• Smart Structures and Systems
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• v.6 no.2
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• pp.167-182
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• 2010

An adaptronic strut for machine tools with parallel kinematics for compensation of the influence of geometric errors is introduced. Implemented within the strut is a piezoelectric sensor-actuator unit separated in function. In the first part of this contribution, the functional principle of the strut is presented. For use of one piezoelectric transducer as both, sensor and actuator as so-called self-sensing actuator, the acquisition of the sensing signal while actuating simultaneously using electrical bridge circuits as well as filter properties are examined. In the second part the control concept developed for the adaptronic strut is presented. A co-simulation model of the strut for simulating the controlled multi-body behavior of the strut is set-up. The control design for the strut as a stand-alone system is tested under various external loads. Finally, the strut is implemented into a model of the complete machine tool and the influence of the controlled strut onto the behavior of the machine tool is examined.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.201-202
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• 2011

본 연구에는 7.0T 동물용 자기공명영상장치를 이용하여 인간의 췌장암 세포인 CFPAC-1를 이종 이식한 쥐에서 자기공명영상을 획득하여 최적화된 검사 Protocol을 정립하며, 동물 실험에서 밝혀진 종양특성과 확산강조영상과의 비교 분석을 해보고 현성확산계수 영상이 췌장암 이종이식 모형의 종양 세포 내부 구조에 관하여 어떠한 정보를 제공 할 수 있는지 알아보고자 한다. 13마리의 쥐의 26개의 종양을 전형적으로 주입 후에 2~4주 뒤에 직경이 5~10mm가 되었을 때 imaged 하였으며, pathologic specimenm을 위해 sacrificed 하였다. isofluoran gas anesthesia를 이용하여 동물 마취 하였다. 사용된 장비로는 small-animal MR images (7.0-T)를 (Bruker BioSpin GmbH, Rheinstetten, Germany)이용하여 Fast T2-weighted 와 single-shot EPI DW image를 얻었다. 종양은 H&E 염색과 CD31와 VEGF에 대한 면역조직학 염색을 하여 종양의 cellularity와 microvessel density(MVD), 종양 내 괴사 정도를 평가하였다. CFPAC-1의 현성확산계수값은 $0.7327{\pm}0.1075{\pm}10^{-3}mm2/s$이였으며, 현성확산계수는 종양내 괴사 정도와 연관성을 보였다(R = 0.7417, p = 0.0001) 이처럼 현성확산계수는 종양 내 괴사 정도 등의 현미경적구조변화를 반영하는 대리인자로 사용될 수 있음을 확인하였다.

• CELLMED
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• v.4 no.3
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• pp.15.1-15.14
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• 2014

Andrographis paniculata (Burm. F.) Wall. Ex Nees (Family: Anthaceae) is a traditionally known Ayurvedic medicinal plant. Several well-controlled clinical trials conducted during recent years have consistently reconfirmed that Andrographis paniculata extracts are effective in suppressing cardinal symptoms of diverse inflammatory and infectious diseases. Despite extensive efforts though, many questions concerning bioactive constituents of such extracts and their modes of actions still remain unanswered. Amongst diverse diterpene lactones isolated to date from such extracts, andrographolide is often considered to be the major, representative, or bioactive secondary metabolite of the plant. Therefore, it has attracted considerable attention of several drug discovery laboratories as a lead molecule potentially useful for identifying structurally and functionally novel drug. Critical analysis of available preclinical and clinical information on Andrographis paniculata extracts and pure andrographolide strongly suggest that they are pharmacologically polyvalent and that they possess adaptogenic properties. Aim of this communication is to summarize and critically analyze such data, and to point out some possibilities for more rationally exploiting their adaptogenic properties for discovering novel therapeutic leads, or for obtaining pharmacologically better standardized phyto-pharmaceuticals.

