• 제목/요약/키워드: Gastric Emptying Time

검색결과 49건 처리시간 0.036초

위암 환자에서 원위부 위절제 후 공장낭 간치술 (Jejunal Pouch Interposition (JPI) after Distal Gastrectomy in Patients with Gastric Cancer)

  • 전해명;김욱;허훈;이준현;원종만
    • Journal of Gastric Cancer
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    • 제4권4호
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    • pp.242-251
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    • 2004
  • 목적: 최근 조기위암 환자가 증가하기 때문에 수술 후 환자의 영양상태 개선을 포함한 삶의 질에 많은 관심이 모아지고 있다. 그러나 원위부 위절제 후 많이 이용되고 있는 Billroth-I, II 및 Roux-en-Y 술식은 남은 위의 작은 용량과 십이지장 우회에 따른 철분, 지방, 칼슘, 카로틴 등의 흡수 장애 등의 단점이 있다. 이를 보완하고자 저자들은 위 원위부 절제 후 소장낭을 저장소 역할을 하게 하고, 또한 십이지장과 문합하여 음식물이 생리적 방향으로 통과하도록 공장낭 간치술을 시행하였다. 대상 및 방법: 2001년 3월부터 2004년 2월까지 가톨릭의과대학 성가병원 외과에서 위암으로 원위부 절제를 시행한 196예를 공장낭 공장낭 간치술(JPI 군, n=100), B-I 군(n=29), B-II군(n=67)으로 나누어, 혈액 및 생화학적 검사의 변화, 몸무게를 포함한 영양학적 변화 및 위내시경 소견과 위 배출시간을 분석하였다. 결과: 환자들의 체중은 3군 모두 술 후 6개월에 최대로 감소된 후 회복되는 경향을 보였으며, 술 후 6개월, 1년, 2년째의 체중 감소율이 JPI군이 $5.14\%,\;3.01\%,\;2.37\%$로 B-I 군의 $8.41\%,\;6.69\%,\;5.90\%$B-II 군의 $7.50\%,\;7.65\%\;5.86\%$에 비해 의의있게 작았다(P=0.011, P=0.000, P=0.013). 검사실 소견은 술 후 6개월에 총 단백이 JPI 군이 B-I과 B-II 군보다 더 높았으며, 특히 1,2기 위암 환자의 경우 술 후 1년째 총 단백과 알부민이 JPI군에서 의의있게 높았다. 그러나 빈혈과 관련된 검사 칼슘, 인, 콜레스테롤, 트리글리세라이드 등에서는 3군 간의 차이는 관찰되지 않았다. 술 후 6개월, 1년, 2년째의 $\^{99m}$Tc-반 고형식(샌드위치)를 이용한 위 배출시간은 JPI 군이 102.5분, 83.1분, 58.1분, B-I 군이 95.5분, 92.0분, 58.5분, B-II 군이 53.9분, 69.1분, 50.2분으로 B-II 군이 가장 빠르고, JPI군이 가장 느리게 관찰되었다. 또한 위 내시경 검사 상 술 후 6개월째 정밀관찰이 불가능한 음식 저류가 JPI 군에서 가장 많았으나 시간이 지나면서 호전되는 것을 관찰하였다. 결론: 공장낭을 이용한 간치술은 기존 술식보다 1시간 정도 수술시간이 더 걸리고, 수술 후 초기에 위 배출시간이 지연되는 경향이 있지만, 몸무게를 포함한 영양학적인 면을 고려할 때, 장기 생존이 기대되는 제 I, II기 위암 환자에게 적용될 수 있는 또 하나의 좋은 재건 술식이라고 생각한다.

