• Journal of Chest Surgery
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• 제55권1호
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• pp.30-36
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• 2022

Background: No consensus exists regarding whether volatile anesthetics are superior to intravenous anesthetics for reducing postoperative pulmonary complications (PPCs) in patients undergoing general anesthesia for surgery. Studies of this issue focused on anatomic pulmonary resection are lacking. This study compared the effects of total intravenous anesthesia (TIVA) versus volatile anesthesia on PPCs after anatomic pulmonary resection in patients with lung cancer. Methods: This retrospective study examined the medical records of patients with lung cancer who underwent lung resection at our center between January 2018 and October 2020. The primary outcome was the incidence of PPCs, which included prolonged air leak, pneumonia, acute respiratory distress syndrome, empyema, atelectasis requiring bronchofiberscopy (BFS), acute lung injury (ALI), bronchopleural fistula (BPF), pulmonary embolism, and pulmonary edema. Propensity score matching (PSM) was used to balance the 2 groups. In total, 579 anatomic pulmonary resection cases were included in the final analysis. Results: The analysis showed no statistically significant difference between the volatile anesthesia and TIVA groups in terms of PPCs, except for prolonged air leak. Neither of the groups showed atelectasis requiring BFS, ALI, BPF, pulmonary embolism, or pulmonary edema after PSM. However, the length of hospitalization, intensive care unit stay, and duration of chest tube indwelling were shorter in the TIVA group. Conclusion: Volatile anesthetics showed no superiority compared to TIVA in terms of PPCs after anatomical pulmonary resection in patients with lung cancer. Considering the advantages of each anesthetic modality, appropriate anesthetic modalities should be used in patients with different risk factors and situations.

• BMB Reports
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• 제47권7호
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• pp.388-392
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• 2014

Berberine, a type of isoquinoline alkaloid isolated from Chinese medicinal herbs, has been reported to have various pharmacological activities. Studies have demonstrated that berberine has beneficial effects on vascular remodeling and alleviates restenosis after vascular injury. However, its mechanism of action on vascular smooth muscle cell migration is not fully understood. We therefore investigated the effect of berberine on human aortic smooth muscle cell (HASMC) migration. Boyden chamber assay was performed to show that berberine inhibited HASMC migration dose-dependently. Real-time PCR and Western blotting analyses showed that levels of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA) were reduced by berberine at both the mRNA and protein levels. Western blotting assay further confirmed that activities of c-Fos, c-Jun, and NF-${\kappa}B$ were significantly attenuated. These results suggest that berberine effectively inhibited HASMC migration, possibly by down-regulating MMP-2, MMP-9, and u-PA; and interrupting AP-1 and NF-${\kappa}B$ mediated signaling pathways.

• Journal of Chest Surgery
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• 제42권6호
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• pp.803-806
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• 2009

남자 49세 환자는 낙상으로 흉부 둔상을 당해 본원 응급센터로 내원한 분으로 단순 흉부 사진상 종격동 기종 및 심낭기종 소견을 보였다. 이에 흉부 컴퓨터 단층 촬영을 하였으며 타 장기 손상이 없는 심낭기종 소견과, 심장을 압박하는 양상이었다. 또한 좌측에 경도의 기흉 소견이 보였다. 국소 마취하에 좌측 폐쇄 흉강 삽관술을 시행하였으며, 전신 마취하에 소절개하여 개방성 심낭막개창술 및 삽관술을 시행하여 좋은 결과를 얻었기에 보고하는 바이다.

• 대한장애인치과학회지
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• 제5권1호
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• pp.23-26
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• 2009

본 증례는 전반적인 치과치료를 위해 본과에 의뢰된 다수의 치아우식증으로 본과에 내원한 중등도 정신지체 환자로, 전치부 개방교합과 함께 상악 전치부의 총생이 있어 이 부분에 대해서는 본원 보철과에 협진을 의뢰하였다. 전신마취 하에 소아치과에서 보존, 외과적 처치 및 치주 치료를 시행하였으며, 보철과에서 상악 좌우측 견치를 지대치로 한 4-unit bridge를 제작, 심미적 결과를 얻었기에 보고하는 바이다. 본 증례 에서와 같이 전신마취 하의 포괄적인 치과치료를 계획함으로써 여러 번 치료의 불편함 없이 한번에 대부분의 치료를 완료할 수 있었다. 또한 환자에게 치과치료에 대한 공포심을 유발하지 않아 환자와 치과의사의 치료적 관계 형 성이 용이하며 양질의 진료가 가능하고 술자 및 환자의 스트레스를 줄일 수 있는 장점이 있다고 할 수 있겠다.

