• 생약학회지
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• 제37권4호
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• pp.246-252
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• 2006

Processing of traditional herbal medicine is one of the pharmaceutical technique in oriental medicine. Most frequently used processing method in oriental medicine are roasting and steaming. In this studies, to elucidate the pharmacological transformation of traditional herbal medicine by means of processing them, Ginseng Radix (root of Panax ginseng, Araliaceae) was used as a sample. Processed ginseng radix (SGR, Sun Ginseng) was prepared by steaming of roots of white ginseng (GR) for 3 hours at $120^{\circ}C$. The biological activities of methanol extract of GR and SGR were investigated. According to DPPH radical scavenging effects, and inhibitory effects of xanthine oxidase and AAPH induced hemolysis, PGR exhibited more effective than those of GR in vitro. And, the antifatigue effect of GR and SGR were investigated using a weight-loading forced swimming test by monitoring swimming times and prolonged intensity exercise model rats by measuring blood biochemical parameters. GR and SGR were significantly prolonged swimming times in 8% body weight ratio loaded mice. Also, they had the inhibitory effects on the decrease of blood glucose levels, the elevation of serum creatinine, lactic acid and free fatty acid, and lactic dehydrogenase activities in forces swimming rats with 1% of the body weight attached to the neck for 3 hours. SGR was more excellent than GR on these effect. Also, these effects were transformed to the n-butanol fraction of methanol extract of SGR. From these results, it can be considered that SGR has antifatigue effect.

• Korean Journal of Acupuncture
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• 제24권3호
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• pp.117-137
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• 2007

Objectives & Methods : The purpose of this study is to observe the effects of Gentianae macrophyllase Radix herbal-acupuncture solution(GR-HAS) at Joksamni(ST36) on Collagen-induced arthritis(CIA) in DBA/1J mice. The author performed several experimental items to analyze arthritis evaluation, change of weight, spleen size and adhesion rate, change of cytokine level, IgG, IgM and anti-collagen II , change of immunocyte count, histological change of CIA mouse joint related with RA. Results : 1. In the GR-HA group, the arthritis index, the incidence of arthritis and joint edema were significantly decreased. 2. In GR-HA group, there were no weight loss and similarly maintained as normal group. Spleen size, adhesion rate and the edema and transformation of knee joint were low and similarly maintained as normal group. 3. In the GR-HA, cytokine level, IgG, IgM and anti-collagen II were significantly decreased. 4. In the GR-HA, the change of immunocyte count were similarly maintained as normal group. 5. In the histological changes of the CIA mouse joint, the cartilage destruction and synovial cell proliferation were decreased in the GR-HA(Hematoxylin and eosin stain). The collagen fiber expressions in the GR-HA were similar with that of the normal group(Masson's Trichrome stain) Conclusions : These results suggest that GR-HA at ST36 has an effect to control immune reaction and suppress inflammation, synovial cell proliferation and cartilage destruction in rheumatoid arthritis.

• 한국안전학회지
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• 제21권4호
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• pp.49-54
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• 2006

The evaluation of elastic-plastic fracture characteristic was investigated in ferrite steel SA 516- Gr70 used for reactor coolant piping elbow and support skirt of pressure vessels. This paper describes the effect of temperature on J-R curve characteristic of this material. The elastic-plastic fracture mechanics parameter J is obtained with unloading compliance method. The test method were analyzed according to ASTM E 813-89 and E 1152-89. Unloading compliance $J_{IC}$ tests were performed on 1 CT specimens at varied temperatures from $25^{\circ}C$ to about $400^{\circ}C$ using a high temperature extensometer. At all temperature, valid $J_{IC}$ measurements could be made and $J_{IC}$ decreased with increasing temperature. SEM fractography schematically illustrates microvoid initiation, growth and coalescence at the tip of a preexisting crack.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(2)
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• pp.771-776
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• 1995

Tensile and J-R tests were carried out to estimate the effects of dynamic strain aging(DSA) on SA106Gr.C piping steel. Tensile tests were performed under temperature range RT to $400^{\circ}C$ md strain rates from $1.39{\times}10^{-4}\;to\;6.95{\times}10^{-2}/s$. Fracture toughness was tested in the temperature range RT to $350^{\circ}C$ and load-line displacement rates 0.4 and 4mm/min. The effects of DSA on the tensile properties were clearly observed for phenomena such serrated flow, variation of ultimate and yield stress, and negative stram rate sensitivity. However, the magnitude of serration and strength increase by DSA was relatively small. this may be due to high ratio of Mn to C. In addition, crack initiation resistance, Ji and crack growth resistance, dJ/da were reduced in the range of $200-300^{\circ}C$, where DSA appeared as serrated flow and UTS hardening. The temperature corresponding to minimum fracture resistance was shifted to higher temperature with increasing loading rate.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.428-428
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• 2017