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바이러스 감염 후 발생한 위마비증 1례 (A Case of Postviral Gastroparesis in a 7-year-old Boy)

  • 김을순;김진숙;박재옥
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제5권1호
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    • pp.73-78
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    • 2002
  • 저자들은 바이러스 감염 후 발생한 복부 팽만과 불편감을 호소하는 7세 남아에서 동위원소를 사용하여 측정한 위배출 시간의 지연이 확인 된 후, domperidone과 erythromycin 치료와 식이 조절로 호전된 특발성 위마비증 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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세팔렉신 함유 생체막점착성 마이크로캅셀의 생체이용율 평가 (Evaluation of Bioavailability of Bioadhesive Microcapsules Containing Cephalexin)

  • 한건;김정환;정연복;지웅길
    • Journal of Pharmaceutical Investigation
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    • 제24권3호
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    • pp.177-186
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    • 1994
  • Bioadhesive microcapsules of cephalexin, using Eudragit RS/RL coated with polycarbophil or carbopol, were evaluated biopharmaceutically. The GI transit of microcapsules in rats was studied. Bioadhesive microcapsules coated with polycarbophil or carbopol were shown to have substantially longer GI transit time than Eudragit RS/RL microcapsule. The delay in transit time was due to bioadhesion of the polymer to the mucin-epithelial cell surface which was clearly observable on animal autopsy. Plasma drug levels in rabbits showed that bioadhesive microcapsules resulted in a longer duration of action and greater bioavailability than other microcapsule or drug powder. Thus, the principle of bioadhesion can significantly improve therapy, due to a reduced rate of gastric emptying, an increase in contact time, and the intimacy of contact of the drug with the absorbing membrane.

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노화에 따른 위장관 기능의 변화 (Aging and Gasroenterrogi Changes)

  • 조우균
    • 한국식품영양학회지
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    • 제6권3호
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    • pp.219-230
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    • 1993
  • This research aims to study the changes In gastrointestinal function attributed to aging In human. The thresholds for recognition and detection of flavors became elevated and salivary gland acinar cells decreased in the old age. But most esophageal function remained relatively Intact. Although gastric emptying time has been slowed with aging, the total intestinal transit time did not differ. Atropic gastritis due to H. pylori in old man decreased secretion of acid and Intrinsic factor and absorbability of calcium and iron. Pancreatic secretion is droned in older persons. Prevalence of gallstones rised with age. Liver size and portal blood flow decreased significantly with age. Mucosal surface area has been reported to be slightly diminished in the aging man. Glucose transporters decreased and Insulin tolerance Increased. Absorption of aromatic amino acid is diminished with age. Dietary protein In that aging human increased fecal nitrogen excretion. Vitamin A tolerance increased. Vitamin D receptor concentration decreased and resistance to 1,25-(OH)2D3 action increased. Permeability of aging small Intestine Increased. Zinc balance dirt not differ Copper absorption appeared not to be significantly affected by age. Neurotensin secretion decreased thus slowed colonic peristaltic movements and Intestinal mucosal growth.

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모유후각자극이 미숙아의 생리적 반응, 구강수유 진행 및 체중에 미치는 영향 (The Effects of Breast Milk Olfactory Stimulation on Physiological Responses, Oral Feeding Progression and Body Weight in Preterm Infants)

  • 이은지
    • 대한간호학회지
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    • 제49권2호
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    • pp.126-136
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    • 2019
  • Purpose: This study was conducted to evaluate the effect of breast milk olfactory stimulation on physiological responses, oral feeding progression, and body weight in preterm infants. Methods: A repeated measures design with nonequivalent control group was used. The participants were healthy, preterm infants born at a gestational age of 28~32 weeks; 12 in the experimental group and 16 in the control group. Data were collected prospectively in the experimental group, and retrospectively in the control group, by the same methods. Breast milk olfactory stimulation was provided 12 times over 15 days. The data were analyzed using the chi-square test, Mann-Whitney U test, Wilcoxon signed rank test and linear mixed models using SPSS 19. Results: The gastric residual volume (GRV) of the experimental group was significantly less than that of the control group. The heart rate, oxygen saturation, respiration rate, transition time to oral feeding, and body weight were not significantly different between the two groups. Conclusion: These findings indicate that breast milk olfactory stimulation reduces GRV and improves digestive function in preterm infants without inducing distress.

