• Geomechanics and Engineering
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• v.38 no.3
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• pp.261-273
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• 2024

This study presents a groundbreaking analytical approach to find an exact solution for the bearing capacity of strip footings on reinforced slopes, utilizing the two-phase approach and slip line method. The two-phase approach is considered as a generalized homogenization technique. The slip line method is leveraged to derive the stress field as a lower bound solution and the velocity field as an upper bound solution, thereby facilitating the attainment of an exact solution. The key finding points out the variation of the bearing capacity factor N_γ with influencing factors including the backfill soil friction angle, the footing setback distance from the slope crest edge, slope angle, strength, and volumetric fraction of inclusion layers. The results are evaluated by comparing them with those of relevant studies in the literature considering analytical and experimental studies. Through the application of the two-phase approach, it becomes feasible to determine the tensile loads mobilized along the inclusion layers associated with the failure zone. It is attempted to demonstrate the results by utilizing non-dimensional graphs to clearly illustrate variable impacts on reinforced soil stability. This research contributes significantly to advancing geotechnical engineering practices, specifically in the realm of static design considerations for reinforced soil structures.

• Steel and Composite Structures
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• v.52 no.4
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• pp.487-499
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• 2024

The primary objective of this study is to analyze the free vibration behavior of a sandwich cylindrical shell with a defective core and wavy carbon nanotube (CNT)-enhanced face sheets, utilizing the three-dimensional theory of elasticity. The intricate equations of motion for the structure are solved semi-analytically using the generalized differential quadrature method. The shell structure consists of a damaged isotropic core and two external face sheets. The distributions of CNTs are either functionally graded (FG) or uniform across the thickness, with their mechanical properties determined through an extended rule of mixture. In this research, the conventional theory regarding the mechanical effectiveness of a matrix embedding finite-length fibers has been enhanced by introducing tube-to-tube random contact. This enhancement explicitly addresses the progressive reduction in the tubes' effective aspect ratio as the filler content increases. The study investigates the influence of a damaged matrix, CNT distribution, volume fraction, aspect ratio, and waviness on the free vibration characteristics of the sandwich cylindrical shell with wavy CNT-reinforced face sheets. Unlike two-dimensional theories such as classical and the first shear deformation plate theories, this inquiry is grounded in the three-dimensional theory of elasticity, which comprehensively accounts for transverse normal deformations.

• Journal of the Korean Data and Information Science Society
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• v.20 no.6
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• pp.1103-1118
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• 2009

When we wish to estimate the mean or total of a finite population, the numbering of the population units is of importance. In this paper, we have proposed two methods for estimating the mean or total of a population having a linear trend, for the case when the reciprocal of the sampling fraction is an even number and the sample size is an odd number. The first method involves drawing a sample by using a method which is a generalization of Singh et al's (1968) modified systematic sampling, and using interpolation in determining the estimator. The second method involves selecting a sample by modified systematic sampling, and estimating the population parameters by the regression estimation method. Under the criterion of the expected mean square error based on Cochran's (1946) infinite superpopulation model, the proposed methods have been compared with existing methods. We have also made a comparison between the two proposed methods.

• Advances in Traditional Medicine
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• v.6 no.3
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• pp.179-185
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• 2006

We investigated the effects of chronic administration of different extracts of ginger rhizome [pet ether extract (PE); toluene fraction (TF) of pet ether extract] on anxiety models: the elevated T-maze (ETM) (for inhibitory avoidance and escape measurements) and the open field test. Ondansetron (1 mg/kg), FE (10, 30 &100 mg/kg) and TF (10 & 30 mg/kg) were administered orally for 15 days. On the $14^{th}$ day mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On $15^{th}$ day mice had two exposures to the enclosed and open arm of the ETM followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pretreated in a similar way. Treatment with Ondansetron (1 mg/kg), PE (100 mg/kg), TF (10 mg/kg) and TF (30 mg/kg) significantly (P<0.05) impaired inhibitory avoidance performance but did not impair escape latency. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with PE and TF. The results suggest that PE and TF of Ginger rhizome exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.

