• Korean Journal of Pharmacognosy
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• v.37 no.4 s.147
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• pp.246-252
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• 2006

Processing of traditional herbal medicine is one of the pharmaceutical technique in oriental medicine. Most frequently used processing method in oriental medicine are roasting and steaming. In this studies, to elucidate the pharmacological transformation of traditional herbal medicine by means of processing them, Ginseng Radix (root of Panax ginseng, Araliaceae) was used as a sample. Processed ginseng radix (SGR, Sun Ginseng) was prepared by steaming of roots of white ginseng (GR) for 3 hours at $120^{\circ}C$. The biological activities of methanol extract of GR and SGR were investigated. According to DPPH radical scavenging effects, and inhibitory effects of xanthine oxidase and AAPH induced hemolysis, PGR exhibited more effective than those of GR in vitro. And, the antifatigue effect of GR and SGR were investigated using a weight-loading forced swimming test by monitoring swimming times and prolonged intensity exercise model rats by measuring blood biochemical parameters. GR and SGR were significantly prolonged swimming times in 8% body weight ratio loaded mice. Also, they had the inhibitory effects on the decrease of blood glucose levels, the elevation of serum creatinine, lactic acid and free fatty acid, and lactic dehydrogenase activities in forces swimming rats with 1% of the body weight attached to the neck for 3 hours. SGR was more excellent than GR on these effect. Also, these effects were transformed to the n-butanol fraction of methanol extract of SGR. From these results, it can be considered that SGR has antifatigue effect.

• Korean Journal of Acupuncture
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• v.24 no.3
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• pp.117-137
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• 2007

Objectives & Methods : The purpose of this study is to observe the effects of Gentianae macrophyllase Radix herbal-acupuncture solution(GR-HAS) at Joksamni(ST36) on Collagen-induced arthritis(CIA) in DBA/1J mice. The author performed several experimental items to analyze arthritis evaluation, change of weight, spleen size and adhesion rate, change of cytokine level, IgG, IgM and anti-collagen II , change of immunocyte count, histological change of CIA mouse joint related with RA. Results : 1. In the GR-HA group, the arthritis index, the incidence of arthritis and joint edema were significantly decreased. 2. In GR-HA group, there were no weight loss and similarly maintained as normal group. Spleen size, adhesion rate and the edema and transformation of knee joint were low and similarly maintained as normal group. 3. In the GR-HA, cytokine level, IgG, IgM and anti-collagen II were significantly decreased. 4. In the GR-HA, the change of immunocyte count were similarly maintained as normal group. 5. In the histological changes of the CIA mouse joint, the cartilage destruction and synovial cell proliferation were decreased in the GR-HA(Hematoxylin and eosin stain). The collagen fiber expressions in the GR-HA were similar with that of the normal group(Masson's Trichrome stain) Conclusions : These results suggest that GR-HA at ST36 has an effect to control immune reaction and suppress inflammation, synovial cell proliferation and cartilage destruction in rheumatoid arthritis.

• Journal of the Korean Society of Safety
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• v.21 no.4 s.76
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• pp.49-54
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• 2006

The evaluation of elastic-plastic fracture characteristic was investigated in ferrite steel SA 516- Gr70 used for reactor coolant piping elbow and support skirt of pressure vessels. This paper describes the effect of temperature on J-R curve characteristic of this material. The elastic-plastic fracture mechanics parameter J is obtained with unloading compliance method. The test method were analyzed according to ASTM E 813-89 and E 1152-89. Unloading compliance $J_{IC}$ tests were performed on 1 CT specimens at varied temperatures from $25^{\circ}C$ to about $400^{\circ}C$ using a high temperature extensometer. At all temperature, valid $J_{IC}$ measurements could be made and $J_{IC}$ decreased with increasing temperature. SEM fractography schematically illustrates microvoid initiation, growth and coalescence at the tip of a preexisting crack.

