• Title/Summary/Keyword: Gene and cell therapy

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Current trends of stem cell-mediated gene therapy (줄기 세포 분야의 유전자 치료 연구 동향)

  • Oh, Yu-Kyoung;Chung, Hyung-Min
    • Journal of Pharmaceutical Investigation
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    • v.32 no.2
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    • pp.65-72
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    • 2002

  • Recently, stem cell-mediated gene therapy is emerging as a novel therapeutic approach. For the successful gene modification of stem cells, the development of a suitable gene transfer technique needs to be preceded. This review focuses on the various gene transfer techniques based on nonviral and viral vectors, and physical methods. The advantages and disadvantages of each gene transfer method are compared, and the general properties of these vectors are discussed in relation to the gene transfer in stem cell research. This review also highlights the therapeutic application of stem cell-mediated gene therapy. The choice of gene transfer vectors may vary depending on the type of the stem cells and the target of stem cell therapy. Of various gene transfer methods, viral vector-based gene therapy has been emphasized due to the higher transfection efficiency. The current status and up-to-date findings of stem cell-mediated gene therapy are discussed in the viewpoint of the various targets of stem cell therapy such as the modification of stem cell potency, the acceleration of regeneration process and the formation of expressional organization.

  • https://doi.org/10.4333/KPS.2002.32.2.065 인용 PDF KSCI