• Journal of Applied Biological Chemistry
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• 제65권1호
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• pp.63-74
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• 2022

Microbial dysbiosis in the gut is associated with human diseases, and variations in mucus alter gut microbiota. Therefore, we explored the effects of mucin on the gut microbiota using a community of 19 synthetic gut microbial species. Cultivation of these species in modified Gifu anaerobic medium (GAM) supplemented with mucin before synthetic community assembly facilitated substantial growth of the Bacteroides, Akkermansia, and Clostridium genera. The results of 16S rRNA microbial relative abundance profiling revealed more of the beneficial microbes Collinsella, Bifidobacterium, Ruminococcus, and Lactobacillus. This increased acetate levels in the community cultivated with, rather than without (control), mucin. We identified differences in predicted cell function and metabolism between microbes cultivated in GAM with and without mucin. Mucin not only changed the composition of the gut microbial community, but also modulated metabolic functions, indicating that it could help to modulate microbial changes associated with human diseases.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2020년도 추계학술발표대회
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• pp.889-892
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• 2020

현재 식품의약품안전처에서 공공데이터 포털에 제공하는 정보에 의하면 국내에는 20,000종 이상의 약이 유통되고 있다. 식약처와 여러 제약회사에서 기본적인 약 정보를 제공하고는 있지만 정확한 처방전이나 설명서가 없는 경우에 무분별한 약 복용의 위험성을 안고 있다. 일부 약 검색을 지원하는 사이트가 있으나 세부 사항을 사용자가 일일이 선택하고 입력해야 정확한 정보를 얻을 수 있다. 본 논문에서는 사용자의 스마트폰을 이용하여 알약을 촬영하면 해당 약을 인식하고 상세 정보를 알려주는 딥러닝 모델을 설계하였다. CNN 신경망을 사용하여 약의 모양, 색상, 마크, 분할선 등을 기준으로 분류하고 인식된 약의 세부 정보는 공공데이터로부터 받아온다.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.940-948
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• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

• 한국전통조경학회지
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• 제34권2호
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• pp.16-26
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• 2016

본고에서는 여러 문헌에 흩어진 강릉지역의 팔경을 수집하고, 팔경과 역사문화와의 관계 팔경의 지역적 분포 경관구성 요소 및 내재적 의미를 다각도로 분석 및 해석하였다. 강릉지역의 팔경은 고려에서 근현대까지 오랜 시간 동안 축적 확장되어 왔으며, 단순히 자연경관의 아름다움뿐 아니라 이 지역을 배경으로 한 역사적인 사실과 그 정서를 반영하고 있다. 또한, 강릉지역 팔경의 형식과 분포를 종합하여 볼 때, 가장 많은 형식을 차지하는 것은 소상유사형(瀟湘類似型)이다. 그 중 반복적으로 나타나는 '저녁밥 짓는 연기'나 '고기 잡기' 등은 당시 강릉지역민들의 생활상을 보여주고 있으며, 이는 마을단위로 이루어진 팔경이라는 사실을 말한다. 강릉지역의 팔경은 넓게는 시(市) 전체, 좁게는 누정(亭)까지 다양한 범위에 분포되어 있다. 대부분의 팔경은 현재 강릉시의 동쪽, 그리고 강동면과 구정면이 접하는 지역에 몰려있다. 강릉 지역의 팔경이 대부분 이곳에 분포되어 있는 상황으로 볼 때, 이 지역이 강릉경관의 핵심을 차지하고 있음을 말해준다. 강릉지역 팔경은 자연요소 60%, 인문요소 36%, 기타 4%로 나타났으며 자연요소에서는 대상 그 자체의 아름다움을, 인문요소와 기타에서는 대상 속에 담긴 전설이나 역사를 담고 있다. 팔경이 표현하는 경관들은 별개의 대상이 아니다. 남대천과 죽도봉, 군선강과 풍호 등 하나의 풍경이 되었다. 또한 신라의 화랑의 이야기가 얽힌 풍호, 군선강 등은 강릉지역의 대표적인 역사경관이 되었으며, 강릉지역의 팔경은 견조도, 한송정, 한송사 등 현재는 존재하지 않는 강릉의 유적 및 전통경관을 유추해 볼 수 있는 중요한 기초자료가 될 것으로 판단된다. 결론적으로 강릉지역의 팔경은 미적대상인 동시에 역사 문화적 장소이고 더 나아가 심상적(心象的) 공간으로 남아 있음을 알 수 있다.

• 치위생과학회지
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• 제24권2호
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• pp.115-123
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• 2024

Background: The population of Gangneung City in South Korea has shown a gradual increase in the proportion of individuals aged 65 years and older, and the most frequently reported diseases for several years have consistently been periodontal diseases, including gingivitis and periodontitis. The regional imbalance in the distribution of dental personnel and resources has emerged as a problem of inequality in the use of dental care. It has been advocated to identify areas with disadvantages in dental care and develop public dental policies based on that. This study aimed to develop a customized oral healthcare program for local seniors based on a Public-Private-Academic Partnership, and to evaluate the oral health status of older adults in Gangneung City. Methods: The participants were residents aged 60 years and above in Gangneung City. A questionnaire including general information, systemic health status, and oral health status was administered to the participants. In addition, oral healthcare and education tailored to each individual's health status were provided once or twice based on their oral health status. The collected data were analyzed using IBM SPSS Statistics 25 for descriptive statistical analysis. Results: Among the older adults in Gangneung City, 75% had at least one prosthesis and exhibited symptoms of gingivitis or periodontitis. Additionally, the modified sulcus bleeding index decreased among participants who underwent the program twice. Over 90% of the participants expressed satisfaction with the program. Conclusion: The program appeared to contribute positively to the oral health promotion among local seniors. Further oral healthcare programs should focus on seniors in rural and old urban areas to reduce disparities in oral health across regions.