Primary Myopathic Chronic Intestinal Pseudo-Obstruction in a Maltese Dog

  • Jung, Joohyun;Choi, Mincheol
    • 한국임상수의학회지
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    • 제33권3호
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    • pp.179-182
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    • 2016
  • An 11-year-old castrated male Maltese had vomiting, diarrhea, and abdominal distension for over two weeks and weight loss for several months. Clinical laboratory studies were not remarkable. Abdominal radiographs showed severe dilated intestine with a gravel sign. Colon was empty with normal diameter in the pneumocolon study. On ultrasonographs, most small bowel loops were dilated without normal peristalsis and showed abnormal thin wall. Barium contrast study revealed remarkably delayed gastric emptying and transit time up to $6^{th}$ day. On exploratory laparotomy, there were no mechanical obstruction and extra-intestinal abnormalities except severe dilated small intestine. Chronic fibrosing lymphohistiocytic leiomyositis with atrophy of tunica muscularis in the small intestines and colon was identified through full thickness biopsy and histopathology. Therefore, primary myopathic chronic intestinal pseudo-obstruction was diagnosed. This dog is survival with symptomatic treatments for eight months.

전침자극이 개의 위장관운동에 미치는 영향 (Effects of Electroacupuncture on Motility of the Castro-intestinal Tract of Dogs)

  • 성재기;남치주
    • 한국임상수의학회지
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    • 제5권1호
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    • pp.9-21
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    • 1988
  • Gastro-intestinal mortility and transit time of barium sulfate after electroacupuncture were investigated in normal dogs and administration of xylatine in dogs. Electroacupuncture was performed with a current of 1.5 volt and 20 Hz at the acupoints of Tsu San Li(right(+) left(-) in dogs for 30 minutes. The results were as follows: 1. After electroacupuncture stimnlation in normal dogs, rates of stomach contractions was not changed, but amplitudes of stomach motility was markadly increased. The electroacupuncture stimulation tasted about 60 minutes after the end of electroacupuncture. 2. The stomach contractions was markedly increased, while the amplitudes of stomach motility was sligltly decreased by the administration of xylazine in dogs. 3. The rates of stomach contractions and amplitudes of motility were markedly increased after administration of xylazine in the electroacupuncture stimulated dogs. 4. Gastric emptying time o barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs(p < 0.01). 5. Small bowel transit time of barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs (p < 0.01). 6. Gastroduodenal transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs was blighty significantly decreased compared to that of dogs dosed with xylazine (p< 0.01). 7. Small bowel transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs markedly decreased compared to that of dogs dosed with xylazine (p < 0.05).

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Short-term Outcomes of Pylorus-Preserving Gastrectomy for Early Gastric Cancer: Comparison Between Extracorporeal and Intracorporeal Gastrogastrostomy

  • Alzahrani, Khalid;Park, Ji-Hyeon;Lee, Hyuk-Joon;Park, Shin-Hoo;Choi, Jong-Ho;Wang, Chaojie;Alzahrani, Fadhel;Suh, Yun-Suhk;Kong, Seong-Ho;Park, Do Joong;Yang, Han-Kwang
    • Journal of Gastric Cancer
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    • 제22권2호
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    • pp.135-144
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    • 2022
  • Purpose: This study aimed to compare the surgical and oncological outcomes between totally laparoscopic pylorus-preserving gastrectomy (TLPPG) with intracorporeal anastomosis and laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) with extracorporeal anastomosis. Materials and Methods: A retrospective analysis was performed in 258 patients with cT1N0 gastric cancer who underwent laparoscopic pylorus-preserving gastrectomy using two different anastomosis methods: TLPPG with intracorporeal anastomosis (n=88) and LAPPG with extracorporeal anastomosis (n=170). The following variables were compared between the two groups to assess the postoperative surgical and oncological outcomes: proximal and distal margins, number of resected lymph nodes (LNs) in total and in LN station 6, operation time, postoperative hospital stay, and postoperative morbidity including delayed gastric emptying (DGE). Results: The average length of the proximal margin was similar between the TLPPG and LAPPG groups (2.35 vs. 2.73 cm, P=0.070). Although the distal margin was significantly shorter in the TLPPG group than in the LAPPG group (3.15 vs. 4.08 cm, P=0.001), no proximal or distal resection margin-positive cases were reported in either group. The average number of resected LN was similar in both groups (36.0 vs. 33.98, P=0.229; LN station 6, 5.72 vs. 5.33, P=0.399). The operation time was shorter in the TLPPG group than in the LAPPG (200.17 vs. 220.80 minutes, P=0.001). No significant differences were observed between the two groups in terms of postoperative hospital stay (9.38 vs. 10.10 days, P=0.426) and surgical complication rate (19.3% vs. 22.9%), including DGE (8.0% vs. 11.8%, P=0.343). Conclusions: The oncological safety and postoperative complications of TLPPG with intracorporeal anastomosis are similar to those of LAPPG with extracorporeal anastomosis.

