• Journal of Korean Tunnelling and Underground Space Association
• /
• v.17 no.6
• /
• pp.575-586
• /
• 2015

In NATM tunnel, the Ground-Lining Interaction model(GLI model) had been proposed a one of the numerical analysis as the ground load estimation method of the concrete lining. But this model was not applied with the interface mechanism between the ground and the support member or concrete lining. Therefor in this study, it is implemented as a model for closer than actual states that the interface element applied to the existing GLI model. And the modified GLI formula is proposed with the ground load estimation that is from the numerical results for each ground and rock cover conditions. Based on the numerical results, the ground load acting on concrete lining is reduced to ave. 88~106% in case of IV ground condition and ave. 47~57% in case of weathered soil condition comparing with the existing GLI model. It can be anticipated that the results obtained from this study can be applied to an estimation of the ground load on the concrete lining modeled like as real states, consistent and economical design.

• Tunnel and Underground Space
• /
• v.20 no.1
• /
• pp.58-64
• /
• 2010

GLI model was verified to consider the interaction between a ground and a tunnel lining and to rationally reduce the ground load acting on the secondary lining(concrete lining) of a tunnel. In this study, the economy and the construction condition of tunnel concrete linings designed by a conventional frame model at Lot O of OO line were highly enhanced through a field design change using GLI model. For a few safe considerations, not only about 50% saving of reinforcing steel could reduce the material cost but also the wide space between bars could make it easy to pour concrete mix without voids. There was large saving effect of reinforcing steel for poor ground conditions because Terzaghi's load used in the conventional frame model produces too much high loads for those conditions.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.8 no.4
• /
• pp.365-375
• /
• 2006

The structural analysis for the secondary lining of tunnels is generally performed by a frame analysis model. This model requires a ground loosening load estimated by some empirical methods, but the load is likely to be subjective and too large. The ground load acting on the secondary lining is due to the loss of the supporting function of the first support members such as shotcrete and rockbolts. Therefore, the equilibrium condition of the ground and the first support members should be considered to estimate the ground load acting on the secondary lining. Ground-lining interaction model, shortly GLI model, is developed on the basis of the concept that the secondary lining supports the ground deformation triggered by the loss of the support capacity of the first support members. Accordingly, the GLI model can take into account the ground load reflecting effectively not only the complex ground conditions but the installed conditions of the first support members. The load acting on the secondary lining besides the ground load includes the groundwater pressure and earthquake load. For the structural reinforcement of the secondary lining based on the ultimate strength design method, the factored load and various load combination should be considered. Since the GLI model has difficulty in dealing with the factored load, introduced in this study is the superposition principle in which the section moment and force of the secondary lining estimated for individual loads are multiplied by the load factors. Finally, the design method of the secondary lining using the GLI model is applied to the case of a shallow subway tunnel.

• Annals of Occupational and Environmental Medicine
• /
• v.34
• /
• pp.14.1-14.14
• /
• 2022

Background: Although spirometry results can be interpreted differently depending on the reference equation used, there are no established criteria for selecting reference equations as part of the special health examinations for Korean workers. Thus, it is essential to examine the current use of reference equations in Korea, quantify their impact on result interpretation, and propose reference equations suitable for Korean workers, while also considering the environmental conditions of special health examination facilities. Methods: The 213,640 results from the special health examination database were analyzed to identify changes in the ratio of measured values to reference values of lung capacity in Korean workers with changes in age or height, and changes in the agreement of interpretations with the reference equation used. Data from 238 organizations that participated in the 2018-2019 quality control assessment by the Korea Occupational Safety and Health Agency were used to identify the spirometer model and reference equations used in each special health examination facility. Results: Korean special health examination facilities used six reference equations, and the rate of normal or abnormal ventilatory diagnoses varied with the reference equation used. The prediction curve of the Global Lung Function Initiative 2012-Northeast Asian (GLI2012) equation most resembled that of the normal group, but the spirometry model most commonly used by examination facilities was not compliant with the GLI2012 equation. With a scaling factor of 0.95 applied to the Dr. Choi equation, the agreement with the GLI2012 equation was > 0.81 for men and women. Conclusions: We propose the GLI2012 equation as reference equation for spirometry in Korean workers. The GLI2012 equation exhibited the most suitable prediction curve against the normal lung function group. For devices that cannot use the GLI2012 equation, we recommend applying a scaling factor of 0.95 to the Dr. Choi equation.

