• 한국재난관리표준학회지
• /
• 제4권1호
• /
• pp.39-47
• /
• 2011

우리나라의 재난및안전관리기본법에서는 표준현장지휘체계는 긴급구조활동에 대한 지휘에 대한 것으로 국한하고 있다. 본 연구에서는 표준현장지휘체계를 다양한 재난에 범용적으로 적용가능하도록 개선방안을 제시하였다. 또한 대규모 재난피해 발생시 모든 대응자원을 신속히 동원하여 재난현장에 제공 지원할 수 있도록 재난안전대책본부의 자원 응원조정 역할의 명확화 등 개선방안을 제시하였다.

• Journal of Microbiology and Biotechnology
• /
• 제33권8호
• /
• pp.1101-1110
• /
• 2023

Streptococcus mutans is the primary causative agent of caries, which is one of the most common human diseases. Thus, rapid and early detection of cariogenic bacteria is critical for its prevention. This study investigated the combination of loop-mediated isothermal amplification (LAMP) and microfluid technology to quantitatively detect S. mutans. A low-cost, rapid microfluidic chip using LAMP technology was developed to amplify and detect bacteria at 2.2-2.2 × 10⁶ colony-forming units (CFU)/ml and its detection limits were compared to those of standard polymerase chain reaction. A visualization system was established to quantitatively determine the experimental results, and a functional relationship between the bacterial concentration and quantitative results was established. The detection limit of S. mutans using this microfluidic chip was 2.2 CFU/ml, which was lower than that of the standard approach. After quantification, the experimental results showed a good linear relationship with the concentration of S. mutans, thereby confirming the effectiveness and accuracy of the custom-made integrated LAMP microfluidic system for the detection of S. mutans. The microfluidic system described herein may represent a promising simple detection method for the specific and rapid testing of individuals at risk of caries.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2007년도 추계학술대회논문집
• /
• pp.589-594
• /
• 2007

In this paper, the optimal command input is considered in order to minimize the residual vibrations of a flexible cantilever beam when the beam simply changes its position by translation or rotation. Although a cantilever beam has many modes of vibration, it is shown that the consideration of the first mode is sufficient in this case. Thus, the problem becomes a singledegree-of-freedom system subjected to a ground excitation. Two simple methods are proposed to find the optimal command input based on the Shock Response Spectrum (SRS). The first method is the simplest and can be applied to lightly damped cases, and the second method is applicable to more general problems. The second method gives almost the same results as the input shaping method. However the proposed method gives a easier and clearer control strategy.

• 한국산업융합학회 논문집
• /
• 제18권4호
• /
• pp.250-258
• /
• 2015

In this research, we proposed a new approach to implement the real-time motion control of biped robot based on voice command for unmanned FA. Voice is one of convenient methods to communicate between human and robots. To command a lot of robot task by voice, voice of the same number have to be able to be recognition voice is, the higher the time of recognition is. In this paper, a practical voice recognition system which can recognition a lot of task commands is proposed. The proposed system consists of a general purpose microprocessor and a useful voice recognition processor which can recognize a limited number of voice patterns. Given biped robots, each robot task is, classified and organized such that the number of robot tasks under each directory is net more than the maximum recognition number of the voice recognition processor so that robot tasks under each directory can be distinguished by the voice recognition command. By simulation and experiment, it was illustrated the reliability of voice recognition rates for application of the manufacturing process.

• 한국통신학회논문지
• /
• 제42권4호
• /
• pp.806-815
• /
• 2017

한국군은 국방시설기준이 정립되어 있으나 대부분 시설위주의 설계기준에 중점을 두고 작성되어 있다. 특히 정보통신분야에서는 세부적인 기준은 제시하지 않고 대략적인 수준으로만 제시되어 있다. 미군의 경우 1990년부터 각 군이 공통적으로 적용 가능한 시설기준에 대하여 통합시설기준서(UFC : Unified Facilities Criteria)를 완성해 모든 사업에 공통적용 할 수 있도록 설계기준을 제시하고 있다. 특히 정보통신분야에서는 시설분야와 연계해서 건물내부체계는 미군의 기지통신 기반구조설계기준(I3A: Installation, Information, Infrastructure Architecture)과 시스템에 대해서는 기지 및 캠퍼스지역 네트워크설계기준(ICAN : Installation and Campus area Network)과 비교를 통해 우리군의 지휘 통제시설 및 일반/행정시설에 대한 바람직한 설계기준선을 제시한다.

• 한국군사과학기술학회지
• /
• 제14권3호
• /
• pp.458-466
• /
• 2011

In war time, minimizing the logistics response time for supporting military operations is strongly needed. In this paper, i propose the mathematical formulation for minimizing the maximal acquisition completion time in wartime or during a state of emergency. The main structure of this formulation is based on the traveling purchaser problem (TPP), which is a generalized form of the well-known traveling salesman problem (TSP). In the case of the general TPP, an objective function is to minimize the sum of the traveling cost and the purchase cost. However, in this study, the objective function is to minimize the traveling cost only. That's why it's more important to minimize the traveling cost (time or distance) than the purchase cost in wartime or in a state of emergency. I generate a specific instance and find out the optimal solution of this instance by using ILOG OPL STUDIO (CPLEX version 11.1).

