• Korean Journal of Plant Resources
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• v.30 no.4
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• pp.378-398
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• 2017

Mt. Deoktaesan(1,113 m) is located in Jinan-gun Baekun-myon and Jangsu-gun Chunchun-myon. Investigated area was decided to include Mt. Deoktaesan, Mt. Seongaksan and its neighbor area, and this study was conducted from March to October, 2015 in 12 days. Based on the voucher, vascular plants in Mt. Deoktaesan were 108 families 341 genera 525 species 4 subspecies 64 varieties 14 forms, totally 607 taxa, which is 12.4% of total Korean flora. Korean endemic plants were 15 species. Among these species, Populus tomentiglandulosa T.B.Lee, Campanula takesimana Nakai and Forsythia koreana (Rehder) Nakai are verified as planted species. Rare and endangered plants of designated by Korea Forest Service were 10 taxa, such as Peucedanum hakuunense Nakai, Paeonia japonica (Makino) Miyabe & Takeda, Koelreuteria paniculata Laxmann, Eranthis stellata Maxim., Eranthis stellata Maxim., Viola albida Palib., Chionanthus retusus Lindl. & Paxton, Campanula takesimana Nakai, Tricyrtis macropoda Miq. and Iris ensata var. spontanea (Makino) Nakai, respectively. Phytogeographical special plants were totally 41 taxa, which were grade 17 taxa of garde I, 12 taxa of grade II, 12 taxa of grade III, 8 taxa of grade IV, and 1 taxon of grade V.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.5 no.1
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• pp.65-75
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• 2005

Purpose: To understand genetic differences and similarities between mucolipidosis and control. Methods: Using the fibroblast of the mucolipidosis II and control, forward and reverse subtracted libraries were constructed. Among these clones, we investigated mutations in the GNPTA (MGC4170) gene, which codes for the ${\alpha}/{\beta}$ subunits of phosphotransferase, and in the GNPTAG gene, which codes for the ${\gamma}$ subunits in 5 Korean patients with mucolipidosis type II or IIIA. Result: Several differentially expressed cDNAs were cloned and their sequences were determined. Mutation analysis of the interested gene, GNPTA was performed and we identified 7 mutations in the GNPTA gene, but none in the GNPTAG gene. The mutations in type II patients included p.Q104X(c.310C>T), p.R1189X(c.3565C>T), p.S1058X(c.3173C>G), p.W894X(c.2681G>A) and p.H1158fsX15(c.3474_3475delTA), all of which are non-sense or frame shift mutations. However, a splicing site mutation, IVS13+1G>A (c.2715+1G>A) was detected along with a non-sense or a frame shift mutation (p.R1189X or p.E858fsX3(c.2574_2575delGA)) in two mucolipidosis type IIIA patients. Conclusion: This report shows that mutations in the GNPTA gene coding for the ${\alpha}{\beta}$subunits of phosphotransferase, and not mutations in the GNPTAG gene, account for most of mutations found in Korean patients with mucolipidosis type II or IIIA.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2818-2824
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• 2014

Trp residue is considered as one of the important constituents in antimicrobial peptides (AMPs) as it presence secured good activities in many cases. However, it is preferable to be changed because of their sensitivity towards light. We have synthesized the short Trp-rich AMP Pac-525 and its analogues to investigate the possibility of His(chx) as possible replacement analogue for Trp in AMPs. Based on the assay result of the antibacterial activity including anti-MRSA activity, His(chx) is considered as good candidate for the Trp replacement. Through these study, we found that His(chx) had several merits to design therapeutic antimicrobial agents compare to Trp in terms of i) increasing antibacterial activity without hemolytic activity, ii) successful in designing the short peptide (only four residues), iii) having anti-MRSA activity, iv) overcoming the light sensitivity. Furthermore, transmission electron microscopy (TEM) and dye leakage experiments suggested that P11 and P16 containing His(chx) kill bacteria via forming pore/ion channels on bacterial cell membranes.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.471-479
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• 2018

Objectives: This study was aimed to analyze the correlation of clinical characteristics of cancer patients treated with Korean Medicine and their natural killer cell activity (NKA). Methods: The medical records of 52 cancer patients who conducted NKA test at Cheonan Korean Medicine Hospital of Daejeon University from March 2016 to May 2018 were reviewed. NKA was determined at Seegene Medical institute using NK Vue Gold(R) kit, evaluating activated $IFN-{\gamma}$ by enzyme immunoassay after incubation of whole blood. Careful investigations were conducted by categorizing the patients by their sex, origin, stage, ECOG scale, and conventional treatment type. We used data from the medical records and statistical analysis using SPSS 25.0 V. Results: The average NKA of all patients was $623.1{\pm}722.0pg/mL$. The NKA value was higher for females than for males. No correlation was evident between age and NKA, but patients aged over 70 years had the lowest NKA average result. Stage III and IV patients showed clearly lower NKA values when compared to stage I and II patients. NKA and ECOG scale values showed no evident relationship. Conclusions: This study presented the characteristics of NKA in cancer patients treated with Korean medicine. The NKA result differed by gender and stage. Based on these findings, further study is needed regarding the clinical meaning of NKA.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.225-225
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• 2010

