• 건축구조
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• 제14권3호
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• pp.32-43
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• 2007

• 대한조선학회논문집
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• 제43권4호
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• pp.422-430
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• 2006

The horn and movable parts around the gap of the conventional semi-spade rudder are visualized by high speed CCD camera with the frame rate of 4000 fps (frame per second) to study the unsteady cavity pattern on the rudder surface and gap. In addition, the pressure measurements are conducted on the rudder surface and inside the gap to find out the characteristics of the flow behavior. The rudder without propeller wake is tested at the range of $1.0{\leq}{\sigma}_v\;1.6$ and at the rudder deflection angle of $-8{\leq}{\theta}{\leq}10^{\circ}$. The time resolved cavity images are captured and show strong cavitation around the rudder gap in all deflection angles. As the deflection angle gets larger, the flow separated from the horn surface increases the strength of cavitation. The accelerated flow along the horn decreases its pressure and the separated flow from the horn increases the pressure abruptly. The pressure distribution inside the gap reveals the flow moving from the pressure to suction side. In the negative deflection angle, the turning area on the movable part initiates the flow separation and cavitation on it.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.2987-2991
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• 2014

Connexin 43 is an important gap junction protein in vertebrates and is known for its tumor suppressive properties. Cx43 is abundantly expressed in the human intestinal epithelial cells and muscularis mucosae. To explore the role of Cx43 in the genesis of human colon cancer, we performed the expression analysis of Cx43 in 80 cases of histopathologically confirmed and clinically diagnosed human colon cancer samples and adjacent control tissue and assessed correlations with clinicopathological variables. Western blotting using anti-Cx43 antibody indicated that the expression of Cx43 was significantly down regulated (75%) in the cancer samples as compared to the adjacent control samples. Moreover, immunohistochemical analysis of the tissue samples confirmed the down regulation of the Cx43 in the intestinal epithelial cells. Cx43 down regulation showed significant association (p<0.05) with the histological type and tumor invasion properties of the cancer. Our data demonstrated that loss of Cx43 may be an important event in colon carcinogenesis and tumor progression, providing significant insights about the tumor suppressive properties of the Cx43 and its potential as a diagnostic marker for colon cancer.

• 노동경제논집
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• 제42권1호
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• pp.43-72
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• 2019

Oaxaca의 임금격차 요인분해법을 활용하여 대기업과 중소기업의 임금격차를 분해한 결과, 공급측 요인의 총임금격차는 44.2%였으며, 근속연수와 학력이 가장 크게 영향을 미쳤다. 그리고 기업의 경영실적 등 수요측 요인에 의한 기업 규모별 임금격차를 분해한 결과, 총임금격차는 44.9%였으며, 임금격차에 미치는 영향력은 노동생산성, 노조, 외주비율 순으로 컸다. 이러한 분석결과는 기업 규모별 임금격차를 해소하기 위해서는 인적자본의 차이 등 공급측 요인뿐만 아니라 기업의 경영실적과 자본구조 등 수요측 요인도 함께 고려할 필요가 있음을 시사한다.

• Toxicological Research
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• 제32권3호
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• pp.239-243
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• 2016

Propolis is a multicomponent, active, complex resinous substance collected by honeybees from a variety of plant sources. We have studied the effect of propolis on neurite outgrowth of SH-SY5Y human neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA). Propolis, at a concentration of $3{\mu}g/mL$, had no significant effect on the viability of differentiating SH-SY5Y cells. However, the neurite outgrowth of the differentiating SH-SY5Y cells treated with propolis ($0.3{\sim}3{\mu}g/mL$) for 48 hr was significantly inhibited in a dose-dependent manner. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.3 to $3{\mu}g/mL$ propolis resulted in decreased level of transglutaminase and 43-kDa growth-associated protein (GAP-43) in a dose-dependent manner. The results indicate that propolis is able to inhibit neurite outgrowth of differentiating SH-SY5Y cells.

• 대한조선학회논문집
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• 제43권5호
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• pp.578-585
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• 2006

Cavitation related erosion damages on semi-spade rudder generally occur at around leading edge of lower-face and behind gap of lower pintle. To get the idea of gap entrance profile for the latter case, a series of tests with large models has been carried out at MOERI. In the tests, the flow pattern around lower pintle have been investigated and visualized by high speed camera. Additionally, cavitation inception tests and pressure measurements have also been conducted for better comparison. As a result a new model (F rudder) has been developed. The new model turned out to have stable pressure distribution along the surface and so the cavitation inception speeds within ${\pm}5^{\circ}$ of rudder angle were delayed approx. 4 knots in average.

