• Genomics & Informatics
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• v.16 no.4
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• pp.37.1-37.3
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• 2018

Gene-gene interaction is a key factor for explaining missing heritability. Many methods have been proposed to identify gene-gene interactions. Multifactor dimensionality reduction (MDR) is a well-known method for the detection of gene-gene interactions by reduction from genotypes of single-nucleotide polymorphism combinations to a binary variable with a value of high risk or low risk. This method has been widely expanded to own a specific objective. Among those expansions, fuzzy-MDR uses the fuzzy set theory for the membership of high risk or low risk and increases the detection rates of gene-gene interactions. Fuzzy-MDR is expanded by a maximum likelihood estimator as a new membership function in empirical fuzzy MDR (EFMDR). However, EFMDR is relatively slow, because it is implemented by R script language. Therefore, in this study, we implemented EFMDR using RCPP ($c^{{+}{+}}$ package) for faster executions. Our implementation for faster EFMDR, called EMMDR-Fast, is about 800 times faster than EFMDR written by R script only.

• Earthquakes and Structures
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• v.21 no.6
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• pp.577-585
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• 2021

In this research, a neural network (NN) method was developed, which combines H-infinity and fuzzy control for the purpose of stabilization and stability analysis of nonlinear systems. The H-infinity criterion is derived from the Lyapunov fuzzy method, and it is defined as a fuzzy combination of quadratic Lyapunov functions. Based on the stability criterion, the nonlinear system is guaranteed to be stable, so it is transformed to be a linear matrix inequality (LMI) problem. Since the demo active vibration control system to the tuning of the algorithm sequence developed a controller in a manner, it could effectively improve the control performance, by reducing the wind's excitation configuration in response to increase in the cost efficiency, and the control actuator.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1993.06a
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• pp.1082-1085
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• 1993

In this paper, we notice the fact that a human learning process is characterized by a process under a natural language environment, and discuss an approach of learning based on indirect linguistic instructions. An instruction is interpreted through some meaning elements and each trend. Fuzzy evaluation rule are constructed for the searched meaning elements of the given instruction, and the performance of a system to be learned is improved by the evaluation rules. In this paper, we propose a framework of learning based on indirect linguistic instruction based learning using fuzzy theory: FULLINS(FUzzy-Learning based on Linguistic IN-Struction). The validity of FULLINS is shown by applying it to helicopter flight control.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.9
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• pp.95-103
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• 1995

Recently the trends toward reduction in size of industrial products have increased the application of micro drilling. But micro drilling has still much difficulty so that the needs for active control which give adaptation to controller are expanding. In this paper initial cutting condition was determined for some sorkpieces by experiment and GA-based Fuzzy controller was devised by genetic algorithms and fuzzy inference. The fuzzy inference has been applied to the various prob- lems. However the determination of the membership function is one of the difficult problem. So we introduce a genetic algorithms and propose a self-tuning method of fuzzy membership function. Based on this intelligent control, automation of micro drilling was carried out like the cutting process of skilled machinist.

• Journal of Digital Convergence
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• v.11 no.2
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• pp.221-228
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• 2013

A number of research studies focus on the efficacy of using such as scenario based learning. However, desirable methods have not been introduced to assess the scenario based learning. This article is to suggest a fuzzy logic based framework for scenario base learning in which more reasonable learning effects are measured. It can be solved uncertain problems of linguistic variables. Also, we suggest three measures of accuracy, comprehensibility and completeness in order to evaluate accurate effects of scenario based learning. This assessment provides the scenario to the learner in which the scenario is presented in an authentic context, and enable the learner to reach an outcome through an adequate sequence and choices. This approach enables the system to present new scenarios and outcomes based on what a user selects. In particular, the application of fuzzy logic in scenario based learning can be easily pursued certain successful path or wrong path all the way through to reach major outcome in real situation.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.1
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• pp.1-5
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• 2009

This paper suggests to apply mirror-reflected method based 2D emotion recognition database to 3D application. Also, it makes facial expression of fuzzy modeling using probability of emotion. Suggested facial expression function applies fuzzy theory to 3 basic movement for facial expressions. This method applies 3D application to feature vector for emotion recognition from 2D application using mirror-reflected multi-image. Thus, we can have model based on fuzzy nonlinear facial expression of a 2D model for a real model. We use average values about probability of 6 basic expressions such as happy, sad, disgust, angry, surprise and fear. Furthermore, dynimic facial expressions are made via fuzzy modelling. This paper compares and analyzes feature vectors of real model with 3D human-like avatar.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.578-589
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• 2003

