• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.1
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• pp.27-32
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• 2019

This study describes the design and implementation of a simulated signal generator to demonstrate the performance of VHF band radar for the detection of small targets in RCS(Radar Cross Section). The transmission and reception antenna beam widths used in the simulated signal generating apparatus may be large, which may cause problems in the degree of isolation. Interference signal immunity and isolation characteristics are improved by considering operating conditions of VHF radar to solve isolation of antennas. Simulated signal generator performs the following: VHF radar transmission and reception correction, simulation signal generation, target Doppler, RCS and distance simulation, remote control, and GPS clock synchronization function. After the fabrication of the simulated signal generator, the main characteristics, such as the output characteristics and the reflection signal simulations, were tested. When the microwave radar assembly is completed in the future, it will be utilized for the performance evaluation of VHF radar.

• Molecules and Cells
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• v.42 no.2
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• pp.135-142
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• 2019

OCT4, also known as POU5F1 (POU domain class 5 transcription factor 1), is a transcription factor that acts as a master regulator of pluripotency in embryonic stem cells and is one of the reprogramming factors required for generating induced pluripotent stem cells. The human OCT4 encodes three isoforms, OCT4A, OCT4B, and OCT4B1, which are generated by alternative splicing. Currently, the functions and expression patterns of OCT4B remain largely unknown in malignancies, especially in human glioblastomas. Here, we demonstrated the function of OCT4B in human glioblastomas. Among the isoform of OCT4B, OCT4B-190 ($OCT4B^{19kDa}$) was highly expressed in human glioblastoma stem cells and glioblastoma cells and was mainly detected in the cytoplasm rather than the nucleus. Overexpression of $OCT4B^{19kDa}$ promoted colony formation of glioblastoma cells when grown in soft agar culture conditions. Clinical data analysis revealed that patients with gliomas that expressed OCT4B at high levels had a poorer prognosis than patients with gliomas that expressed OCT4B at low levels. Thus, $OCT4B^{19kDa}$ may play a crucial role in regulating cancer cell survival and adaption in a rigid environment.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.275-283
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• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.133-141
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• 2019

Crew rostering in railway operations is usually done by arranging a crew diagram in accordance with working standards every month. This study was done to identify the problems related to the creation of crew rosters in railway operations and to suggest an optimum crew rostering method that can be applied in railway operations planning. To do this, the work standards of a railway company were identified, and a genetic algorithm was used to develop an optimal roster with equal working time while considering actual working patterns. The optimization process is composed of analysis of the input data, creation of work patterns, creation of a solution, and optimization steps. To verify the method, the roster derived from the proposed process was compared with a manually created roster. The results of the study could be used to reduce the deviation of business hours when generating a roster because the standard deviation of working time is the objective function.

• Computers and Concrete
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• v.23 no.6
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• pp.433-444
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• 2019

As rice husk ash (RHA) is not produced in controlled manufacturing process like cement, its properties vary significantly even within the same lot. In fact, properties of Rice Husk Ash Based Concrete (RHABC) are largely dictated by uncertainty leading to huge deviations from their expected values. This paper proposes a Robust Cost Optimization (RCO) procedure for RHABC, which minimizes such unwanted deviation due to uncertainty and provides guarantee of achieving desired strength and workability with least possible cost. The RCO simultaneously minimizes cost of RHABC production and its deviation considering feasibility of attaining desired strength and workability in presence of uncertainty. RHA related properties have been modeled as uncertain-but-bounded type as associated probability density function is not available. Metamodeling technique is adopted in this work for generating explicit expressions of constraint functions required for formulation of RCO. In doing so, the Moving Least Squares Method is explored in place of conventional Least Square Method (LSM) to ensure accuracy of the RCO. The efficiency by the proposed MLSM based RCO is validated by experimental studies. The error by the LSM and accuracy by the MLSM predictions are clearly envisaged from the test results. The experimental results show good agreement with the proposed MLSM based RCO predicted mix properties. The present RCO procedure yields RHABC mixes which is almost insensitive to uncertainty (i.e., robust solution) with nominal deviation from experimental mean values. At the same time, desired reliability of satisfying the constraints is achieved with marginal increment in cost.

