• Nuclear Engineering and Technology
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• v.56 no.5
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• pp.1845-1853
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• 2024

The setpoint of the reactor trip system shall be set to consider the measurement uncertainty of the instrument channel and provide a reasonable and sufficient margin between the analytical limit and the trip setpoint. A comparative analysis was conducted to find out an appropriate uncertainty combination method through an example problem. The four methods were evaluated; 1) ISA-67.04.01 method, 2) the GUM95 method, 3) the modified GUM method developed by Fotowicz, and 4) the modified IEC61888 method proposed by authors for the pressure instrument channel presented in ISA-RP67.04.02 example. The appropriateness of each method was validated by comparing it with the result of Monte Carlo simulation. As a result of the evaluation, all methods are appropriate when all measurement uncertainty elements are normally distributed as expected. But ISA-67.04 method and GUM95 method overestimated the channel uncertainty if there is a dominant input element with rectangular distribution among the uncertainty input elements. Modified GUM95 methods developed by Fotowicz and modified IEC61888 method by authors are able to produce almost the same level of channel uncertainty as the Monte Carlo method, even when there is a dominant rectangular distribution among the uncertainty components, without computer-assisted simulations.

• Biomolecules & Therapeutics
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• v.22 no.2
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• pp.161-165
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• 2014

The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in solution increased with increasing concentrations of gellan gum. In vitro study showed that the release of ranitidine from these gels was characterized by an initial phase of high release (burst effect) and translated to the second phase of moderate release. Single photon emission computing tomography technique was used to evaluate the stomach residence time of gel containing $^{99m}Tc$ tracer. The animal experiment suggested in situ gel had feasibility of forming gels in stomach and sustained the ranitidine release from the gels over the period of at least 8 h. In conclusion, the in situ gel system is a promising approach for the oral delivery of ranitidine for the therapeutic effects improvement.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.67-72
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• 2023

A simple and accurate method was developed for the quantitative analysis of oleanonic acid (OA) from mastic gum. The analysis was carried out using reverse-phase high-performance liquid chromatography combined with a photodiode array detector (HPLC/PDA). Our optimized method was validated by measuring various parameters, using an INNO C18 column fitted with a gradient elution system. The results revealed limits of detection and quantification of 0.34 and 1.042 ㎍/mL, respectively. The OA calibration curve exhibited excellent linearity over the concentration range of 0.0625 to 2.0 mg/mL, with r² =0.9996. Accuracy tests revealed a high recovery rate of 99.44-103.66%, with precision values below 0.15%. These results suggest that the present analytical method can identify and quantify OA in mastic gum with high precision. The HPLC approach developed in this study might be applied to routine analyses and large-scale extraction procedures for OA content quantification.

• KSBB Journal
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• v.5 no.3
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• pp.235-240
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• 1990

A quantitative physiological approach has been employed to estimate the metabolic parameters such as specific uptake rates of nutrients and specific production rate in continuous culture of Pseudomonas elodea for gellan gum production. The estimated values of metabolic parameters are used for process improvement. During the exponential growth phase, the specific growth rate was 0.16hr-1 in batch culture. The gellan gum concentration increased up to 0.7g dry weight/100g broth and the apparent viscosity of the culture broth was about 4,500 cp.(72hrs culture). The ratio of specific uptake rate of carbon to that of nitrogen were found to be optimum at about 3.0mg-carbon/mg-nitro-gen. With the improved medium, the maximum gellan production rate, 0.6g dry weight/1/hr, was obtained at D=0.14 hr-1. The shear stresses of culture broth were fairly well correlated with shear rates by using Casson equation and at highly viscous culture broth, oxygen transfer coefficient was greatly reduced.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.7
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• pp.977-987
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• 2019

Objective: The use of tannin extract and other phytochemicals as dietary additives in ruminants is becoming more popular due to their wide biological actions such as in methane mitigation, bypass of dietary protein, intestinal nematode control, among other uses. Unfortunately, some have strong astringency, low stability and bioavailability, and negatively affecting dry matter intake and digestibility. To circumvent these drawbacks, an effective delivery system may offer a promising approach to administer these extracts to the site where they are required. The objectives of this study were to encapsulate acacia tannin extract (ATE) with native starch and maltodextrin-gum arabic and to test the effect of encapsulation parameters on encapsulation efficiency, yield and morphology of the microparticles obtained as well as the effect on rumen in vitro gas production. Methods: The ATE was encapsulated with the wall materials, and the morphological features of freeze-dried microparticles were evaluated by scanning electron microscopy. The in vitro release pattern of microparticles in acetate buffer, simulating the rumen, and its effect on in vitro gas production was evaluated. Results: The morphological features revealed that maltodextrin/gum-arabic microparticles were irregular shaped, glossy and smaller, compared with those encapsulated with native starch, which were bigger, and more homogenous. Maltodextrin-gum arabic could be used up to 30% loading concentration compared with starch, which could not hold the core material beyond 15% loading capacity. Encapsulation efficiency ranged from $27.7%{\pm}6.4%$ to $48.8%{\pm}5.5%$ in starch and $56.1%{\pm}4.9%$ to $64.8%{\pm}2.8%$ in maltodextrin-gum arabic microparticles. Only a slight reduction in methane emission was recorded in encapsulated microparticles when compared with the samples containing only wall materials. Conclusion: Both encapsulated products exhibited the burst release pattern under the pH conditions and methane reduction associated with tannin was marginal. This is attributable to small loading percentages and therefore, other wall materials or encapsulation methods should be investigated.

