• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.686-697
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• 2018

Purpose: Several markers for eosinophilic inflammation have been proposed to predict response to asthma treatment. However, definitive criteria for treatment decisions have not yet been established. We investigate a potentially useful relatively non-invasive biomarker, eosinophil-derived neurotoxin (EDN), to predict favorable responses to budesonide or montelukast, common treatment for children with asthma. Methods: Young children (1 to 6 years old) were enrolled in this randomized, parallel, 2-group, open-label trial. Criteria for eligibility included: 1) being symptomatic during the run-in period; and 2) having a serum EDN (sEDN) level ${\geq}53ng/mL$, with positive specific immunoglobulin E to house dust mite. Eligible patients were randomly placed into 2 groups: the BIS group received budesonide inhalation suspension (BIS) 0.5 mg once daily; the MONT group received montelukast 4 mg once daily. Ineligible patients were invited to receive montelukast 4 mg once daily (OBS group). Treatment period was 12 weeks. Results: Asthma control days increased significantly in the BIS and MONT groups (P < 0.000) over the 12-week study period. There was no significant change in sEDN in the BIS group but there was a significant decrease in the MONT group (P < 0.000). Patients in the OBS group with high EDN levels (> 53 ng/mL) showed a significant decrease due to MONT treatment (P = 0.023). Rescue medication usage significantly decreased in the BIS and MONT groups (P < 0.000). Conclusions: EDN is a useful relatively non-invasive biomarker for predicting responses to montelukast and budesonide treatment of preschool children with beta2-agonist responsive recurrent wheeze and multiple-trigger wheeze (Trial registry at UMIN Clinical Trials Registry, UMIN000008335).

• Journal of Preventive Medicine and Public Health
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• 제56권2호
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• pp.111-127
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• 2023

Objectives: Pre-pregnancy diet has an important role in preparing for healthy generation. However, evidence on this issue has been scarce. A scoping review synthesising current evidence will support the demand to map 'what has been researched' on pre-pregnancy diet and maternal and child health. Methods: Systematic search was performed using PICOS (Population, Intervention, Comparison, Outcomes, and Study design) framework in electronic databases. Articles were screened for eligibility, summarized, and the quality was assessed using the National Institute of Health assessment tool. The review structure complies with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guide. Results: Forty-two articles were included after full-text screening. Twenty-five studies were in high-income countries (HICs), six in each upper-middle income, five in lower-middle income countries (LMICs), and one in low-income countries (LIC). Based on the regions: North America (n=16), Europe (n=5), South America (n=4), Australia (n=4), Asia (n=5), Middle East (n=2), and sub-Saharan Africa (n=1). The two-most observed diet-related exposures were dietary pattern (n=17) and dietary quality (n=12). The most assessed outcome was gestational diabetes mellitus (n=28) and fetal and newborn anthropometry (n=7). The average quality score±standard deviation was 70±18%. Conclusions: Research related to pre-pregnancy diet is still concentrated in HICs. The context of diet may vary; therefore, future research is encouraged in LMICs and LICs context, and Mediterranean, South-East Asia, Pacific, and African regions. Some maternal and child nutrition-related morbidity, such as anemia and micronutrient deficiencies, have not been discussed. Research on these aspects will benefit to fill in the gaps related to pre-pregnancy diet and maternal and child health.

• Korean Journal of Radiology
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• 제23권3호
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• pp.355-369
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• 2022

Objective: To evaluate the completeness of the reporting of systematic reviews and meta-analyses published in a general radiology journal using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Materials and Methods: Twenty-four articles (systematic review and meta-analysis, n = 18; systematic review only, n = 6) published between August 2009 and September 2021 in the Korean Journal of Radiology were analyzed. Completeness of the reporting of main texts and abstracts were evaluated using the PRISMA 2020 statement. For each item in the statement, the proportion of studies that met the guidelines' recommendation was calculated and items that were satisfied by fewer than 80% of the studies were identified. The review process was conducted by two independent reviewers. Results: Of the 42 items (including sub-items) in the PRISMA 2020 statement for main text, 24 were satisfied by fewer than 80% of the included articles. The 24 items were grouped into eight domains: 1) assessment of the eligibility of potential articles, 2) assessment of the risk of bias, 3) synthesis of results, 4) additional analysis of study heterogeneity, 5) assessment of non-reporting bias, 6) assessment of the certainty of evidence, 7) provision of limitations of the study, and 8) additional information, such as protocol registration. Of the 12 items in the abstract checklists, eight were incorporated in fewer than 80% of the included publications. Conclusion: Several items included in the PRISMA 2020 checklist were overlooked in systematic review and meta-analysis articles published in the Korean Journal of Radiology. Based on these results, we suggest a double-check list for improving the quality of systematic reviews and meta-analyses. Authors and reviewers should familiarize themselves with the PRISMA 2020 statement and check whether the recommended items are fully satisfied prior to publication.

