• Title/Summary/Keyword: GO analysis

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Comparison of Expression Profiles between Trophozoite and Cyst of Acanthamoeba castellanii

  • Moon, Eun-Kyung;Kong, Hyun-Hee
    • Biomedical Science Letters
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    • v.18 no.3
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    • pp.313-318
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    • 2012
  • Acanthamoeba is an opportunistic pathogen known to cause granulomatous amoebic encephalitis and amebic keratitis. Acanthamoeba exhibits life cycle consisting of trophozoite and cyst, and the cyst is highly resistant to variable antibiotics and therapeutic agents. To understand the encystation mechanism of Acanthamoeba, the expression profiles of trophozoite and cyst were compared by gene ontology (GO) analysis. Ribosomal proteins and cytoskeletal proteins were highly expressed in trophozoite. In cyst, various protease, and signal transduction - and protein turnover - related proteins were highly expressed. These results correlated with eukaryotic orthologous groups (KOG) assignment and microarray analysis of Acanthamoeba trophozoite and cyst ESTs. The information of differential expression profiles of trophozoite and cyst would provide important clues for research on encystation mechanism of cyst forming protozoa including Acanthamoeba.

Gene-set based genome-wide association analysis for the speed of sound in two skeletal sites of Korean women

  • Kwon, Ji-Sun;Kim, Sangsoo
    • BMB Reports
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    • v.47 no.6
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    • pp.348-353
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    • 2014
  • The speed of sound (SOS) value is an indicator of bone mineral density (BMD). Previous genome-wide association (GWA) studies have identified a number of genes, whose variations may affect BMD levels. However, their biological implications have been elusive. We re-analyzed the GWA study dataset for the SOS values in skeletal sites of 4,659 Korean women, using a gene-set analysis software, GSA-SNP. We identified 10 common representative GO terms, and 17 candidate genes between these two traits (PGS < 0.05). Implication of these GO terms and genes in the bone mechanism is well supported by the literature survey. Interestingly, the significance levels of some member genes were inversely related, in several gene-sets that were shared between two skeletal sites. This implies that biological process, rather than SNP or gene, is the substantial unit of genetic association for SOS in bone. In conclusion, our findings may provide new insights into the biological mechanisms for BMD.

Analysis of Impact Load for Optimum of Suspension Parameter of Yard AGV (야드형 AGV-서스펜션 파라미터의 최적화를 위한 충격하중 해석)

  • 홍도관;김재헌;안찬우;전언찬;김중완
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2002.11a
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    • pp.161-167
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    • 2002
  • Cai-go management facility of harbor are required an expansion due to increase of cargo quantity. Design technology of Yard AGV call be possible to deal many cargo rapidly and accurately. So it is produced a profit about cal-go management. This study is presented optimum of suspension parameter for design technology Yard AGV. Model I, II are modeled about Initial of container weight, height. When the maximum stroke of suspension is 0.26m, optimum is achieved to reduce the reaction force at the minimum. Also, the reaction force is study to become stability in I second. A change of spring constant and coefficient of damper make change the reaction force and minimum reaction force appear in optimum value. All modeling and analysis are used combination. contact element of Ansys program.

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Analysis on the Construction Cost of Spatial Structures-Focused on the Roof Structure (대공간구조물의 건설 비용 분석-지붕구조체 중심으로)

  • Jang, Myung-Ho;Cheong, Myung-Chae;Sur, Sam-Yeol
    • Journal of Korean Association for Spatial Structures
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    • v.7 no.1 s.23
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    • pp.87-94
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    • 2007
  • An economic analysis is one of the most important factor to determine tile project feasibility. In some mega project, however, it is not unique factor to make a Go or No-Go decision because of overriding this work, an economic aspect by some project indirect factor such as political, social, environmental and technical factor, etc. The purpose of the this study is to investigate the cost model effects of spatial structure.

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Enhanced Mechanical Properties of Functionalized Graphene Oxide/linear Low Density Polyethylene Composites Prepared by Melt Mixing

  • Chhetri, Suman;Samanta, Pranab;Murmu, Naresh Chandra;Kuila, Tapas;Lee, Joong Hee
    • Composites Research
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    • v.29 no.4
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    • pp.173-178
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    • 2016
  • Graphene oxide (GO) was concurrently reduced and functionalized using long alkyl chain dodecyl amine (DA). The DA functionalized GO (DA-G) was assumed to disperse homogenously in linear low density polyethylene (LLDPE). Subsequently, DA-G was used to fabricate DA-G/LLDPE composites by melt mixing technique. Fourier transform infrared spectra analysis was performed to ascertain the simultaneous reduction and functionlization of GO. Field emission scanning electron microscopy analysis was performed to ensure the homogenous distribution and dispersion of DA-G in LLDPE matrix. The enhanced storage modulus value of the composites validates the homogenous dispersion of DA-G and its good interfacial interaction with LLDPE matrix. An increased in tensile strength value by ~ 64% also confirms the generation of good interface between the two constituents, through which efficient load transfer is possible. However, no significant improvement in glass transition temperature was observed. This simple technique of fabricating LLDPE composites following industrially viable melt mixing procedure could be realizable to developed mechanically strong graphene based LLDPE composites for future applications.

