• 구강회복응용과학지
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• 제25권4호
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• pp.437-444
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• 2009

본 연구에서는 여러 automixing 레진시멘트의 물성과 상아질에 대한 전단결합강도를 평가, 비교하고자 하였다. Self-adhesive automixing 레진시멘트인 Rely-X Unicem(3M ESPE, St. Paul, USA), Embrace resin cement(Pulpdent, Oakland, USA)와 chemical polymerizing automixing 레진시멘트인 Resiment Ready-Mix(J.L.Blosser Inc., Liberty Missouri, USA)를 사용하였다. 물성을 평가하기 위하여 레진시멘트를 테프론 주형에 주입한 후 자가중합을 시키고 24시간 동안 빛이 차단된 상태로 100% 상대습도에 보관 후 만능 시험기를 이용하여 압축강도, 간접인장강도, 굴곡강도를 측정하였다. 상아질에 대한 전단결합강도를 평가하기 위하여 발거한 하악 제3대구치의 협측 상아질을 노출 시킨 후 일정한 크기로 레진시멘트를 부착시킨 뒤 만능 시험기를 이용하여 전단결합강도를 측정하였다. SPSS Ver 12.0(SPSS Inc., Chicago, IL, USA)을 사용하여 95% 유의수준에서 One way ANOVA test로 분석하였으며 Scheffe test로 사후검정 하였다. 연구결과, chemical polymerizing automixing 레진시멘트가 self-adhesive automixing 레진시멘트에 비해 상대적으로 높은 물리적 성질과 상아질에 대한 전단결합강도를 보였다.

• Restorative Dentistry and Endodontics
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• 제27권5호
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• pp.521-529
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• 2002

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used, which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination, the one group was prepared crown-down technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Glidden burs(#1, #2, and #3) to coronal preparation and GT rotary files .08/20 and .06/30 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows : Subgroup 1, obturated with single cone method Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, .06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were demineralized in 10% nitric acid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A)at $\times$8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany) The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows 1. In canal prepared with GT$^{TM}$ rotary file, shaphing time taked more than the group of using Gates Glidden drill to coronal preparation without statistical significance (p>0.05) 2. The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3 The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files and Gates Glidden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method, The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files and Gates Glidden drill showed more apical leakage than the group of lateral condensation using same shaping method with-out statistical significance (p＞0.05).

• Toxicological Research
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• 제20권2호
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• pp.89-100
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• 2004

The comet assay (also called the single-cell gel electrophoresis assay) has been widely used for detecting DNA damage and repair in individual cells. Since the conventional methods of evaluating comet assay data using frequency statistics are unsatisfactory we developed a new quantitative measure of DNA damage/repair that is based on all information residing in the dose/time-response curves of a comet experiment. Blood samples were taken from 25 breast cancer patients before undergoing radiotherapy. The comet assay was performed under alkaline conditions using isolated lymphocytes. Tail DNA, tail length, tail moment and tail inertia of the comet were measured for each patient at four doses of $\gamma$-rays (0, 2, 4 and 8 Gy) and at four time points after irradiation (0, 10, 20 and 30 min) using 100 cells each. The resulting three-dimensional dose-time response surface was modeled by multiple regression, and the second derivative, termed 2D, on dose and time was determined. A software module was programmed in SAS/AF to compute 2D values. We applied the new method successfully to data obtained from cancer patients to be assessed for their radiation sensitivity. We computed the 2D values for the four damage measures, i.e., tail moment, tail length, tail DNA and tail inertia, and examined the pairwise correlation coefficients of 2D both on the log scale and the unlogged scale. 2D values based on tail moment and tail DNA showed a high correlation and, therefore, these two damage measures can be used interchangeably as far as DNA repair is concerned. 2D values based on tail inertia have a correlation profile different from the other 2D values which may reflect different facets of DNA damage/repair. Using the dose-time response surface, other statistical models, e.g., the proportional hazards model, become applicable for data analysis. The 2D approach can be applied to all DNA repair measures, Le., tail moment, tail length, tail DNA and tail inertia, and appears to be superior to conventional evaluation methods as it integrates all data of the dose/time-response curves of a comet assay.

