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The Result of Radiation Therapy of Glottic Laryngeal Carcinoma for 20 Years (성문암(聲門癌) 방사선치료(放射線治療) 20년(年) 성적(成績))

  • Cho Chul-Koo;Koh Kyoung-Hwan;Yoo Seong-Yul
    • Korean Journal of Head & Neck Oncology
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    • v.4 no.1
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    • pp.41-51
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    • 1988
  • To evaluate the result of radiation therapy for twenty years experience, a total of 115 cases of pathologically proven glottic carcinoma had been analyzed according tot survival respectively. All the patients had been treated with radiation therapy in curative intent using Co-60 teletherapy machine. The results are as follows: 1) Accoridng to sex, 5YSR & 10YSR were 58.7% and 50.4% in male patients, and 80.0% & 72.0% in female. 2) According to T staging, 5YSR & 10YSR were 83.4% & 83.4% in T1, 69.2% & 60.0% in T2, 34.3% & 21.8% in T3, 32.0% & 0% in T4. 3) According to N staging, 5YSR & 10YSR were 63.8% & 59.2% in node-negative groups, and 30.7% & 15.4% in node-positive groups. 4) According to the histologic grade, 5YSR & 10YSR were 66.8% & 57.6% in G1, 61.3% 54.3% in G2, and 35.0% 35.0% in G3. 5) According to AJC staging, 5YSR & 10YSR were 83.4%% 83.4% in stage I, 72.0% & 62.7% in stage II, 36.8% & 28.3% in stage III, and 14.3% & 7.1% in stage IV. 6) In summary, 5YSR & 10YSR wre 60.4% & 52.8% in glottic carcinoma.

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Idiopathic multicentric Castleman disease presenting progressive reticular honeycomb infiltration of lung and immunoglobulin G and immunoglobulin G4 dominant hypergammaglobulinemia: a case report

  • Kim, Hyun-Je;Hong, Young-Hoon
    • Journal of Yeungnam Medical Science
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    • v.39 no.2
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    • pp.153-160
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    • 2022
  • Multicentric Castleman disease (MCD) is an uncommon systemic lymphoproliferative disorder that may cause multiple organ damage. Castleman disease-associated diffuse parenchymal lung disease (DPLD) has not been well studied. A 32-year-old man was referred to our hospital for progressive generalized weakness, light-headedness, and dyspnea on exertion for more than one year. Laboratory evaluations showed profound anemia, an elevated erythrocyte sedimentation rate, and an increased C-reactive protein level with polyclonal hypergammaglobulinemia. Chest radiography, computed tomography (CT), and positron emission tomography-CT scan demonstrated diffuse lung infiltration with multiple cystic lesions and multiple lymphadenopathy. In addition to these clinical laboratory findings, bone marrow, lung, and lymph node biopsies confirmed the diagnosis of idiopathic MCD (iMCD). Siltuximab, an interleukin-6 inhibitor, and glucocorticoid therapy were initiated. The patient has been tolerating the treatment well and had no disease progression or any complications in 4 years. Herein, we report this case of human herpesvirus-8-negative iMCD-associated DPLD accompanied by multiple cystic lesions, multiple lymphadenopathy, and polyclonal hypergammaglobulinemia with elevated immunoglobulin G (IgG) and IgG4 levels. We recommend a close evaluation of MCD in cases of DPLD with hypergammaglobulinemia.

Survival in clinical stage I endometrial cancer with single vs. multiple positive pelvic nodes: results of a multi-institutional Italian study

