• 한국환경보건학회지
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• 제19권2호
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• pp.61-68
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• 1993

This study aimed at evaluating the preventive effect of Glycyrrhizae Radix and Glycine Semen Extract (GGE) against NAC intoxication. NAC is widely used pesticide in many countries and derivative of carbamats and GGE is well-known antidote to some kinds of toxicants which was referenced from oriental medicine text. The results obtained were as follows: 1) After injecting NAC (100,140 mg/kg), determined Ch.E activities decrease 44.77~50.86% for all experimental groups at one hour after exposure, and were gradually recovered in the course of time. 2) In toxicity test of GGE, there were no sign of death or poisoning up to 5000 mg/kg of GGE for p.o. in mice. From this, we suggest that the LD$_{50}$ of GGE would be above 5000 mg/kg. 3) The Ch.E activity in control group was 471.43 $\pm$ 4.85 luff, group I was 215.27 $\pm$ 23.13 IU/l, group II and group III were 304.03 $\pm$ 9.03 IU/l, 433.81 $\pm$ 21.73 IU/l, respectively. Compare to the control group with experimental group I, remarkable difference revealed (p< 0.01), but the Ch.E activities of group II and III were similar to those of control group. This is indicate that GGE possess a potent activity of recovering Ch.E. GGE had a very remarkable preventive effect on NAC toxicity, and it was able to know that Ch.E activity dramatically increased according to GGE dosage increasing. 4) When GGE and NAC were administered by p.o. simultaneously, LD$_{50}$ and confidence intervals of each group were as follows: the control group: 270 mg/kg, 234.99~310.23 mg/kg, group I and II (GGE 500 mg/kg, 1000 mg/kg by p.o.): 310 mg/kg, 271.69~353.71mg/kg, and 325 mg/kg, 285.09~370.50 mg/kg, respectively. In the comparison with the control group, the protective index was 1.1 and 1.2, respectively. From the above result, GGE has reactivation effect to decreasing Ch.E activity induced by exposure to NAC. Furthermore, GGE shows a preventive effect on NAC intoxication.

• 한국식품저장유통학회지
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• 제9권2호
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• pp.174-178
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• 2002

감초추출물의 농도를 100 ppm, 200 ppm, 300 ppm and 400 ppm로 조절하여 콩을 발아시켜 재배한 콩나물의 아미노산, 유기산 및 유리당 함량을 재배 2일, 3일 및 4일째에 분석하였다. 총 아미노산 함량은 100 ppm에서 3일간 재배하였을 때가 가장 높았고, 또한 재배일수가 길어질수록 aspartic acid 함량은 증가하지만, glutamic acid 함량은 오히려 감소하는 경향을 나타내었다. 총 유리당은 GGE 콩나물의 경우 대조군에 비하여 낮은 함량을 나타내었으며, 그러나 재배일수가 증가할수록 그 함량은 많아졌다 Sucrose함량은 재배일수가 길어질수록 감소하였으나, 다른 유리당은 오히려 증가하였다 총 유기산은 재배일수가 증가할수록 많은 함량을 나타내었으며, 200 ppm으로 재배한 콩나물이 가장 많은 함량을 나타내었다. 결론적으로 감초추출물은 콩나물의 품질증진을 위한 아미노산 및 유기산 함량을 증가시키는 발아 및 재배수로서 효과적일 것으로 판단된다.

• 동의생리병리학회지
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• 제23권6호
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• pp.1385-1391
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• 2009

The purpose of this research was to investigate the effects of the extracts of Glycyrrhiza uralensis (GE) and the combined extracts of Glycine max Merr. and Glycyrrhiza uralensis (GGE) on the activity of murine splenocytes and macrophages. GE and GGE were administered orally twice a day for 7 days at the dose of 500 mg/kg. GE decreased the viability of T- and B-lymphocytes in splenocytes, but GGE increased the viability of B-lymphocytes in splenocytes. GE increased the population of B-lymphocytes in splenocytes, but decreased the population of T-lymphocytes and splenic $CD4^+$ cells. Also, GGE decreased the population of B-lymphocytes in splenocytes, but increased the population of T-lymphocytes and splenic $CD4^+$ cells. Furthermore, GE and GGE enhanced the phagocytic activity of peritoneal macrophages and the production of nitric oxide. These results suggest that the regulative action of immune response of GGE is more potent than their of GE.

