• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권2호
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• pp.79-85
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• 2018

Objectives: The aim of this study was to evaluate the effects of herbal extracts on bone regeneration. Two known samples were screened. Materials and Methods: We previously established a rat calvaria defect model using a combination of collagen scaffold and herbal extracts. An 8 mm diameter trephine bur with a low-speed dental hand piece was used to create a circular calvaria defect. The experimental group was divided into 4 classifications: control, collagen matrix, Danshen with collagen, and Ge Gan with collagen. Animals in each group were sacrificed at 4, 6, 8, and 10 weeks after surgery, and bone regeneration ability was evaluated by histological examination. Results: Results revealed that both Danshen and Ge Gan extracts increased bone formation activity when used with collagen matrix. All groups showed almost the same histological findings until 6 weeks. However, after 6 weeks, bone formation activity proceeded differently in each group. In the experimental groups, new bone formation activity was found continuously up to 10 weeks. In the Danshen and Ge Gan groups, grafted materials were still present until 10 weeks after treatment, as evidenced by foreign body reactions showing multinucleated giant cells in chronic inflammatory vascular connective tissue. Conclusion: Histological analyses showed that Danshen and Ge Gan extractions increased bone formation activity when used in conjunction with collagen matrix.

• 대한한방내과학회지
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• 제12권2호
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• pp.138-147
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• 1991

Review of literature on stomachache. According to investigated the pathology of a stomachache about all sorts of falling ill, I have been obtained following conclusions. 1. The cause of Ui Wan Tong are clod-wet-ui wan, sik juk, dam eum, a huy1 be made of gi bul soon (氣不順). 2. Pain of Je sang bu are called jung wan tong, dae bok tong, jung cho tong, cause are sik juk, han sa, chung juk. pain of je ha bu are called so bok tong, hache tong, soh bok tong, so bok are devided two part, one is so eum sin the other is gul eum gan, cause are jo gyul dae jang, yul gyu1 bang kwang, hyul gyul bang kwang, porak hu ect. 3. Pain of je bu are called je bok tong, hwan je e tong, so bok je ju tong, and cause are juk yu1, jo si, dam hwa. Pain of yang hyup bu are called yang hyup ha so bok tong, yang bang ge hyup tong, yang hup jisang tong, cause are ban gi,yang myung jo geom. According to above results, the patholosy of a stomach ache about the part of falling ill in a course of transformation on the epidemic fever comes into the viscera.

• 혜화의학회지
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• 제9권1호
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• pp.399-407
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• 2000

According to the literature on the genital cold sign, results were as follows. 1. Genital cold sign is that patient feel cold the part outer reproductive system. 2. The primary cause of genital cold sign is the kidney yang vacuity, and the others are the spleen vacuity, fulling down damp-heat, vacuity consumption, frenetic movement of ministerial fire, dedilitation of kidney yin, insecurity of kidney yang, impairment spleen with vacuity consumption, 3. The primary treatment of genital cold sign is warming and recuperating kidney, and the others are enrich yin and norishing blood, supplement the vital energy and enrich blood, clearing away dampness, etc. 4. For the medical prescriptions are used PalMiHyan(八味丸), GeJiGaYongGolMoReoTang(桂枝加龍骨牡蠣湯), GoJinTang(固眞湯), GaGamNaiGoHyan(加減內固丸), SipBoHyan(十補丸), YoSuYuTang(吳茱萸湯), ChungHonTang(淸魂湯), HuiChunSan(回春散), JoYangSan(助陽散), ChungHonTang(淸魂湯), YoncDamSaGanTane(龍膽瀉肝湯), SiHo-SoengSoepTang(柴胡勝濕湯).

• 대한한방내과학회지
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• 제13권2호
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• pp.77-83
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• 1992