• Earthquakes and Structures
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• v.16 no.5
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• pp.563-573
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• 2019

When generating spectrum-compatible artificial ground motion in engineering practices, the effect of the variation in fitting parameters on the distribution of the peak ground displacement (PGD) has not yet drawn enough attention. In this study, a method for simulating ground motion matching for multiple targets is developed. In this method, a frequency-dependent amplitude envelope function with statistical parameters is introduced to simulate the nonstationarity of the frequency in earthquake ground motion. Then, several groups of time-history acceleration with different temporal and spectral nonstationarities were generated to analyze the effect of nonstationary parameter variations on the distribution of PGD. The following conclusions are drawn from the results: (1) In the simulation of spectrum-compatible artificial ground motion, if the acceleration time-history is generated with random initial phases, the corresponding PGD distribution is quite discrete and an uncertain number of PGD values lower than the limit value are observed. Nevertheless, the mean values of PGD always meet the requirement in every group. (2) If the nonstationary frequencies of the ground motion are taken into account when fitting the target spectrum, the corresponding PGD values will increase. A correlation analysis shows that the change in the mean and the dispersion values, from before the frequencies are controlled to after, correlates with the modal parameters of the predominant frequencies. (3) Extending the maximum period of the target spectrum will increase the corresponding PGD value and, simultaneously, decrease the PGD dispersion. Finally, in order to control the PGD effectively, the ground motion simulation method suggested in this study was revised to target a specified PGD. This novel method can generate ground motion that satisfies not only the required precision of the target spectrum, peak ground acceleration (PGA), and nonstationarity characteristics of the ground motion but also meets the required limit of the PGD, improving engineering practices.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.4
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• pp.587-604
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• 2021

Because the library cannot be run independently and used by many applications, it is important to detect vulnerabilities in the library. Fuzzing, which is a dynamic analysis, is used to discover vulnerabilities for the library. Although this fuzzing technique shows excellent results in terms of code coverage and unique crash counts, it is difficult to apply its effects to library fuzzing. In particular, a fuzzing executable and a seed corpus are needed that execute the library code by calling a specific function sequence and passing the input of the fuzzer to reproduce the various states of the library. Generating the fuzzing environment such as fuzzing executable and a seed corpus is challenging because it requires both understanding about the library and fuzzing knowledge. We propose a novel method to improve the ease of library fuzzing and enhance code coverage and crash detection performance by using a test framework. The systems's performance in this paper was applied to nine open-source libraries and was verified through comparison with previous studies.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.14 no.3
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• pp.41-48
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• 2004

Finite field multiplication and division are important arithmetic operation in error-correcting codes and cryptosystems. The elements of the finite field GF($2^m$) are represented by bases with a primitive polynomial of degree m over GF(2). We can be easily realized for multiplication or computing multiplicative inverse in GF($2^m$) based on a normal basis representation. The number of product terms of logic function determines a complexity of the Messay-Omura multiplier. A normal basis exists for every finite field. It is not easy to find the optimal normal element for a given primitive polynomial. In this paper, the generating method of normal basis is investigated. The normal bases whose product terms are less than other bases for multiplication in GF($2^m$) are found. For each primitive polynomial, a list of normal elements and number of product terms are presented.

• Steel and Composite Structures
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• v.37 no.6
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• pp.663-678
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• 2020

This paper proposes a novel topology optimization method generating multiple materials for external linear plane crack structures based on the combination of IsoGeometric Analysis (IGA) and eXtended Finite Element Method (X-FEM). A so-called eXtended IsoGeometric Analysis (X-IGA) is derived for a mechanical description of a strong discontinuity state's continuous boundaries through the inherited special properties of X-FEM. In X-IGA, control points and patches play the same role with nodes and sub-domains in the finite element method. While being similar to X-FEM, enrichment functions are added to finite element approximation without any mesh generation. The geometry of structures based on basic functions of Non-Uniform Rational B-Splines (NURBS) provides accurate and reliable results. Moreover, the basis function to define the geometry becomes a systematic p-refinement to control the field approximation order without altering the geometry or its parameterization. The accuracy of analytical solutions of X-IGA for the crack problem, which is superior to a conventional X-FEM, guarantees the reliability of the optimal multi-material retrofitting against external cracks through using topology optimization. Topology optimization is applied to the minimal compliance design of two-dimensional plane linear cracked structures retrofitted by multiple distinct materials to prevent the propagation of the present crack pattern. The alternating active-phase algorithm with optimality criteria-based algorithms is employed to update design variables of element densities. Numerical results under different lengths, positions, and angles of given cracks verify the proposed method's efficiency and feasibility in using X-IGA compared to a conventional X-FEM.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.3
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• pp.433-441
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• 2022

In general, in an emergency generator system for an electric facility including an induction motor load, an emergency power generation facility larger than the facility load capacity is built due to the initial starting current of the induction motor. In order to reduce this economic burden, various methods to reduce the inrush current of induction motors are applied to suppress the additional expansion of generators due to the reduction of power generation facilities and the increase in electrical facilities. Among these methods, when a system with a built-in soft start function of an induction motor using an inverter is built, it is the best way to reduce the inrush current of the induction motor to less than the rated current. However, in this case, the installation cost of the inverter to drive the induction motor increases. This paper proposes a soft start method of an induction motor by expanding the frequency and voltage control operation area of an emergency generator. In addition, proposed a speed calculation method based on power factor information, which is essential information for stable soft start of an induction motor, and a method for generating a speed command value of the governor for starting with maximum torque.