• Radiation Oncology Journal
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• 제9권2호
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• pp.265-270
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• 1991

대장-직장암은 한국에서 남녀 모두 4위의 비교적 높은 빈도를 보이고 있으며 점점 증가되는 추세에 있다. 근치적 수술요법이 주 치료방법으로 사용되어 왔으나 그 생존율은 $20\~50\%$에 불과하다. 국소재발은 특히 직장암에서 가장 흔한 실패의 원인으로서 근치적 복합요법의 발달에도 불구하고 $40\~92\%$의 높은 국소재발율이 보고되고 있어 생존율를 높이고 생존의 질을 높이기 위하여는 국소재발을 줄이는 노력이 필수적이다. 수술중 방사선 치료는 수술중에 원하는 부위에만 다량의 방사선을 한번에 조사하는 방법으로 최근 보고에서 국소재발율을 $5\%$까지 줄일 수 있었다고 보고되고 있다. 영남대학병원 치료방사선과에서는 국내에서는 처음으로 91년 5월 30일 직장암 환자에 수술중 방사선 치료를 실시한 후 현재까지 6명의 대장 직장암 환자에 수술중 방사선 치료를 실시하였기에 환자선택, 치료선량, 선량분포, 수술 및 방사선치료과정등을 보고하고저 한다.

• 한국건설관리학회논문집
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• 제17권3호
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• pp.108-115
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• 2016

공공택지지구의 공동주택용지 매입을 통한 아파트 개발사업에서 원재료인 토지에 투자하는 부분에 대해서는 사업시행자의 내부화된 정보와 개별적인 분석에 의존하여 투자결정모형을 일반화하기 어려웠다. 이에 본 연구는 아파트 개발사업에서 가장 중요한 공동주택용지 투자가격 결정을 위해 토지의 개별 특성과 아파트 시장요인이 공동주택용지 가격에 어떠한 영향을 미치는 지에 대해 분석하였다. 이를 위해 다중회귀분석방법을 활용한 횡단면 분석을 한 결과, 토지총금액에 영향을 주는 요인은 토지면적, 용적률, 건폐율, 지방권인지 여부였으며, 지상연면적당 토지가격에 영향을 주는 요인은 아파트 비율, 아파트 매매가격 및 전세가격, 분양이득변수, 지방권인지 여부, 아파트 가격지수 1년간 상승률 등으로 나타났다. 이러한 연구결과를 통해 토지 자체의 개별요인에 의한 가격결정 요인과 완제품 시장인 아파트 시장과 원재료 시장인 토지시장과의 연관성을 규명하여, 시장요인에 근거한 객관적인 토지투자가격 결정모형을 도출하였다. 이를 통해 공동주택용지를 공급하는 사업자는 사업지구 조성 시 공동주택용지 매각금액의 적정성을 추정할 수 있고, 토지수요자인 건설사업자는 토지투자를 위한 가격결정 범위를 추정하는 데 실질적으로 기여할 수 있을 것으로 기대한다.

• Journal of Hospice and Palliative Care
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• 제20권3호
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• pp.159-166
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• 2017

항레트로바이러스제 치료의 확립, 조기치료로 HIV 감염인들의 바이러스의 조절과 면역저하의 개선이 이루어지고 있다. 다수의 환자들이 더 이상 에이즈 관련 합병증으로 사망하지 않고, 심혈관질환, 대사성질환, 간질환, 신장질환, 신경계질환과 같은 만성합병질환을 갖고 고령화되고 있다. 그러나 지금도 여전히 사회적 차별과 낙인이 존재하는 가운데 후기 발현자로 후천면역결핍증 상태로 방문하여 사망하거나 중증의 신경계합병증으로 장애를 갖는 환자들이 있다. 환자의 다양한 증상들에 대해 이른 시기부터의 완화의료적 접근이 필요하다. 원위 대칭성 감각 다발신경병증 등의 환자의 만성 통증은 저평가되어 왔고 이에 대한 적극적인 통증 중재가 필요하다. 이전 호스피스 기준은 현재 시점에서 새롭게 제시한다. 감염인의 약제 지속 등의 의학적 필요, 심리적 상태, 사회적 여건에 대한 이해가 필요하다. 표준주의 감염관리 원칙을 준수한다면 만성질환으로서의 보편적 호스피스 진료의 제공이 가능하겠다. 생의 말기 빠르고 적극적인 호스피스팀의 개입을 통해 환자들이 존엄하게 삶을 마무리하실 수 있도록 임상경험이 늘어나고, 제도가 마련되길 바란다.