  • Uccella, Stefano;Falcone, Francesca;Greggi, Stefano;Fanfani, Francesco;De Iaco, Pierandrea;Corrado, Giacomo;Ceccaroni, Marcello;Mandato, Vincenzo Dario;Bogliolo, Stefano;Casarin, Jvan;Monterossi, Giorgia;Pinelli, Ciro;Mangili, Giorgia;Cormio, Gennaro;Roviglione, Giovanni;Bergamini, Alice;Pesci, Anna;Frigerio, Luigi;Uccella, Silvia;Vizza, Enrico;Scambia, Giovanni;Ghezzi, Fabio
    • Journal of Gynecologic Oncology
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    • v.29 no.6
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    • pp.100.1-100.13
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    • 2018
  • Objective: To investigate survival outcomes in endometrioid endometrial cancer (EEC) patients with single vs. multiple positive pelvic lymph nodes. Methods: We performed a retrospective evaluation of all consecutive patients with histologically proven International Federation of Gynecology and Obstetrics (FIGO) stage IIIC1 EEC who underwent primary surgical treatment between 2004 and 2014 at seven Italian gynecologic oncology referral centers. Patients with pre- or intra-operative evidence of extra-uterine disease (including the presence of bulky nodes) and patients with stage IIIC2 disease were excluded, in order to obtain a homogeneous population. Results: Overall 140 patients met the inclusion criteria. The presence of >1 metastatic pelvic node was significantly associated with an increased risk of recurrence and mortality, compared to only 1 metastatic node, at both univariate (recurrence: hazard ratio [HR]=2.19; 95% confidence interval [CI]=1.2-3.99; p=0.01; mortality: HR=2.8; 95% CI=1.24-6.29; p=0.01) and multivariable analysis (recurrence: HR=1.91; 95% CI=1.02-3.56; p=0.04; mortality: HR=2.62; 95% CI=1.13-6.05; p=0.02) and it was the only independent predictor of prognosis in this subset of patients. Disease-free survival (DFS) and disease-specific survival (DSS) were significantly longer in patients with only 1 metastatic node compared to those with more than 1 metastatic node (p=0.008 and 0.009, respectively). Conclusion: The presence of multiple metastatic nodes in stage IIIC1 EEC represents an independent predictor of worse survival, compared to only one positive node. Our data suggest that EEC patients may be categorized according to the number of positive nodes.

Effects of Tuber Position and Number of Nodes on Growth of Saururus chinensis Baill (삼백초(三白草)의 종근(種根)사용 부위(部位)와 마디수가 근경(根莖) 및 지상부(地上部) 생육(生育)에 미치는 영향(影響))

  • Park, Jae-Ho;Park, Boo-Gyu;Kim, Min-Ja;Park, Seong-Gyu;Kim, Jin-Han
    • Korean Journal of Medicinal Crop Science
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    • v.6 no.4
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    • pp.286-293
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    • 1998
  • This study was carried out to find the effects of seed tuber position and number of nodes on growth of Saururus chinensis Baill. at experimental field of Chungbuk Provincial Rural Development Administration from 1996 to 1997. Seed tubers were divided into upper, middle and lower parts, and they were prepared to 1-, 2-, 3-node cuttings in each. Percentage of sprouting in planting of middle part was highest of 92%, and the percent increased by increasing the number of nodes. Growth of shoot and root tuber was the most favorable with planting of 3-node cuttings of middle part, and leaf area index (LAI) was highest of 3.10 in the same treatment. Dry matter weight and percentage of root tuber were highest of $821g/m^2$ and 28 % with planting of 3-node cuttings of middle part. Yield of dry leaf and root tuber were highest of 272kg/10a and 821kg/10a with planting of 3-node cuttings of middle part.

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Regrowth Patterns of the Perennial Weeds Treated with Sulfonylureas and Starch Degradation in the Rhizome (Sulfonylurea계 제초제가 처리된 다년생 잡초의 재생양상과 저장전분량의 변화)

  • Hwang, I.T.;Lee, K.H.;Hong, K.S.;Kim, J.S.;Lee, B.H.;Cho, K.Y.
    • The Korean Journal of Pesticide Science
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    • v.6 no.1
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    • pp.36-41
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    • 2002
  • Characteristics of regrowth and starch degradation in perennial weed rhizomes were investigated in a greenhouse. Cyperus serotinus started regrowth at 24 days after treatment of 1.25 g ai/ha of pyrazosulfuron-ethyl. The regrowth of Sagittaria trifolia, Eleocharis kuroguwai, and S. pygmaea required $30{\sim}39$ days, and Potamogeton distinctus regrew at 55 days after treatment of 1.25 g ai/ha of pyrazosulfuron-ethyl. However, all of 5 perennial weeds hardly regrew until 45 days after treatment more than 5 g ai/ha of pyrazosulfuron-ethyl. Regrowth of C. serotinus 4-node rhizomes was 2 times higher than 2-node rhizomes, and $1{\sim}1.5g$ of E. kuroguwai large tubers regrew faster than $0.3{\sim}0.5g$ of small tubers treated with bensulfuron-methyl. Regrowth of C. serotinus was enhanced with delayed application of bensulfuron-methyl, however, 2-leaf stage of E. kuroguwai plants regrew better than 3 leaf stage of plants when treated with equal volume of bensulfuron-methyl. The critical periods of S. trifolia and E. kuroguwai growth depending upon the rhizome detachment were 12 and 18 days after sprouting, respectively. The starch stacked in the S. trifolia and E. kuroguwai tubers were exhausted at 18 and 27 days after sprouting, respectively. The highest level of sugar contents was showed at 9 days after sprouting in S. trifolia, and 18 days after sprouting in E. kuroguwai.

