• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.6
• /
• pp.627-636
• /
• 2018

Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have been reported to be significantly involved. The efficacy of 6-shogaol on proliferation of endometriotic lesions and inflammatory pathways in experimentally-induced EM model was explored in this study. EM was stimulated in Sprague-Dawley rats by implantation of autologous endometrium onto the peritoneum abdominal wall. Separate groups were treated with 6-shogaol (50, 100 or 150 mg/kg b.wt/day) via oral gavage for one month period. Gestrinone (GTN) group received GTN (0.5 mg/kg/day) as positive control. Five weeks after implantation, the spherical volume of ecto-uterine tissues was determined. Treatment with 6-shogaol significantly reduced the implant size. Histological analysis reported atrophy and regression of the lesions. 6-shogaol administration effectively down-regulated $NF-{\kappa}B$ signaling, VEGF and VEGFR-2 (Flk-1) expression in the endometriotic lesions. Excess production of $IL-1{\beta}$ and IL-6 (pro-inflammatory cytokines), PGE2 and nitric oxide (NO) were reduced. Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and $COX-2/NF-{\kappa}B$-mediated inflammatory cascades.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.18
• /
• pp.8321-8325
• /
• 2016

Background: The incidence of hydatidiform mole (HM) differs among regions but has declined significantly over time. In Thailand, the initiation of universal health coverage in 2002 has resulted in a change of medical services countrywide. However, impacts of these policies on gestational trophoblastic disease (GTD) cases in Thailand have not been reported. This study aimed to find the incidence of hydatidiform mole (HM) in King Chulalongkorn Memorial Hospital (KCMH) from 1994-2013, comparing before and after the implementation of the universal coverage health policy. Materials and Methods: All cases of GTD in KCMH from 1994-2013 were reviewed from medical records. The incidence of HM, patient characteristics, treatment and remission rates were compared over two study decades between 1994-2003 and 2004-2013. Results: Hydatidiform mole cases decreased from 204 cases in the first decade to 111 cases in the seond decade. Overall incidence of HM was 1.70 per 1,000 deliveries. The incidence of HM in the first and second decades were 1.70 and 1.71 per 1,000 deliveries, respectively (p=0.65, 95%CI 1.54-1.88). Referred cases of nonmolar gestational trophoblastic neoplasia (GTN) increased from 12 (4.4%) to 23 (14.4%, p<0.01). Vaginal bleeding was the most common presenting symptom which decreased from 89.4% to 79.6% (p=0.02). Asymptomatic HM patients increased from 4.8% to 10.2% (p=0.07). Rate of postmolar GTN was 26%. Conclusions: The number of HM cases in this study decreased over 2 decades but incidence was unchanged. Referral rates of malignant cases were more common after universal health coverage policy initiation. Classic clinical presentation was decreased significantly in the last decade.

• Journal of the Korea Society of Computer and Information
• /
• v.18 no.1
• /
• pp.83-91
• /
• 2013

As humans perform many tasks using computers, HCI(Human-Computer Interaction) has received much attention these days. One objective of HCI research is to propose how to design more consistent systems. In order to evaluate the consistency of HCI devices from the user's perspective, several models such as TAG(Task Action Grammar), GOMS(Goals-Operators-Methods-Selection Rule), and GTN(General Transition Network) have been developed. TAG specifies actions to perform tasks in terms of rule schema. It has been verified that the less the number of rule schema is, the better users perform the tasks due to assumably higher consistency. This paper hypothesizes that the consistency of systems depends not only on the number of rule schema but also on the distances between rule schema. That is, the closer the rule schema are, the easier it is to acquire the whole set of rule schema. An experiment supported this hypothesis. Therefore, distances between rule schema should be considered as well as the number of rule schema when designing systems.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.22 no.6
• /
• pp.541-548
• /
• 2009

In this study, Charpy impact test and numerical studies were performed to examine the effects of failure behavior and energy absorption on the notch position. For this purpose, carbon steel plate(SA-516 Gr. 70) with thickness of 25mm usually used for pressure vessel was welded by SMAW(Shielded Metal-Arc Welding)method and specimens were fabricated from the welded plate. The Charpy impact tests were then performed with specimens having different notch positions varying within HAZ. A series of three-dimensional FE analysis which simulates the Charpy test and crack propagation are carried out as well. We divided HAZ into two, three and four regions to apply mechanical properties of HAZ to FE-analys. Results reveal that the absorbed energies during impact test depend significantly on the notch position. To obtain the results of reliability, HAZ should be divided into at least three regions.

• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.49-54
• /
• 2004

Several cell models, so-called local approach, have been proposed as engineering approaches to numerically simulate ductile fracture characteristics. In this paper, two- and three-dimensional finite element analyses incorporating both modified GTN and Rousselier models were carried out. Smooth and notched bars and CT25 specimens were assessed for StE460 and DIN22NiMoCr37 materials which were quoted from previous researches. Micro-mechanical parameters used in the assessment were established by fitting the numerical results with the experiments, and J-R curves derived from the simulations were found to be in good agreement with the corresponding experimental results.

• Advances in nano research
• /
• v.3 no.1
• /
• pp.13-27
• /
• 2015

Size dependent emission properties and the interband optical transition energies in group-III nitride based quantum dots are investigated taking into account the geometrical confinement. Exciton binding energy and the optical transition energy in $Ga_{0.9}In_{0.1}N$/GaN and $Al_{0.395}In_{0.605}N$/AlN quantum dots are studied. The largest intersubband transition energies of electron and heavy hole with the consideration of geometrical confinement are brought out. The interband optical transition energies in the quantum dots are studied. The exciton oscillator strength as a function of dot radius in the quantum dots is computed. The interband optical absorption coefficients in GaInN/GaN and AlInN/AlN quantum dots, for the constant radius, are investigated. The result shows that the largest intersubband energy of 41% (10%) enhancement has been observed when the size of the dot radius is reduced from $50{\AA}$ to $25{\AA}$ of $Ga_{0.9}In_{0.1}N$/GaN ($Al_{0.395}In_{0.605}N$/AlN) quantum dot.

• Journal of Korea Port Economic Association
• /
• v.18 no.2
• /
• pp.47-64
• /
• 2002

Global Shipping companies and harbor facilities have tried to construct e-business network to strengthen the competitiveness in this rapidly changing cyber environment. from now on, in a few years, it will be backward enterprises and business that could not adapt this e-business currency, international shipping companies has been together The intta and The GTnexus web site for customer need to fulfill Gradually this currency is going to expand in the world The goal of this research is to study up-to-date internet marketing strategy and global shipping company's present condition of on-line marketing. it will be helpful to make domestic marketing business competitive and to acquire superior position for Domestic shipping company in market.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3625-3628
• /
• 2014

Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.1
• /
• pp.387-390
• /
• 2012

A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a salvage setting was unclear. To evaluate the efficacy and safety of the 5 FU plus Act D regimen utilized in this condition, all GTN patients resistant to at least three previous chemotherapy regimens who received the 5 FU plus Act D regimen between August 2009 and January 2011 at Chiang Mai University Hospital were reviewed. There were five cases who met the criteria. Four of those patients were in FIGO stage III to IV with a WHO scoring of more than 12. The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.30 no.4 s.247
• /
• pp.393-401
• /
• 2006

The influences of stress triaxiality on ductile fracture have been investigated for various specimens and structures. With respect to a transferability issue, recently, the interests on local approaches reflecting micromechanical specifics are increased again due to rapid progress of computational environments. In this paper, the applicability of the local approaches has been examined through a series of finite element analyses incorporating modified GTN and Rousselier models as well as fracture toughness tests. The ductile crack growth of nuclear carbon steels is assessed to verify the transferability among compact tension (CT) specimens with different in-plane size. At first, the basic material constants were calibrated for standard CT specimens and used to predict fracture resistance (J-R) curves of larger CT specimens. Then, the in-plane size effects were examined by comparing the numerically estimated J-R curves with the experimentally determined ones. The assessment results showed that the in-plane size effect should be considered for realistic engineering application and the damage models might be used as useful tool for ductile fracture evaluation.