• The Journal of Engineering Geology
• /
• v.16 no.4 s.50
• /
• pp.327-335
• /
• 2006

Three processing strategies of seismic refraction data are tested in terms of velocity and depth profiles or structures for mapping of geological discontinuities: GRM(generalized reciprocal method), GLI(generalized linear inversion), Tomography. The test data used in this study are the shot gathers reconstructed by numerical modeling for the structures of 3 planar layers(horizontal, inclined), the buried vertical fracture zones, and vertical fault zones. Tomography is shown to be very efficient for mapping of more complicated tone such as vertical fault and buried fracture zones, whereas GRM and GLI can be useful for horizontal and/or inclined layers, probably on their bases of analysis of first arrivals in travel time curves.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.437-442
• /
• 2015

Aim: To establish a pancreatic cancer stem cell model using human pancreatic cancer cells in nude mice to provide a platform for pancreatic cancer stem cell research. Materials and Methods: To establish pancreatic cancer xenografts using human pancreatic cancer cell line SW1990, nude mice were randomly divided into control and gemcitabine groups. When the tumor grew to a volume of $125mm^3$, they treated with gemcitabine at a dose of 50mg/kg by intraperitoneal injection of 0.2ml in the gemcitabine group, while the mice in control group were treated with the same volume of normal saline. Gemcitabine was given 2 times a week for 3 times. When the model was established, the proliferation of pancreatic cancer stem cells was observed by clone formation assay, and the protein and/or mRNA expression of pancreatic stem cell surface markers including CD24, CD44, CD133, ALDH, transcription factors containing Oct-4, Sox-2, Nanog and Gli, the key nuclear transcription factor in Sonic Hedgehog signaling pathway was detected by Western blot and/or RT-PCR to verify the reliability of this model. Results: This model is feasible and safe. During the establishment, no mice died and the weight of nude mice maintained above 16.5g. The clone forming ability in gemcitabine group was stronger than that of the control group (p<0.01). In gemcitabine group, the protein expression of pancreatic cancer stem cell surface markers including CD44, and ALDH was up-regulated, the protein and mRNA expression of nuclear transcription factor including Oct-4, Sox-2 and Nanog was also significantly increased (P<0.01). In addition, the protein expression of key nuclear transcription factor in Sonic Hedgehog signaling pathway, Gli-1, was significantly enhanced (p<0.01). Conclusions: The pancreatic cancer stem cell model was successfully established using human pancreatic cancer cell line SW1990 in nude mice. Gemcitabine could enrich pancreatic cancer stem cells, simultaneously accompanied by the activation of Sonic Hedgehog signaling pathway.

• Asian-Australasian Journal of Animal Sciences
• /
• v.30 no.4
• /
• pp.462-469
• /
• 2017

Objective: The aim of this study is to identify genomic regions or genes controlling growth traits in pigs. Methods: Using a panel of 54,148 single nucleotide polymorphisms (SNPs), we performed a genome-wide Association (GWA) study in 562 pure Yorshire pigs with four growth traits: average daily gain from 30 kg to 100 kg or 115 kg, and days to 100 kg or 115 kg. Fixed and random model Circulating Probability Unification method was used to identify the associations between 54,148 SNPs and these four traits. SNP annotations were performed through the Sus scrofa data set from Ensembl. Bioinformatics analysis, including gene ontology analysis, pathway analysis and network analysis, was used to identify the candidate genes. Results: We detected 6 significant and 12 suggestive SNPs, and identified 9 candidate genes in close proximity to them (suppressor of glucose by autophagy [SOGA1], R-Spondin 2 [RSPO2], mitogen activated protein kinase kinase 6 [MAP2K6], phospholipase C beta 1 [PLCB1], rho GTPASE activating protein 24 [ARHGAP24], cytoplasmic polyadenylation element binding protein 4 [CPEB4], GLI family zinc finger 2 [GLI2], neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [NYAP2], and zinc finger protein multitype 2 [ZFPM2]). Gene ontology analysis and literature mining indicated that the candidate genes are involved in bone, muscle, fat, and lung development. Pathway analysis revealed that PLCB1 and MAP2K6 participate in the gonadotropin signaling pathway and suggests that these two genes contribute to growth at the onset of puberty. Conclusion: Our results provide new clues for understanding the genetic mechanisms underlying growth traits, and may help improve these traits in future breeding programs.

• Asian Journal of Atmospheric Environment
• /
• v.5 no.2
• /
• pp.79-85
• /
• 2011

The purpose of this study is to evaluate the strength of the near-UV wavelength of 380 nm relative to visible and near-IR bands, and to find the suitable wavelength for detecting aerosols by using the Global Imager (GLI) sensor aboard the Advanced Earth Observing Satellite-II (ADEOS-II). Sensitivity analysis is performed for the retrieval of biomass burning aerosols by employing the radiative transfer model Rstar5b. It is determined that background surface reflectance in the blue band is similar to that in the near-UV band, and that wavelengths in the blue bands are more sensitive to the Aerosol Optical Thickness (AOT) than wavelengths in the near-UV band. The Total Ozone Mapping Spectrometer (TOMS) Aerosol Index (AI) is used in the indirect method used for aerosol retrieval, and the wavelength pair 380 nm and 460 nm is determined to be the most sensitive to the AOT. The results of this study suggest that wavelengths in the blue bands are suitable for detecting biomass burning aerosols over the Korean peninsula.