• The Korean Journal of Pharmacology
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• v.25 no.1
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• pp.101-107
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• 1989

To evaluate disposition characteristics of procainamide and its active metabolite, N-acetylprocainamide (NAPA), cross-over study for procainamide and NAPA was performed in 5 male adult dogs. After single administration of 10 mg/kg procainamide over 15 minutes, the range of measured plasma NAPA concentrations during experimental period were 0.03 to 0.124 ug/ml and early 'dip' phenomenon was distinct on NAPA concentration to time curve in all 5 dogs. Volume of distribution (Vss) and central compartment volume (Vc) of procainamide were $1.20{\pm}0.27\;L/kg$ of body weight and $0.36{\pm}0.08\;L/kg$, respectively. Vss and Vc of NAPA were $1.21{\pm}0.21\;L/kg$ and $0.26{\pm}0.07\;L/kg$, respectively. Intercompartmental clearance (Clint) of procainamide was 3.44 L/kg/hr and that of NAPA was 1.62 L/kg/hr. Total body clearance (Cl) of procainamide and NAPA were $0.47{\pm}0.08$ and $0.35{\pm}0.08\;L/kg/hr$. The half-life $(t_{1/2{\beta}})$ of procainamide and NAPA were 2.85 hrs and 2.77 hrs, respectively. Metabolic clearance (Clm)of procainamide by N-acetylation was $18.24{\pm}6.22\;ml/kg/hr$, which corresponded to 3.9% of total procainamide clearance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.460-469
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• 2020

The purpose of this study was to examine the predictive factors for health promotion behaviors of older adults in rural areas. A theoretical substruction was constructed to test hypothetical models based on Pender's health promotion model. The data was collected from 199 older adults aged 65 years or older, who resided in G city, by using a structured questionnaire. The questionnaires contained items on individual characteristics, health literacy, self efficacy and health promoting behavior. The data was analyzed with a t-test, ANOVA, Pearson's correlation coefficients and hierarchical multiple regression analysis using SPSS 20.0 for Windows. The predictive factors for the health promotion behavior were the number of health information channels (β=.16, p=.031) and self efficacy (β=.53, p<.001). The total explanatory power of these factors was 30.8%. A nursing intervention plan for improving health promoting behaviors of older adults should be developed and applied, with a focus on self-efficacy and health information channels. Further longitudinal studies are needed to help confirm relevant measurement of the level of health promoting behaviors of older adults.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.646-657
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• 2018

Purpose: This study is to investigate factors affecting depression in nursing students. Methods: A survey was conducted with 216 nursing students in college at P city, D city, and K province. Data was collected from April 15 to May 21, 2018, and analyzed by descriptive statistics, t-test, one-way ANOVA and hierarchical regression with IBM SPSS Statistics 24.0. Results: There was a significant positive correlation between verbal violence and depression(r=.261, p<.001), between physical threat and depression(r=.291, p<.001). Also, Self-esteem had a significant positive correlation with resilience(r=.685, p<.001) and negative correlation with depression(r=-.590, p<.001). Moreover, resilience had a significant negative correlation with depression(r=-.612, p<.001). In the hierarchical analysis, factors affecting the nursing students' depression were resilience(${\beta}=-.337$, p<.001), self-esteem(${\beta}=-.279$, p<.001), physical threat(${\beta}=.177$, p=.001). The variable that had the highest impact on depression was resilience and the explanatory power of the regression model was 51.5%(F=17.965, p<.001). Conclusion: The findings of this study indicate that the major factors influencing nursing students depression are physical threat, self-esteem and resilience. Therefore, it suggests that an intervention program will be required to prevent violence during the clinical practice, enhances self-esteem and improves resilience in order to reduce depression of nursing students.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.12A
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• pp.2027-2035
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• 2001

In this paper, we present an audio stream delivery using the AMR (Adaptive Multi-Rate) coder that was adopted by ETSI and 3GPP as a standard vocoder for next generation IMT-2000 service in which includes combined sender (FEC) and receiver reconstruction technique in the Internet. By use of the media-specific FEC scheme, the possibility to recover lost packets can be much increased due to the addition of repair data to a main data stream, by which the contents of lost packets can be recovered. The AMR codec is based on the code-excited linear predictive (CELP) coding model. So we use a frame erasure concealment for CELP-based coders. The proposed scheme is evaluated with ITU-T G.729 (CS-ACELP) coder and AMR - 12.2 kbit/s through the SNR (Signal to Noise Ratio) and the MOS (Mean Opinion Score) test. The proposed scheme provides 1.1 higher in Mean Opinion Score value and 5.61 dB higher than AMR - 12.2 kbit/s in terms of SNR in 10% packet loss, and maintains the communicab1e quality speech at frame erasure rates lop to 20%.