• 대한장애인치과학회지
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• 제12권2호
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• pp.87-91
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• 2016

저자는 소하악증으로 인해 기도유지가 어려우며 섭식 장애로 인한 다발성 우식을 보이는 피에르 로빈 증후군 환아의 증례를 보고하는 바이다. 환자는 소하악증 및 구개열, 심방중격 결손, 새끼 손가락의 측만지증(clinodactyly), 외사시(exotropia) 등의 증상을 동반하고 있었으며, 신체 발육이 매우 저하된 상태로 섭식 장애로 인한 구강내 침식 및 다발성 우식의 소견을 보이고 있었다. 환아는 가벼운 자폐 증상을 가지고 있으며 어린 나이로 협조를 구하기가 어려웠고 광범위한 치료가 필요한 상황이었으며 의식하 진정법시 하악의 발육 저하로 인한 기도 확보의 어려움이 예상되었기에 전신마취하 치과치료를 시행하였다. 피에르 로빈 증후군은 기도유지의 어려움과 섭식 장애로 구강위생 관리에 불리한 조건을 가지고 있지만 나이가 듦에 따라 점차 정상적인 하악의 성장이 이루어지므로 행동조절에 의한 일상적인 치과 처치도 가능할 것이다.

• 대한장애인치과학회지
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• 제15권1호
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• pp.55-59
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• 2019

PRS는 소하악증, 설하수증, 구개열의 세가지 임상적 특징을 갖는 질환으로 상기도 폐쇄로 인한 호흡곤란, 섭식장애를 나타낸다. PRS 환아는 치과 치료 시 호흡 관리에 대한 고려가 필요하고 또한 다양한 증후군이 동반될 수 있어 치과 치료시 전신적인 상태에 대한 고려가 필요하다. 본 증례에서는 다발성 치아우식증을 주소로 내원한 PRS 환자에 대한 보고로 기도 확보 및 유지의 어려움이 예상되었으나 치과적 치료를 전신마취 하 성공적으로 시행되었다.

• 대한기관식도과학회지
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• 제9권1호
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• pp.92-95
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• 2003

Laryngeal foreign bodies are not common among the foreign bodies of aerodigestive tract. It is relatively easy to diagnose in acute phase of entry because of a readily\ulcorner available history of intake, and signs or symptoms referable to the foreign body in the highly sensitive air passage. However, on occasion, sudden death by respiratory failure occurs due to complete obstruction of airway. Therefore, it is common and safe to remove the laryngeal foreign bodies by suspension laryngoscope under general anesthesia after tracheostomy. Recently, the authors experienced a case of metallic foreign body in larynx penetrating neck, which was removed by suspension laryngoscope under general anesthesia without any life threatening complication.

• 대한기관식도과학회지
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• 제9권1호
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• pp.101-104
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• 2003

One of major problem in endotracheal intubation for general anesthesia is intrathoracic tracheal obstruction induced by tumor such as, intrathoracic goiter and malignant lymphoma etc. Small amount of secretion or hemorrhage and mild tracheal edema may cause aggravation of tracheal obstruction during endotracheal intubation. Also, it is too difficult to perform the emergency tracheostomy in middle tracheal obstruction. We tried to perform femorofemoral cardiopulmonary bypass without endotracheal intubation for induction of general anesthesia in case of middle tracheal obstruction and We reported with review of literature.

• 대한치과의사협회지
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• 제49권12호
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• pp.739-748
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• 2011

Patients with severe mental challenges are often subjected to extensive dental problems. Their impaired communication and lack of cooperation unable to receive timely dental treatments, which deteriorates their adverse oral conditions. In spite of a limited time frame, well-planned comprehensive treatments can be delivered in an one-day operation setting under general anesthesia. This multidisciplinary treatment regimen primarily comprises of single-visit endodontics, direct bonded restoration, periodontal treatment, and surgical extraction. Further, one or two additional visits for prosthetic procedures are able to accomplish functional reestablishment and esthetic enhancement. This article discusses on clinical managements for severely mentally challenged patients under a single-day operation.

• Journal of Dental Anesthesia and Pain Medicine
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• 제17권1호
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• pp.65-69
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• 2017

Patients with severe gag reflex (SGR) have difficulty getting the treatment they require in local clinics, and many tend to postpone the start of their treatment. To address this problem, dentists have used behavioral techniques and/or pharmacological techniques for treatment. Among the pharmacological methods available, propofol IV sedation is preferred over general anesthesia because it is a simpler procedure. Propofol in combination with remifentanil is characterized by stable sedative effects and quick recovery, leading to a deep sedation. Remifentanil acts to reduce the pain caused by lipid-soluble propofol on injection. The synergistic effects of propofol-remifentanil include reduction in the total amount of drug required to achieve a desired sedation level and anti-emetic effects. In this case report, we outline how the use of propofol-remifentanil IV sedation enabled us to successfully complete a wide range of dental treatments in a patient with SGR.