The fuzzy rat that expresses hypersecretion of sebum and hyperplastic sebaceous glands is a genetic mutant for the study of many pharmacological aspects especially human acne. Through this model, we examined the effects of several phospholipids on the secretion of sebum after topical application. The phospholipid derivatives were phosphatidylcholine (PC), hydrogenated phosphatidylcholine (HPC), phosphati dylserine (PS) and hydrogenated phosphatidylserine(HPS). All agents were dissolved into the vehicle (1, 3-Butanediol, ethanol and water) at 0.5％ weight volume and applied on the dorsal area of the fuzzy rat. To observe histological changes, the skin biopsies were stained with Oil Red O and the size and morphology of sebaceous gland was observed under microscope. Topical treatment with PC and/or HPC showed a marked decrease in sebum excretion. Especially hydrogenated PC (HPC) appeared to have more predominant sebosuppressive function than any other treatment. The other agents such as PS and HPS showed a marginal effect on sebum secretion. With the sebosuppressive activity, HPC and PC seem to have a good potential application on acne treatment. In order to obtain more insights into possible mechanisms behind the above observations, effects of each phospholipid on the expression of peroxisome proliferator-activated receptor (PPAR) genes were investigated. Recently, it has been demonstrated that expression and activation of PPAR subtypes appear to modulate the accumulation of cytoplasmic fat droplets that characterizes the sebocyte differentiation(1). It was also previously suggested that PPAR${\gamma}$ antagonist would seem possible to interfere sebum production without side effects (2). In this study we examined the diverse effects of the tested phospholipids on the expression of several PPAR genes based on reverse transcription-polymerase chain reaction (RT-PCR) from the topically treated skin of fuzzy rats. The results and possible implications are discussed.

• Proceedings of the Korea Database Society Conference
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• 1999.06a
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• pp.253-260
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• 1999

The recycling cell formation problem means that disposal products me classified into recycling part families using group technology in their end of life phase. Disposal products have the uncertainties of product status by usage influences during product use phase and recycling cells are formed design, process and usage attributes. In order to treat the uncertainties, fuzzy set theory and fuzzy logic-based neural network model are applied to recycling cell formation problem far disposal products. In this paper, a heuristic approach fuzzy ART neural network is suggested. The modified fuzzy ART neural network is shown that it has a great efficiency and give an extension for systematically generating alternative solutions in the recycling cell formation problem. We present the results of this approach applied to disposal refrigerators and the comparison of performances between other algorithms. This paper introduced a procedure which integrates economic and environmental factors into the disassembly of disposal products for recycling in recycling cells. A qualitative method of disassembly analysis is developed and its ai is to improve the efficiency of the disassembly and to generated an optimal disassembly which maximize profits and minimize environmental impact. Three criteria established to reduce the search space and facilitate recycling opportunities.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 1999.03a
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• pp.253-260
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• 1999

The recycling cell formation problem means that disposal products are classified into recycling part families using group technology in their end of life phase. Disposal products have the uncertainties of product status by usage influences during product use phase and recycling cells are formed design, process and usage attributes. In order to treat the uncertainties, fuzzy set theory and fuzzy logic-based neural network model are applied to recycling cell formation problem for disposal products. In this paper, a heuristic approach for fuzzy ART neural network is suggested. The modified Fuzzy ART neural network is shown that it has a great efficiency and give an extension for systematically generating alternative solutions in the recycling cell formation problem. We present the results of this approach applied to disposal refrigerators and the comparison of performances between other algorithms. This paper introduced a procedure which integrates economic and environmental factors into the disassembly of disposal products for recycling in recycling cells. A qualitative method of disassembly analysis is developed and its aim is to improve the efficiency of the disassembly and to generated an optimal disassembly which maximize profits and minimize environmental impact. Three criteria established to reduce the search space and facilitate recycling opportunities.

• International Journal of Control, Automation, and Systems
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• v.4 no.4
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• pp.438-447
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• 2006

Fuzzy controller's design depends mainly on the rule base and membership functions over the controller's input and output ranges. This paper presents two different approaches to deal with these design issues. A simple and efficient approach; namely, Fuzzy Subtractive Clustering is used to identify the rule base needed to realize Fuzzy PI and PD type controllers. This technique provides a mechanism to obtain the reduced rule set covering the whole input/output space as well as membership functions for each input variable. But it is found that some membership functions projected from different clusters have high degree of similarity. The number of membership functions of each input variable is then reduced using a similarity measure. In this paper, the fuzzy subtractive clustering approach is shown to reduce 49 rules to 8 rules and number of membership functions to 4 and 6 for input variables (error and change in error) maintaining almost the same level of performance. Simulation on a wide range of linear and nonlinear processes is carried out and results are compared with fuzzy PI and PD type controllers without clustering in terms of several performance measures such as peak overshoot, settling time, rise time, integral absolute error (IAE) and integral-of-time multiplied absolute error (ITAE) and in each case the proposed schemes shows an identical performance.