• Pediatric Infection and Vaccine
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• 제24권1호
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• pp.37-43
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• 2017

목적: 백일해는 백신접종으로 예방이 가능한 질환이지만 세계적으로 증가하고 있고, 국내에서도 환자가 증가하고 있는 추세이다. 저자들은 최근 창원 지역에서 발생한 백일해 환자의 역학적인 특징과 임상 양상을 알아보고자 이 연구를 실시하였다. 방법: 2015년 7월부터 2016년 3월까지 호흡기 증상을 주소로 창원파티마병원 소아청소년과에 내원하는 환자 중 1주 이상의 기침을 하면서 발작적인 기침, 기침 후 구토, 흡기 시 '흡' 소리(whooping), 야간 기침이 동반된 환자들을 대상으로 호흡기 검체를 채취하여 백일해에 대한 배양, 중합연쇄반응검사를 실시하였고, 혈액의 항백일해 독소 항체검사(anti-pertussis toxin of ELISA kit, IBL International GmbH)를 실시하였다. 기저에 질환이 있거나 최근 1년 안에 DTaP 혹은 Tdap 백신 접종을 한경우에는 제외하였다. 결과: 연구 기간 동안 대상 환자 50명 중 진단된 환자는 37명이었다. 이 중 중합연쇄반응검사에서 양성인 환자는 2명이었고 혈청검사에서 양성인 환자는 37명이었다. 환자의 연령은 생후 1개월부터 15세였다. 항생제 사용 후 모든 환자가 합병증 없이 회복되었다. 결론: 2015년 7월부터 2016년 3월까지 창원 지역에 백일해의 유행이 있었으며, 이 연구 결과는 향후 국내에서 발생하는 백일해 역학 연구에 도움이 될 것으로 판단한다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2007년도 학술발표회 논문집
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• pp.831-835
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• 2007

금강은 우리나라 중부 내륙에서 서해로 흐르는 유로연장 401km, 유역면적이 전 국토면적의 약 10%에 해당하는 $9,886km^2$에 이르는 남한의 5대강 중 하나이다. 1981년, 이 강의 하구로부터 150km 상류지점인 대전시 동북쪽 16km, 청주시 남쪽 16km의 대전시와 충청북도가 만나는 지점에 대청다목적댐이 준공되었다. 대청다목적댐은 높이 72m, 길이 495m, 체적 123만$4,000m^3$의 콘크리트 중력식 댐과 석괴식 댐으로 구성된 복합형 댐으로서, 이 댐의 주요시설로는 저수용량 14억9,000만$m^3$의 본 댐과 조정지 댐이 있다. 그 후 1992년에는 대청 조정지 댐 하류 200m 지점에 현도 지방 산업단지 취수장(시설용량: $17,600m^3$/일)이 건설되었으며, 통상 하루 약 7,500톤의 물을 인근의 공단에 공급해오고 있다. 하지만 최근, 취수량이 급격히 감소됨에 따라, 인근 공단으로의 물 공급에 많은 어려움이 발생하고 있다. 이에 대한 대처 방안으로서 한국수자원공사는 취수장 관리자의 요구에 따라 조정지 댐 방류 수문 위치조정 및 방류량 조절 등의 조치를 취하고 있지만, 그 효과는 정량적으로 검토되어지지 않았다. 그러므로 본 연구에서는 위에서 명기한 조치의 실효성을 파악 하고자, 수문의 위치변화에 따른 취수구 부근의 수리특성을 조사하였다. 구체적인 조사항목은 다음과 같다. 첫째, 하천용 유량측정장비 (StreamPro ADCP (Teledyne RD Instruments))를 이용한 방류구와 취수구 사이의 유량 조사 둘째, 다 항목 수질 및 3차원 유속 측정장비 (ADV6600 (Sontek / YSI, Inc.))를 이용한 취수구 앞에서의 유속, 유향 및 수위변동 조사 셋째, 수위계 (Orphimedes (OTT MESSTECHNIK GmbH & Co. KG)) 및 파고계 (Compact-WH (Alec Electronics Co., Ltd.))를 이용한 하천을 횡단하는 취수구 좌 우 지점에서의 수위변동 모니터링 그 결과 방류수문의 위치변화에 따른 취수구 인근의 수리학적 특성은 조정지 댐의 방류수문으로부터 약 100 - 150 m 하류의 횡단면에서는 유속분포의 차이가 발견 되었으나 하류로 흐름이 진행됨에 따라 그 차이는 감쇄되고 약 200m 떨어진 취수구 앞의 횡단면에서는 유속분포가 거의 동일함을 알 수 있었다.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.132-144
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• 2017