• 품질경영학회지
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• 제43권2호
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• pp.127-140
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• 2015

Purpose: To obtain the area for improvement, the Importance-Performance analysis(IPA) uses relatively simple questions, that is, satisfaction and importance at attribute level. However, no attempt has been made to consider the gap between own company's performance and those of competitors in IPA, in the field of quality management. This study is aimed to suggest a new prioritizing method for improvement and to test for validity of the proposed technique. Methods: This study used data collected from Song and Lim(2015), which is satisfaction of employees, customers and competitors as well as importance data for 7 quality attributes of K animal hospital. A correlation comparison with other priority methods such as Bacon(2003)'s model and Matzler and Hinterhuber(1998)'s QI index is conducted. Results: The priority results by the proposed method shows better in correlation coefficient with customer perceived priority for improvement than other methods. Conclusion: From the result of the current study, it can be concluded that the result of the proposed method is valid, while it is relatively easy to understand and analyze, and therefore no additional survey is necessary for improvement priority.

• 품질경영학회지
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• 제43권3호
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• pp.397-408
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• 2015

Purpose: Express mail service(EMS) supplied by 'Korea POST'is an international postal service which brings letters, documents and parcels to a destination abroad in the fastest and safest way. This service is in a tough competition with global companies such as TNT, FedEx, DHL or UPS. To build an effective strategy for being competitive, an intensive study on EMS service quality should be accomplished from a customer's perspective. Methods: Kano model and improvement gap analysis are used to categorize and prioritize EMS service quality attributes. A 5-point Lickert scale is employed to apply the Kano model and improvement gap analysis. Each quality attribute can be classified as weak in comparison with competitors, critical for improvement, or potentially competitive. Results: Price, on-time delivery and delivery quality are to be kept as is; fast delivery, parking convenience and staff expertise can be potentially competitive; and the other attributes are considered to be critical for improvement. Conclusions: Fast reimbursement and proper compensation when shipping items are lost or damaged are to be improved with high priority. Efforts to secure fast delivery, parking convenience and staff expertise are needed to be competitive in the future.

• Nuclear Engineering and Technology
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• 제43권5호
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• pp.447-458
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• 2011

This paper proposes an approximated contact force model to identify the nonlinear behavior of a fuel rod with gap supports; also, the numerical prediction of interfacial forces in the mechanical contact of fuel rods with gap supports is studied. The Newmark integration method requires the current status of the contact force, but the contact force is not given a priori. Taylor's expansion can be used to predict the unknown contact force; therefore, it should be guaranteed that the first derivative of the contact force is continuous. This work proposes a continuous and differentiable contact force model with the ability to estimate the current state of the contact force. An approximated convex and differentiable potential function for the contact force is described, and a variational formulation is also provided. A numerical example that considers the particularly stiff supports has been studied, and a fuel rod with hardening supports was also examined for a realistic simulation. An approximated proper solution can be obtained using the results, and abrupt changes from the contacting state to non-contacting state, or vice versa, can be relieved. It can also be seen that not only the external force but also the developed contact force affects the response.

• 한방재활의학과학회지
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• 제18권3호
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• pp.19-39
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• 2008

목 적 : 천궁은 중추신경계 신경조직의 손상을 감소시키는 데에 유효한 것으로 보고되었다. 따라서 손상 척수신경에서 천궁에 의한 각각의 신경조직의 반응성을 조사하기 위하여 흰쥐의 손상된 척수 신경에 천궁 추출물을 처리하여 관찰하였다. 방 법 : 흰쥐의 척수조직에 타박손상을 가한 후 천궁을 처리하고 손상부위의 GAP-43과 Cdc2 및 Erk1/2 단백질의 수준, 축삭 및 성상세포의 수, 아교상혼의 정도를 각각 확인하여 손상부위 및 피질척수로의 재성장 여부를 관찰하였다. 결 과 : 천궁처리에 의하여 손상부위에서는 GAP-43과 Cdc2 및 Erk1/2 단백질의 수준이 증가하였다. 손상척수 부위에서 성상세포의 수는 천궁처리에 의하여 비손상대조군에 비해 증가하였다. CSPG 단백질에 의하여 확인된 아교상흔의 정도는 천궁처리에 의하여 감소하였다. Dil에 의한 정방향 염색에 의하여 피질척수로를 확인하였으며, 측방축삭의 싹돌기는 천궁처리에 의하여 손상부위 상단부 및 하단부에 각각 증가하였다. 고분자미세관을 손상척수부위에 이식하여 미세관내부로 축삭 및 비신경세포의 이주양상을 분석한 결과 천궁처리에 의하여 축삭 및 성상교세포의 이주증가를 확인하였다. 결론 : 천궁이 손상척수신경부위에서 비신경세포 특히 성상세포의 활성화에 기여함을 알 수 있었다. 이러한 활성화는 손상 피질척수로 축삭의 재성장 반응을 증가시키는 효과가 있는 것으로 판단된다.