• 철학연구
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• 제105권
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• pp.269-290
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• 2008

이 논문에서는 '후향적인 인과관계'를 주장하는 견해들을 크게, 자의적인 행위에 근거한 접근방법, 분석수준별 차이에 근거한 접근방법, 물리방정식에 의한 접근방법, 물리현상에 근거한 접근방법으로 나누어 고찰하고, 그 각각의 특징과 문제점들을 지적했다. 이어서 후향적인 인과성을 펼치는 어떠한 견해도 아직은 설득력 있게 받아들여지지 않고 있음을 밝혔다. 후향적인 인과관계를 펼치는 견해들이 인과성분석에서 주류는 아닐지라도, 상호조건적 동시발생적인 측면에 근거해 대칭적인 관계 속에서 인과관계를 파악하거나, 전체상적인 접근에 의거해 서로가 직접 간접으로 인과관계를 유지하는 것으로 파악할 경우는 어느 정도 논거가 선다. 특히 인과그물이나 전체상적인 측면에서 접근할 경우는 더욱 그렇다. 그러나 유용성이라는 측면에서 본다면, 후향적인 인과성고찰은 원인선행설에 비해 그 설득력이 약하다. 이런 점에서 현재로서는 결과가 원인에 앞서지 못한다는 견해가 주류를 이룰 수밖에 없다.

• Journal of Ginseng Research
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• 제43권3호
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• pp.460-474
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• 2019

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

• 한국철학논집
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• 제35호
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• pp.7-42
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• 2012

호락논쟁의 핵심 쟁점은 '담연허명(湛然虛明)한 심(心)'과 '청탁수박(淸濁粹駁)이 뒤섞인 기질(氣質)'의 관계를 어떻게 설명하느냐 하는 것이었다. 호론(湖論)에서는 기질(氣質)을 '심(心)의 재질(才質)'로 보아 심(心)과 기질(氣質)을 동위(同位)로 규정했으며, 낙론(洛論)에서는 기질(氣質)을 '이목구비(耳目口鼻)의 형기(形氣)'로 보아 심(心)과 기질(氣質)을 이위(異位)로 규정한 것이다. 그런데 낙론(洛論)의 이위론(異位論)은 이심이성론(二心二性論)에 빠짐은 물론, 성리학의 전반적 체계와도 크게 어긋나는 것이다. 그렇다면 우리는 호론(湖論)의 주장처럼 심(心)과 기질(氣質)을 동위(同位)로 이해해야 할 것이다. 문제는 호론(湖論)이 심(心)과 기질(氣質)을 동위(同位)로 규정하는 데 그치지 않고 동시(同時)로 규정했다는 점이다. 호론(湖論)의 주장처럼 심(心)(담연허명(湛然虛明))과 기질(氣質)(청탁수박(淸濁粹駁))을 동위동시(同位同時)로 규정하면, 인간의 심(心) 성(性)에서 '순선(純善)의 가능근거'를 확보하기 어려운바, 그리하여 낙론(洛論)에서는 호론(湖論)에 대해 "순자(荀子)의 성악설(性惡說)이나 양웅(揚雄)의 성선악혼설(性善惡混說)과 같다"고 비판했던 것이다. 한말(韓末)의 유학자 성암(醒菴) 이철영(李喆榮)은 '담연허명한 심(心)'과 '청탁수박이 뒤섞인 기질(氣質)'의 관계, 즉 '중저미발(中底未發)'과 '부중저미발(不中底未發)'의 관계를 '동위이시(同位異時)'로 규정했는바, 동위이시론(同位異時論)이야말로 심(心)과 기질(氣質)의 관계에 대한 정확한 해명이었던 것이다.

• Animal Bioscience
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• 제34권7호
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• pp.1105-1115
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• 2021