적외선 영역에서의 밴드갭 에너지를 가지고 있는 III-V 족 화합물 반도체 물질인 $InAs_xSb_{1-x}$는 좋은 성장 안정성과 높은 전자, 홀 이동도를 가지며, 제작 비용이 적게 드는 등 적외선 광소자 제작에 많은 이점을 가지고 있기 때문에 그에 관한 연구가 최근 활발히 진행 되고 있다. 하지만 이러한 $InAs_xSb_{1-x}$를 소자 제작에 이용하기 위해서는 임의의 As 함량에 따른 InAsSb의 물질의 광학적 특성 정보가 필요하다. 본 연구에서는 1.5~6.0 eV 에너지 구간에서 $InAs_xSb_{1-x}$ ($0{\leq}x{\leq}1$) 화합물의 임의의 As 함량에 따른 유전함수를 분석하고 그 분석 변수들을 보고하고자 한다. 기성박막층착장치 (molecular beam epitaxy)를 이용하여 GaAs 기판 위에 성장 시킨 $InAs_xSb_{1-x}$ (x = 0.000, 0.127, 0.337, 0.491, 0.726, 1.000) 박막의 순수한 유전함수 $\varepsilon$을 화학적 에칭을 통해 산화막 층을 제거하여 타원편광분석법을 이용하여 얻었다. 측정된 유전율 함수는 Gaussian-broadened polynomial 들의 합으로서 반도체 물질의 유전함수를 정확히 기술하는 변수화 모델을 이용하여 재현하였다. 변수화 모델을 통해 얻어진 각각의 변수들을 As 조성비 x 에 대한 다항식으로 피팅하여 임의의 As 조성비에 대한 변수 값을 얻었다. 그 결과 임의의 조성비에 따른 $InAs_xSb_{1-x}$ ($0{\leq}x{\leq}1$) 의 유전율 함수를 얻어낼 수 있었다. 우리는 이러한 결과가 물질의 실시간 성장 모니터링이나 다층구조 분석, 광소자의 제작 등에 유용한 정보를 제공할 것으로 확신한다.

• The Journal of Korean Medicine
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• v.32 no.2
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• pp.42-62
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• 2011

Objective: This study was designed to identify and explore the pathological patterns of functional dyspepsia (FD) patients. We also evaluated the usefulness of the Pattern Identification Questionnaire by comparing it with other assessment tools for FD. Methods: We recruited 97 FD patients based on the Rome III criteria for FD diagnosis. The pathological patterns of the subjects were determined by the Pattern Identification Questionnaire. Their dyspepsia-related symptoms were assessed using the Gastrointestinal Symptom Questionnaire (GIS) and the Pyeongwi-san (Pingwei-san) Patternization Questionnaire. Depressive symptoms were evaluated with the Beck Depression Inventory (BDI) and quality of life with the Functional Dyspepsia-Related Quality of Life (FD-QoL) Questionnaire. Tongue coating was measured by the Digital Tongue Diagnosis System (DTDS). Results: The male to female ratio was 1:1.1, and the forties and fifties age groups were largest in number. The spleen deficiency and phlegm-dampness pattern was the most common pattern found among the FD patients. No significant differences in the GIS, BDI, FD-QoL, and DTDS scores were found among the five pattern types. All pattern types showed significant correlation with GIS, Pyeongwi-san Patternization Questionnaire, and FD-QoL scores. Conclusions: Pattern Identification Questionnaire can not only identify the pathological pattern types of FD patients but also evaluate the severity of their symptoms. Compared to conventional assessment tools for FD, it could enable a more dynamic evaluation of FD patients reflecting the severity of dyspeptic symptoms and the quality of life. Further studies on the Pattern Identification of FD patients are anticipated in order to improve the diagnosis and therapy for Korean FD patients.

• The Journal of Korean Physical Therapy
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• v.14 no.2
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• pp.16-25
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• 2002

Low energy laser irradiation(LELI) therapy in physical therapy is widespread but the mechanisms are not fully understood. The purpose of the present study was to examine the epidermal growth factor(EGF)'s expression within lumbar spinal cord which corresponding with crushed extensor digitorum longus(EDL) of rats after low-power laser irradiation applied. After a crushed injury on the right EDL, low-power laser irradiation was applied by using 2000mW, 2000Hz, 830nm GaAlAs(Gallium-aluminum-arsenide) semiconductor diode laser. The laser treatment was performed with 10 minutes daily for 3days. After EDL crush injury, EGF immunoreactive positive neurons in experimental group were progressively decreased from the first to third days. Especially 1 day subgroup is highly expressed in dorsal horn(Lamina I, II, III) and around of central cannal of spinal cord(Lamina VII). Control group was only expressed slightly at 3 days. This study suggests that LELI stimulate that release and migration of EGF in spinal cord, which distict to wound site, therfore promote wound healing of EDL crush injury.

