• Korean Journal of Organic Agriculture
• /
• v.32 no.1
• /
• pp.1-24
• /
• 2024

Considering the continuous growth in the production and consumption of Gastrodia elata, it's crucial to accurately understand the consumer demand for Gastrodia elata products and develop health products tailored to consumer preferences. In this study, we surveyed 400 consumers each from South Korea and China to gauge their perceptions and buying intentions concerning Gastrodia elata products. The results revealed that Korean consumers predominantly evaluate Gastrodia elata products based on health consciousness, whereas Chinese consumers emphasize the product's external characteristics. In Korea, Gastrodia elata products are mainly promoted for their health benefits and are primarily consumed in ingestible forms. In contrast, in China, Gastrodia elata is frequently used as a culinary ingredient. These findings underscore that consumer perceptions and buying intentions can differ depending on how a product is advertised and presented. Future studies should take into account the evolving international Gastrodia elata market and the surging demand, incorporating diverse countries and cities. It will also be imperative to maintain ongoing monitoring, drawing insights from the industrial growth drive model.

• Natural Product Sciences
• /
• v.3 no.2
• /
• pp.104-105
• /
• 1997

In the course of continous work on tubers of Gastrodia elata, a new constituent was isolated from the ethyl acetate soluble fraction prepared from the methanol extract. The structure of the compound was identified as ${\alpha},{\alpha}'-[bis-2-(5-carboxaldehydo)furanyl]-dimethyl$ ether from the elemental analytical and spectroscopic data. This compound was once isolated from Cirsium chlorolepis and named as cirsiumaldehyde. This is the first furan type compound isolated from Gastrodia elata.

• Natural Product Sciences
• /
• v.6 no.2
• /
• pp.53-55
• /
• 2000

In the course of continous work for the discovery of anti-thrombotic constituents from tubers of Gastrodia elata, citric acid 1,5-dimethyl ester was isolated from ethylacetate soluble fraction prepared from the methanol extract. The structure of the compound was determined by the spectroscopic data. The anti-thrombotic effect of this compound was observed with prolonging the bleeding time in thrombin-induced thrombosis model of mice.

• Archives of Pharmacal Research
• /
• v.20 no.1
• /
• pp.91-92
• /
• 1997

In the course of continous work on tubers of Gastrodia elata, a new constituent, 4, 4$^{I}$-dihydroxybenzyl sulfoxide was isolated from the ethyl acetate soluble fraction prepared from the methanol extract. The structure of the compound was identified from the elemental analytical and spectroscopic data in comparison with those of non-substituted benzyl sulfoxide.e.

• Natural Product Sciences
• /
• v.12 no.2
• /
• pp.101-103
• /
• 2006

In the course of the continual work on the fresh tubers of Gastrodia elata, a fructoside constituent was isolated from the n-butanol soluble fraction prepared from the methanol extract. The structure of this compound was identified as $n-butyl-{\beta}-D-fructopyranoside$ from various spectroscopic data including $^1H-\;and\;^{13}C-NMR$, HMQC, HMBC, and FABMS.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.24 no.5
• /
• pp.807-813
• /
• 2010

Impairment of balance between bone-resorbing osteoclasts and bone-forming osteoblasts result in bone disease. Especially, increased osteoclast formation and activity are responsible for bone diseases such as osteoporosis, rheumatoid arthritis, periodontal disease. Natural metabolites of plants have recently received much attention as an alternative tools for the development of novel therapeutic strategy. The aim of this study was to search the natural products to inhibit osteoclast differentiation and was to evaluate of its mechanism. Water extract of Gastrodia elata Blune significantly inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation in bone marrow macrophages (BMMs) in a dose dependent manner. However, water extract of Gastrodia elata Blune did not affect cytotoxicity when compared with control. The mRNA expression of c-Fos, NFATc1, and TRAP induced by RANKL was inhibited by water extract of Gastrodia elata Blune treatment. Also, water extract of Gastrodia elata Blune inhibited the protein expression of c-Fos and NFATc1 expression in BMMs treated with RANKL. Water extract of Gastrodia elata Blune suppressed the phosphorylation of p38 induced by RANKL. In general, RANKL considerably inhibited the expression level of Id2 and MafB known as negative regulators of osteoclastogenesis, but RANKL did not inhibit Id2 and MafB expression in BMMs when it was co-treated with Gastrodia elata Blune. Taken together, these results suggest that Gastrodia elata Blune may be a useful drug in the treatment of bone-related disease.