Topological Properties of Recursive Circulants : Disjoint Paths (재귀원형군의 위상 특성 : 서로소인 경로)

  • Park, Jeong-Heum;Jwa, Gyeong-Ryong
    • Journal of KIISE:Computer Systems and Theory
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    • v.26 no.8
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    • pp.1009-1023
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    • 1999
  • 이 논문은 재귀원형군 G(2^m , 2^k ) 그래프 이론적 관점에서 고찰하고 정점이 서로소인 경로에 관한 위상 특성을 제시한다. 재귀원형군은 1 에서 제안된 다중 컴퓨터의 연결망 구조이다. 재귀원형군 {{{{G(2^m , 2^k )의 서로 다른 두 노드 v와 w를 잇는 연결도 kappa(G)개의 서로소인 경로의 길이가 두 노드 사이의 거리d(v,w)나 혹은 G(2^m , 2^k )의 지름 \dia(G)에 비해서 얼마나 늘어나는지를 고려한다. 서로소인 경로를 재귀적으로 설계하는데, 그 길이는 k ge2일 때 d(v,w)+2^k-1과 \dia(G)+2^k-1의 최솟값 이하이고, k=1일 때 d(v,w)+3과 \dia(G)\+2의 최솟값 이하이다. 이 연구는 (2^m , 2^k )의 고장 감내 라우팅, 고장 지름이나 persistence의 분석에 이용할 수 있다.Abstract In this paper, we investigate recursive circulant G(2^m , 2^k ) from the graph theory point of view and present topological properties concerned with node-disjoint paths. Recursive circulant is an interconnection structure for multicomputer networks proposed in 1 . We consider the length increments of {{{{kappa(G)disjoint paths joining arbitrary two nodes v and win G(2^m , 2^k )compared with distance d(v,w)between the two nodes and diameter {{{{\dia(G)of G(2^m , 2^k ), where kappa(G)is the connectivity of G(2^m , 2^k ). We recursively construct disjoint paths of length less than or equal to the minimum of {{{{d(v,w)+2^k-1and \dia(G)+2^k-1for kge2 and the minimum of d(v,w)+3 and \dia(G)+2for k=1. This work can be applied to fault-tolerant routing and analysis of fault diameter and persistence of G(2^m , 2^k )

Localization Algorithm in Wireless Sensor Networks using the Acceleration sensor (가속도 센서를 이용한 무선 센서 네트워크하에서의 위치 인식 알고리즘)

  • Hong, Sung-Hwa;Jung, Suk-Yong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.4
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    • pp.1294-1300
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    • 2010
  • In an environment where all nodes move, the sensor node receives anchor node's position information within communication radius and modifies the received anchor node's position information by one's traveled distance and direction in saving in one's memory, where if there at least 3, one's position is determined by performing localization through trilateration. The proposed localization mechanisms have been simulated in the Matlab. In an environment where certain distance is maintained and nodes move towards the same direction, the probability for the sensor node to meet at least 3 anchor nodes with absolute coordinates within 1 hub range is remote. Even if the sensor node has estimated its position with at least 3 beacon information, the angle ${\theta}$ error of accelerator and digital compass will continuously apply by the passage of time in enlarging the error tolerance and its estimated position not being relied. Dead reckoning technology is used as a supplementary position tracking navigation technology in places where GPS doesn't operate, where one's position can be estimated by knowing the distance and direction the node has traveled with acceleration sensor and digital compass. The localization algorithm to be explained is a localization technique that uses Dead reckoning where all nodes are loaded with omnidirectional antenna, and assumes that one's traveling distance and direction can be known with accelerator and digital compass. The simulation results show that our scheme performed better than other mechanisms (e.g. MCL, DV-distance).

The Effects of BGG on Various Immunological Factors Related to Pathogenesis of Allergic Dermatitis in NC/Nga Mice Induced by Der-f (보음거풍지양탕(補陰祛風止痒湯)이 아토피 피부염을 유발(誘發)한 NC/Nga 생쥐의 면역(免疫) 조절작용(調節作用)에 미치는 영향(影響))