• Journal of Soil and Groundwater Environment
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• v.27 no.5
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• pp.10-17
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• 2022

Inorganic acids such as HCl, HNO₃, and H₂SO₄ have been commonly applied to soil washing of heavy metals-contaminated soil due to their cost-effectiveness. However, implementing the 'Chemical Substance Control Act' requires off-site risk assessment of the chemicals used in the soil washing. Therefore, in this study, organic acids or Fe(III)-based washing agents were evaluated to replace commonly used inorganic acids. Ferric removed heavy metals via H⁺ generated by hydrolysis, which is similar to the HCl used in the control group. Oxalic acid and citric acid were effective to remove Cu, Zn, and Cd from soil. Organic acids could not remove Pb because they could form Pb-organic acid complexes with low solubility. Furthermore, Pb could be adsorbed onto the iron-organic acid complex on the soil surface. Ferric could remove exchangeable-carbonate, Fe-Mn hydroxide, and organic matter and sulfides bound heavy metals (F1, F2, and F3). Organic acids could remove the exchangeable-carbonate and Fe-Mn hydroxide bound metals (F1&F2). Therefore, this research shows that the fractionation of heavy metals in the soil and the properties of washing agents should be considered in the selection of agents in the process design.

• Journal of Korean Biological Nursing Science
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• v.24 no.1
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• pp.17-25
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• 2022

Purpose: To determine the prognostic role of muscle area and muscle radiation attenuation in the erector spinae (ES) and multifidus (MF) muscles in patients undergoing gastrectomy. Methods: Patients with stage I-III gastric cancer undergoing gastrectomy were retrospectively enrolled in this study. Clinicopathologic characteristics were collected and analyzed. Both paraspinal muscle index of ES/MF muscles (PMI_EM) and paraspinal muscle radiation attenuation in the same muscles (PMRA_EM) were analyzed at the 3rd lumbar level using axial computed tomographic images. Cox regression analysis was applied to estimate overall survival (OS) and disease-free survival (DFS). Results: There was only a weak correlation between PMI_EM and PMRA_EM (r= 0.28). Multivariate Cox regression revealed that PMRA_EM, but not PMI_EM, was an important determinant of survival. PMRA_EM along with age, tumor-node-metastasis (TNM) stage, perineural invasion, and serum albumin level were significant determinants of both OS and DFS that constituted Model 1. Harrell's concordance index and integrated area under receiver operating characteristic curve were greater for Model 1 than for Model 2 (consisting of the same covariates as Model 1 except PMRA_EM) or Model 3 (consisting of only TNM stage). Conclusion: PMRA_EM, but not PMIEM, was an important determinant of survival. Because there was only a weak correlation between PMI_EM and PMRA_EM in this study, it was presumed that they were mutually exclusive. Model 1 consisting of age, TNM stage, perineural invasion, serum albumin level, and PMRA_EM was greater than nested models (i.e., Model 2 or Model 3) in predicting survival outcomes.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.4
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• pp.41-47
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• 2022

Ag sintering technologies have received great attention as it was applied to the inverter of Tesla's electric vehicle Model III. Ag sinter bonding technology has advantages in heat dissipation design as well as high-temperature stability due to the intrinsic properties of the material, so it is useful for practical use of SiC and GaN devices. This study was carried out to understand the sinter joining temperature effect on the robust Ag sintered joints in air without pressure within 10 min. Electroplated Ag finished Cu dies (3 mm × 3 mm × 2 mm) and substrates (10 mm × 10 mm × 2 mm) were introduced, respectively, and nano Ag paste was applied as a bonding material. The sinter joining process was performed without pressure in air with the bonding temperature as a variable of 175 ℃, 200 ℃, 225 ℃, and 250 ℃. As results, the bonding temperature of 175 ℃ caused 13.21 MPa of die shear strength, and when the bonding temperature was raised to 200 ℃, the bonding strength increased by 157% to 33.99 MPa. When the bonding temperature was increased to 225 ℃, the bonding strength of 46.54 MPa increased by about 37% compared to that of 200 ℃, and even at a bonding temperature of 250 ℃, the bonding strength exceeded 50 MPa. The bonding strength of Ag sinter joints was directly influenced by changes in the necking thickness and interfacial connection ratio. In addition, developments in the morphologies of the joint interface and porous structure have a significant effect on displacement. This study is systematically discussed on the relationship between processing temperatures and bonding strength of Ag sinter joints.