• Parasites, Hosts and Diseases
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• v.50 no.3
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• pp.199-205
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• 2012

Toxoplasmic encephalitis is caused by reactivation of bradyzoites to rapidly dividing tachyzoites of the apicomplexan parasite Toxoplasma gondii in immunocompromised hosts. Diagnosis of this life-threatening disease is problematic, because it is difficult to discriminate between these 2 stages. Toxoplasma PCR assays using gDNA as a template have been unable to discriminate between an increase or decrease in SAG1 and BAG1 expression between the active tachyzoite stage and the latent bradyzoite stage. In the present study, real-time RT-PCR assay was used to detect the expression of bradyzoite (BAG1)- and tachyzoite-specific genes (SAG1) during bradyzoite/tachyzoite stage conversion in mice infected with T. gondii Tehran strain after dexamethasone sodium phosphate (DXM) administration. The conversion reaction was observed in the lungs and brain tissues of experimental mice, indicated by SAG1 expression at day 6 after DXM administration, and continued until day 14. Bradyzoites were also detected in both organs throughout the study; however, it decreased at day 14 significantly. It is suggested that during the reactivation period, bradyzoites not only escape from the cysts and reinvade neighboring cells as tachyzoites, but also converted to new bradyzoites. In summary, the real-time RT-PCR assay provided a reliable, fast, and quantitative way of detecting T. gondii reactivation in an animal model. Thus, this method may be useful for diagnosing stage conversion in clinical specimens of immunocompromised patients (HIV or transplant patients) for early identification of tachyzoite-bradyzoite stage conversion.

• YAKHAK HOEJI
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• v.41 no.1
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• pp.60-73
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• 1997

In order to design a 24 hr sustained release preparation of sulindac for oral administration, fast release pellet (FR), slow release pellet (SR) and two combined formulation (1 : 1 and 1 : 2) were prepared. The pharmacokinetic effect of such preparations has been evaluated using rabbits as a suitable in vivo model, and tested in man. Dose determination was carried out using curve fitting according to RSTPJP II program. In bioavailability test using rabbit, AUCs of sulindac in a few designed formulations were similar to each other. $C_{max}$- of RF and SR were 1.8 times and 1.2 times higher, respectively, compared to that of combined formulation (FR:SR=1:1). While plasma concentration of FR and SR decreased rapidly, that of combined formulation (FR:SR 1:1) lasted at the level close to $C_{max}$ for 24 hrs. Plasma concentration of sulfide form from the combined pellet(FR:SR=1:1) lasted for 24 hrs, and its AUC value was 1.4-fold, 2.7-fold. and 1.2-fold greater than FR pellet, SR pellet and combined pellet (FR:SR 1 : 2). Thus, the combined pellet of 1:1 ratio was found to be the most effective for oral sustained release formulation. Bioavailability test in human showed that AUC of sulfide from TSRP (1 : 1) was approximately 1.5 times greater than total AUC of Immbaron$^{\circledR}$ administered twice in a day. While $T_{max}$ of sulfide from lmmbaron$^{\circledR}$ was 4.33 +/- 1.37 hr (lst administration) and 3.33 ${pm}$ 0.82 hr (2nd administration), respectively, that of sulfide from TSRP increased to 7.17 ${pm}$ 2.86 hr. Plasma concentration of sulfide from TSRP was sustained at more, than 1.0 ${\mu}g{\cdot}$hr/ml until 24 hrs after one dose administration. In addition, TSRP may decrease local adverse reaction in the stomach, since plasma concentration of sulfide from the combined pellet was low within 2hrs in the stomach. In conclusion, it is suggested that TSRP formulation may be effective for oral 24 hr sustained release formulation of sulindac dosing 300 ~ 350mg once a day.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.613-624
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• 2020

This study is a descriptive research to grasp the effects of nursing performance on emotional labor, job stress and resilience in general hospital nurses. Method: I surveyed them using a structured questionnaire for collecting data from Aug. 20, 2019 to Sep. 2, 2019. The collected data were analyzed by the frequency, the percentage, t-test, ANOVA, Scheffe's Test, Pearson's Correlation Coefficient, and Multiple Regression Analysis. Results: The factors affecting nursing performance of the subjects were resilience (β=0.58, p<.001), and current position is head nurse (β=0.21, p<.01), the number of working years at current working place (β=0.18, p<.05). The F statistics for the fit of the estimated regression model was very significant as 30.901(p<.001) and the explanatory power was 42.4%. Conclusion: The results of this study showed that resilience was the most influential factor to nursing performance of general hospital nurses, and the number of working years at current working place was the most influential factor to the performance of head nurses. Therefore, it is necessary to develop practical programs strengthening resilience of nurses for the improvement of nursing performance and to apply strategies on development.