• Korean Journal of Pharmacognosy
• /
• v.26 no.4
• /
• pp.385-389
• /
• 1995

MeOH extract of Gastrodia elata was fractionated to five solvent fractions, hexane fr (fr I), 90% MeOH fr (fr II), EtOAc fr (fr III), BuOH fr (fr IV) and $H_2O$ fr (fr V). Among the five fractions, fr II, III and IV showed platelet anti-aggregating effects against ADP or collagen induced rat platelet aggregation in vitro. Fr II , III and IV were also tested in vivo, in the mouse and rat models of thrombosis. Oral administration of fr II, III or IV enhanced the recovery from the thrombotic shock in the mouse model of thrombosis to 32-40% from 17% of recovery with the control group of mice. Treatment with fr II, III or IV also attenuated the sudden reduction in the blood platelet count following intravenous collagen injection to rat. The above results were indicative of the presence of anti-platelet and anti-thrombotic components in this plant.

• Archives of Pharmacal Research
• /
• v.21 no.3
• /
• pp.357-360
• /
• 1998

Two new 4-hydroxybenzyl alcohol derivatives (1 and 2) were isolated from the methanol extract obtained from fresh tubers of Gastrodia elata together with 4-hydroxybenzyl methyl ether, 4-hydroxybenzyl alcoho, bis(4-hydroxyphenyl)methane, 4-hydroxybenzaldehyde, $\beta$-sitosterol and plamitic acid. 1 and 2 were identified as 3-O-($4^1$-hydroxybenzyl)-$\beta$-sitosterol and 4-[$4^1$-($4^{11}$-hydroxybenzyloxy)benzyloxy]benzyl methyl ether, respectively, according to the spectroscopic data.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1998.11a
• /
• pp.181-181
• /
• 1998

Gastrodia elata Blume (Orchidaceae) is a saprophyte growing in the woods of Korea, China and Japan. The tubers of this plant have been considered as one of the very important herbal medicines in oriental countries and were used for the treatment of headaches, migraine, dizzines, childhood convulsion, epilepsy, rheumatism, neuralgia and other neuralgic and nervous affections. In the course of our search for plants with anti-platelet and/or

• Archives of Pharmacal Research
• /
• v.27 no.4
• /
• pp.381-385
• /
• 2004

Nine phenolic ($1\~9$) and two furan type (10, 11) compounds, were isolated from the methanolic extract of the tuber of Gastrodia elata Blume (Orchidaceae) in the course of continuing search for platelet anit-aggregating plant components. Compound 1 was identified as 4,4'-dihy-droxybenzyl sulfone, a novel compound for the best of our knowledge. Compound 10, 5-hydroxymethyl-2-furancarboxaldehyde, was isolated for the first time from this plant. Compound 1 ($IC_{50};\;83{\mu}M$) was about four times more inhibitory to U46619 induced aggregation than ASA ($IC_{50};\340{\mu}M$). Compound 9, 4,4'-dihydroxy-dibenzylether, ($IC_{50};\;5{\mu}M$, $3{\mu}M\;and\;33{\mu}M$, respectively) was $10\~}80$ fold more potent than ASA ($IC_{50};\;420\;{\mu}M,\;53\;{\mu}M\;and\;340\;{\mu}M$ respectively) to collagen, epinephrine and U46619 induced aggregation, although it is less active than ASA to AA induced aggregation.