• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2265-2270
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• 2016

Background: Chronic myeloid leukemia (CML) is one of the most frequent hematopoietic malignancies in the elderly population; however, knowledge is limited regarding the genetic factors associated with increased risk for CML. Polymorphisms affecting microRNA (miRNA) biogenesis or mRNA:miRNA interactions are important risk factors in the development of different types of cancer. Thus, we carried out a case-control study to test the association with CML susceptibility of gene variants located in the miRNA machinery genes AGO1 (rs636832) and GEMIN4 (rs2740348), as well as in the miRNA binding sites of the genes BRCA1 (rs799917) and KRAS (rs61764370). Materials and Methods: We determined the genotype of 781 Mexican-Mestizo individuals (469 healthy subjects and 312 CML cases) for the four polymorphisms using TaqMan probes to test the association with CML susceptibility. Results: We found a borderline association of the minor homozygote genotype of the KRAS_rs61764370 polymorphism with an increased risk for CML susceptibility (P = 0.06). After gender stratification, this association was significant only for women (odds ratio [OR] = 13.41, P = 0.04). The distribution of the allelic and genotypic frequencies of the four studied SNPs was neither associated with advanced phases of CML nor treatment response. Conclusions: To the best of our knowledge, this study is the first to show a significant association of the KRAS_rs61764370 SNP with CML. To further determine such an association of with CML susceptibility, our results must be replicated in different ethnic groups.

• Journal of Biosystems Engineering
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• v.33 no.2
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• pp.124-129
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• 2008

In this study, fuel qualities including kinematic viscosity and pour point in the various temperature, calorific value and combustion characteristics of two biodiesels based on the soybean and waste oil blended with light oil were investigated and discussed in order to figure out to confirm fuel compatibility taking the place of light oil in the hot air heater or boiler. As biodiesel content ratio increased calorific value of biodiesel decreased, and the difference was 13% between 100%-biodiesel and light oil. In general, pour points of the biodiesels were higher than light oil, and as biodiesel content ratio increased pour point increased. About 15 cSt was the pour point of biodiesels and light oil, which occurred at 3 to $4^{\circ}C$ in the biodiesels and $-25^{\circ}C$ in the light oil. Flame dimensions of biodiesels and light oil were almost same at the same combustion condition in the burner of the hot air heater. CO concentrations in the exhaustion gas were far lower than those of the light oil. Though pour point of biodiesel is a little inferior to light oil, still biodiesel can be an alternative fuel substituting for light oil in combustion system without much modifying the current oil combustion mechanism.

• Journal of the Ergonomics Society of Korea
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• v.24 no.3
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• pp.35-41
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• 2005

The KOSHA codes H-31 and H-30 provide general guidelines to establish a prevention program for work-related musculoskeletal disorders(WMSD). Understanding of the components and practitioner needs for a WMSD prevention program is necessary for effective revision and implementation of the KOSHA codes. The present study established a comprehensive structure for a WMSD prevention program and surveyed practitioner needs for the KOSHA codes. The comprehensive prevention program structure, consisting of 7 parts(organization, education, risk management, medical management, program evaluation, and record keeping) and 90 items, was constructed by analyzing WMSD prevention guidelines published by various government agencies such as KOSHA, OSHA and NIOSH. Next, 20 practitioners, from four industry sectors(auto manufacturing, auto part manufacturing, shipbuilding, and machinery), working in a safety and health department or labor union, were interviewed to collect opinions for the KOSHA codes in terms of relevance, government support, and additional information needed. Guidelines of the KOSHA codes requiring modifications and government supports were identified, which can be used to revise the KOSHA codes and to establish a government policy to promote the implementation of the KOSHA codes. Lastly, the survey revealed that integrated, customized, quantitative, and case information for WMSD prevention is additionally needed, which can be used as design guidelines for a WMSD prevention program manual for practitioners.

• The Transactions of the Korean Institute of Power Electronics
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• v.11 no.3
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• pp.266-273
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• 2006

In difference with the rotary type electrical machinery, the single-sided linear induction motor(SLIM) that generates the direct thrust, is widely used for the operation system of electrified railroad, lope-less elevation system, conveyer system, and so on. The operational principle of single-sided linear induction motor is constructively similar to the general rotary Induction motor It Is difficult to realize the complicate linear induction motor which is applied space vector pulse width modulation(SVPWM) system, but widely used in vector motor control system or servo control system because of its high performance in current control. In this paper, we has modeled the dynamic characteristic analyzing methode, and calculated efficiently the end effect by using equivalent circuit methode in the operating linear Induction motor control system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.4
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• pp.731-742
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• 1998

Bolted opening structures is widely applied for class 1 machinery of nuclear plant with strict design requirement. As the shape of the bolted opening structure is non-axisymmetric due to the existence of stud bolts although it is almost axi-symmetric, 3D analysis is required to satisfy such kind of design requirements. Because as much as possible trial computations are need to get an optimal design condition in the limited period of basic design, an easy and fast analysis tool is useful in the design stage. In the paper, a transformation technique of non-axisymmetric problem into quasi-axisymmetric has been proposed based on the general purpose commercial code ANSYS. Both the pre-processor which incorporates the technique and prepares data and post-processor which prepares arranged results from the huge output of commercial code have been developed to help the design engineers.