Spatiotemporal Gait Parameters That Predict Gait Function Based on Timed Up and Go Test Performance in the Hemiplegic Stroke Patients

  • Kim, Jeong-Soo;Kim, Jeong-Ah;Jeon, Hye-Seon;Yu, Kyung-Hoon
    • Physical Therapy Korea
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    • v.20 no.4
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    • pp.40-46
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    • 2013
  • The purpose of this study was to determine which spatiotemporal gait parameters obtained during hemiplegic walking could be a predictive factor for the Timed Up and Go test (TUG). Two hundreds nine subjects who had suffered a stroke were recruited for this study. They were participated in two assessments; the TUG test and gait analysis. The relationship between the TUG test and spatiotemporal parameters was analyzed using Pearson's correlation coefficients. In addition, to predict the spatiotemporal gait parameters that correlated most with the TUG scores, we used multiple linear regression analyses (stepwise method). The results show that the normalized velocity was strongly correlated with the TUG performance (r=-.72, p<.001). Additionally, single support percentage (SSP), double support percentage (DSP), step time difference (STD), and step length difference (SLD) significantly were correlated with the TUG test. Normalized velocity, STD, DSP of affected side, and SSP of non-affected side explained 53%, 8%, 3%, 2%, of variance in the TUG test respectively. In conclusion, an increase in gait velocity and a decrease in STD would be effective indicators of improvement on the functional mobility in the stroke rehabilitation.

Impact of Gratifications Obtained on Behavioral Intention Watching OTT Services (OTT 시청에 따른 획득충족이 이용자의 행동 의도에 미치는 영향)

  • Song, Keun-Tae
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.4
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    • pp.331-338
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    • 2022
  • The purpose of this study is to examine the effect of Gratifications Obtained (GO) on behavioral intention targeting Over-the-Top (OTT). The study chooses quality of content, variety of content, leisure activity, entertainment, the convenience of watching, and reasonable rate ratio as factors of GO. The number of subjects for the research is 330 people aged from their twenties to thirties in Daegu and Gyeongbok province. This study employs multi-regression analysis to analyze the impacts of GO on behavioral intention. The analysis shows that quality of content and variety of content influence behavioral intention at a significance level of 0.01, and entertainment and the convenience of watching influence at a significance level of 0.05.

Data Preprocessing and ML Analysis Method for Abnormal Situation Detection during Approach using Domestic Aircraft Safety Data (국내 항공기 위치 데이터를 활용한 이착륙 접근 단계에서의 항공 위험상황 탐지를 위한 데이터 전처리 및 머신 러닝 분석 기법)

  • Sang Ho Lee;Ilrak Son;Kyuho Jeong;Nohsam Park
    • Journal of Platform Technology
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    • v.11 no.5
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    • pp.110-125
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    • 2023
  • In this paper, we utilize time-series aircraft location data measured based on 2019 domestic airports to analyze Go-Around and UOC_D situations during the approach phase of domestic airports. Various clustering-based machine learning techniques are applied to determine the most appropriate analysis method for domestic aviation data through experimentation. The ADS-B sensor is solely employed to measure aircraft positions. We designed a model using clustering algorithms such as K-Means, GMM, and DBSCAN to classify abnormal situations. Among them, the RF model showed the best performance overseas, but through experiments, it was confirmed that the GMM showed the highest classification performance for domestic aviation data by reflecting the aspects specialized in domestic terrain.

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Development of Reduced Graphene Oxide/Sr0.98Y0.08TiO3-δ Anode for Methane Fuels in Solid Oxide Fuel Cells (메탄연료사용을 위한 고체산화물 연료전지용 Reduced Graphene Oxide/Sr0.98Y0.08TiO3-δ 연료극 개발)

  • Hyung Soon Kim;Jun Ho Kim;Su In Mo;Gwang Seon Park;Jeong Woo Yun
    • Korean Chemical Engineering Research
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    • v.61 no.2
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    • pp.296-301
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    • 2023
  • Solid oxide fuel cell has received more attention recently due to the fuel flexibility via internal reforming. Commonly used Ni/YSZ anode, however, can be easily deactivated by carbon coking in hydrocarbon fuels. The carbon deposition problem can minimize by developing alternative perovskite anode. This study is focused on improving conductivity and catalytic activity of the perovskite anode by introducing rGO (reduced graphene oxide). Sr0.92Y0.08TiO3(SYT) anode with perovskite structure was synthesized with 1wt% of rGO. The presence of rGO during anode fabricating process and cell operation is confirmed through XPS and Raman analysis. The maximum power density of rGO/SYT anode improved to 3 times in H2 and 6 times in CH4 comparing to that of SYT anode due to the high electrical conductivity and good catalytic activity for CH4.