• 동서간호학연구지
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• 제26권2호
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• pp.167-175
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• 2020

Purpose: This study aims to understand the effect of attitudes toward COVID-19, subjective norms, and intentions toward social distancing as a preventative measure for COVID-19 in nursing university students, and to provide basic data for COVID-19 prevention. Methods: A cross-sectional study design was used in this study. The participants included 169 nursing students at a university in G city. Data were collected from 22 May 2020 to 1 June 2020. A self-report questionnaire was used. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and multiple regression analyses with the IBM/SPSS 26.0 for Window Program. Results: Intention was the most influential factor on social distancing (β=.29, p=.002), followed by the number of breakfasts per week (β=.18, p=.005), school grade (β=-.16, p<.001), and smoking status (β=-.13, p=.046). These variables explained 35.0% of factors influencing social distancing (F=12.24, p<.001). Conclusion: The results of this study are meaningful and present a direction for nursing students and future medical personnel to effectively perform social distancing. It is necessary to educate nursing students so that they can practice proper health care habits and intentions for social distancing.

• Journal of Microbiology and Biotechnology
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• 제30권3호
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• pp.352-358
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• 2020

In this study we investigated the immune effects of oral administration of anionic macromolecules extracted from Codium fragile (CFAM) and red ginseng extract mixture on the peritoneal macrophage cells in immune-suppressed mice. Cyclophosphamide (CY) induces the immune-suppressed condition. CY-treated mice were orally fed with different concentrations of CFAM supplemented with red ginseng extract and the peritoneal macrophages collected. CY treatment significantly decreased the immune activities of peritoneal macrophages, compared to the normal mice. The administration of CFAM mixed with red ginseng extract significantly boosted the viability of macrophage cells and nitric oxide production of peritoneal macrophages. Further, the oral administration of CFAM mixed with red ginseng extract up-regulated the expression of iNOS, COX-2, and TLR-4 as well as cytokines such as IL-1β, IL-6, TNF-α, and IFN-γ more than the red ginseng-treated group. This study showed that CFAM enhanced the immune activity of red ginseng extract in the peritoneal macrophage cells of immune-suppressed mice. Furthermore, CFAM might be used as a co-stimulant of red ginseng extract through the regulation of macrophage cells for the enhancement of human health and immunity.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제36권6호
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• pp.298-302
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• 2014

The radial forearm free flap (RFFF) is a thin and pliable tissue with many advantages for tongue reconstruction. However, tongues reconstructed with RFFF occasionally need revision surgery because inadequate defect measurement at primary surgery can lead to bulkiness and limited movement of reconstructed tongue. In this case, the patient underwent partial glossectomy and RFFF reconstruction for treatment of tongue cancer five years prior. We could not make a lower denture for the patient, because the alveolo-lingual sulcus of tongue was almost lost. So we performed vestibuloplasty with a modified Kazanjian method on the lingual vestibule of the mandibular right posterior area, and defatting surgery to debulk the flap. After surgery, we observed that the color and texture of the revised tongue changed to become similar with adjacent tissue. The patient obtained a more functional and esthetic outcome. Accordingly, we present a case report with a review of relevant literature.

• 한국지하수토양환경학회지:지하수토양환경
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• 제15권4호
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• pp.46-52
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• 2010

Acid mine drainage occurs when sulfide minerals are exposed to an oxidizing environment. The objective of this study was to inhibit the oxidation of pyrite by applying various coating agent such as $KH_2PO_4$, MgO and $KMnO_4$ over its surface as an oxidation inhibitors. Experiments were conducted for 8 days to test the feasibility of oxidation inhibitors. The optimal condition of coating agent for standard pyrite and IK mine was the combination of 0.01M $KH_2PO_4$, 0.01M NaOAc and 0.01M NaClO. Otherwise, for YD mine the combination of 0.01M $KMnO_4$, 0.01M NaOAc and 0.01M NaClO. The $SO_4^{2-}$ reduction efficiency of pyrite, IK and YD mine samples was 70, 92 and 84%, respectively. For 8 days, no significant increase of $SO_4^{2-}$ from pyrite sample coated with inhibitor was observed. The pH of solution remains in between 4 to 6 for the reaction conditions.

• 한국자원식물학회지
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• 제24권6호
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• pp.688-695
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• 2011

The composition of free sugar, free amino acid, and fatty acid in tubers of the cultivars 'Superior', 'Sinnamjak', and 'Chubaek' were evaluated at the two sites with different altitude, Gangneung (20 m altitude) as lowland and Daekwallyeong (760 m altitude) as highland. The average reducing sugar content of the three potato cultivars harvested in Daekwallyeong and Gangneung was 1.1% and 2.3%, respectively, which showed two-fold difference between the two locations. Average total sugar content was also two-folds lower in potatoes harvested in Daekwallyeong (6.3%) than those harvested in Gangneung (12.2%). Average content of free amino acids of the three potato cultivars harvested in Daekwallyeong and Gangneung was 1,325 mg/100g and 1,051 mg/100g, respectively. The cultivar 'Chubaek' has the highest amino acid content among the three tested cultivars. Potatoes from Daekwallyeong have higher unsaturated fatty acid levels than those from Gangneung. During the tuber development, unsaturated fatty acids levels increased in tubers grown in Daekwallyeong, but decreased in those grown in Gangneung. These results indicate that the quality of potatoes from Daekwallyeong is from Gangneung for food processing purpose for human consumption.