Clinical studies were done on 43 cases of Tan-San(呑酸) patient which were treated by outpatient, took medicine with Ge-Wool-Hwa-Dam-Jeon (開鬱火痰煎) in Dept. of 2nd clinic, Christian Oriental Hospital from June in 1991 to end of May in 1992. The results were as follows. 1. The ratio of sex and age was 37.2% males (16 cases) and 62.7% females (27 cases) somewhat higher than males, In the age distribution, the highiest decade was thirtieth decade 48.83% (21 cases). 2. In the vocational distribution, housewives 51.16% (22 cases), commerces 23.25% (10 cases), company employee, teachers, students were in order of frequency and in the regional distribution was city 93.02% (40 cases), from village 6.97% (3 cases). 3. In the type distribution, the highiest frequency was Gan-Gi-Beom-Wi(肝氣犯胃) type 53.48% (23 cases), and Sik-Jeok (食積) 18.8% (8 cases), Bi-Gi-Heo(脾氣虛) 16.27% (7 cases) were in order of frequency. 4. In the western name of a disease distribution, the highiest frequency was chronic gastritis 37.20% (16 cases). 5. In the period of history, the highiest freguency was between six months and one year 23.25% (10 cases), furthermore between 5 years and 10 years 2.32% (40 cases). 6. In the treatment period, the highiest frequency was between 3 weeks and 4 weeks 38.46% (10 cases), and between one month and 2 months 30.76% (8 cases) was in order of frequency. 7. Treatment progress found out progressed 74.2% (26 cases) among the 35 cases which was known treatment progress.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4795-4800
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• 2014

Background: Few studies have directly compared clinical efficacy and safety among Chinese herb injections (CHIs) for gastric cancer (GC). The present study aimed to compare CHIs combined with FOLFOX regimens for GC to show which provides the best CHIs results. Materials and Methods: 9 electronic databases and 6 gray literature databases were comprehensive searched in April 20, 2013. According to inclusion and exclusion criteria, two reviewers independently selected and assessed the included trials. The risk of bias tool described in the Cochrane Handbook version 5.1.0 and CONSORT statement were used to assess the quality of the trials. All calculations and graphs were performed and produced using ADDIS 1.16.5 software. Results: A total of 541 records were searched and 38 RCTs met the inclusion criteria (2,761 participants), involving 10 CHIs. The results of network meta-analysis showed that compared with FOLFOX alone, combinations with Kanglaite, Astragalus polysaccharides, Cinobufacini, or Yadanziyouru injections could furthest strengthen ORR, improve the quality of life, reduce nausea and vomiting, and reduce the incidence of leukopenia (III-IV). Conclusions: Kanglaite injection, Astragalus polysaccharides injection, Yadanziyouru injection were superior to other CHIs in clinical efficacy and safety for GC. The conclusions now need to be confirmed by large sample size direct head-to-head studies.

• 셀메드
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• 제2권2호
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• pp.16.1-16.5
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• 2012

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu- Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai- Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6789-6794
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• 2015

Background: To analyze the expression of estrogen receptors (ER), progesterone receptors (PR), C-erbB-2 and Ki-67 in endometrial carcinoma (EC) and their relationships with the clinicopathological features. Materials and Methods: Sixty-seven EC samples, 53 normal endometrial samples and 53 atypical hyperplasia endometrial samples were all selected in Shaanxi Provincial People's Hospital from Jun., 2012 to Jun., 2014. The expression of ER, PR, C-erbB-2 and Ki-67 in EC tissue, normal endometrial tissue and atypical hyperplasia endometrial tissue was respectively detected using immunohistochemical SP method. The relationships between the expression of ER, PR, C-erbB-2 and Ki-67 and the patients' clinicopathological features as well as their correlations in EC tissue were also analyzed. Results: The positive expression rates of ER and PR in EC tissue were 44.8% and 41.8%, respectively, dramatically lower than in atypical hyperplasia endometrial tissue and normal endometrial tissue (P<0.01). The positive expression rates of C-erbB-2 and Ki-67 in EC tissue were 80.6% and 64.2%, respectively, significantly higher than in atypical hyperplasia endometrial tissue and normal endometrial tissue (P<0.01). In EC tissue, the expression of ER and PR was closely associated with the differentiated degrees and depth of myometrial invasion (P<0.05), while that of C-erbB-2 and Ki-67 with the clinical staging, differentiated degrees, depth of myometrial invasion and presence or absence of lymph node metastasis (P<0.05). Spearman correlation analysis further displayed that the expression of ER was positively correlated with PR (r=0.393, P=0.001), but negatively with C-erbB-2 and Ki-67 (r=-0.469, P=0.000; r=-0.329, P=0.007); The expression of PR was negatively correlated with C-erbB-2 and Ki-67 (r=-0.273, P=0.025; r=-0.251, P=0.041), but that of C-erbB-2 positively with Ki-67 (r=0.342, P=0.005). Conclusions: Abnormal expression of ER, PR, C-erbB2 and Ki-67 might play an important role in endometrial malignant transformation and cell differentiation, so their joint detection is likely to be a comprehensive combination of immune factors, which is of great importance for EC prognosis.