In this study, three optimization techniques efficiency is assessed for calibration of the GR4J model for streamflow simulation in Selmacheon, Boryeong Dam and Kyeongancheon watersheds located in South Korea. The Penman-Monteith equation is applied to estimate the potential evapotranspiration, model calibration, and validation is carried out using the readily available daily hydro-meteorological data. The Shuffled Complex Evolution-University of Arizona(SCE-UA), Uniform Adaptive Monte Carlo (UAMC), and Coupled Latin Hypercube and Rosenbrock (CLHR) optimization techniques has been used to evaluate the robustness, performance and optimized parameters of the three catchments. The result of the three algorithms performances and optimized parameters are within the recommended ranges in the tested watersheds. The SCE-UA and CLHR outputs are found to be similar both in efficiency and model parameters. However, the UAMC algorithms performances differently in the three tested watersheds.

• 대한토목학회논문집
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• 제43권1호
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• pp.43-54
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• 2023

기후변화가 고착화되면서 강수와 기온 변동으로 인한 가뭄 및 홍수 발생이 증가하고 있다. 유역 단위의 유출량 예측은 기후변화로 인한 자연재해에 대비하기 위한 수자원 관리의 시작이라 할 수 있다. 하지만, 기후변화와 유출모형의 불확실성은 정확한 유출 분석을 어렵게 한다. 본 연구에서는 이러한 불확실성을 완화하기 위하여 기후 스트레스 시나리오에 따른 두 개의 집중형 수문모형, 즉 IHACRES와 GR4J를 이용하여 강수 및 기온 변화에 따른 유출량 변화를 비교, 분석하였다. 연구 대상 지역은 합천댐과 섬진강댐 유역이며, Nash-Sutcliffe Efficiency (NSE) 및 Kling Gupta Efficiency (KGE)를 목적함수로 하여 각 모형의 매개변수를 최적화하였다. 모형의 보정과 검정은 20년(1995년-2014년)의 유출자료를 활용하였으며, 보정 및 검정 기간은 각각 7:3 비율로 설정하였다. 두 모형 모두 보정과 검정 기간에 비교적 높은 신뢰도(NSE>0.74, KGE>0.75)를 보여, 모형이 과거 사상을 재현하기에 적합하고, 모의 결과가 비교적 유사함을 확인하였다. 다음으로, 기후변동이 유출에 미치는 영향을 평가하기 위해 동일한 모의 기간에 대해 강수는 -50 %에서 +50 %의 범위를 1 %씩, 기온은 0 ℃에서 8 ℃까지 0.1 ℃씩 구분하여 총 8,181개의 기후조건 시나리오를 구축하였다. 이후, 기후 스트레스 시나리오에 따른 두 모형의 최대유량, 풍수량, 평수량을 비교 및 분석하였다. 기후 스트레스 영향을 반영한 연최대유량과 풍수량의 경우, 강수 감소에 따른 유출 패턴은 두 모형에서 비슷하였으나, 강수와 기온이 증가할수록 상이한 결과를 얻었다. 이와 반대로, 풍수량의 경우 강수와 기온 변화의 차이가 커질수록 두 모형은 유사한 결과를 얻었다. 즉, 유역의 탄력적 기후변화 대응을 위해서는 모형의 불확실성에 대한 정량적 평가가 필요하다는 것을 시사한다.

• 한국수자원학회논문집
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• 제54권12호
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• pp.1295-1304
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• 2021

수자원의 효율적인 이용과 관리를 위해서는 기본적으로 강우-유출에 대한 신뢰성 있는 해석이 필요하지만 이를 위한 연속적인 수문자료가 부족하고, 실측 및 모형 등을 통한 강우-유출자료의 확보는 여전히 요원한 실정이다. 특히 미계측 유역의 경우는 합리적인 강우-유출 모의 개선의 일환으로 모형 적용시 필요한 매개변수를 계측유역에서 미계측 유역으로 전이하는 지역화 방안이 활용되고 있다. 본 연구에서는 하천 내 미계측 유역 또는 가뭄모니터링이 필요한 지점에서 GR4J 모형을 선정하여 강우-유출과정의 상태변수를 추출하고 SCEM-UA 기법을 이용한 매개변수 최적화를 진행하였다. 모형을 통해 획득한 유역특성인자와 매개변수 상관성 분석을 위해 Copula 함수를 이용하여 지역화하였으며 미계측 유역에 대한 강우-유출 분석을 수행하였다. 분석과정에서 대상 유역의 중간상태변수를 추출하고 이를 수문변량 인자인 하천수위와 지하수위에 대해 각각의 상관성을 분석하였다. 나아가 강우-유출 모의 과정에서 GR4J 모형의 상태변수를 산출하고 지수화시켜 수문학적 가뭄지수(SSDI)를 산정하였으며 이를 대표 가뭄지수인 SPI와 비교분석하여 산정된 가뭄지수의 수문학적 적합성 평가를 수행하였으며 이를 토대로 미계측 유역에서의 가뭄 모니터링 및 가뭄정보제공 체계구축과 활용 가능성을 확인할 수 있었다.

