and design preferences.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.10 no.4
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• pp.128-134
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• 2011

Note that k-anonymity algorithm has been widely discussed in the area of privacy protection. In this paper, a new search algorithm to achieve k-anonymity for database application is introduced. A lattice is introduced to form a solution space for a k-anonymity problem and then a hybrid search method composed of tabu search and genetic algorithm is proposed. In this algorithm, the tabu search plays the role of mutation in the genetic algorithm. The hybrid method with independent tabu search and genetic algorithm is compared, and the hybrid approach performs the best in average case.

• Computers and Concrete
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• v.5 no.5
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• pp.475-490
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• 2008

The paper explores the potential of applicability of Genetic programming approach (GP), adopted in this investigation, to model the combined effects of five independent variables to predict the mini-slump, the plate cohesion meter, the induced bleeding test, the J-fiber penetration value, and the compressive strength at 7 and 28 days of self-compacting slurry infiltrated fiber concrete (SIFCON). The variables investigated were the proportions of limestone powder (LSP) and sand, the dosage rates of superplasticiser (SP) and viscosity modifying agent (VMA), and water-to-binder ratio (W/B). Twenty eight mixtures were made with 10-50% LSP as replacement of cement, 0.02-0.06% VMA by mass of cement, 0.6-1.2% SP and 50-150% sand (% mass of binder) and 0.42-0.48 W/B. The proposed genetic models of the self-compacting SIFCON offer useful modelling approach regarding the mix optimisation in predicting the fluidity, the cohesion, the bleeding, the penetration, and the compressive strength.

• Proceedings of the IEEK Conference
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• 1999.06a
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• pp.452-455
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• 1999

We introduce an evolutionary approach to on-line learning for mobile robot control using reconfigurable hardware. We use genetic programming as an evolutionary engine. Control programs are encoded in tree structure. Genetic operators, such as node mutation, adapt the program trees based on a set of training cases. This paper discusses the advantages and constraints of the evolvable hardware approach to robot learning and describes a FPGA implementation of the presented genetic programming method.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.9
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• pp.1636-1641
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• 2008

In this study, we introduce a new approach to Parallel Genetic Algorithms (PGA) which combines AHFCGA with crossover operator. As to crossover operators, we use three types of the crossover operators such as modified simple crossover(MSX), arithmetic crossover(AX), and Unimodal Normal Distribution Crossover(UNDX) for real coding. The AHFC model is given as an extended and adaptive version of HFC for parameter optimization. The migration topology of AHFC is composed of sub-populations(demes), the admission threshold levels, and admission buffer for the deme of each threshold level through succesive evolution process. In particular, UNDX is mean-centric crossover operator using multiple parents, and generates offsprings obeying a normal distribution around the center of parents. By using test functions having multimodality and/or epistasis, which are commonly used in the study of function parameter optimization, Experimental results show that AHFCGA can produce more preferable output performance result when compared to HFCGA and RCGA.

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.6
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• pp.573-579
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• 2008

This paper introduces a new approach to develop a fast gait for quadruped robot using GP(genetic programming). Planning gaits for legged robots is a challenging task that requires optimizing parameters in a highly irregular and multidimensional space. Several recent approaches have focused on using GA(genetic algorithm) to generate gait automatically and shown significant improvement over previous results. Most of current GA based approaches used pre-selected parameters, but it is difficult to select the appropriate parameters for the optimization of gait. To overcome these problems, we proposed an efficient approach which optimizes joint angle trajectories using genetic programming. Our GP based method has obtained much better results than GA based approaches for experiments of Sony AIBO ERS-7 in Webots environment.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.1
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• pp.1-6
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• 2021

Next-generation sequencing (NGS) technologies have changed the process of genetic diagnosis from a gene-by-gene approach to syndrome-based diagnostic gene panel sequencing (DPS), diagnostic exome sequencing (DES), and diagnostic genome sequencing (DGS). A priori information on the causative genes that might underlie a genetic condition is a prerequisite for genetic diagnosis before conducting clinical NGS tests. Theoretically, DPS, DES, and DGS do not require any information on specific candidate genes. Therefore, clinical NGS tests sometimes detect disease-related pathogenic variants in genes underlying different conditions from the initial diagnosis. These clinical NGS tests are expensive, but they can be a cost-effective approach for the rapid diagnosis of rare disorders with genetic heterogeneity, such as the glycogen storage disease, familial intrahepatic cholestasis, lysosomal storage disease, and primary immunodeficiency. In addition, DES or DGS may find novel genes that that were previously not linked to human diseases.

• Journal of Satellite, Information and Communications
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• v.6 no.1
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• pp.6-11
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• 2011

In this paper presents a new approach to evaluate reliability indices of electric distribution systems using genetic Algorithm (GA). The use of reliability evaluation is an important aspect of distribution system planning and operation to adjust the reliability level of each area. In this paper, the reliability model is based on the optimal load transferring problem to minimize load generated load point outage in each sub-section. This approach is one of the most difficult procedures and become combination problems. A new approach using GA was developed for this problem. GA is a general purpose optimization technique based on principles inspired from the biological evolution using metaphors of mechanisms such as natural selection, genetic recombination and survival of the fittest. Test results for the model system with 24 nodes 29 branches are reported in the paper.