• 유체기계공업학회:학술대회논문집
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• 2002.12a
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• pp.152-157
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• 2002

A cross-flow fan is widely used on many industrial fields: a blower for the general industry, mining industry, automobile and home appliances. The design point of the cross-flow fan is generally chosen by based on the region within low static pressure and high flow rate. It relatively makes high dynamic pressure at low speed because a working fluid passes through an impeller blade twice. However, it has low static pressure efficiency between $30\%$ and $40\%$ because of relative high impact loss. Recently, in the air-conditioning systems, the operating behaviors at the off-design points are highly regarded to broaden the application area for various air-cooling loads. Especially, at the low flow rate, there exists a rapid pressure head reduction, a noise increase and an irregular flow against a rearguider as a scroll of centrifugal fan. Numerical analyses are carried out for cross-flow fan including the impeller, the rearguider and the stabilizer. Numerical domains are discretized by hexahedral cells. Three-dimensional, unsteady governing equations are solved using FVM, SIMPLE algorithm, sliding grid system and standard k-$\epsilon$ turbulence model.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.5
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• pp.112-119
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• 2009

Cam mechanisms are one of the most popular devices for generating irregular motion and are widely used in many automatic equipments, such as textile machinery, internal combustion engines and other automatic devices. In order to obtain the positive motion of follower by rotating cam, its shape should be correctly designed and manufactured. However, complex engineering tasks are required in a design and manufacturing of cams. And also, the manufacturing of general cam is demanded high costs. For the designing of cam, it must be decided that what kind of motion has to be transmitted to follower before selecting the curve of cam and designing profile of cam. However, even though the exact profile of cam is designed at the progress of design, if it doesn't have precision at the manufacturing progress, it's impossible to get expected result. We will develop cam simulation apparatus for measuring cam curve and get profile data before analyzing an error through comparison with design data of cam.

• Korea-Australia Rheology Journal
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• v.15 no.3
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• pp.117-124
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• 2003

Elastohydrodynamic lubrication (EHL) film is measured under the condition of viscosity index improver added to base oil. In-situ optical contact method using the interference principle make the measuring resolution of ~5 nm possible and enables the measuring range all over the contact area of up to ~300 $\mu\textrm{m}$ diameter. What is more important to the developed method by the author is that the measurement of EHL film thickness is possible in the range from 100 nm to 2 $\mu\textrm{m}$, which is the regime of worst contact failures in precision machinery. Viscosity index improver (VII) is one of the major additives to the modem multigrade lubricants for the viscosity stability against temperature rise. However, it causes shear thinning effects which make the film thickness lessened very delicately at high shear rate (over $10^5 s^{-1}$) of general EHL contact regime. In order to exactly verify the VIIs performance of viscosity stability at such high shear rate, it is necessary to make the measurement of EHL film thickness down to ~100 nm with fine resolution for the preliminary study of viscosity control. In this work, EHL film thickness of VII added lubricant is measured with the resolution of ~5 nm, which will give very informative design tool for the synthesis of lubricants regarding the matter of load carrying capacity at high shear rate condition.

• Agricultural and Biosystems Engineering
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• v.1 no.1
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• pp.30-37
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• 2000

Wet porous media representing agronomic soil that contains variable water content with variable electrolyte concentration was measured to study the shape of the curves of the electric double layer capacitance versus frequency (from 10 KHz to 10 MHz. This was done in an attempt to find the lowest practical operating frequency for developing low cost dielectric constant soil moisture probes. Cellulose sponge was used as the porous media. A high frequency electronic bridge circuit was developed for measuring the equivalent network parallel resistance and capacitance of porous media. It appears that the effects of the electric double layer component of the total parallel network capacitance essentially disappear at operating frequencies greater than approximately 25 MHz at low electrolyte concentrations but are still important at 50 MHz at higher concentrations. At these frequencies, the double layer capacitance masks the diffusion region capacitance where true water content capacitance values reside. The general shape of the curve of volumetric water content versus porous media dielectric constant is presented, with an empirical equation representing data for this type of curve. It was concluded that the lowest frequency where dielectric constant values which represent true water content information will most likely be found is between 30 and 50 MHz at low electrolyte concentrations but may be above 50 MHz when the total electrolyte concentration is near the upper level required for most mesophyte plant nutrition.

• Tribology and Lubricants
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• v.21 no.2
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• pp.53-62
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• 2005

In this study a general Galerkin FE lubrication analysis method was utilized to analyze the complex lubrication performance of a spiral groove seal having an additional inner circular groove, which was designed for a chemical process mixer operating at a low speed of the maximum 500 rpm. Equilibrium seal clearance analyses under varying outer pressure revealed that the seal maintains a certain levitation seal clearance under the outer pressure of more than about 1.5 bar, regardless of a rotating speed. Also, under the normal outer pressure of 11 bar, the axial stiffness of the seal was predicted to have a high value of more than 7.0 e + 07 N/m, regardless of a rotating speed and thereby, the seal is expected to maintain a stable thickness of lubrication film under a certain external excitation acting. A seal levitation test rig was designed and constructed. Experimental results at 500 rpm agreed well with analytical predictions and the applied lubrication analysis method was verified.