• Geomechanics and Engineering
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• v.7 no.6
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• pp.665-678
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• 2014

In discrete element modeling, 2D software has been widely used in order to gain further insights into the fundamental mechanisms with less computational time. The porosities used in 2D DEM studies should be determined with appropriate approaches based on 3D laboratory porosities. This paper summarizes the main approaches for converting porosities from 3D to 2D for DEM studies and theoretical evaluations show that none of the current approaches can be widely used in dealing with soil mechanical problems. Therefore, a parabolic equation and a criterion have been suggested for the determination of 2D porosities in this paper. Moreover, a case study has been used to validate that the 2D porosity obtained from the above suggestion to be rational with both the realistic contact force distribution in the specimen and the good agreement of the DEM simulation results of direct shear tests with the corresponding experimental data. Therefore, the parabolic equation and the criterion are suggested for the determination of 2D porosities in a wide range of polydisperse particle systems, especially in dealing with soil mechanical problems.

• International Journal of Human Ecology
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• v.5 no.2
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• pp.111-122
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• 2004

This paper outlines the findings of a consumer survey conducted in 1996 and 2001 by the University of Bonn, Germany, across 15 European countries. The survey involved a sample of 3,300 respondents in 1996 and around 11,000 respondents in 2001, throughout all 15 EU countries. Children and adolescents, between the ages of 10 and 17, were surveyed about their consumption habits and their attitudes towards the environment. The paper outlines the key findings on 'Children's fears and future prospects'. Children are exposed to a great mass of information, not only derived from the media but also from what they experience directly in their everyday-life. Some of this information translates into worries that adopt a clearer (more realistic) form when children become adolescents, as they might be easily involved in those events, and the understanding of the processes that may cause or continue them is deeper. Today's children and adolescents are under more pressure, since the social/political/economical spectrum is constantly changing. Change produces anxiety, fear of what will result from these transformations, as it implies that the social order will be reorganized. This paper reports on a long term comparative study among children and adolescents throughout the European Union, analyzed by country, age group and gender. It draws different preoccupations of young generations and consequent future expectations. It concludes by considering the influence of social and political organizations, as well as the family, on children and adolescents, as these might help to sustain a positive attitude towards various future events.

• Journal of Technologic Dentistry
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• v.34 no.2
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• pp.67-73
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• 2012

연구 목적: 임플란트의 하부구조를 상부 구조와 연결하는 레진시멘트의 접착강도를 높이기 위한 기계적 화학적인 표면처리 방법들이 연구 되고 있다. 이 연구에서 다양한 크기의 $Al_2O_3$ sandblasting과 Silano Pen으로 표면처리한 티타늄과 레진 시멘트의 접착강도를 알아보고자 한다. 연구 방법: 12개의 티타늄(Ti-6A1-4V)시편을 디스크 형태로 제작하여 자가중합 수지에 매립하였다. 이들을 각각 6개의 군으로 나누어 $50{\mu}m$, $90{\mu}m$, $110{\mu}m$ 등 3가지 크기의 $Al_2O_3$로 sandblasting 하는 조건과 $Al_2O_3$로 sandblasting한 후 Silano Pen(Bredent, bredent GmbH &Co.KG, Senden, Germany)을 사용한 군으로 나누었다. 표면처리 한 티타늄 표면에 레진시멘트(Duolink dual syringe, Bisco, USA)으로 접착하였다. 그 후 증류수($37^{\circ}C$)에 24시간 보관 후 접착강도 실험을 시행하였고, SEM을 사용하여 표면처리 한 표면과 접착강도 실험 후 파절양상을 관찰하였다. 결과: 통계학적 분석에 따르면 Silano Pen을 사용하여 표면처리한 군들의 접착강도가 높았다(P<0.05). 결론: Silano Pen을 사용하는 것이 티타늄과 레진시멘트의 접착강도를 증가 시킨다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.10
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• pp.4703-4723
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• 2018