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

• International Journal of Railway
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• 제1권4호
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• pp.143-148
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• 2008

This paper is the output of a collaborative European project concerning the barrier free accessibility for disabled persons to regional and long distance trains in Europe. Disabled people represent around 13% of the population in Europe. This is approximately 63 million people. The range of disabilities includes people with reduced mobility including wheel chair users, viewing and hearing impaired people and other forms of impairment. Improving accessibility aims at contributing to the provision of public transport services to all citizens in an equitable way. The purpose of the project was to analyse and to evaluate the existing solutions at selected European railways for all required modules at the entrance (doors, information and safety solutions), to derive a design concept, to develop a mock-up in meeting the needs of rail travellers with the above mentioned impairments and to test it with user groups. The project also aims at deriving components for the determination of standards. The EUPAX Design Mock-up test was performed to verify the advantages of the layout of the train segment including the different modules such as access area (including the access door, gaps between platform and train as well as boarding aid devices), entrance vestibule, information systems inside and outside the train, emergency facilities, toilet with all conveniences and the additional test arrangements regarding push buttons, steps and emergency equipment. For this purpose a questionnaire was developed for the assessment of the EUPAX segment and the additional test arrangements. With the help of this questionnaire it was possible to execute a quantitative and qualitative evaluation. During three test phases 67 experts and handicapped persons from 6 countries have evaluated the Industrial Design mock-up based on this questionnaire. The test group covered persons from North (Denmark) to the South (Italy) and from the West (Spain) to the Middle of Europe (Germany). This is especially important for the generalization (harmonisation) of the results for all European countries. According to COST 335 the information for people with reduced mobility should be clear, concise, accurate and timely. So that all information can be received from persons, they must be transferred on at least two of the three possible ways (acoustical, visual, tactile), a so called "2-sense-principle". Based on the results ergonomic specifications/ solutions for the ergonomic design of the access area, the acoustic, visual and tactile information and the emergency devices including the emergency communication system were developed, related to the benefiting passenger groups.

• 대한치과기공학회지
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• 제35권4호
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• pp.405-414
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• 2013

Purpose: The purpose of this study was to examine the relationship of the general characteristics of health-related majors to their life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, somatic symptom scale and college life stress scale. And it's also meant to analyze influential factors for their stress about college life. Methods: The subjects in this study were the students who were in the department of dental laboratory technology and the department of dental hygiene at a college located in the region of Iksan, North Jeolla Province. Data were gathered in November and December, 2012. The life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, physical symptom scale, somatic symptom scale and college life stress scale of the general characteristics were analyzed by t-test and one way analyses of variance (ANOVA) and the Duncan's multiple range test at the 95% confidence level to assess the statistical significance. And stepwise multiple regression analysis was conducted to determine what factors would affect the stress of the students about college life. The data were analyzed with the windows ver. 12.0(SPSS GmbH, Germany) statistical software program. Results: Among the general characteristics, there were significant differences according to gender and age in all the variables that were life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, physical symptom scale and college life stress scale. 61.3% of the students responded they slept for six hours or less, and the respondents who slept for six hours or less scored significantly statistically lower in health perception scale, subjective wellbeing scale and physical symptom scale. As for college life stress, the respondents who got depressed more often, whose subjective peace or happiness was lower, whose life expectancy was lower, who had worse physical symptoms, whose living standard was lower and whose academic year was lower were under heavier stress about their college lives. Conclusion: As the worse physical health and worse mental health(life expectancy, depression, health perception, subjective wellbeing and physical symptoms, etc.) of the college students led to heavier stress about college life, how to promote their physical health and mental health should discreetly be considered, and every necessary measure should be taken to improve their physical and mental health.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
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• pp.235-240
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• 2006