Objective: To conserve and utilize the genetic resources of a traditional Chinese indigenous pig breed, Liangshan pig, we assessed the genetic diversity, genetic structure, and genetic distance in this study. Methods: We used 50K single nucleotide polymorphism (SNP) chip for SNP detection of 139 individuals in the Liangshan Pig Conservation Farm. Results: The genetically closed conserved population consisted of five overlapping generations, and the total effective content of the population (Ne) was 15. The whole population was divided into five boar families and one non-boar family. Among them, the effective size of each generation subpopulation continuously decreased. However, the proportion of polymorphic markers (P_N) first decreased and then increased. The average genetic distance of these 139 Liangshan pigs was 0.2823±0.0259, and the average genetic distance of the 14 boars was 0.2723±0.0384. Thus, it can be deduced that the genetic distance changed from generation to generation. In the conserved population, 983 runs of homozygosity (ROH) were detected, and the majority of ROH (80%) were within 100 Mb. The inbreeding coefficient calculated based on ROH showed an average value of 0.026 for the whole population. In addition, the inbreeding coefficient of each generation subpopulation initially increased and then decreased. In the pedigree of the whole conserved population, the error rate of paternal information was more than 11.35% while the maternal information was more than 2.13%. Conclusion: This molecular study of the population genetic structure of Liangshan pig showed loss of genetic diversity during the closed cross-generation reproduction process. It is necessary to improve the mating plan or introduce new outside blood to ensure long-term preservation of Liangshan pig.

• Journal of Animal Science and Technology
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• 제62권6호
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• pp.777-789
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• 2020

Intense artificial selection has been imposed to Luzhong mutton sheep population in the past years. Improvements on growth and reproductive performance are two breeding goals in the present herd. Although some progresses were phenotypically observed possibly due to inbreeding induced by strong selection in terms of these traits, the genomic evaluation was poorly understood. Therefore, a high-density SNP array was used to characterize the pattern of runs of homozygosity (ROH), estimate inbreeding and inbreeding depressions on early growth performance and litter size based upon ROH, and scan positive selection signatures of recent population. Consequently, a low inbreeding level was observed which had negative effects on litter size, but not on early growth performance. And 160 genes were under selection, of which some were reported to be linked to several traits of sheep including body weight, litter size, carcass and meat quality, milk yield and composition, fiber quality and health, and the top genes were associated with growth (growth hormone [GH]- growth hormone receptor [GHR]- Insulin-like growth factor 1 [IGF1] axis) and litter size (bone morphogenic proteins [BMPs]-associated). The effectiveness of previous breeding measures was highlighted, but purging selection was proposed to alleviate the inbreeding depression on litter size, providing some genomic insights to breeding management of Luzhong mutton sheep.

• 한국정보전자통신기술학회논문지
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• 제15권5호
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• pp.360-366
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• 2022

본 논문은 흑백 사진으로만 남아 있는 한국의 전통 고궁 사진을 적대적 생성 신경망 기법의 하나인 Pix2Pix를 활용하여 컬러 사진으로 복원하기 위한 학습 모델 구조를 제시한다. Pix2Pix는 합성 이미지를 생성기와 합성 여부를 판정하는 판별기의 학습 모델 조합으로 구성된다. 본 논문은 판별기의 수용 영역을 조절하여 인공지능 모델을 학습하고 그 결과를 고궁 사진이 가지는 특성을 고려하여 분석하는 내용을 다룬다. 기존에 흑백 사진 복원에 사용하는 Pix2Pix의 수용 영역은 주로 고정된 크기로 사용하였으나 이미지의 변화가 다양한 고궁 사진을 복원함에 있어서는 고정된 수용 영역을 일률적으로 적용하기에 적합하지 않다. 본 논문에서는 고궁의 특성을 반영할 수 있는 판별기의 수용 영역을 확인하기 위해 기존의 고정된 수용 영역의 크기를 변화시켜 나타나는 결과를 관찰하였다. 실험은 사전에 준비한 고궁 사진을 기반으로 판별기의 수용 영역을 조정하고 모델의 학습을 진행하였다. 판별기의 수용 영역 변화에 따른 모델의 손실을 측정하고 최종 학습한 학습 모델을 복원 대상 흑백 사진에 대입하여 복원 결과를 확인한다.