• 한국중재학회지:중재연구
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• 제8권1호
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• pp.293-322
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• 1998

General Administrative Procedures of the Preshipment Inspection 1. Initial notification Preshipment Inspection is initiated by Agency when it receives notice either from the importing country, or the seller, that an export needs to be imspected 1.1 Notice from the importing country 1.2 Notice from the seller 2. Preliminary price verification After receipt of initial notification, Agency undertakes, Where possible, a preliminary price verification, based upon the Inspection Order and other contractual documents received. 3. Customs classification When required by the Government of the importing country. Agency forms an opinion of the Customs Classification Code based upon the Customs Tariff Book and Rules of Classification of the country of importation. The Customs Classification Code determines the tariff rate on the basis of which the importer will be required to pay import duties. 4. Import eligibility 5. Arrangements for physical inspection 5.1 Inspection request from seller 5.2 Place of inspection 5.3 Date of inspection 5.4 Physical inspection procedures 6. Physical inspection results When the physical inspection is completed, the inspector submits his report to the Agency office and the result of inspection will be communicated to the seller and, where applicable, the place of inspection. The result will state: satisfactory or conditional of unsatisfactory. The seller is welcome to present his views in writting to Agency in the event there is any query regarding the issuance of a conditional of unsatisfactory inspection result. 6.1 Satisfactory 6.2 Conditional 6.3 Unsatisfactory 7. Shipment of the goods The seller is advised to check with Agency prior to shipment if the physical inspection result has not been received or there are any doubts concerning whether a Clean Report of Findings will be issued. 8. Final price verification and classification Based on the results of physical inspection and appropriate final documents, Agency finalises the price verification and the Agency opinion of Customs classification code. When the preliminary price verification has not resulted in any unresolved questions and the inspection result and other documents received are consistent with the preliminary documentation, Agency will not normally require any additional information. The main exception would be if the terms of sale require reference to prices at the date of shipment. 9. The Report of Findings 9.1 Types of Reports of Findings - Clean Reports of Findings(CRF) The Agency will issue a Clean Reports of Findings(CRF), or equivalent document, normally within two working days after receipt of the necessary correct final documents and a satisfactory result in all aspects of the inspection. - Discrepancy Report.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5263-5272
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• 2012

Background: Gastric cancer (GC) is one of the most common cancers in China. Adjuvant chemotherapy (AC) is a routine auxiliary treatment for GC recommended by the guidelines issued in 2011 by the Ministry of Health of the People's Republic of China, but the relevant credible consequences in China have been insufficient because of China's late start and ethical concerns. Methods: A series of databases, including Cochrane Library, MEDLINE, EMBASE, the Chinese database of the National Knowledge Infrastructure and the VIP database, were searched by 2 reviewers independently for studies investigating AC for GC through March 2012. The retrieved literature was screened according to the eligibility criteria. Results: A total of 35 randomized control trials (RCTs) were subjected to the final analysis, including 4,043 patients in treatment group and 3,884 in the control group, as well as 4 clinical-control trials (CCTs), which accessed the final analysis with 238 and 252 patients, respectively. AC reduced the risk of death as a protective treatment with statistical significance (HR=0.91, 95%CI: [0.85, 0.97], P=0.002), and it seemed more effective for Asian than non-Asian patients. The effects of AC were not influenced by the starting time (P>0.05). D2 lymphadenectomy-based chemotherapy was effective (HR=0.89, 95%CI: [0.80, 0.99], P=0.04). Oral S-1 40 mg/m2 after D2 lymphadenectomy might be a better choice for Asians with advanced GC and might result in a greater reduction of adverse events than in non-Asian patients. GRADE quality assessment determined that the strength of the evidence from foreign studies from Europe, the United States and Asian countries other than China was high, while it was moderate for Chinese studies. Conclusion: AC was effective or even curative in Chinese patients in general, although it is still necessary to optimize a targeted AC scheme for Chinese patients with GC.