  • Bang, Chan-Kuk;Choi, Jeong-Jun;Eom, Dong-Myung;Kim, Dong-Hee
    • Journal of Haehwa Medicine
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    • v.16 no.2
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    • pp.147-169
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    • 2007
  • To evaluate the therapeutic effects of BGG on atopic dermatitis, we investigated the composition of immune cells of lymph node, PBMC and skin of Dermatophagoides farinae-induced NC/Nga mice. The levels of immunoglobulins in serum were analyzed at the protein level and the amount of pathologic cytokines were investigated using CD3/CD28 stimulated splenocytes. The results are summarized below; 1. BGG showed no cytotoxic effect up to $200\;{\mu}g/m{\ell}$ on mLFC in vitro. 2. BGG showed no hepatotoxicity in vivo based on the levels of ALT and AST. 3. Atopic dermatitis was improved through naked eye examination. BGG reduced the skin clinical index from 2.9 to 1.3 (p<0.01). 4. H&E and toluidine blue staining of tissue biopsies revealed that BGG inhibited the infiltration of lymphocytes and mast cells to skin. 5. BGG reduced the number of CD19 positive B cells in PBMCs by 16% (p<0.01), whereas cells were increased by 26% (p<0.05) in lymph nodes. 6. BGG reduced the numbers of B220+/CD23+ cells by 15% (p<0.01) and 33% in PBMCs and lymph node, respectively. 7. BGG reduced the numbers of B220+/IgE+ cells in PBMCs and lymph node by 21% and 33% (p<0.01), respectively. 8. BGG suppressed the levels of IgE (13%, p<0.001) as well as IgM (34%, p<0.001), IgG2a (40%, p<0.001) and IgG2b (26%, p<0.05). 9. BGG reduced the levels of IL-4 and IFN-$\gamma$ by 7% (p<0.05) and 13% (p<0.001) in anti-CD3 and anti-CD28-activated splenocytes, respectively. 10. BGG considerably inhibited the production of TNF-$\alpha$ and IL-6 by 42% (p<0.01) and 15% in the serum, respectively. Based on the results above, we concluded that BGG has therapeutic effects on atopic dermatitis by regulating the differentiation of B cells and isotype switching of IgE. Further investigations on the molecular mechanisms of BGG on atopic dermatitis are anticipated.

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Minimized Transmit Power Full Duplex NOMA Relay System for 5G Wireless Networks (5G 무선 네트워크 효율성 향상을 위한 Full Duplex NOMA Relay 최소 전송전력 시스템)

  • Kim, Kyuha;Yoo, Wonsuk;Chung, Jong-Moon
    • Journal of Internet Computing and Services
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    • v.20 no.3
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    • pp.13-24
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    • 2019
  • The key concept of NOMA among 5G network technologies is to set the power allocation coefficient for each node. In this study, we implemented the algorithm that calculates the uplink/downlink power allocation coefficients which is the key concept of NOMA technology through analysis of minimum SNR required for successful decoding at the receiver, based on Full Duplex NOMA relay system. The performance comparison between the proposed algorithm and the existing power allocation methods is performed and the performance is confirmed in terms of ergodic sum capacity and outage probability.

Cyclin G2 Expression in Gastric-cancer Tissues (위암조직에서 Cyclin G2 발현의 의의)

  • Choi, Min-Gew;Hong, Seong-Kweon;Park, Sung-Bae;Paik, Yong-Hae;Noh, Jae-Hyung;Sohn, Tae-Sung;Kim, Sung-Joo;Kim, Sung
    • Journal of Gastric Cancer
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    • v.5 no.4 s.20
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    • pp.273-280
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    • 2005
  • Purpose: Cyclin G2 has been reported to be a negative cell-cycle regulator in various cancer tissues. However, the pattern of cyclin G2 expression in gastric cancer is relatively unknown. We investigated the expression of cyclin G2 in gastric cancer tissues and evaluated the clinical significance of its expression. Materials and Methods: Well-preserved gastric cancer tissues were consecutively obtained from 172 patients who underwent gastric cancer operations at Samsung Medical Center between November 1994 and December 1997. Cyclin G2 expression in the tissues was examined immunohistochemically, and the clinicopathological features and prognostic significance according to the expression were analyzed. Results: Of the 172 gastric cancer tissues, cyclin G2 expression was positive in 43 tissues (25.0%). According to the stage, cyclin G2 expression was lower in more advanced stages (P<0.001). Negative expression of cyclin G2 was positively correlated with more advanced depth of tumor invasion (P<0.05), presence of lymph-node metastasis (P<0.05) and presence of lymphatic invasion (P<0.05). The prognosis of the cyclin G2(+) group was significantly better than that of the cyclin G2(-) group (P<0.001). Multivariate analysis revealed that T stage, lymph-node metastasis, distant metastasis, and lymphatic invasion were independent prognostic factors, but the expression of cyclin G2 was not. Conclusion: Cyclin G2 was expressed in 25% of the gastric cancer tissues, and negative expression of cyclin G2 was associated with more advanced tumor progression. Cyclin G2 may be a negative cell-cycle regulator in gastric cancer, and further studies are necessary to elucidate its exact role in the mechanism of carcinogenesis.

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