In recent years, dense small cell network has been deployed to address the challenge that has resulted from the unprecendented growth of mobile data traffic and users. It has proven to be a cost efficeient solution to offload traffic from macro-cells. Software defined heterogeneous wireless network can decouple the control plane from the data plane. The control signal goes through the macro-cell while the data traffic can be offloaded by small cells. In this paper, we propose a framework for cell virtualization and user association in order to satisfy versatile requirements of multiple tenants. In the proposed framework, we propose an interference graph partioning based virtual-cell association and customized physical-cell association for multi-homed users in a software defined small cell network. The proposed user association scheme includes 3 steps: initialization, virtual-cell association and physical-cell association. Simulation results show that the proposed virtual-cell association outperforms the other schemes. For physical-cell association, the results on resource utilization and user fairness are examined for mobile users and infrastructure providers.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7811-7816
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• 2014

Background: Despite advances in radiotherapy, overall survival of glioblastoma multiforme (GBM) patients is still poor. Moreover dosimetrical analyses with these newer treatment methods are insufficient. The current study is aimed to compare intensity modulated radiation therapy (IMRT) linear accelerator (linac) and helical tomotherapy (HT) treatment plans for patients with prognostic aggressive brain tumors. Material and Methods: A total of 20 GBM patient plans were prospectively evaluated in both linac and HT planning systems. Plans are compared with respect to homogenity index, conformity index and organs at risk (OAR) sparing effects of the treatments. Results: Both treatment plans provided good results that can be applied to GBM patients but it was concluded that if the critical organs with relatively lower dose constraints are closer to the target region, HT for radiotherapeutical application could be preferred. Conclusion: Tomotherapy plans were superior to linear accelerator plans from the aspect of OAR sparing with slightly broader low dose ranges over the healthy tissues. In case a clinic has both of these IMRT systems, employment of HT is recommended based on the observed results and future re-irradiation strategies must be considered.

• Nuclear Engineering and Technology
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• v.49 no.2
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• pp.327-334
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• 2017

Common-cause failure (CCF) events can significantly impact the availability of safety systems of nuclear power plants. For this reason, the International Common Cause Data Exchange (ICDE) project was initiated by several countries in 1994. Since 1997 it has been operated within the Organisation for Economic Co-operation and Development (OECD)/Nuclear Energy Agency (NEA) framework and has successfully been operated over six consecutive terms (the current term being 2015-2017). The ICDE project allows multiple countries to collaborate and exchange CCF data to enhance the quality of risk analyses, which include CCF modeling. As CCF events are typically rare, most countries do not experience enough CCF events to perform meaningful analyses. Data combined from several countries, however, have yielded sufficient data for more rigorous analyses. The ICDE project has meanwhile published 11 reports on the collection and analysis of CCF events of specific component types (centrifugal pumps, emergency diesel generators, motor operated valves, safety and relief valves, check valves, circuit breakers, level measurement, control rod drive assemblies, and heat exchangers) and two topical reports. This paper presents recent activities and lessons learnt from the data collection and the results of topical analysis on emergency diesel generator CCF impacting entire exposed population.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.315-323
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• 2009

Pressure oscillations triggered by the unstable interaction of dynamic flow features of the hydraulic turbine with the hydraulic plant system - including the electrical design - can at times reach significant levels and could lead to damage of plant components or could reduce component lifetime significantly. Such a problem can arise for overload as well as for part load operation of the turbine. This paper discusses an approach to analyze the overload high pressure oscillation problem using computational fluid dynamic (CFD) modeling of the hydraulic machine combined with a network modeling technique of the hydraulic system. The key factor in this analysis is the determination of the overload vortex rope volume occurring within the turbine under the runner which is acting as an active element in the system. Two different modeling techniques to compute the flow field downstream of the runner will be presented in this paper. As a first approach, single phase flow simulations are used to evaluate the vortex rope volume before moving to more sophisticated modeling which incorporates two phase flow calculations employing cavitation modeling. The influence of these different modeling strategies on the simulated plant behavior will be discussed.