• 한국중재학회지:중재연구
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• 제25권4호
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• pp.119-136
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• 2015

The contracting parties must be provided a litigation scheme in order to resolve a dispute. This means taking advantage of effective measures for mediation or arbitration. A lease transaction is likely to occur mainly after a dispute. It is necessary to take the appropriate measures in advance. In general, when a variety of contracts are created, conflicts arise and disputes have to be resolved through mediation and arbitration documents, and adjustment or intervention is called for. Arbitration system is a system that is established based on the trust of the arbitral tribunal. For such system, quality education for enhancing professionalism required of the arbitrator is important. A party responding to an arbitration agreement presents a problem. The current system must ensure that there are no disadvantaged parties. However, a party must depend on an arbitration agreement that is part of the law rescue system. A litigation support by the local Bar Association must be carried out. It should be notified of the contents of the contract to select a strategy that will best resolve the conflict. In the case of lease transactions, there is a need to create a scheme to make a standard agreement that inserts an arbitration clause. Lease sale and purchase agreement or lease agreement is a form of contract that has been frequently used. Here, the arbitration agreement clause for a lawyer that will serve as arbitrator should be inserted. It is a scheme that can be activated for individuals in poor areas. In addition, it is possible to see it taking a scheme to take advantage of the lawyer system for the future of the town. The Attorney System of a town is a system that the Korean Bar Association, Legal Department has put in place since 2013. If a real estate trade dispute occurs, the role of the intermediary attorney should be to carry out his duties efficiently. In the case of real estate transaction conflicts, the lawyer of the village should be registered as the arbitrator. It is important to establish a basis of regulations through this type of real estate transaction accident analysis. Before proceeding with various adjustment systems, it is desirable to expand the arbitration region. Now we need a realtor amendment. It is the part where fragmentation of intermediary qualification is required, along with the eligibility of a subdivision.

• KDI Journal of Economic Policy
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• 제13권1호
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• pp.115-134
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• 1991

연금계획(年金計劃)은 그 계획의 형태와 관계없이 경제(經濟) 및 인구(人口)와 여러가지 경로로 상호반응(相互反應)한다. 인구(人口)의 연령구조변화(年齡構造變化)는 연금수급권자(年金受給權者)의 수(數)에 영향을 미치고 인구변화(人口變化)는 노동력(勞動力)의 규모(規模)나 연령구성(年齡構成)에 또한 영향을 미쳐서 연금계획(年金計劃)이 국가재정(國家財政) 또는 국민소득규모(國民所得規模)에 영향을 미치게 된다. 인구변수(人口變數)는 따라서 국민연금계획(國民年金計劃)의 경제적(經濟的) 부담(負擔)과 그 부담을 지탱해 주는 경제력(經濟力) 양자에 영향을 미치게 된다. 그동안의 연금(年金)에 관련된 추계(推計)는 경제적(經濟的) 제변수(諸變數)를 외생변수(外生變數)로 가정(假定)하고 연금재정(年金財政)을 시뮬레이션하여 왔는데 연금기금(年金基金)이 소규모(小規模)인 초기단계(初期段階)에서는 무난한 방법(方法)이라고 볼 수 있지만 공적연금제도(公的年金制度)의 규모가 커지고 연금제도가 경제(經濟) 제변수(諸變數)에 영향을 미치는 단계에서는 이러한 상호반응관계(相互反應關係)를 반영(反映)하여야 한다. 본(本) 모형(模型)은 경제를 인구노동부문(人口勞動部門), 일반경제부문(一般經濟部門), 연금부문(年金部門)으로 3등분하여 상호연계시킴으로써 연금부문내(年金部門內)의 변수(變數)들이 일반경제(一般經濟)에 미치는 효과를 측정할 수 있도록 하여 연금재정운영방식(年金財政運營方式), 연금급부(年金給付)의 실질가치(實質價値) 유지방법(維持方法), 저축행태(貯蓄行態), 연금급부율(年金給付率), 인구구조(人口構造)의 변화(變化) 등 연금제도(年金制度)와 관련한 제변수(諸變數)가 국민경제(國民經濟)에 어떤 영향을 미치는가를 분석(分析)하고 있다. 시뮬레이션의 결과 적립방식(積立方式)의 연금제도도입(年金制度導入)은 본격적인 연금급부(年金給付)가 시작되는 시점(時點)까지는 경제성장(經濟成長)을 오히려 돕는 역할을 수행하는 것으로 나타났고, 연금급부지출(年金給付支出)이 총수입(總收入)을 초과하는 시점(時點) 이후부터는 경제(經濟)에 부담을 가중시켜 경제성장률(經濟成長率)을 둔화시키는 것으로 나타났으며 물가지수연동제(物價指數連動制) 대신에 임금지수연동제(賃金指數連動制)를 도입할 경우 연금급부지출(年金給付支出)이 증대되어 연금재정수지(年金財政收支)를 더 악화시키는 것으로 나타났다. 또한 출생률(出生率) 및 사망률(死亡率) 수준도 장기적인 부담(負擔)을 결정하는 요소로 분석되었다.