• BMB Reports
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• v.49 no.11
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• pp.623-628
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• 2016

GPR78 is an orphan G-protein coupled receptor (GPCR) that is predominantly expressed in human brain tissues. Currently, the function of GPR78 is unknown. This study revealed that GPR78 was expressed in lung cancer cells and functioned as a novel regulator of lung cancer cell migration and metastasis. We found that knockdown of GPR78 in lung cancer cells suppressed cell migration. Moreover, GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA- and Rac1-dependent manner. At the molecular level, GPR78 regulated cell motility through the activation of $G{\alpha}q$-RhoA/Rac1 pathway. We further demonstrated that in vivo, the knockdown of GPR78 inhibited lung cancer cell metastasis. These findings suggest that GPR78 is a novel regulator for lung cancer metastasis and may serve as a potential drug target against metastatic human lung cancer.

• Magazine of the Korea Concrete Institute
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• v.12 no.3
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• pp.78-84
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• 2000

• Structural Engineering and Mechanics
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• v.78 no.2
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• pp.175-186
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• 2021

Due to the increasing environmental pollution caused by scrap tires, a solution is being sought to recycle and use them in a field of civil engineering, i.e., construction. This paper will provide a brief overview of previous researches that give detailed information on the advantages and disadvantages, considering the microstructural and mechanical characteristics of self-compacting concrete, when waste tire rubber as an aggregate is added. With this aim, a database of 144 different mixtures of self-compacting concrete with partial substitute of natural aggregate with recycled tire rubber (self-compacting rubberized concrete, SCRC) provided by various researchers was created. In this study we show that Gaussian process regression (GPR) modelling is an appropriate method for predicting compressive strength of SCC with recycled tire rubber particles and is in accordance with the results displayed by SEM images.

• International Journal of Highway Engineering
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• v.19 no.5
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• pp.59-68
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• 2017

PURPOSES : The objective of this study is to evaluate the potential risk level of road cave-ins due to subsurface cavities based on the deflection basin measured with falling weight deflectometer (FWD) tests. METHODS: Ground penetrating radar (GPR) tests were conducted to detect road cavities. Then FWD tests were conducted on 13 pavement test sections with and without a cavity. FWD deflections and a deflection ratio was used to evaluate the effect of geometry of the cavity and pavement for road cave-in potentials. RESULTS : FWD deflection of cavity sections measured at 60 cm or a closer offset distance to a loading center were 50% greater than more robust sections. The average deflection ratio of the cavity sections to robust sections were 1.78 for high risk level cavities, 1.51 for medium risk level cavities, and 1.16 for low risk level cavities. The relative remaining service life of pavement with a cavity evaluated with an surface curvature index (SCI) was 8.1% for the high level, 21.8% for the medium level, and 89.8% compared to pavement without a cavity. CONCLUSIONS : FWD tests can be applied to detect a subsurface cavity by comparing FWD deflections with and without a cavity measured at 60 cm or a closer offset distance to loading center. In addition, the relative remaining service life of cavity sections based on the SCI can used to evaluate road cave-in potentials.