• Journal of the Korean Applied Science and Technology
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• v.38 no.4
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• pp.941-950
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• 2021

This study was conducted to identify the factors affecting the health-promoting lifestyle of the school-age obese children. Method: Data Collection for this study was conducted form July 20 to August 2, 2019 using a structured questionnaire. We analyzed the collected data by frequency, percentage, ANOVA, t-test, Pearson's Correlation Coefficient, and Multiple Regression Analysis. Results: The factors affecting the health-promoting lifestyle of the subjects, multiple regression analysis results showed that Dietary Self-Efficacy(𝛽=.406, p=.001), Physical Activity Self-Efficacy(𝛽=.245, p=.038), Furthermore, the F statistics for the fitness of the estimated regression model were 6.34(p<.001), which was significant. The explanatory power was 24.2%. Conclusion: The results of this study showed that Dietary Self-Efficacy and Physical Activity Self-Efficacy of the school-age obese children was the most influential factor on health-promoting lifestyle. Consequently, the results of this study suggest that it is necessary to find ways to improve Dietary Self-Efficacy and Physical Activity Self-Efficacy in order to improve health-promoting lifestyle of nurses, and it is considered to be useful as basic data for developing intervention programs to improve health-promoting lifestyle.

• 한국노년학
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• v.37 no.3
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• pp.655-667
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• 2017

This study aimed to identify workplace learning, job satisfaction and geriatric nursing practice, find the correlations between each variable, and investigate affecting factors on geriatric nursing practice. Subjects were 146 nurses in 9 long-term care hospitals including G City, and data were collected from May 1, 2016 through Jun. 30, 2016. Data analysis included independent t-test, one-way ANOVA, Pearson's correlation coefficient and multiple regression using the SPSS/WIN 20.0 program. The results showed that the correlations between each variable showed that incidental learning, a subregion of workplace learning (r=.20, p=.014), and job satisfaction (r=.29, p<.001) had a positive correlation with geriatric nursing practice, respectively. The affecting factors on geriatric nursing practice were job satisfaction, daytime working and nursing experience, and the explanatory power of the model was 20%(F=4.91, p<.001). Based on the results, job satisfaction should be increased to improve the quality of nursing in long-term care hospitals and various methods might be discussed to improve the job satisfaction. Daytime working was suggested one factor on geriatric nursing practice because nursing was provided mainly during daytime, and nursing experience was also one factor on geriatric nursing practice, so highly experienced geriatric nurses could provide high quality elderly patient care.

• The Korea Journal of Herbology
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• v.34 no.2
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• pp.41-47
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• 2019

Objectives : A traditional herbal prescription, Kyung-Ok-Ko (KOK), has long been used in oriental medicine as an invigorant for age-related diseases, such as amnesia and stroke. However, the beneficial value of KOK for immune responses is largely unknown. Based on the above mentioned effects of KOK, other previous reports, and its use in traditional medicine, we hypothesized that KOK displays beneficial effects against methotrexate (MTX)-induced immune suppression. Methods : We investigated the effects of KOK (0.6 g/kg/day, oral (p.o.)) on deteriorated immunity caused by MTX (2 mg/kg/day, p.o.) in an immune suppression mouse model. MTX was fed to mice once a day for 7 days. After the immune responses of the mice deteriorated by MTX treatment, KOK in water was fed to the mice once a day for 14 days. We then measured the expression levels of various cytokines, such as T helper cell (Th1, Th2) cytokines, and the number of immune cells, such as spleen T cells, B cells, and macrophages. Results : The data showed that MTX decreased Th1 profiles (interferon $(IFN)-{\gamma}$, interleukin (IL)-2, IL-12) and the number of immune cells, and increased Th2 profiles (IL-4, IL-5, IL-13), which were normalized significantly by post-administration of KOK. However, there was no significant difference in body-weight gain between MTX- and KOK-treated mice. Conclusion : These results indicate that KOK has immune-enhancing functions and reduces immunotoxicity of MTX, suggesting that supplementation with KOK will improve immune responses clinically and be useful for the prevention of immune-related diseases.