• Proceedings of the Korean Nuclear Society Conference
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• 1995.05a
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• pp.771-776
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• 1995

Tensile and J-R tests were carried out to estimate the effects of dynamic strain aging(DSA) on SA106Gr.C piping steel. Tensile tests were performed under temperature range RT to $400^{\circ}C$ md strain rates from $1.39{\times}10^{-4}\;to\;6.95{\times}10^{-2}/s$. Fracture toughness was tested in the temperature range RT to $350^{\circ}C$ and load-line displacement rates 0.4 and 4mm/min. The effects of DSA on the tensile properties were clearly observed for phenomena such serrated flow, variation of ultimate and yield stress, and negative stram rate sensitivity. However, the magnitude of serration and strength increase by DSA was relatively small. this may be due to high ratio of Mn to C. In addition, crack initiation resistance, Ji and crack growth resistance, dJ/da were reduced in the range of $200-300^{\circ}C$, where DSA appeared as serrated flow and UTS hardening. The temperature corresponding to minimum fracture resistance was shifted to higher temperature with increasing loading rate.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.428-428
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• 2017

In this study, three optimization techniques efficiency is assessed for calibration of the GR4J model for streamflow simulation in Selmacheon, Boryeong Dam and Kyeongancheon watersheds located in South Korea. The Penman-Monteith equation is applied to estimate the potential evapotranspiration, model calibration, and validation is carried out using the readily available daily hydro-meteorological data. The Shuffled Complex Evolution-University of Arizona(SCE-UA), Uniform Adaptive Monte Carlo (UAMC), and Coupled Latin Hypercube and Rosenbrock (CLHR) optimization techniques has been used to evaluate the robustness, performance and optimized parameters of the three catchments. The result of the three algorithms performances and optimized parameters are within the recommended ranges in the tested watersheds. The SCE-UA and CLHR outputs are found to be similar both in efficiency and model parameters. However, the UAMC algorithms performances differently in the three tested watersheds.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.43-54
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• 2023

Due to climate change, drought and flood occurrences have been increasing. Accurate projections of watershed discharges are imperative to effectively manage natural disasters caused by climate change. However, climate change and hydrological model uncertainty can lead to imprecise analysis. To address this issues, we used two lumped models, IHACRES and GR4J, to compare and analyze the changes in discharges under climate stress scenarios. The Hapcheon and Seomjingang dam basins were the study site, and the Nash-Sutcliffe efficiency (NSE) and the Kling-Gupta efficiency (KGE) were used for parameter optimizations. Twenty years of discharge, precipitation, and temperature (1995-2014) data were used and divided into training and testing data sets with a 70/30 split. The accuracies of the modeled results were relatively high during the training and testing periods (NSE>0.74, KGE>0.75), indicating that both models could reproduce the previously observed discharges. To explore the impacts of climate change on modeled discharges, we developed climate stress scenarios by changing precipitation from -50 % to +50 % by 1 % and temperature from 0 ℃ to 8 ℃ by 0.1 ℃ based on two decades of weather data, which resulted in 8,181 climate stress scenarios. We analyzed the yearly maximum, abundant, and ordinary discharges projected by the two lumped models. We found that the trends of the maximum and abundant discharges modeled by IHACRES and GR4J became pronounced as changes in precipitation and temperature increased. The opposite was true for the case of ordinary water levels. Our study demonstrated that the quantitative evaluations of the model uncertainty were important to reduce the impacts of climate change on water resources.

• Journal of Korea Water Resources Association
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• v.54 no.12
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• pp.1295-1304
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• 2021

For the efficient use and management of water resources, a reliable rainfall-runoff analysis is necessary. Still, continuous hydrological data and rainfall-runoff data are insufficient to secure through measurements and models. In particular, as part of the reasonable improvement of a rainfall-runoff model in the case of an ungauged watershed, regionalization is being used to transfer the parameters necessary for the model application to the ungauged watershed. In this study, the GR4J model was selected, and the SCEM-UA method was used to optimize parameters. The rainfall-runoff model for the analysis of the correlation between watershed characteristics and parameters obtained through the model was regionalized by the Copula function, and rainfall-runoff analysis with the regionalized parameters was performed on the ungauged watershed. In the process, the intermediate state variables of the rainfall-runoff model were extracted, and the correlation analysis between water level and the ground water level was investigated. Furthermore, in the process of rainfall-runoff analysis, the Standardized State variable Drought Index (SSDI) was calculated by calculating and indexing the state variables of the GR4J model. and the calculated SSDI was compared with the standardized Precipitation index (SPI), and the hydrological suitability evaluation of the drought index was performed to confirm the possibility of drought monitoring and application in the ungauged watershed.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.258-266
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• 2020