위배출 신티그래피에서 수학적 모델을 이용한 지연영상 시간의 단축 (Reducing the Scan Time in Gastric Emptying Scintigraphy by Using Mathematical Models)

  • 윤민기;황경훈;최원식;이병일;이재성
    • 대한핵의학회지
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    • 제39권4호
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    • pp.257-262
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    • 2005
  • 목적 : 위배출신티그래피는 일반적으로 15분 간격으로 2시간 동안 촬영된다. 본 연구는 수학적 함수를 이용하여 90분까지 얻은 위잔류율 측정치를 가지고 비선형 곡선을 구한 후, 120분의 위잔류율을 예측함으로써 90분 이후의 지연영상 촬영시간을 절약할 수 있는지에 대하여 알아보았다. 대상 및 방법 : 환자들은 74 MBq (2 mCi) Tc-99m DTPA가 들어 있는 계란찜을 섭취한 직후 촬영을 시행하였다. 환자들을 반위배출시간에 따라 두 군으로 나누어 후향적으로 연구하였다. Group I은 반위배출시간이 90분 이하($T_{1/2}\;{\leq}90\;min$)인 51명(남자 21명, 여자: 30명, 평균나이: $44.6{\pm}13.5$세)이었고, Group II는 90분 초과 120분 이하($90\;min)인 45명(남자: 15, 여자:30, 평균나이 $45.6{\pm}15.9$)이었다. 0, 15, 30, 45, 60, 75, 90분에서의 위잔류율을 측정하여 비선형 곡선인 단순지수함수, power exponential function, modified power exponential function을 구하였고, 또한 50, 75, 90분의 측정치로 후기 단순지수함수를 구하였다($MATLAB^{\circledR}$ 5.3). 얻어진 함수식을 통해 120분에서의 위잔류율 예측치를 구한 후, 120분 측정치와의 상관관계를 알아보았다. ($MedCalc^{\circledR}$ 6.0). 결과: 120분 위잔류율의 측정치와 예측치의 상관계수(r)는 각각의 함수식에 따라 다음과 같다; 단순지수함수 (Group I: 0.8858, Group II: 0.5982, p<0.0001), power exponential function (Group I: 0.8755, Group II: 0.6008, p<0.0001), modified power exponential function (Group I: 0.8892, Group II: 0.5882, p<0.0001), 후기 단순지수함수 (Group I:0.9085, Group II:0.6832, p<0.0001). Group I에서만 함수식 모두에서 측정치와 예측치 간에 통계학적으로 의미있게 강한 상관관계를 보였다. 각 상관계수 간에 유의한 차이는 없었으나 후기지수함수식이 다른 함수식에 비하여 변수(parameter)와 입력될 측정치의 개수가 적어 예측치를 구하기가 간편하였다. 결론: 반위배출 시간이 90분 이하인 경우에 120분에서의 위잔류율을 예측할 수 있어 90분 이후의 촬영시간을 절약할 수 있다. 또한, 후기지수함수식이 다른 함수식에 비하여 예측치를 구하기가 간편하므로 임상적으로 더 유용하다.