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권8호
• /
• pp.3997-4000
• /
• 2012

MicroRNAs (miRNAs) play roles in the clinic, both as diagnostic and therapeutic tools. The identification of relevant microRNAs is critically required for ovarian cancer because of the prevalence of late diagnosis and poor treatment options currently. To identify miRNAs involved in the development or progression of ovarian cancer, we analyzed gene expression profiles downloaded from Gene Expression Omnibus. Comparison of expression patterns between carcinomas and the corresponding normal ovarian tissues enabled us to identify 508 genes that were commonly up-regulated and 1331 genes that were down-regulated in the cancer specimens. Function annotation of these genes showed that most of the up-regulated genes were related to cell cycling, and most of the down-regulated genes were associated with the immune response. When these differentially expressed genes were mapped to MiRTarBase, we obtained a total of 18 key miRNAs which may play important regulatory roles in ovarian cancer. Investigation of these genes and microRNAs should help to disclose the molecular mechanisms of ovarian carcinogenesis and facilitate development of new approaches to therapeutic intervention.

• Archives of Pharmacal Research
• /
• 제28권9호
• /
• pp.1092-1096
• /
• 2005

Huperzine A-loaded microspheres composed of poly(D,L-lactide-co-glycolide) were prepared by an O/w emulsion solvent evaporation method. The characterization of the microspheres such as drug loading, size, shape and release profile was described. The in vitro release in the initial 7 days was nearly linear with $10\%$ released per day. Thereafter drug release rate became slow gradually and about $90\%$ drug released at day 21. The in vitro release rate determined by dialysis bag method had a good correlation with the in vivo release rate. Huperzine A aqueous solution was intramuscularly injected (i.m.) at 0.4mg/kg and microspheres were intra­muscularly injected at 8.4 mg eq huperzine A/kg in rats. The maxium plasma concentration $(C_{max})$ after i.m. microspheres was only $32\%$ of that after i.m. solution. Drug in plasma could be detectd until day 14 and about $5\%$ of administered dose was residued at the injection site at day 14. The relative bioavailability of huperzine A microspheres over a period of 14 days was $94.7\%$. Inhibition of acyecholinesterase activity (AchE) in rat's cortex, hippocampus and striatum could sustain for about 14 days. In conclusion, huperzine A-loaded microspheres possessed a prolonged and complete drug release with significant inhibition of AchE for 2 weeks in rats.

• BMB Reports
• /
• 제37권5호
• /
• pp.546-551
• /
• 2004

The increasing pace of development in molecular biology during the last decade has had a direct effect on mass testing and diagnostic applications, including blood screening. We report the model Microarray that has been developed for Hepatitis B virus (HBV) and Hepatitis D virus (HDV) detection. The specific primer pairs of PCR were designed using the Primer Premier 5.00 program according to the conserved regions of HBV and HDV. PCR fragments were purified and cloned into pMD18-T vectors. The recombinant plasmids were extracted from positive clones and the target gene fragments were sequenced. The DNA microarray was prepared by robotically spotting PCR products onto the surface of glass slides. Sequences were aligned, and the results obtained showed that the products of PCR amplification were the required specific gene fragments of HBV, and HDV. Samples were labeled by Restriction Display PCR (RD-PCR). Gene chip hybridizing signals showed that the specificity and sensitivity required for HBV and HDV detection were satisfied. Using PCR amplified products to construct gene chips for the simultaneous clinical diagnosis of HBV and HDV resulted in a quick, simple, and effective method. We conclude that the DNA microarray assay system might be useful as a diagnostic technique in the clinical laboratory. Further applications of RD-PCR for the sample labeling could speed up microarray multi-virus detection.

• 한국항공우주학회지
• /
• 제46권8호
• /
• pp.639-651
• /
• 2018

본 논문은 인공위성의 자세명령을 해석적으로 생성하는 기법을 제안한다. 실제 위성에서는 1) 구동기 성능, 2) 위성체 유연구조, 3) 원격명령 데이터크기 등과 같은 제한조건들이 존재하고, 이로 인해 해석적인 자세명령 해를 구하기 어렵다. 따라서 본 논문에서는 고유축 회전, 프로파일 형상화를 통해 문제를 단순화하는 방법을 제안하고, 최종적으로 해석적 해를 유도하였다. 생성된 자세명령은 온-보드 자세제어기의 피드포워드 입력 형태로 사용되어 위성의 기동성을 높일 수 있다. 각속도 경계조건에 따라 rest-to-rest 기동과 spin-to-spin 기동으로 나누어 자세명령 해를 유도하였다. 시뮬레이션 예제를 통해 제안된 자세명령생성 기법이 구동기 제한조건을 지키면서 초기/최종 시간에서의 경계조건도 잘 만족하는 것을 확인하였다. 제안된 해석 해는 자세명령을 비교적 적은 수의 파라미터로 구현할 수 있어 원격명령 데이터크기 측면에서 경쟁력이 있다. 또한, 해석 해로 반복계산이 필요없어 온-보드 자세명령생성 자동화에도 기여할 수 있을 것으로 판단된다.