• Journal of Ginseng Research
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• 제44권2호
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• pp.258-266
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• 2020

Background: Oxidative stress-induced cardiomyocytes apoptosis is a key pathological process in ischemic heart disease. Glutathione reductase (GR) reduces glutathione disulfide to glutathione (GSH) to alleviate oxidative stress. Ginsenoside Rb1 (GRb1) prevents the apoptosis of cardiomyocytes; however, the role of GR in this process is unclear. Therefore, the effects of GRb1 on GR were investigated in this study. Methods: The antiapoptotic effects of GRb1 were evaluated in H9C2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, annexin V/propidium iodide staining, and Western blotting. The antioxidative effects were measured by a reactive oxygen species assay, and GSH levels and GR activity were examined in the presence and absence of the GR inhibitor 1,3-bis-(2-chloroethyl)-1-nitrosourea. Molecular docking and molecular dynamics simulations were used to investigate the binding of GRb1 to GR. The direct influence of GRb1 on GR was confirmed by recombinant human GR protein. Results: GRb1 pretreatment caused dose-dependent inhibition of tert-butyl hydroperoxide-induced cell apoptosis, at a level comparable to that of the positive control N-acetyl-L-cysteine. The binding energy between GRb1 and GR was positive (-6.426 kcal/mol), and the binding was stable. GRb1 significantl reduced reactive oxygen species production and increased GSH level and GR activity without altering GR protein expression in H9C2 cells. Moreover, GRb1 enhanced the recombinant human GR protein activity in vitro, with a half-maximal effective concentration of ≈2.317 μM. Conversely, 1,3-bis-(2-chloroethyl)-1-nitrosourea co-treatment significantly abolished the GRb1's apoptotic and antioxidative effects of GRb1 in H9C2 cells. Conclusion: GRb1 is a potential natural GR agonist that protects against oxidative stress-induced apoptosis of H9C2 cells.

• 대한기계학회논문집 C: 기술과 교육
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• 제4권2호
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• pp.101-109
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• 2016

발전소 내열강의 물성치는 고온 가동시간이 누적됨에 따라 열시효의 영향을 받는다. 본 연구에서는 제 4 세대 원자력시스템의 재료로 널리 채택되고 있는 Mod.9Cr-1Mo (ASME Grade 91)강을 대상으로 항복강도, 인장강도 및 파괴거동에 열시효가 미치는 영향에 대해 조사 및 분석하였다. 국내에서 가동 중인 초초임계(USC) 화력발전소의 배관계통에서 채취한, 73,716 시간의 가동 이력을 겪은 Gr.91 강 재료가 재료 실험을 위해 사용되었고, 동 시험결과와 가동 이력을 겪지 않은 신재의 시험결과를 비교 분석하였다. 또한 ASME 코드의 물성치와 RCC-MRx 의 물성치와 비교 분석하였고, 이들 설계기술기준 물성치의 보수성은 신재 및 가동 이력을 겪은 재료의 시험결과와 비교 분석을 통해 정량화하였다.

• Journal of Welding and Joining
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• 제34권3호
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• pp.61-68
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• 2016

Characteristics of dissimilar metal welds between alloy steel ASTM A387 Gr. 91 and carbon steel ASTM A516 Gr.70 made with Flux cored arc welding(FCAW) have been evaluated in terms of microstructure, mechanical strength, chemical analysis by EDS as well as corrosion test. Three heat inputs of 15.0, 22.5, 30.0kJ/cm were employed to make joints of dissimilar metals with E91T1-B9C wire. Post-weld heat treatment was carried out at $750^{\circ}C$ for 2.5 h. Based on microstructural examination, tempered martensite and lower bainite were formed in first layer of weld metal. The amount of tempered martensite was decreased and the amount of lower bainite was increased with increasing heat input and layer. Heat affected zone of alloy steel showed the highest hardness due to the formation of tempered Martensite and lower Bainite. Tensile strengths of dissimilar welds decreased with increasing heat inputs. Dissimilar welds seemed to have a good hot cracking resistance due to the low HCS index below 4. The salt spray test of dissimilar metals showed that the corrosion rate increased with increasing heat inputs due to the increase of the amount of lower Bainite.