• Journal of the Korean Institute of Gas
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• v.20 no.2
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• pp.66-71
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• 2016

Nowadays, a number of sensors which are placed in industrial complex are monitoring areas involving chemical leak and other faults. However, even in the presence of the sensors, chemical leaks, sometimes involving huge amount of chemicals, continuously led to big losses in the industrial complex. In most industries, sensor installation has been performed using past experience or using senor manufacturers' guideline; which leads to poor performance of the installed sensor grid. Therefore, we investigate an optimal placement methodology of point sensors for rapid detention and response when chemical leaks happen. This research suggests a generalized formulation suitable for the optimized decision making of minimizing number of sensors to be placed and increasing the fraction of covered scenarios under assumption of negligible effect of other structures. The proposed method has been verified for suitable performance for simple leak scenario simulations, by achieving the safety objectives and guaranteeing safe process operations.

• Wind and Structures
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• v.29 no.6
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• pp.457-469
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• 2019

In this paper, a numerical solution is presented for supersonic flutter analysis of cantilever non-symmetric functionally graded (FG) sandwich plates. The plate is considered to be composed of two different functionally graded face sheets and an isotropic homogeneous core made of ceramic. Based on the first order shear deformation theory (FSDT) and linear piston theory, the set of governing equations and boundary conditions are derived. Dimensionless form of the governing equations and boundary conditions are derived and solved numerically using generalized differential quadrature method (GDQM) and critical velocity and flutter frequencies are calculated. For various values of the yaw angle, effect of different parameters like aspect ratio, thickness of the plate, power law indices and thickness of the core on the flutter boundaries are investigated. Numerical examples show that wings and tail fins with larger length and shorter width are more stable in supersonic flights. It is concluded for FG sandwich plates made of Al-Al₂O₃ that increase in volume fraction of ceramic (Al₂O₃) increases aeroelastic stability of the plate. Presented study confirms that improvement of aeroelastic behavior and weight of wings and tail fins of aircrafts are not consistent items. It is shown that value of the critical yaw angle depends on aspect ratio of the plate and other parameters including thickness and variation of properties have no considerable effect on it. Results of this paper can be used in design and analysis of wing and tail fin of supersonic airplanes.

• Steel and Composite Structures
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• v.42 no.2
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• pp.243-256
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• 2022

A coupled finite element method (FEM)-boundary element method (BEM) for analyzing the hydroelastic response of functionally graded carbon nanotube-reinforced composite (FG-CNTRC) floating plates under moving loads is firstly introduced in this article. For that aim, the plate displacement field is described utilizing a generalized shear deformation theory (GSDT)-based FEM, meanwhile the linear water-wave theory (LWWT)-relied BEM is employed for the fluid hydrodynamic modeling. Both computational domains of the plate and fluid are coincidentally discretized into 4-node Hermite elements. Accordingly, the C1-continuous plate element model can be simply captured owing to the inherent feature of third-order Hermite polynomials. In addition, this model is also completely free from shear correction factors, although the shear deformation effects are still taken into account. While the fluid BEM can easily handle the free surface with a lower computational effort due to its boundary integral performance. Material properties through the plate thickness follow four specific CNT distributions. Outcomes gained by the present FEM-BEM are compared with those of previously released papers including analytical solutions and experimental data to validate its reliability. In addition, the influences of CNT volume fraction, different CNT configurations, water depth, and load speed on the hydroelastic behavior of FG-CNTRC plates are also examined.