• Journal of Veterinary Science
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• 제21권1호
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• pp.13.1-13.14
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• 2020

Currently, the systems for culturing buffalo spermatogonial stem cells (SSCs) in vitro are varied, and their effects are still inconclusive. In this study, we compared the effects of culture systems with undefined (foetal bovine serum) and defined (KnockOut Serum Replacement) materials on the in vitro culture of buffalo SSC-like cells. Significantly more DDX4- and UCHL1-positive cells (cultured for 2 days at passage 2) were observed in the defined materials culture system than in the undefined materials system (p < 0.01), and these cells were maintained for a longer period than those in the culture system with undefined materials (10 days vs. 6 days). Furthermore, NANOS2 (p < 0.05), DDX4 (p < 0.01) and UCHL1 (p < 0.05) were expressed at significantly higher levels in the culture system with defined materials than in that with undefined materials. Induction with retinoic acid was used to verify that the cultured cells maintained SSC characteristics, revealing an SCP3+ subset in the cells cultured in the defined materials system. The expression levels of Stra8 (p < 0.05) and Rec8 (p < 0.01) were significantly increased, and the expression levels of ZBTB16 (p < 0.01) and DDX4 (p < 0.05) were significantly decreased. These findings provided a clearer research platform for exploring the mechanism of buffalo SSCs in vitro.

• Korean Chemical Engineering Research
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• 제61권1호
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• pp.123-141
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• 2023

인공신경망을 이용한 모델 개발에서 데이터의 품질은 모델 성능에 큰 영향을 주고, 양질의 충분한 데이터가 인공신경망 훈련을 위해 필요하다. 하지만, 공학 분야에서는 적은 양의 데이터로 모델을 개발해야 하는 경우가 자주 발생한다. 본 논문은 토양에 살포된 축산 분뇨로부터 암모니아 방출량에 대한 적은 수의 데이터(83 개)를 사용하여 인공신경망 모델의 예측 성능을 향상할 수 있는 방안을 제시하였다. Michaelis-Menten 식으로 표현되는 암모니아 방출량 문제는 11개 입력변수에 대하여 2개 출력변수로 구성되었다. 출력변수는 최대 질소 발생량(N_max, kg/ha)과 N_max의 절반에 도달하는 시간(K_m, h) 이다. 범주형 입력변수에 대해 다차원 등간격 기법인 one-hot encoding 을 이용하여 데이터 전처리를 수행하였고, 훈련데이터 66개에 대하여 generative adversarial network (GAN)을 이용하여 13개 데이터를 추가로 보강하였다. 또한, 인공신경망의 초매개변수인 은닉층 수, 각 은닉층 내 뉴런 수, 활성화 함수의 최적 조합을 찾기 위하여 Gaussian process (GP)를 사용하였다. 기존의 인공신경망 구조(Lim et al., 2007) 는 17개 평가데이터에 대하여 mean absolute error (MAE)는 K_m에서 0.0668, N_max에서 0.1860이었다. 본 연구에서 제시된 인공신경망 모델은 K_m에서 0.0414, N_max에서 0.0818로 MAE 가 기존 모델 대비 각각 38%, 56% 감소하였다. 본 연구에서 제시된 방법은 적은 양의 데이터를 갖는 문제에서 인공신경망 성능을 향상하기 위하여 활용할 수 있을 것이다.

• 대한한방내과학회지
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• 제44권2호
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• pp.231-243
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• 2023

Background: Diabetic polyneuropathy is the most common complication in diabetics, occurring in 50% of all cases. About 10-20% of all diabetics are accompanied by neurological pain, showing a tendency to increase with age. Clinical aspects are very diverse, from mild abnormalities on nerve conduction tests to severe abnormalities in all sensory, motor, and autonomic nerves; however, sensory symptoms usually precede motor symptoms. Patients typically express sensory symptoms, such as positive and negative symptoms, which decrease the quality of life and have marked clinical implications, such as increased morbidity and mortality. Although Western medical drugs, such as tricyclic antidepressants, anticonvulsants, and narcotic analgesics, are used for diabetic polyneuropathy, a standard treatment has not been established. Case report: A 65-year-old male with paresthesia and pain due to diabetic polyneuropathy was treated with Uchashinki-hwan, acupuncture, electroacupuncture, moxibustion, and Jungsongouhyul pharmacopuncture for 10 days. We used the Toronto Clinical Neuropathy Scoring System, EuroQol-5 Dimension, and Visual Analog Scale to evaluate symptoms. Subsequently, the Neuropathy Scoring System, EuroQol-5 Dimension, and subjective discomfort improved. Conclusion: The present case report suggests that combined Korean medicine treatment might be an effective treatment for paresthesia and pain with diabetic polyneuropathy. Several follow-up studies should be conducted to clarify the effectiveness of the treatment.

• Nutrition Research and Practice
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• 제17권4호
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• pp.682-697
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• 2023

BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.