• 대한의생명과학회지
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• 제29권4호
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• pp.242-248
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• 2023

Platelets are activated at the sites of vascular injury by a number of molecules, including adenosine diphosphate, collagen and thrombin. The full platelet aggregation is absolutely essential for the normal hemostasis. Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and is known to have various effects such as antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. However, the platelet inhibitory effect of Glycyrrhiza glabra extract (GGE) has not been identified. In this study, we investigated if GGE inhibited platelet aggregation. We observed that GGE inhibited collagen-induced platelet aggregation, Ca²⁺ mobilization, and thromboxane A2 generation. In addition, GGE suppressed phosphorylation of phosphatidylinositol-3 kinase (PI3K), Akt and elevated phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R), vasodilator stimulated phosphoprotein (VASP). Taken together, GGE showed strong antiplatelet effects and may be used to block platelet-mediated cardiovascular diseases.

• Annals of Clinical Neurophysiology
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• 제22권2호
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• pp.92-103
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• 2020

Background: The purpose of this study was to identify the top-100 cited articles on genetic generalized epilepsy (GGE) published in journals that have made key contributions to the field of epilepsy. Methods: We searched the Web of Science website produced by Clarivate Analytics for articles on GGE, and sorted them according to the number of citations to identify the top-100 cited articles. We then manually reviewed the contents of the top-100 cited articles, which were designated as "citation classics". Results: The top-100 cited articles were published in 27 journals, with the largest proportion appearing in Epilepsia (19 articles). The articles originated from institutions in 17 countries, with 31 articles from the USA. The institution associated with the largest numbers of articles in the field of GGE was the University of Melbourne, Australia (9 articles). Panayiotopoulos C. P. was the first author of three articles, and was listed most frequently in the GGE citation classics. The publication years were concentrated in the 2000s, when 56 articles were published. The most-common study topics were genetics (35 articles) and neuroimaging (17 articles). Conclusions: This study has identified the top-100 cited articles on GGE. These citation classics represent the landmark articles on GGE, and they provide useful insights into international research leaders and the research trends in the field.

• 융합보안논문지
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• 제13권6호
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• pp.51-59
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• 2013

3.20, 6.25 등 사이버공격을 받은 우리 정부는 지난 공격의 배후를 지목했으나, 공격행위에 대한 처벌이나 제제에 대해 논할 수 있는 국제적 논의의 장은 없었다. 이렇게 특정 국가가 공격을 주도했음을 입증하는 증거를 갖고 있더라도 규탄, 제재, 처벌 등이 불가능했기에 에스토니아 사태 이후 지속적으로 유사한 악의적 행위들이 반복되고 있다. 현재 사이버안보에 관한 국제적 논의는 크게 국제적 수준, 지역적 수준 및 양자간 협력의 3계층으로 나뉘어 진행되고 있다. 이 중 국제적 사이버안보 규범 논의 방향 정립은 주로 국제연합과 세계 사이버스페이스 총회 2개 축으로 움직이고 있다. 물론 민간 중심의 인터넷 거버넌스 논의나 UN 전문기구인 국제전기통신연합 등에서도 사이버보안 이슈가 논의되고 있으나 본 논문에서는 2013년 주요 성과가 도출된 국제연합의 정부전문가그룹(GGE) 활동 결과와 우리 정부가 주최한 제3차 세계 사이버스페이스 총회의 사이버안보 논의 흐름을 분석하여 2014년부터 시작될 제4차 UN 전문가그룹(GGE)의 활동을 예상해보고 앞으로의 사이버안보 논의 방향을 짚어보고자 한다. 또한 이러한 논의들에 대한 국내 대응전략을 도출해보고자 한다.

• 한국작물학회지
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• 제60권3호
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• pp.349-354
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• 2015

The AMMI (additive main effects and multiplicative interaction) and GGE (genotype main effect and genotype by environment interaction) biplot which were accounted for a substantial part of total sum of square in the analysis of variance suggested to be more appropriate models for explaining G $\times$ E interaction. The grain yield of total ten sesame genotypes was significantly affected by environment which explained 61% of total variation, whereas genotype and genotype x environment interaction (G $\times$ E) were explained 16%, 24% respectively. From the results of experiment, three genotypes Miryang49, Koppoom and Ansan were unstable, whereas other three genotypes Kyeongbuk18, Miryang50 and Kanghuk which were shorter projections to AEA ordinate were relatively stable over the environments. Yangbak which was closeness to the mean yield and short projection of the genotype marker lines was regarded as genotype indicating good performance with stability. Ansan, Miryang48 and Yangbaek showed the best performance in the environments of Naju, Suwon, Iksan and Andong. Similarly, genotype Miyrang47 exhibited the best performance in the environments of Chuncheon and Miryang. Andong is the closest to the ideal environment, and therefore, is the most desirable among eight environments.

• 지구물리와물리탐사
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• 제14권1호
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• pp.123-126
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• 2011

• 지구물리와물리탐사
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• 제19권4호
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• pp.249-249
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• 2016

• 지구물리와물리탐사
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• 제23권4호
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• pp.267-267
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• 2020