Background: Oxidative stress-induced cardiomyocytes apoptosis is a key pathological process in ischemic heart disease. Glutathione reductase (GR) reduces glutathione disulfide to glutathione (GSH) to alleviate oxidative stress. Ginsenoside Rb1 (GRb1) prevents the apoptosis of cardiomyocytes; however, the role of GR in this process is unclear. Therefore, the effects of GRb1 on GR were investigated in this study. Methods: The antiapoptotic effects of GRb1 were evaluated in H9C2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, annexin V/propidium iodide staining, and Western blotting. The antioxidative effects were measured by a reactive oxygen species assay, and GSH levels and GR activity were examined in the presence and absence of the GR inhibitor 1,3-bis-(2-chloroethyl)-1-nitrosourea. Molecular docking and molecular dynamics simulations were used to investigate the binding of GRb1 to GR. The direct influence of GRb1 on GR was confirmed by recombinant human GR protein. Results: GRb1 pretreatment caused dose-dependent inhibition of tert-butyl hydroperoxide-induced cell apoptosis, at a level comparable to that of the positive control N-acetyl-L-cysteine. The binding energy between GRb1 and GR was positive (-6.426 kcal/mol), and the binding was stable. GRb1 significantl reduced reactive oxygen species production and increased GSH level and GR activity without altering GR protein expression in H9C2 cells. Moreover, GRb1 enhanced the recombinant human GR protein activity in vitro, with a half-maximal effective concentration of ≈2.317 μM. Conversely, 1,3-bis-(2-chloroethyl)-1-nitrosourea co-treatment significantly abolished the GRb1's apoptotic and antioxidative effects of GRb1 in H9C2 cells. Conclusion: GRb1 is a potential natural GR agonist that protects against oxidative stress-induced apoptosis of H9C2 cells.

• Transactions of the KSME C: Technology and Education
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• v.4 no.2
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• pp.101-109
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• 2016

The material properties of heat resistant materials at power plants are affected by thermal aging as operating time is accumulated. In this study, the influence of thermal aging on yield strength, tensile strength and fracture behavior for Mod.9Cr-1Mo (ASME Grade 91) steel which is a material widely adopted for Generation IV nuclear energy system has been investigated and analyzed. Service exposed Gr.91 steel materials sampled from a piping system of an ultra-supercritical (USC) plant in Korea with accumulated operation time of 73,716 hours were used for material testing. The test results of the service exposed material specimens were compared with those of the virgin Gr.91 steel specimens. Those test data were compared with the material properties of ASME code and RCC-MRx code. Conservatisms of the material properties in the design codes have been quantified based on the comparisons of those from virgin and service exposed material specimens.

• Journal of Welding and Joining
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• v.34 no.3
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• pp.61-68
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• 2016

Characteristics of dissimilar metal welds between alloy steel ASTM A387 Gr. 91 and carbon steel ASTM A516 Gr.70 made with Flux cored arc welding(FCAW) have been evaluated in terms of microstructure, mechanical strength, chemical analysis by EDS as well as corrosion test. Three heat inputs of 15.0, 22.5, 30.0kJ/cm were employed to make joints of dissimilar metals with E91T1-B9C wire. Post-weld heat treatment was carried out at $750^{\circ}C$ for 2.5 h. Based on microstructural examination, tempered martensite and lower bainite were formed in first layer of weld metal. The amount of tempered martensite was decreased and the amount of lower bainite was increased with increasing heat input and layer. Heat affected zone of alloy steel showed the highest hardness due to the formation of tempered Martensite and lower Bainite. Tensile strengths of dissimilar welds decreased with increasing heat inputs. Dissimilar welds seemed to have a good hot cracking resistance due to the low HCS index below 4. The salt spray test of dissimilar metals showed that the corrosion rate increased with increasing heat inputs due to the increase of the amount of lower Bainite.