• Geomechanics and Engineering
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• v.12 no.6
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• pp.871-882
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• 2017

Indirect measure of the tensile strength of laboratory samples is an important topic in rock engineering. One of the most important tests, the Brazilian strength test is performed to obtain the tensile strength of rock, concrete and other quasi brittle materials. Because the measurements are provided indirectly and the inspected rock materials may have heterogeneous properties, uncertainty quantification is required for a reliable test evaluation. In addition to the conventional measurement evaluation uncertainty methods recommended by the Guide to the Expression of Uncertainty in Measurement (GUM), such as Taylor's and Monte Carlo Methods, a fuzzy set-based approach is also proposed and resulting uncertainties are discussed. The results showed that when a tensile strength measurement is measured by a laboratory test, its uncertainty can also be expressed by one of the methods presented.

• Phonetics and Speech Sciences
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• v.1 no.4
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• pp.133-144
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• 2009

This paper presents a method for constructing and using transliteration rules which are based on Phonics, an instructional method for speaking and writing English letters. Conventional approaches to automatic transliteration often focused on statistical methods. However, the construction or the collection of correct transliteration examples is always the bottleneck of the statistical transliteration model. Also, in practical domains where the collection of such data is very difficult, such as education and tourism, it is reasonable to build a system without much qualified data. Furthermore, compared with Korean orthography of borrowed foreign words, the proposed approach is much easier to construct, and can generate more refined rules. The experimentation result shows that the proposed approach can improve the performance of a statistical-based transliteration system.

• Journal of the Korean Applied Science and Technology
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• v.27 no.4
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• pp.407-414
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• 2010

New biological treatments were being developed at a record place, but their potential could be compromised by a significant obstacle: the delivery of these drugs into a body. Pharmaceutical delivery is now nearly as important as product. New systems are being developed, and Drug Delivery Markets Series cover these new systems. Transdermal Delivery System(TDS) is often used as a method of drug dosage into the epidermic skin. An approach used to delivery drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other methods of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharides, such as karaya gum and glucomannan, were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, drug contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in fibric acid(ciprofibrate) such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. Especially, this result suggests a possible use of polysaccharide gel ointment matrix as a transdermal delivery system of anti-hyperlipoproteinemic agent.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.4
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• pp.239-247
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• 2022

Objective: Asafoetida is a gum derived from Ferula assa-foetida, which is used in traditional Iranian medicine to treat some reproductive system disorders. The effects of asafoetida on ovarian tissue, expression of certain genes associated with polycystic ovary syndrome (PCOS), and levels of liver, kidney, and blood cell factors after treatment in a rat model were investigated. Methods: Thirty rats were divided into five groups: normal, polycystic, and treatment with three doses of asafoetida (12.5, 25, and 50 mg/kg for 3 weeks after PCOS induction). PCOS was induced by letrozole at a dose of 1 mg/kg administered orally for 3 weeks. Blood samples were taken, and the ovaries were removed and prepared for histomorphometric examination. Liver and kidney parameters were measured. The mRNA expression levels of luteinizing hormone receptor, CYP11A1, adenosine monophosphate-activated protein kinase, adiponectin, and adiponectin receptors 1 and 2 were also measured by real-time polymerase chain reaction. Results: The levels of liver, kidney, and blood parameters did not significantly differ between the treatment groups and the control group. At doses of 25 and 50 mg/kg, ovarian histopathology, especially the thicknesses of the theca and granulosa layers, was significantly improved relative to the PCOS group. The expression of target genes also improved in the 25 and 50 mg/kg treatment groups. Conclusion: Asafoetida can be used to treat PCOS as a complementary approach to conventional therapies. Asafoetida appears to act by regulating and activating metabolic and ovarian cycle enzymes.

• Analytical Science and Technology
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• v.15 no.6
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• pp.580-583
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• 2002

New approach is developed employing the overall uncertainty obtained from multiple measurements to evaluate the statistical significance for the difference between a given reference value and its measured value determined in a lab. The overall uncertainty is determined by separate combinations of the uncertainties arising from systematic and random effects. It is shown that the uncertainty term in regular t-test can be underestimated by n measurements.