• Steel and Composite Structures
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• v.43 no.1
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• pp.91-106
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• 2022

This paper has focused on presenting a three dimensional theory of elasticity for free vibration of 3D-graphene foam reinforced polymer matrix composites (GrF-PMC) cylindrical panels resting on two-parameter elastic foundations. The elastic foundation is considered as a Pasternak model with adding a Shear layer to the Winkler model. The porous graphene foams possessing 3D scaffold structures have been introduced into polymers for enhancing the overall stiffness of the composite structure. Also, 3D graphene foams can distribute uniformly or non-uniformly in the shell thickness direction. The effective Young's modulus, mass density and Poisson's ratio are predicted by the rule of mixture. Three complicated equations of motion for the panel under consideration are semi-analytically solved by using 2-D differential quadrature method. The fast rate of convergence and accuracy of the method are investigated through the different solved examples. Because of using two-dimensional generalized differential quadrature method, the present approach makes possible vibration analysis of cylindrical panels with two opposite axial edges simply supported and arbitrary boundary at the curved edges. It is explicated that 3D-GrF skeleton type and weight fraction can significantly affect the vibrational characteristics of GrF-PMC panel resting on two-parameter elastic foundations.

• Advances in nano research
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• v.12 no.1
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• pp.81-99
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• 2022

The aim of current work is to evaluate thermo-electrical characteristics of graphene nanoplatelets Reinforced Composite (GNPRC) coupled with magneto-electro-elastic (MEE) face sheet. In this regard, a cylindrical smart nanocomposite made of GNPRC with an external MEE layer is considered. The bonding between the layers are assumed to be perfect. Because of the layer nature of the structure, the material characteristics of the whole structure is regarded as graded. Both mechanical and thermal boundary conditions are applied to this structure. The main objective of this work is to determine critical temperature and critical voltage as a function of thermal condition, support type, GNP weight fraction, and MEE thickness. The governing equation of the multilayer nanocomposites cylindrical shell is derived. The generalized differential quadrature method (GDQM) is employed to numerically solve the differential equations. This method is integrated with Deep Learning Network (DNN) with ADADELTA optimizer to determine the critical conditions of the current sandwich structure. This the first time that effects of several conditions including surrounding temperature, MEE layer thickness, and pattern of the layers of the GNPRC is investigated on two main parameters critical temperature and critical voltage of the nanostructure. Furthermore, Maxwell equation is derived for modeling of the MEE. The outcome reveals that MEE layer, temperature change, GNP weight function, and GNP distribution patterns GNP weight function have significant influence on the critical temperature and voltage of cylindrical shell made from GNP nanocomposites core with MEE face sheet on outer of the shell.

• Tuberculosis and Respiratory Diseases
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• v.44 no.6
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• pp.1285-1295
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• 1997

Background : EGFR is one of the initial step in signal transduction pathway about multistep carcinogenesis. It is homologous to oncogene erbB-2 and is the receptor for EGF and TGF alpha. EGFR has important role in the growth and differentiation of tumor cells. So, EGFR in non-small cell lung cancer was examined to search for possible evidence as clinical prognostic factor. Methods : To investigate the role of EGFR in lung cancer, the author performed immunohistochemical stain of EGFR on 57 resected primary non-small cell lung cancer specimens. And the author analyzed the correlation between EGFR expression, clinical parameters, Sand $G_1$ phase fraction and survival. Results : 1) EGFR were detected in 56% of total 57 patients (according to histologic type, squamous cancer 50%, adenocarcinoma 63%, large cell cancer 75%) (according to TNM stage, stage I 64%, stage II 38%, stage III 55%) (according to cellular differentiation, well 50%, moderately 52%, poorly 65%). All differences were insignificant 2) Using the flow cytometric analysis, mean S-phase fraction of EGFR (+) and (-) group were 22.3(${\pm}10.5$)%. 18.0(${\pm}10.9$)% (p>0.05), mean $G_1$-phase fraction of EGFR (+) and (-) group were 68.4(${\pm}11.6$)%, 71.1(${\pm}12.8$)%, (p>0.05) 3) Two-year survival rate of EGFR (+) and (-) group were 53%, 84%, median survival time of EGFR (+) and (-) group were 26, 53 months. (p<0.05, Kaplan-Meier, generalized Wilcox) Conclusion : EGFR immunostaining may be a simple and useful method for survival prediction in non-small cell lung cancer.