The paper will give an overview of the mission of GalTeC and then concentrate on two main aspects. The first more detailed aspect, is the analysis of the key performance parameters for the Galileo system services and presenting a technical overview of methods and algorithms used. The second more detailed aspect, is the service volume prediction including service dimensioning using the Prediction tool. In order to monitor and validate the Galileo SIS performance for Open Service (OS) and Safety Of Life services (SOL) regarding the key performance parameters, different analyses in the SIS domain and User domain are considered. In the SIS domain, the validation of Signal-in-Space Accuracy SISA and Signal-in-Space Monitoring Accuracy SISMA is performed. For this purpose first of all an independent OD&TS and Integrity determination and processing software is developed to generate the key reference performance parameters named as SISRE (Signal In Space Reference Errors) and related over-bounding statistical information SISRA (Signal In Space Reference Accuracy) based on raw measurements from independent sites (e.g. IGS), Galileo Ground Sensor Stations (GSS) or an own regional monitoring network. Secondly, the differences of orbits and satellite clock corrections between Galileo broadcast ephemeris and the precise reference ephemeris generated by GalTeC will also be compared to check the SIS accuracy. Thirdly, in the user domain, SIS based navigation solution PVT on reference sites using Galileo broadcast ephemeris and the precise ephemeris generated by GalTeC are also used to check key performance parameters. In order to demonstrate the GalTeC performance and the methods mentioned above, the paper presents an initial test result using GPS raw data and GPS broadcast ephemeris. In the tests, some Galileo typical performance parameters are used for GPS system. For example, the maximum URA for one day for one GPS satellite from GPS broadcast ephemeris is used as substitution of SISA to check GPS ephemeris accuracy. Using GalTeC OD&TS and GPS raw data from IGS reference sites, a 10 cm-level of precise orbit determination can be reached. Based on these precise GPS orbits from GalTeC, monitoring and validation of GPS performance can be achieved with a high confidence level. It can be concluded that one of the GalTeC missions is to provide the capability to assess Galileo and general GNSS performance and prediction methods based on a regional and global monitoring networks. Some capability, of which first results are shown in the paper, will be demonstrated further during the planned Galileo IOV phase, the Full Galileo constellation phase and for the different services particularly the Open Services and the Safety Of Life services based on the Galileo Integrity concept.

• Annals of Laboratory Medicine
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• 제38권6호
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• pp.578-584
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• 2018

Background: Accurate, rapid, and cost-effective screening tests for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection may be useful in laboratories that cannot afford automated chemiluminescent immunoassays (CLIAs). We evaluated the diagnostic performance of a novel rapid automated fluorescent lateral flow immunoassay (LFIA). Methods: A fluorescent LFIA using a small bench-top fluorescence reader, Automated Fluorescent Immunoassay System (AFIAS; Boditech Med Inc., Chuncheon, Korea), was developed for qualitative detection of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and antibody to HCV (anti-HCV) within 20 minutes. We compared the diagnostic performance of AFIAS with that of automated CLIAs-Elecsys (Roche Diagnostics GmbH, Penzberg, Germany) and ARCHITECT (Abbott Laboratories, Abbott Park, IL, USA)-using 20 seroconversion panels and 3,500 clinical serum samples. Results: Evaluation with the seroconversion panels demonstrated that AFIAS had adequate sensitivity for HBsAg and anti-HCV detection. From the clinical samples, AFIAS sensitivity and specificity were 99.8% and 99.3% for the HBsAg test, 100.0% and 100.0% for the anti-HBs test, and 98.8% and 99.1% for the anti-HCV test, respectively. Its agreement rates with the Elecsys HBsAg, anti-HBs, and anti-HCV detection assays were 99.4%, 100.0%, and 99.0%, respectively. AFIAS detected all samples with HBsAg genotypes A-F and H and anti-HCV genotypes 1, 1a, 1b, 2a, 2b, 4, and 6. Cross-reactivity with other infections was not observed. Conclusions: The AFIAS HBsAg, anti-HBs, and anti-HCV tests demonstrated diagnostic performance equivalent to current automated CLIAs. AFIAS could be used for a large-scale HBV or HCV screening in low-resource laboratories or low-to middle-income areas.